Biological Psychiatry-Cognitive Neuroscience and Neuroimaging最新文献

{"title":"Brain Age Is Not a Significant Predictor of Relapse Risk in Late-Life Depression","authors":"Helmet T. Karim ,&nbsp;Andrew Gerlach ,&nbsp;Meryl A. Butters ,&nbsp;Robert Krafty ,&nbsp;Brian D. Boyd ,&nbsp;Layla Banihashemi ,&nbsp;Bennett A. Landman ,&nbsp;Olusola Ajilore ,&nbsp;Warren D. Taylor ,&nbsp;Carmen Andreescu","doi":"10.1016/j.bpsc.2024.09.009","DOIUrl":"10.1016/j.bpsc.2024.09.009","url":null,"abstract":"<div><h3>Background</h3><div>Late-life depression (LLD) has been associated cross-sectionally with lower brain structural volumes and accelerated brain aging compared with healthy control participants (HCs). There are few longitudinal studies on the neurobiological predictors of recurrence in LLD. We tested a machine learning brain age model and its prospective association with LLD recurrence risk.</div></div><div><h3>Methods</h3><div>We recruited individuals with LLD (<em>n</em> = 102) and HCs (<em>n</em> = 43) into a multisite, 2-year longitudinal study. Individuals with LLD were enrolled within 4 months of remission. Remitted participants with LLD underwent baseline neuroimaging and longitudinal clinical follow-up. Over 2 years, 43 participants with LLD relapsed and 59 stayed in remission. We used a previously developed machine learning brain age algorithm to compute brain age at baseline, and we evaluated brain age group differences (HC vs. LLD and HC vs. remitted LLD vs. relapsed LLD). We conducted a Cox proportional hazards model to evaluate whether baseline brain age predicted time to relapse.</div></div><div><h3>Results</h3><div>We found that brain age did not significantly differ between the HC and LLD groups or between the HC, remitted LLD, and relapsed LLD groups. Brain age did not significantly predict time to relapse.</div></div><div><h3>Conclusions</h3><div>In contrast to our hypothesis, we found that brain age did not differ between control participants without depression and individuals with remitted LLD, and brain age was not associated with subsequent recurrence. This is in contrast to existing literature which has identified baseline brain age differences in late life but consistent with work that has shown no differences between people who do and do not relapse on gross structural measures.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages 103-110"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated Extracellular Free Water in the Brain Predicts Clinical Improvement in First-Episode Psychosis","authors":"Tyler A. Lesh ,&nbsp;Daniel Bergé ,&nbsp;Jason Smucny ,&nbsp;Joyce Guo ,&nbsp;Cameron S. Carter","doi":"10.1016/j.bpsc.2024.09.014","DOIUrl":"10.1016/j.bpsc.2024.09.014","url":null,"abstract":"<div><h3>Background</h3><div>Despite the diverse nature of clinical trajectories after a first episode of psychosis, few baseline characteristics have been predictive of clinical improvement, and the neurobiological underpinnings of this heterogeneity remain largely unknown. Elevated extracellular free water (FW) in the brain is a diffusion imaging measure that has been consistently reported in different phases of psychosis that may indicate a neuroinflammatory state. However, its predictive capacity in terms of clinical outcomes is unknown.</div></div><div><h3>Methods</h3><div>We used diffusion imaging to determine FW and tissue-specific fractional anisotropy (FA-t) in first-episode psychosis. Forty-seven participants were categorized as clinical improvers (<em>n</em> = 26) if they achieved a 20% decrease in total Brief Psychiatric Rating Scale score at 12 months. To determine the predictive capacity of FW and FA-t, these measures were introduced in a stepwise logistic regression model to predict clinical improvement. For measures that survived the model, regional between-group differences were also investigated in cortical surface or white matter tracts, as applicable.</div></div><div><h3>Results</h3><div>Both higher gray matter FW (odds ratio 1.698; 95% CI, 1.134–2.542) and FA-t (odds ratio, 1.358; 95% CI, 0.905–2.038) predicted improver status. FW in gray matter was also linearly correlated with the Brief Psychiatric Rating Scale total score at the 12-month follow-up. When we examined regional specificity, we found that improvers showed greater FW predominantly in temporal regions and higher FA-t values in several white matter tracts, including the bilateral longitudinal superior fasciculus.</div></div><div><h3>Conclusions</h3><div>Our results show that elevated FW in gray matter and FA-t predict further clinical improvement during the initial phases of psychosis. The potential roles of brain inflammatory processes in predicting clinical improvement are discussed.