Seminars in Oncology Nursing最新文献

{"title":"Development and Validation of a Patient-Reported Outcome Measure to Assess the Impact of Steroids in the Treatment of Myeloma: The Steroid Symptom Questionnaire-Multiple Myeloma.","authors":"Tracy King, Louise Acret, Claudia Rutherford, Margaret-Ann Tait, Jacqueline Jagger, Julija Sipavicius, Georgia McCaughan, Douglas Joshua, Kate White","doi":"10.1016/j.soncn.2025.151943","DOIUrl":"https://doi.org/10.1016/j.soncn.2025.151943","url":null,"abstract":"<p><strong>Objectives: </strong>Steroids routinely used in the treatment of multiple myeloma (MM) are associated with adverse effects affecting health-related quality of life (HRQoL). No assessment tool existed to measure the impact of steroids in this population. We developed and psychometrically evaluated the Steroid Symptom Questionnaire-Multiple Myeloma (SSQ-MM).</p><p><strong>Methods: </strong>A conceptual framework for steroid-related PROs was developed through a systematic review and qualitative interviews. An existing tool was adapted and pretested with patients (n = 5), carers (n = 3), and clinicians (n = 9) for relevance and face validity. In field test 1, the draft-SSQ-MM was administered to 70 patients. Items were chosen based on item-level analysis for acceptability. In Field Test 2, the psychometric properties of the final SSQ-MM were assessed in 140 patients as part of a multicenter study. The SSQ-MM was administered alongside the EORTC QLQ-C30 and MY20, with the SSQ-MM administered again 1 week later.</p><p><strong>Results: </strong>The SSQ-MM contains 20 items. Stability reliability was supported (ICC = 0.846), and item-total correlations ranged between 0.266 and 0.677, excluding hiccups and blood glucose, which were retained due to clinical relevance. Exploratory factor analysis supported a total score and four multi-item subscales with acceptable internal consistency (α = 0.64 to 0.82). We found evidence of convergent and divergent validity between scales measuring similar and dissimilar constructs on QLQ-C30. The SSQ-MM total score was able to differentiate between patient groups clinically known to differ.</p><p><strong>Conclusions: </strong>The SSQ-MM provides a validated PROM for use in research and clinical settings to assess the impact of steroids and identify those who may benefit from dose reduction to improve PROs, including HRQoL.</p><p><strong>Implications for nursing practice: </strong>Integrating assessment of steroid adverse effects using the SSQ-MM into routine nursing care can help direct timely interventions or referrals to assist patients better manage the emotional and behavioural effects of steroids. Dose optimisation may reduce steroid effects and improve HRQoL.</p>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":" ","pages":"151943"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer Care for Refugees in Türkiye: Challenges and Achievements","authors":"Seda Güney ,&nbsp;Özlem Çiçek Doğan ,&nbsp;Gülcan Bağçivan","doi":"10.1016/j.soncn.2025.151879","DOIUrl":"10.1016/j.soncn.2025.151879","url":null,"abstract":"<div><h3>Objectives</h3><div>In Türkiye, which hosts over 3.6 million Syrian refugees seeking safety and stability, reducing inequalities in access to adequate cancer care is pivotal and multifaceted. This study aims to critically discuss cancer care provided for refugees in Türkiye, focusing on the barriers they face, and the progress in addressing these challenges.</div></div><div><h3>Method</h3><div>This discussion paper employs an environmental scan approach. Literature searches in both English and Turkish were conducted using databases Web of Science, PubMed, TR Dizin, and MEDLINE, focusing on keywords such as “refugees,” “cancer care,” and “immigrants.” Policy documents and regulations related to refugee health in Türkiye were also reviewed. The analysis incorporated information from official websites and online resources, including the Turkish Ministry of Health (MoH), Directorate General of Migration Management (DGMM), World Health Organization (WHO)United Nations High Commissioner for Refugees (UNHCR), United Nations Development Program (UNDP), and reports from the EU-funded SIHHAT Project. The Conceptual Framework for Health Service Use was utilized to structure the reporting and analysis of the literature, ensuring a comprehensive assessment of access to cancer care among refugees.</div></div><div><h3>Results</h3><div>Findings reveal multiple factors influence refugees' access to cancer care in Türkiye. Predisposing factors, such as language barriers, limited health literacy, and cultural beliefs about cancer, impact refugees’ willingness and ability to seek timely care. Enabling factors, including legal status, economic constraints, and availability of refugee-specific health services, significantly shape their access to diagnosis and treatment. Although policy reforms and community-based interventions aim to improve cancer care accessibility, need-based factors, such as delays in diagnosis and inadequate continuity of care, continue to hinder optimal healthcare utilization.