Pulmonology最新文献

{"title":"Physiotherapists in intensive care units: Where are we?","authors":"F. Ramalho , A. Oliveira , A. Machado , V. Azevedo , M.R. Gonçalves , G. Ntoumenopoulos , A. Marques","doi":"10.1016/j.pulmoe.2024.02.004","DOIUrl":"10.1016/j.pulmoe.2024.02.004","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":null,"pages":null},"PeriodicalIF":10.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043724000163/pdfft?md5=8d86ee388cd497115984c5c866f76dd8&pid=1-s2.0-S2531043724000163-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139984491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical usefulness of serum angiotensin converting enzyme in silicosis","authors":"J. Blanco-Pérez ,&nbsp;Á. Salgado-Barreira ,&nbsp;S. Blanco-Dorado ,&nbsp;M.E. González Bello ,&nbsp;A.C. Caldera Díaz ,&nbsp;A. Pérez-Gonzalez ,&nbsp;A. Pallarés Sanmartín ,&nbsp;A. Fernández Villar ,&nbsp;F.J. Gonzalez-Barcala","doi":"10.1016/j.pulmoe.2022.06.002","DOIUrl":"10.1016/j.pulmoe.2022.06.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Silicosis is an irreversible and incurable disease. Preventive measures to eliminate exposure are the only effective way to reduce morbidity and mortality. In such situations, having a biomarker for early diagnosis or to predict evolution would be very useful in order to improve control of the disease. The elevation of serum angiotensin-converting enzyme (sACE) in silicosis has been described in previous studies, although its relationship with severity and prognosis is not clear.</p></div><div><h3>Aims</h3><p>To determine the levels of sACE in a cohort of patients with exposure to silica dust with and without silicosis, and to assess their impact on the prognosis of the aforementioned patients.</p></div><div><h3>Method</h3><p>Prospective observational study on patients treated in a silicosis clinic from 2009 to 2018. sACE levels and pulmonary function tests were performed. Radiological progression was assessed in patients who had already had 2 X-rays of the thorax and / or two CT scans with at least a 1-year interval, from the time of inclusion in the study.</p></div><div><h3>Results</h3><p>A total of 413 cases of silicosis were confirmed, as well as 73 with exposure to silica dust but without silicosis. The mean sACE level for healthy subjects was 27.5±7.3U/L, for exposed patients without silicosis it was 49.6±24.2U/L, for simple silicosis it was 57.8±31,3U/L and for complicated silicosis it was 74.5±38.6U/L. Patients with a higher sACE generally progressed radiologically during follow-up (73.3±38.0 vs. 60.4±33.7; <em>p</em>&lt;.001) and so the category of silicosis changed (73,9±38.1 vs. 62.5±34.6; <em>p</em>&lt;.021).</p></div><div><h3>Conclusions</h3><p>sACE was elevated in patients with silicosis, and the greater its severity, the higher it was, which is associated with disease progression measured radiologically or as a category change of silicosis.</p></div>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":null,"pages":null},"PeriodicalIF":10.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043722001301/pdfft?md5=86d12652d0b79a78b6bb1a9fb6875294&pid=1-s2.0-S2531043722001301-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40656080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are we overlooking the lung function in the definition of severe asthma remission?","authors":"S. Nolasco ,&nbsp;R. Campisi ,&nbsp;N. Crimi ,&nbsp;C. Crimi","doi":"10.1016/j.pulmoe.2023.11.004","DOIUrl":"10.1016/j.pulmoe.2023.11.004","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":null,"pages":null},"PeriodicalIF":10.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043723002027/pdfft?md5=7bb8535e4b758819550ae731efc84a0a&pid=1-s2.0-S2531043723002027-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139024102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproducibility, validity, and reliability of the incremental step test for subjects with moderate to severe asthma","authors":"R.C.C. Barbosa ,&nbsp;R.A. Silva ,&nbsp;A.C. Lunardi ,&nbsp;S.T.C. Silva ,&nbsp;S.D. Corso ,&nbsp;A.J. Fonseca ,&nbsp;R. Stelmach ,&nbsp;C.R.F. Carvalho","doi":"10.1016/j.pulmoe.2022.02.002","DOIUrl":"10.1016/j.pulmoe.2022.02.002","url":null,"abstract":"<div><h3>Objective</h3><p>We investigated the measurement properties of the incremental step test in subjects with moderate to severe asthma.