Pulmonology最新文献

{"title":"Regarding the prognostic factors in patients with ALK-positive non-small cell lung cancer treated with crizotinib","authors":"Limei Hu , Youjun Xie , Hongying Zhao","doi":"10.1016/j.pulmoe.2024.02.007","DOIUrl":"10.1016/j.pulmoe.2024.02.007","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 4","pages":"Pages 406-407"},"PeriodicalIF":10.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043724000199/pdfft?md5=8ee48f5a07ad4c0dd58d049fc6635268&pid=1-s2.0-S2531043724000199-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139944691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there any physiological reason to train expiratory muscles in people with mild COPD?","authors":"M. Paneroni , M. Vitacca , B. Salvi , C. Simonelli , M. Arici , N. Ambrosino","doi":"10.1016/j.pulmoe.2024.04.004","DOIUrl":"10.1016/j.pulmoe.2024.04.004","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 4","pages":"Pages 393-396"},"PeriodicalIF":10.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043724000497/pdfft?md5=4c66e6180038134f8798c55625023a2f&pid=1-s2.0-S2531043724000497-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140856961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic role of internal mammary lymph node involvement in tuberculous pleurisy: a multicenter study","authors":"G. Levi ,&nbsp;C. Rocchetti ,&nbsp;F. Mei ,&nbsp;G.M. Stella ,&nbsp;S. Lettieri ,&nbsp;F. Lococo ,&nbsp;F. Taccari ,&nbsp;C. Seguiti ,&nbsp;M. Fantoni ,&nbsp;F. Natali ,&nbsp;P. Candoli ,&nbsp;C. Bortolotto ,&nbsp;V. Pinelli ,&nbsp;M. Mondoni ,&nbsp;P. Carlucci ,&nbsp;A. Fabbri ,&nbsp;M Trezzi ,&nbsp;L. Vannucchi ,&nbsp;M. Bonifazi ,&nbsp;F. Porcarelli ,&nbsp;G.P. Marchetti","doi":"10.1016/j.pulmoe.2022.01.010","DOIUrl":"10.1016/j.pulmoe.2022.01.010","url":null,"abstract":"<div><h3>Background and objectives</h3><p>Diagnosis of tuberculous pleurisy (TP) may be challenging and it often requires pleural biopsy. A tool able to increase pre-test probability of TP may be helpful to guide diagnostic work-up and enlargement of internal mammary lymph node (IMLN) has been suggested to play a potential role.</p><p>The aim of the present investigation was to assess role of IMLN involvement in TP in a multi-centric case-control study, by comparing its prevalence and test performance to those observed in patients with infectious, non-tuberculous pleurisy (NTIP), and in controls free from respiratory diseases (CP).</p></div><div><h3>Methods</h3><p>A total of 419 patients, from 14 Pulmonology Units across Italy were enrolled (127 patients affected by TP, 163 affected by NTIP and 129 CP). Prevalence, accuracy and predictive values of ipsilateral IMLN involvement between cases and control groups were assessed, as well as concordance between chest computed tomography (CT scan) and thoracic ultrasound (TUS) measurements.</p></div><div><h3>Results</h3><p>The prevalence of ipsilateral IMLN involvement in TP was significantly higher than that observed in NTIP and CP groups (respectively 77.2%, 39.3% and 14.7%). Results on test performance, stratified by age, revealed a high positive predictive value in patients aged ≤50 years, while a high negative predictive value in patients aged &gt;50 years. The comparison between CT scan and ultrasound showed moderate agreement (Kappa=0.502).</p></div><div><h3>Conclusions</h3><p>Evaluation of IMLN involvement plays a relevant role in assessing the pre-test probability of TP. Considering the increasing global prevalence of mycobacterial infections, a tool able to guide diagnostic work-up of suspected TP is crucial, especially where local sources are limited.</p></div>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 4","pages":"Pages 330-336"},"PeriodicalIF":10.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043722000228/pdfft?md5=b60ab61f62b399c1b7c51c33e4655723&pid=1-s2.0-S2531043722000228-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39652009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary embolism recurrence diagnosed by endobronchial ultrasound","authors":"A. Bugalho","doi":"10.1016/j.pulmoe.2023.12.004","DOIUrl":"10.1016/j.pulmoe.2023.12.004","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 4","pages":"Pages 410-411"},"PeriodicalIF":10.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043723002428/pdfft?md5=30a509d71584fde274aa1a2992d981d3&pid=1-s2.0-S2531043723002428-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139106813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiotherapists in intensive care units: Where are we?","authors":"F. Ramalho ,&nbsp;A. Oliveira ,&nbsp;A. Machado ,&nbsp;V. Azevedo ,&nbsp;M.R. Gonçalves ,&nbsp;G. Ntoumenopoulos ,&nbsp;A. Marques","doi":"10.1016/j.pulmoe.2024.02.004","DOIUrl":"10.1016/j.pulmoe.2024.02.004","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 4","pages":"Pages 319-323"},"PeriodicalIF":10.