</div></div><div><h3>Conclusion</h3><div>To ensure more inclusive cancer care, future strategies should focus on improving healthcare system navigation, strengthening financial and structural support, and enhancing the cultural competence of healthcare professionals. A comprehensive and sustainable approach is needed to bridge gaps and promote equitable cancer care access for all refugee populations.</div></div><div><h3>Implications for Nursing Practice</h3><div>Nurses are crucial in improving cancer care for refugees by providing culturally sensitive education, enhancing communication between patients and healthcare providers, and advocating for health policies that address refugees’ specific needs. Strengthening the role of nurses in multidisciplinary teams will further enhance the delivery of holistic and patient-centered cancer care for refugees.</div></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"41 3","pages":"Article 151879"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences in Recruitment for Hispanic, Non-Hispanic Black, and Other Non-White Cancer Survivors Through Community Outreach and Other Targeted Approaches","authors":"Memnun Seven ,&nbsp;Emefa Awo Adawudu ,&nbsp;Ann Marie Moraitis ,&nbsp;Brenda D Evans ,&nbsp;Susan Sturgeon ,&nbsp;Jennifer Wenzel ,&nbsp;Marilyn J. Hammer","doi":"10.1016/j.soncn.2024.151719","DOIUrl":"10.1016/j.soncn.2024.151719","url":null,"abstract":"<div><h3>Objectives</h3><div>Recruitment of racial/ethnic underserved populations in oncology research is essential to address health disparities. This article presents strategies and lessons learned from community outreach and other approaches for recruiting non-Hispanic Black, Hispanic, and other non-White survivors of cancer into a pilot study that investigated biopsychosocial determinants of health behaviors.</div></div><div><h3>Methods</h3><div>We critically examined the participant recruitment approaches to explore challenges and successful strategies and develop recommendations for future studies. Direct recruitment strategies included engaging with research staff members’ personal community contacts/liaisons and participating in community outreach events (eg, farmers’ markets, block parties, library events, cancer awareness events). Indirect recruitment strategies included posting and distribution of study flyers in community centers (eg, LIVESTRONG® at the YMCA, churches, libraries), online platforms (eg, FORCE, Survivor Journey website), and invitation letters sent to individuals identified as eligible through a single state cancer registry.</div></div><div><h3>Results</h3><div>Between April 2022 and May 2023, among the 64 individuals recruited, 36 were non-Hispanic Black, 25 were Hispanic, and three were American Indian/Alaska Native people. The use of a state cancer registry (64.1%), snowballing/word of mouth (7.8%), and advertisement through an established cancer support organization (ie, FORCE) website (7.8%) were the most effective strategies in this study.</div></div><div><h3>Conclusion</h3><div>Recruitment of non-Hispanic Black, Hispanic, and other non-White people into biobehavioral studies through community-engaged research is challenging and requires long-term commitment and engagement with partners from target communities and affiliated organizations.</div></div><div><h3>Implication for Nursing Practice</h3><div>Registries and community outreach events can build trust for successful enrollment. Using multiple strategies can provide the best opportunities to reach diverse populations and enroll them in cancer-related research studies.</div></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"41 3","pages":"Article 151719"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Cold Therapy on the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Oncology Patients: A Systematic Review Study","authors":"Zeliha Genç ,&nbsp;Ayda Kebapçı ,&nbsp;Gülbeyaz Can","doi":"10.1016/j.soncn.2025.151849","DOIUrl":"10.1016/j.soncn.2025.151849","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study was to investigate the effect of cold therapy on the prevention of chemotherapy-induced peripheral neuropathy in oncology patients.</div></div><div><h3>Methods</h3><div>This review was prepared based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes. The Medline, CINAHL, Embase, Cochrane Library, PubMed, Scopus and Web of Science databases were searched for studies published between January 1997 and June 2024. Two reviewers independently evaluated study suitability and extracted data. The Jadad critical appraisal scale and Methodological Index for Non-Randomized Studies (MINORS) risk of bias tool was used for quality assessment. The findings of this review are presented using a narrative synthesis.