</p></div><div><h3>Methods</h3><p>Subjects with moderate to severe persistent asthma were recruited from a tertiary university hospital specializing in treating severe asthma. All subjects performed one cardiopulmonary exercise test (CPET) and two incremental step tests (IST) in random sequences. Pulmonary gas exchange was measured during all exercise tests. The measurement properties investigated were reliability by intraclass correlation coefficient (ICC), measurement error by the standard error of measurement and minimum detectable difference, construct validity by Pearson's correlation, and interpretability by the ceiling and floor effects.</p></div><div><h3>Results</h3><p>Fifty subjects (38 females, mean [SD], age 43.7 [11.6] yr, % FEV₁ 70 [14.3], BMI 28.5 [5.3] kg/m²) completed the study. The peak oxygen uptake (peak VO₂) for the CPET was 27.6 [±6.8] ml/kg/min, for the first IST was 22.3 [±5.3] ml/kg/min and for the second IST was 23.3 [±5.3] ml/kg/min. The IST presented excellent reliability (ICC=0.93, CI95% 0.88-0.96), very good measurement error (2.5%), and construct validity for peak VO₂ measurement compared to the CPET (<em>r</em> = 0.85; <em>p</em> &lt; 0.001) to assess exercise capacity in subjects with moderate to severe asthma, with appropriate ceiling (10%) and floor (0%) effects.</p></div><div><h3>Conclusion</h3><p>The IST presented excellent reliability and very good measurement error and validity to assess exercise capacity in subjects with moderate to severe asthma, without ceiling or floor effects.</p></div>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":null,"pages":null},"PeriodicalIF":10.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043722000290/pdfft?md5=3bcef3d33db67e1b3a205ce1687f7cfe&pid=1-s2.0-S2531043722000290-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76744278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mould exposure and COPD outcomes: Association or causation?","authors":"Hiroshi Ito","doi":"10.1016/j.pulmoe.2023.10.001","DOIUrl":"10.1016/j.pulmoe.2023.10.001","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":null,"pages":null},"PeriodicalIF":10.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043723001927/pdfft?md5=d1635319b0e3f15b3eb8cdebb9fcab8e&pid=1-s2.0-S2531043723001927-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138435392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue 2 - “Update on adverse respiratory effects of indoor air pollution” Part 1): Indoor air pollution and respiratory diseases: A general update and a Portuguese perspective","authors":"J.C. Rufo ,&nbsp;I. Annesi-Maesano ,&nbsp;P. Carreiro-Martins ,&nbsp;A. Moreira ,&nbsp;A.C. Sousa ,&nbsp;M.R. Pastorinho ,&nbsp;N. Neuparth ,&nbsp;L. Taborda-Barata","doi":"10.1016/j.pulmoe.2023.03.006","DOIUrl":"10.1016/j.pulmoe.2023.03.006","url":null,"abstract":"<div><h3>Objective</h3><p>To quantify the impact of different air pollutants on respiratory health based on robust estimates based on international data and to summarise the evidence of associations between indoor exposure to those pollutants and respiratory morbidity in the Portuguese population.</p></div><div><h3>Results</h3><p>Several systematic reviews and meta-analyses (MA) at the world level demonstrate the impact of indoor air quality on respiratory health, with indoor particulate matter and gasses exerting a significant effect on the airways. Volatile organic compounds (VOC) have been related to asthma and lung cancer. However, only meta-analyses on biomass use allowed documentation of long-term respiratory effects. While early publications concerning Portuguese-based populations mainly focused on indoor exposure to environmental tobacco smoke, later studies relocated the attention to relevant exposure environments, such as day care buildings, schools, residences and nursing homes. Looking at the pooled effects from the reviewed studies, high levels of carbon dioxide and particulate matter in Portuguese buildings were significantly associated with asthma and wheezing, with VOC and fungi showing a similar effect in some instances.</p></div><div><h3>Conclusions</h3><p>Despite the significant reduction of indoor air pollution effects after the 2008 indoor smoking prohibition in public buildings, studies show that several indoor air parameters are still significantly associated with respiratory health in Portugal. The country shares the worldwide necessity of standardisation of methods and contextual data to increase the reach of epidemiological studies on household air pollution, allowing a weighted evaluation of interventions and policies focused on reducing the associated respiratory morbidity.