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages 111-119"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Effort Discounting Reveals Domain-General and Social-Specific Motivation Components","authors":"Chloe M. Savage ,&nbsp;Greer E. Prettyman ,&nbsp;Adrianna C. Jenkins ,&nbsp;Joseph W. Kable ,&nbsp;Paige R. Didier ,&nbsp;Luis Fernando Viegas de Moraes Leme ,&nbsp;Daniel H. Wolf","doi":"10.1016/j.bpsc.2024.07.020","DOIUrl":"10.1016/j.bpsc.2024.07.020","url":null,"abstract":"<div><h3>Background</h3><div>Social motivation is crucial for healthy interpersonal connections and is impaired in a subset of the general population and across many psychiatric disorders. However, compared with nonsocial (e.g., monetary) motivation, social motivation has been understudied in quantitative behavioral work, especially regarding willingness to exert social effort. We developed a novel social effort discounting task, paired with a monetary task to examine motivational specificity. We expected that social task performance would relate to general motivation and also show selective relationships with self-reported avoidance tendencies and with sociality.</div></div><div><h3>Methods</h3><div>An analyzed sample of 397 participants performed the social and nonsocial effort discounting task online, along with self-report measures of various aspects of motivation and psychiatric symptomatology.</div></div><div><h3>Results</h3><div>Social and nonsocial task motivation correlated strongly (ρ = 0.71, <em>p</em> &lt; .001). Both social and nonsocial task motivation related similarly to self-reported general motivation (social, β = 0.16; nonsocial, β = 0.13) and to self-reported approach motivation (social, β = 0.14; nonsocial, β = 0.11), with this common effect captured by a significant main effect across social and nonsocial conditions. Significant condition interaction effects supported a selective relationship of social task motivation with self-reported sociality and also with avoidance motivation.</div></div><div><h3>Conclusions</h3><div>Our novel social effort discounting task revealed both domain-general and social-specific components of motivation. In combination with other measures, this approach can facilitate further investigation of common and dissociable neurobehavioral mechanisms to better characterize normative and pathological variation and develop personalized interventions targeting specific contributors to social impairment.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages 37-44"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141794268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S2451-9022(24)00365-3","DOIUrl":"10.1016/S2451-9022(24)00365-3","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages A5-A10"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143164481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Neural Signature for Reappraisal as an Emotion Regulation Strategy: Relationship to Stress-Related Suicidal Ideation and Negative Affect in Major Depression","authors":"Sarah Herzog ,&nbsp;Noam Schneck ,&nbsp;Hanga Galfalvy ,&nbsp;Tse Hwei-Choo ,&nbsp;Mike Schmidt ,&nbsp;Christina A. Michel ,&nbsp;M. Elizabeth Sublette ,&nbsp;Ainsley Burke ,&nbsp;Kevin Ochsner ,&nbsp;J. John Mann ,&nbsp;Maria A. Oquendo ,&nbsp;Barbara H. Stanley","doi":"10.1016/j.bpsc.2024.08.011","DOIUrl":"10.1016/j.bpsc.2024.08.011","url":null,"abstract":"<div><h3>Background</h3><div>Impaired emotion regulation (ER) contributes to major depression and suicidal ideation and behavior. ER is typically studied by explicitly directing participants to regulate, but this may not capture spontaneous tendencies of individuals with depression to engage ER in daily life.</div></div><div><h3>Methods</h3><div>In 82 participants with major depressive disorder, we examined the relationship of spontaneous engagement of ER to real-world responses to stress. We used a machine learning–derived neural signature reflecting neural systems that underlie cognitive reappraisal (an ER strategy) to identify reappraisal-related activity while participants recalled negative autobiographical memories under the following conditions: 1) unstructured recall; 2) distanced recall, a form of reappraisal; and 3) immersed recall (comparison condition). Participants also completed a week of ecological momentary assessment measuring daily stressors, suicidal ideation, and negative affect.</div></div><div><h3>Results</h3><div>Higher reappraisal signature output for the unstructured period, a proxy for the spontaneous tendency to engage ER, was associated with greater increases in suicidal ideation following stressors (<em>b</em> = 0.083, <em>p</em> = .041). Higher signature output for distanced recall, a proxy for the capacity to engage ER when directed, was associated with lower negative affect following stressors (<em>b</em> = −0.085, <em>p</em> = .029). Output for the immerse period was not associated with ecological momentary assessment outcomes.</div></div><div><h3>Conclusions</h3><div>Findings suggest that in major depressive disorder, the spontaneous tendency to react to negative memories with attempts to reappraise may indicate greater reactivity to negative cues, while intact capacity to use reappraisal when directed may be associated with more adaptive responses to stress. These data have implications for understanding stress-related increases in suicide risk in depression.