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043724000163/pdfft?md5=8d86ee388cd497115984c5c866f76dd8&pid=1-s2.0-S2531043724000163-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139984491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical usefulness of serum angiotensin converting enzyme in silicosis","authors":"J. Blanco-Pérez ,&nbsp;Á. Salgado-Barreira ,&nbsp;S. Blanco-Dorado ,&nbsp;M.E. González Bello ,&nbsp;A.C. Caldera Díaz ,&nbsp;A. Pérez-Gonzalez ,&nbsp;A. Pallarés Sanmartín ,&nbsp;A. Fernández Villar ,&nbsp;F.J. Gonzalez-Barcala","doi":"10.1016/j.pulmoe.2022.06.002","DOIUrl":"10.1016/j.pulmoe.2022.06.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Silicosis is an irreversible and incurable disease. Preventive measures to eliminate exposure are the only effective way to reduce morbidity and mortality. In such situations, having a biomarker for early diagnosis or to predict evolution would be very useful in order to improve control of the disease. The elevation of serum angiotensin-converting enzyme (sACE) in silicosis has been described in previous studies, although its relationship with severity and prognosis is not clear.</p></div><div><h3>Aims</h3><p>To determine the levels of sACE in a cohort of patients with exposure to silica dust with and without silicosis, and to assess their impact on the prognosis of the aforementioned patients.</p></div><div><h3>Method</h3><p>Prospective observational study on patients treated in a silicosis clinic from 2009 to 2018. sACE levels and pulmonary function tests were performed. Radiological progression was assessed in patients who had already had 2 X-rays of the thorax and / or two CT scans with at least a 1-year interval, from the time of inclusion in the study.</p></div><div><h3>Results</h3><p>A total of 413 cases of silicosis were confirmed, as well as 73 with exposure to silica dust but without silicosis. The mean sACE level for healthy subjects was 27.5±7.3U/L, for exposed patients without silicosis it was 49.6±24.2U/L, for simple silicosis it was 57.8±31,3U/L and for complicated silicosis it was 74.5±38.6U/L. Patients with a higher sACE generally progressed radiologically during follow-up (73.3±38.0 vs. 60.4±33.7; <em>p</em>&lt;.001) and so the category of silicosis changed (73,9±38.1 vs. 62.5±34.6; <em>p</em>&lt;.021).</p></div><div><h3>Conclusions</h3><p>sACE was elevated in patients with silicosis, and the greater its severity, the higher it was, which is associated with disease progression measured radiologically or as a category change of silicosis.</p></div>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 4","pages":"Pages 370-377"},"PeriodicalIF":10.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043722001301/pdfft?md5=86d12652d0b79a78b6bb1a9fb6875294&pid=1-s2.0-S2531043722001301-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40656080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are we overlooking the lung function in the definition of severe asthma remission?","authors":"S. Nolasco ,&nbsp;R. Campisi ,&nbsp;N. Crimi ,&nbsp;C. Crimi","doi":"10.1016/j.pulmoe.2023.11.004","DOIUrl":"10.1016/j.pulmoe.2023.11.004","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 4","pages":"Pages 324-326"},"PeriodicalIF":10.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043723002027/pdfft?md5=7bb8535e4b758819550ae731efc84a0a&pid=1-s2.0-S2531043723002027-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139024102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproducibility, validity, and reliability of the incremental step test for subjects with moderate to severe asthma","authors":"R.C.C. Barbosa ,&nbsp;R.A. Silva ,&nbsp;A.C. Lunardi ,&nbsp;S.T.C. Silva ,&nbsp;S.D. Corso ,&nbsp;A.J. Fonseca ,&nbsp;R. Stelmach ,&nbsp;C.R.F. Carvalho","doi":"10.1016/j.pulmoe.2022.02.002","DOIUrl":"10.1016/j.pulmoe.2022.02.002","url":null,"abstract":"<div><h3>Objective</h3><p>We investigated the measurement properties of the incremental step test in subjects with moderate to severe asthma.</p></div><div><h3>Methods</h3><p>Subjects with moderate to severe persistent asthma were recruited from a tertiary university hospital specializing in treating severe asthma. All subjects performed one cardiopulmonary exercise test (CPET) and two incremental step tests (IST) in random sequences. Pulmonary gas exchange was measured during all exercise tests. The measurement properties investigated were reliability by intraclass correlation coefficient (ICC), measurement error by the standard error of measurement and minimum detectable difference, construct validity by Pearson's correlation, and interpretability by the ceiling and floor effects.