</div></div><div><h3>Results</h3><div>Overall, cold therapy was effective in preventing CIPN in more than half of the studies. Cold therapy methods such as cold hilotherapy, frozen gloves and socks, cold mitts and slippers, and cooling gloves/socks were found to be the most effective in six studies. In contrast, three studies that applied interventions like frozen gloves and socks, crushed ice, and various cooling methods did not show a significant effect.</div></div><div><h3>Conclusion</h3><div>Cold therapy was found to be a reasonable option for preventing CIPN in patients receiving taxane-based chemotherapy, as it does not result in serious side effects. Due to the heterogeneity of studies with different methods, sample sizes and measurement procedures for CIPN, it is difficult to make a clear statement about the duration and temperature of cold application that the patient can tolerate.</div></div><div><h3>Implications for Nursing Practice</h3><div>Cold therapy can provide a useful option for the prevention of CIPN in patients receiving taxane-based chemotherapy. Nurses should increase patient and provider awareness of the benefits of cold therapy for CIPN.</div></div><div><h3>PROSPERO registration ID</h3><div>CRD42024619942</div></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"41 3","pages":"Article 151849"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoting Equity in Cancer Care: A Nursing Priority for Overcoming Barriers","authors":"Ashleigh Ward,&nbsp;Memnun Seven,&nbsp;Gülcan Bagçivan,&nbsp;Amanda Drury","doi":"10.1016/j.soncn.2025.151900","DOIUrl":"10.1016/j.soncn.2025.151900","url":null,"abstract":"","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"41 3","pages":"Article 151900"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengthening Cancer Nursing Workforce to Overcome Inequities in Cancer Care for People Living in Remote, Border, and Outer Island Areas of Indonesia","authors":"Ariesta Milanti ,&nbsp;Arisda Oktalia ,&nbsp;Retno Purwanti ,&nbsp;Fialisa Asriwhardhani","doi":"10.1016/j.soncn.2025.151888","DOIUrl":"10.1016/j.soncn.2025.151888","url":null,"abstract":"<div><h3>Objectives</h3><div>Promoting equitable cancer care is a tremendous challenge in Indonesia. This report highlights the Indonesian government’s efforts to establish equitable cancer care service for people living in remote, border, and outer island areas in Indonesia and the aspects of cancer nursing workforce that support the agenda.</div></div><div><h3>Methods</h3><div>This opinion paper integrates the critical aspects of cancer nurses' strengthening into the Indonesian government’s policy on equitable cancer care. Insights were drawn from the situational analysis of the cancer nursing workforce and 1-year evaluation of the national cancer care referral network program. The program will enable every regency/city, including those in the remote areas of Indonesia, to deliver specialist cancer care.</div></div><div><h3>Results</h3><div>A significant expansion of cancer care services that also cover remote areas requires strengthening the local cancer nursing workforce. Nurses should be equipped with extra capacities in terms of clinical competencies, professional competencies, communication skills, cultural awareness, and community engagement skills to effectively serve people in remote areas.</div></div><div><h3>Conclusions</h3><div>Overcoming inequities in cancer care requires comprehensive policies and programs, with strengthening the nursing workforce as one of the foundational pillars.</div></div><div><h3>Implications for Nursing Practice</h3><div>Cancer nurses working in remote areas should seize the educational opportunities coming from the national cancer care program. On the other hand, cancer nurses from more developed regions in Indonesia should also play an active role as preceptors to those in the least developed regions.</div></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"41 3","pages":"Article 151888"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Interplay of Psycho-Social Determinants on Quality of Life and Health Behaviors Among Hispanic, Non-Hispanic Black Cancer Survivors","authors":"Memnun Seven ,&nbsp;Ann Marie Moraitis ,&nbsp;Jessica Pearlman ,&nbsp;Allecia E. Reid ,&nbsp;Susan Sturgeon ,&nbsp;Jennifer Wenzel ,&nbsp;Marilyn J. Hammer","doi":"10.1016/j.soncn.2024.151698","DOIUrl":"10.1016/j.soncn.2024.151698","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to explore psycho-social factors (i.e., socio-demographics, health insurance, stress) associated with Quality of life (QOL) and the degree to which self-reported access to healthcare and health behaviors (i.e., fruit and vegetable consumption, physical activity) mediate the effects of psycho-social factors on QOL among Hispanic, non-Hispanic Black (NHB), and other non-White cancer survivors.