Quality of life associated with breathlessness in the multinational Burden of Obstructive Lung Disease (BOLD) study: A cross-sectional analysis.

IF 10.4 2区医学 Q1 RESPIRATORY SYSTEM

Pulmonology Pub Date : 2025-12-31 Epub Date: 2025-04-02 DOI:10.1080/25310429.2025.2470566

Alexander Müller, Emiel F M Wouters, Peter Burney, James Potts, Joao Cardoso, Mohammed Al Ghobain, Michael Studnicka, Daniel Obaseki, Asma Elsony, Kevin Mortimer, David Mannino, Rain Jõgi, Rana Ahmed, Asaad Nafees, Maria Fatima Rodrigues, Cristina Bárbara, Rune Nielsen, Thorarinn Gíslason, Hamid Hacene Cherkaski, Karima El Rhazi, Christer Janson, Mahesh Padukudru Anand, Sanjay Juvekar, Herminia Brites Dias, Frits M E Franssen, Dhiraj Agarwal, Sylvia Hartl, Terence Seemungal, Stefanni Nonna Paraguas, Imed Harrabi, Meriam Denguezli, Abdul Rashid, Gregory Erhabor, Mohammed El Biaze, Parvaiz Koul, Daisy J A Janssen, André F S Amaral

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引用次数: 0

Abstract

Introduction: Evidence of an association between breathlessness and quality of life from population-based studies is limited. We aimed to investigate the association of both physical and mental quality of life with breathlessness across several low-, middle- and high-income countries.

Methods: We analysed data from 19 714 adults (31 sites, 25 countries) from the Burden of Obstructive Lung Disease (BOLD) study. We measured both mental and physical quality of life components using the SF-12 questionnaire, and defined breathlessness as grade ≥2 on the modified Medical Research Council scale. We used multivariable linear regression to assess the association of each quality-of-life component with breathlessness. We pooled site-specific estimates using random-effects meta-analysis.

Results: Both physical and mental component scores were lower in participants with breathlessness compared to those without. This association was stronger for the physical component (coefficient = -7.59; 95%CI -8.60, -6.58; I² = 78.5%) than for the mental component (coefficient = -3.50; 95%CI -4.36, -2.63; I² = 71.4%). The association between physical component and breathlessness was stronger in high-income countries (coefficient = -8.82; 95%CI -10.15, -7.50). Heterogeneity across sites was partly explained by sex and tobacco smoking.

Conclusion: Quality of life is worse in people with breathlessness, but this association varies widely across the world.

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多国阻塞性肺疾病负担（BOLD）研究中与呼吸困难相关的生活质量：一项横断面分析

基于人群的研究表明呼吸困难和生活质量之间存在关联的证据是有限的。我们的目的是调查几个低收入、中等收入和高收入国家的身心生活质量与呼吸困难的关系。方法：我们分析了来自阻塞性肺疾病负担（BOLD）研究的19 714名成年人（31个地点，25个国家）的数据。我们使用SF-12问卷测量了精神和身体生活质量组成部分，并将呼吸困难定义为在修订的医学研究委员会量表中≥2级。我们使用多变量线性回归来评估每个生活质量组成部分与呼吸困难的关系。我们使用随机效应荟萃分析汇总了特定地点的估计。结果：与没有呼吸困难的参与者相比，呼吸困难的参与者的身体和精神成分得分都较低。这种相关性在物理成分上更强(系数= -7.59；95%ci -8.60, -6.58；I2 = 78.5%)大于脑力成分(系数= -3.50；95%ci -4.36, -2.63；i2 = 71.4%)。在高收入国家，身体因素与呼吸困难之间的关联更强(系数= -8.82；95%ci -10.15, -7.50)。性别和吸烟在一定程度上解释了不同地区的差异。结论：呼吸困难患者的生活质量较差，但这种关联在世界各地差异很大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pulmonology Medicine-Pulmonary and Respiratory Medicine

CiteScore

14.30

自引率

5.10%

发文量

159

审稿时长

19 days

期刊介绍： Pulmonology (previously Revista Portuguesa de Pneumologia) is the official journal of the Portuguese Society of Pulmonology (Sociedade Portuguesa de Pneumologia/SPP). The journal publishes 6 issues per year and focuses on respiratory system diseases in adults and clinical research. It accepts various types of articles including peer-reviewed original articles, review articles, editorials, and opinion articles. The journal is published in English and is freely accessible through its website, as well as Medline and other databases. It is indexed in Science Citation Index Expanded, Journal of Citation Reports, Index Medicus/MEDLINE, Scopus, and EMBASE/Excerpta Medica.