</p></div><div><h3>Results</h3><p>Fifty subjects (38 females, mean [SD], age 43.7 [11.6] yr, % FEV₁ 70 [14.3], BMI 28.5 [5.3] kg/m²) completed the study. The peak oxygen uptake (peak VO₂) for the CPET was 27.6 [±6.8] ml/kg/min, for the first IST was 22.3 [±5.3] ml/kg/min and for the second IST was 23.3 [±5.3] ml/kg/min. The IST presented excellent reliability (ICC=0.93, CI95% 0.88-0.96), very good measurement error (2.5%), and construct validity for peak VO₂ measurement compared to the CPET (<em>r</em> = 0.85; <em>p</em> &lt; 0.001) to assess exercise capacity in subjects with moderate to severe asthma, with appropriate ceiling (10%) and floor (0%) effects.</p></div><div><h3>Conclusion</h3><p>The IST presented excellent reliability and very good measurement error and validity to assess exercise capacity in subjects with moderate to severe asthma, without ceiling or floor effects.</p></div>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 4","pages":"Pages 344-351"},"PeriodicalIF":10.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043722000290/pdfft?md5=3bcef3d33db67e1b3a205ce1687f7cfe&pid=1-s2.0-S2531043722000290-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76744278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mould exposure and COPD outcomes: Association or causation?","authors":"Hiroshi Ito","doi":"10.1016/j.pulmoe.2023.10.001","DOIUrl":"10.1016/j.pulmoe.2023.10.001","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 4","pages":"Pages 408-409"},"PeriodicalIF":10.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043723001927/pdfft?md5=d1635319b0e3f15b3eb8cdebb9fcab8e&pid=1-s2.0-S2531043723001927-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138435392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue 2 - “Update on adverse respiratory effects of indoor air pollution” Part 1): Indoor air pollution and respiratory diseases: A general update and a Portuguese perspective","authors":"J.C. Rufo ,&nbsp;I. Annesi-Maesano ,&nbsp;P. Carreiro-Martins ,&nbsp;A. Moreira ,&nbsp;A.C. Sousa ,&nbsp;M.R. Pastorinho ,&nbsp;N. Neuparth ,&nbsp;L. Taborda-Barata","doi":"10.1016/j.pulmoe.2023.03.006","DOIUrl":"10.1016/j.pulmoe.2023.03.006","url":null,"abstract":"<div><h3>Objective</h3><p>To quantify the impact of different air pollutants on respiratory health based on robust estimates based on international data and to summarise the evidence of associations between indoor exposure to those pollutants and respiratory morbidity in the Portuguese population.</p></div><div><h3>Results</h3><p>Several systematic reviews and meta-analyses (MA) at the world level demonstrate the impact of indoor air quality on respiratory health, with indoor particulate matter and gasses exerting a significant effect on the airways. Volatile organic compounds (VOC) have been related to asthma and lung cancer. However, only meta-analyses on biomass use allowed documentation of long-term respiratory effects. While early publications concerning Portuguese-based populations mainly focused on indoor exposure to environmental tobacco smoke, later studies relocated the attention to relevant exposure environments, such as day care buildings, schools, residences and nursing homes. Looking at the pooled effects from the reviewed studies, high levels of carbon dioxide and particulate matter in Portuguese buildings were significantly associated with asthma and wheezing, with VOC and fungi showing a similar effect in some instances.</p></div><div><h3>Conclusions</h3><p>Despite the significant reduction of indoor air pollution effects after the 2008 indoor smoking prohibition in public buildings, studies show that several indoor air parameters are still significantly associated with respiratory health in Portugal. The country shares the worldwide necessity of standardisation of methods and contextual data to increase the reach of epidemiological studies on household air pollution, allowing a weighted evaluation of interventions and policies focused on reducing the associated respiratory morbidity.</p></div>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 4","pages":"Pages 378-389"},"PeriodicalIF":10.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043723000855/pdfft?md5=336c51d404a275ab2c3d70002b5bd019&pid=1-s2.0-S2531043723000855-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9524134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}