</div></div><div><h3>Methods</h3><div>The descriptive cross-sectional study enrolled a total of 74 Hispanic (<em>n</em> = 26), NHB (<em>n</em> = 42), and other non-White (<em>n</em> = 6) people affected by cancer. QOL, physical activity, diet, stress, and survivorship care data were collected prospectively between June 2022-September 2023.</div></div><div><h3>Results</h3><div>The mean scores of QOL were moderate for global health (59.4 ± 21.4) and functional status (64.8 ± 22.2) and low for symptom experience (33.6 ± 19.4). Of the participants, 35.1% (<em>n</em> = 24) reported at least one challenge in accessing healthcare. The average daily consumption of fruits and vegetables was 2.44 ± 0.61 cup equivalents. Most participants had insufficient (37.8%) or minimal (47.3%) engagement in physical activity. Men and those with higher stress levels reported lower global health status. Higher stress level was associated with an increased likelihood of lower physical activity. Private insurance and some college education were associated with an increased likelihood of consuming more fruit and vegetables. Self-reported access to healthcare did not mediate the association between any of the variables and the global health score of QOL.</div></div><div><h3>Conclusions</h3><div>Hispanic, NHB and other non-White cancer survivors had moderate global health and functional status with lower symptom burden. Further research with a large sample is needed to explore the associations between health behaviors, access to care challenges, and other factors that may better explain determinants of QOL among non-White cancer survivors.</div></div><div><h3>Implications for Nursing Practice</h3><div>Findings suggest that tailored interventions should consider the interplay of psychosocial determinants to optimize health behaviors and QOL.</div></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"41 3","pages":"Article 151698"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatigue Scale for Children With Cancer: A Systematic Review and Reliability Generalization Meta-analysis","authors":"Hyejung Lee ,&nbsp;Yoojin Kim ,&nbsp;Sumi Oh ,&nbsp;Chang-gi Park ,&nbsp;Hyunsoo Kim","doi":"10.1016/j.soncn.2025.151885","DOIUrl":"10.1016/j.soncn.2025.151885","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to evaluate the overall reliability of the Fatigue Scale, the most widely used instrument for assessing fatigue severity in paediatric oncology patients, and to identify factors influencing the magnitude of reliability estimates.</div></div><div><h3>Methods</h3><div>PubMed, CINAHL, PsycINFO, Medline, Scopus, Embase, and Google Scholar were systematically searched. From an initial 492 articles identified, 21 were selected for the final analysis. Reliability generalization meta-analyses were performed using Cronbach's alpha extracted from individual studies. A random-effects model was applied for the analysis.</div></div><div><h3>Results</h3><div>Most studies employed a cross-sectional design to assess fatigue symptoms in children and adolescents with various types of cancer. The mean weighted effect size for the total sample (n = 3,750) was 0.915 (95% CI = [0.888, 0.934]). A diagnosis of leukaemia/lymphoma was a significant moderator in the parent sample (effect estimate = 0.003, <em>P</em> &lt; .01), while the use of a language other than English significantly moderated reliability in both the parent (effect estimate = 0.301, <em>P</em> &lt; .01) and staff (effect estimate = –0.306, <em>P</em> &lt; .01) samples.</div></div><div><h3>Conclusions</h3><div>The Fatigue Scale is a highly reliable tool for assessing fatigue symptoms across different paediatric oncology populations. However, the reliability of the scale may be influenced by a diagnosis of leukaemia/lymphoma in children and language translation when used by parents and staff, requiring careful consideration when comparing and interpreting results.</div></div><div><h3>Implications for Nursing Practice</h3><div>A reliable tool, the Fatigue Scale, is crucial for guiding clinical nurses and researchers. They can adopt the scale to assess the effects of an intervention aimed at relieving fatigue in paediatric oncology patients.</div></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"41 3","pages":"Article 151885"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Does Family Function Affect the Activation Of patients With Cancer Anorexia Undergoing Chemotherapy? A Mixed Methods Study","authors":"Hongyue Zhong ,&nbsp;Fangyi Li ,&nbsp;Tian Xiao ,&nbsp;Chunmei Liu ,&nbsp;Qing Li ,&nbsp;Li Li ,&nbsp;Ruihan Xiao ,&nbsp;Linyu Zhou ,&nbsp;Xueqin Qiu ,&nbsp;Xiaoju Chen","doi":"10.1016/j.soncn.2025.151904","DOIUrl":"10.1016/j.soncn.2025.151904","url":null,"abstract":"<div><h3>Objective</h3><div>To understand the current status of patient activation among chemotherapy patients with Cancer-related Anorexia (CA) and explore the relationship between family function, negative emotions, and patient activation. Additionally, to clarify patients’ experiences in self-management and examine how family function influences their activation in disease management.