</p></div>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":null,"pages":null},"PeriodicalIF":10.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043723000855/pdfft?md5=336c51d404a275ab2c3d70002b5bd019&pid=1-s2.0-S2531043723000855-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9524134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of 5 weeks of oral acetazolamide on patients with pulmonary vascular disease: A randomized, double-blind, cross-over trial","authors":"M. Lichtblau ,&nbsp;S. Saxer ,&nbsp;J. Müller ,&nbsp;P. Appenzeller ,&nbsp;C. Berlier ,&nbsp;S.R. Schneider ,&nbsp;L. Mayer ,&nbsp;M. Furian ,&nbsp;E.I. Schwarz ,&nbsp;E.R. Swenson ,&nbsp;K.E. Bloch ,&nbsp;S. Ulrich","doi":"10.1016/j.pulmoe.2022.11.004","DOIUrl":"10.1016/j.pulmoe.2022.11.004","url":null,"abstract":"<div><h3>Background</h3><p>The carbonic anhydrase inhibitor acetazolamide stimulates ventilation through metabolic acidosis mediated by renal bicarbonate excretion. In animal models, acetazolamide attenuates acute hypoxia-induced pulmonary hypertension (PH), but its efficacy in treating patients with PH due to pulmonary vascular disease (PVD) is unknown.</p></div><div><h3>Methods</h3><p>28 PVD patients (15 pulmonary arterial hypertension, 13 distal chronic thromboembolic PH), 13 women, mean±SD age 61.6±15.0 years stable on PVD medications, were randomised in a double-blind crossover protocol to 5 weeks acetazolamide (250mg b.i.d) or placebo separated by a ≥2 week washout period. Primary endpoint was the change in 6-minute walk distance (6MWD) at 5 weeks. Additional endpoints included safety, tolerability, WHO functional class, quality of life, arterial blood gases, and hemodynamics (by echocardiography).</p></div><div><h3>Results</h3><p>Acetazolamide had no effect on 6MWD compared to placebo (treatment effect: mean change [95%CI] -18 [-40 to 4]m, p=0.102) but increased arterial blood oxygenation through hyperventilation induced by metabolic acidosis. Other measures including pulmonary hemodynamics were unchanged. No severe adverse effects occurred, side effects that occurred significantly more frequently with acetazolamide vs. placebo were change in taste (22/0%), paraesthesia (37/4%) and mild dyspnea (26/4%).</p></div><div><h3>Conclusions</h3><p>In patients with PVD, acetazolamide did not change 6MWD compared to placebo despite improved blood oxygenation. Some patients reported a tolerable increase in dyspnoea during acetazolamide treatment, related to hyperventilation, induced by the mild drug-induced metabolic acidosis. Our findings do not support the use of acetazolamide to improve exercise in patients with PVD at this dosing.</p></div><div><h3>ClinicalTrials.gov Identifier</h3><p>NCT02755298</p></div>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":null,"pages":null},"PeriodicalIF":10.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043722002628/pdfft?md5=82004c4d139febe713929a0ef3b88629&pid=1-s2.0-S2531043722002628-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10526778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of thoracic surgery training in the Iberian Peninsula: A call for European uniformity","authors":"Álvaro Fuentes-Martín ,&nbsp;Luís Lourenço Graça","doi":"10.1016/j.pulmoe.2024.01.004","DOIUrl":"10.1016/j.pulmoe.2024.01.004","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":null,"pages":null},"PeriodicalIF":10.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043724000102/pdfft?md5=7b6d6182fdf0837921847f727333c866&pid=1-s2.0-S2531043724000102-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140307811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehabilitation and physiotherapists in the critical care medicine.","authors":"E Clini, S Costi, M Girardis","doi":"10.1016/j.pulmoe.2024.04.006","DOIUrl":"https://doi.org/10.1016/j.pulmoe.2024.04.006","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posters","authors":"","doi":"10.1016/S2531-0437(24)00118-1","DOIUrl":"10.1016/S2531-0437(24)00118-1","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":null,"pages":null},"PeriodicalIF":10.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043724001181/pdfft?md5=3e928808414aa5ac7067dc28e575f985&pid=1-s2.0-S2531043724001181-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142230681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}