Alexander Müller, Emiel F M Wouters, Peter Burney, James Potts, Joao Cardoso, Mohammed Al Ghobain, Michael Studnicka, Daniel Obaseki, Asma Elsony, Kevin Mortimer, David Mannino, Rain Jõgi, Rana Ahmed, Asaad Nafees, Maria Fatima Rodrigues, Cristina Bárbara, Rune Nielsen, Thorarinn Gíslason, Hamid Hacene Cherkaski, Karima El Rhazi, Christer Janson, Mahesh Padukudru Anand, Sanjay Juvekar, Herminia Brites Dias, Frits M E Franssen, Dhiraj Agarwal, Sylvia Hartl, Terence Seemungal, Stefanni Nonna Paraguas, Imed Harrabi, Meriam Denguezli, Abdul Rashid, Gregory Erhabor, Mohammed El Biaze, Parvaiz Koul, Daisy J A Janssen, André F S Amaral
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引用次数: 0
Abstract
Introduction: Evidence of an association between breathlessness and quality of life from population-based studies is limited. We aimed to investigate the association of both physical and mental quality of life with breathlessness across several low-, middle- and high-income countries.
Methods: We analysed data from 19 714 adults (31 sites, 25 countries) from the Burden of Obstructive Lung Disease (BOLD) study. We measured both mental and physical quality of life components using the SF-12 questionnaire, and defined breathlessness as grade ≥2 on the modified Medical Research Council scale. We used multivariable linear regression to assess the association of each quality-of-life component with breathlessness. We pooled site-specific estimates using random-effects meta-analysis.
Results: Both physical and mental component scores were lower in participants with breathlessness compared to those without. This association was stronger for the physical component (coefficient = -7.59; 95%CI -8.60, -6.58; I2 = 78.5%) than for the mental component (coefficient = -3.50; 95%CI -4.36, -2.63; I2 = 71.4%). The association between physical component and breathlessness was stronger in high-income countries (coefficient = -8.82; 95%CI -10.15, -7.50). Heterogeneity across sites was partly explained by sex and tobacco smoking.
Conclusion: Quality of life is worse in people with breathlessness, but this association varies widely across the world.
PulmonologyMedicine-Pulmonary and Respiratory Medicine
CiteScore
14.30
自引率
5.10%
发文量
159
审稿时长
19 days
期刊介绍：
Pulmonology (previously Revista Portuguesa de Pneumologia) is the official journal of the Portuguese Society of Pulmonology (Sociedade Portuguesa de Pneumologia/SPP). The journal publishes 6 issues per year and focuses on respiratory system diseases in adults and clinical research. It accepts various types of articles including peer-reviewed original articles, review articles, editorials, and opinion articles. The journal is published in English and is freely accessible through its website, as well as Medline and other databases. It is indexed in Science Citation Index Expanded, Journal of Citation Reports, Index Medicus/MEDLINE, Scopus, and EMBASE/Excerpta Medica.
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