</div></div><div><h3>Methods</h3><div>A total of 302 chemotherapy patients with CA participated in the questionnaire survey. The investigation utilized a general information questionnaire, the Patient Activation Measure, the Hospital Anxiety and Depression Scale, and the Family Care Index Questionnaire. Based on the quantitative research, qualitative research was conducted, involving semi-structured interviews with 16 chemotherapy patients with CA.</div></div><div><h3>Results</h3><div>The patient activation score for chemotherapy patients with CA was 66.08 ± 13.70, indicating a moderate level. Structural equation modeling analysis revealed that anxiety and depression acting as partial mediators between family function and patient activation. Interview results identified 3 main barriers to patient activation among chemotherapy patients with CA: (1) lack of self-management knowledge, (2) inadequate self-management behaviors, and (3) intrusion of negative emotions. Additionally, family function was found to promote patient activation through 2 key themes: (1) positive family adjustment and (2) a closer overall family atmosphere.</div></div><div><h3>Conclusions</h3><div>By integrating quantitative and qualitative evidence, this study uncovers the multifaceted processes shaping patient activation among individuals undergoing chemotherapy with CA. Family function emerges as a critical factor in both emotional regulation and the enhancement of patient activation.</div></div><div><h3>Implications for nursing practice</h3><div>The findings can guide healthcare professionals in helping chemotherapy patients with CA to identify the strengths and resources within family support, fully harnessing the role of family function to enhance patient activation.</div></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"41 3","pages":"Article 151904"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Experience of Patients with Cancer and Their Informal Caregivers Related to Adoptive Cell Therapy: A Qualitative Systematic Review.","authors":"Nina Canova, Kylie Teggart, Alexia Cavin-Trombert, Manuela Eicher, Francesca Bosisio, Sara Colomer-Lahiguera","doi":"10.1016/j.soncn.2025.151912","DOIUrl":"https://doi.org/10.1016/j.soncn.2025.151912","url":null,"abstract":"<p><strong>Objectives: </strong>Adoptive cell therapy (ACT) is a growing personalized immuno-oncology approach, delivered both in standard of care (SOC) and clinical trial (CT) settings. Understanding patient and informal caregivers (ICs) experiences is crucial to optimizing care. This qualitative systematic review explores the ACT experience across three elements: actors (patients and ICs), settings (CT and SOC), and phases of the care continuum.</p><p><strong>Methods: </strong>A systematic search was conducted across Medline, Embase, CINAHL, APA PsycInfo, Cochrane, Web of Science, ProQuest Dissertations & Theses, and Google Scholar up to May 8, 2024. Studies were appraised using the JBI Critical Appraisal Checklist for Qualitative Research, with data extracted and synthesized using a meta-aggregation approach. MAXQDA was used to generate co-occurrence networks between key elements and inductively derived codes. A comparative sentiment analysis highlighted emotional differences between CT and SOC settings.</p><p><strong>Results: </strong>Nineteen qualitative studies were included, capturing experiences of patients (n = 19) and ICs (n = 7) receiving chimeric antigen receptor T cell (n = 17) and tumor-infiltrating lymphocyte (n = 2) therapy in CT (n = 13) and SOC (n = 9) settings. Findings revealed phase-specific challenges across physical, cognitive, psychological, emotional, social, financial, professional, communication, and informational domains. These challenges originate from ACT-related toxicities, care pathway complexity, and the novel nature of the therapy.</p><p><strong>Conclusions: </strong>This review identifies the key challenges faced by patients and ICs throughout the ACT care pathway, emphasizing the need for tailored interventions based on the phase and setting, as well as improved support systems.</p><p><strong>Implications for nursing practices: </strong>Recommended strategies include developing decision support tools, establishing caregiver support programs, and implementing navigation services to enhance patient and ICs experiences.</p>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":" ","pages":"151912"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}