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages 94-102"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"History of Peripartum Depression Moderates the Association Between Estradiol Polygenic Risk Scores and Basal Ganglia Volumes in Major Depressive Disorder","authors":"Yasmin A. Harrington ,&nbsp;Marco Paolini ,&nbsp;Lidia Fortaner-Uyà ,&nbsp;Melania Maccario ,&nbsp;Elisa M.T. Melloni ,&nbsp;Sara Poletti ,&nbsp;Cristina Lorenzi ,&nbsp;Raffaella Zanardi ,&nbsp;Cristina Colombo ,&nbsp;Francesco Benedetti","doi":"10.1016/j.bpsc.2024.09.011","DOIUrl":"10.1016/j.bpsc.2024.09.011","url":null,"abstract":"<div><h3>Background</h3><div>The neurobiological differences between women who have experienced a peripartum episode and those who have only had episodes outside of this period are not well understood.</div></div><div><h3>Methods</h3><div>Sixty-four parous female patients with major depressive disorder who had either a positive (<em>n</em> = 30) or negative (<em>n</em> = 34) history of peripartum depression (PPD) underwent magnetic resonance imaging acquisition to obtain structural brain images. An independent 2-sample <em>t</em> test comparing patients with and without a history of PPD was performed using voxel-based morphometry analysis. Additionally, polygenic risk scores for estradiol were calculated, and a moderation analysis was conducted between 3 estradiol polygenic risk scores and PPD history status on extracted cluster volumes using IBM SPSS PROCESS macro.</div></div><div><h3>Results</h3><div>The voxel-based morphometry analysis identified larger gray matter volumes in bilateral clusters encompassing the putamen, pallidum, caudate, and thalamus in patients with a PPD history than in patients without a history. The moderation analysis identified a significant interaction effect between 2 estradiol polygenic risk scores and PPD history on gray matter cluster volumes, with a positive effect in women with PPD and a negative effect in women with no history of PPD.</div></div><div><h3>Conclusions</h3><div>Our findings demonstrate that women who have experienced a peripartum episode are neurobiologically distinct from women who have no history of PPD in a cluster within the basal ganglia, an area important for motivation, decision making, and emotional processing. Furthermore, we show that the genetic load for estradiol has a differing effect in this area based on PPD status, which supports the claim that PPD is associated with sensitivity to sex steroid hormones.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages 7-16"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural Signature of Reappraisal: Tendency Versus Capacity","authors":"Agnieszka Zuberer","doi":"10.1016/j.bpsc.2024.11.016","DOIUrl":"10.1016/j.bpsc.2024.11.016","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages 5-6"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatiotemporal Eye Movement Dynamics Reveal Altered Face Prioritization in Early Visual Processing Among Autistic Children","authors":"Jason W. Griffin ,&nbsp;Adam Naples ,&nbsp;Raphael Bernier ,&nbsp;Katarzyna Chawarska ,&nbsp;Geraldine Dawson ,&nbsp;James Dziura ,&nbsp;Susan Faja ,&nbsp;Shafali Jeste ,&nbsp;Natalia Kleinhans ,&nbsp;Catherine Sugar ,&nbsp;Sara Jane Webb ,&nbsp;Frederick Shic ,&nbsp;James C. McPartland ,&nbsp;Autism Biomarkers Consortium for Clinical Trials","doi":"10.1016/j.bpsc.2024.08.017","DOIUrl":"10.1016/j.bpsc.2024.08.017","url":null,"abstract":"<div><h3>Background</h3><div>Reduced social attention—looking at faces—is one of the most common manifestations of social difficulty in autism that is central to social development. Although reduced social attention is well characterized in autism, qualitative differences in how social attention unfolds across time remains unknown.</div></div><div><h3>Methods</h3><div>We used a computational modeling (i.e., hidden Markov modeling) approach to assess and compare the spatiotemporal dynamics of social attention in a large, well-characterized sample of children with autism (<em>n</em> = 280) and neurotypical children (<em>n</em> = 119) (ages 6–11) who completed 3 social eye-tracking assays at 3 longitudinal time points (baseline, 6 weeks, 24 weeks).</div></div><div><h3>Results</h3><div>Our analysis supported the existence of 2 common eye movement patterns that emerged across 3 eye-tracking assays. A focused pattern was characterized by small face regions of interest, which had high a probability of capturing fixations early in visual processing. In contrast, an exploratory pattern was characterized by larger face regions of interest, with a lower initial probability of fixation and more nonsocial regions of interest. In the context of social perception, children with autism showed significantly more exploratory eye movement patterns than neurotypical children across all social perception assays and all 3 longitudinal time points. Eye movement patterns were associated with clinical features of autism, including adaptive function, face recognition, and autism symptom severity.</div></div><div><h3>Conclusions</h3><div>Decreased likelihood of precisely looking at faces early in social visual processing may be an important feature of autism that is associated with autism-related symptomology and may reflect less visual sensitivity to face information.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages 45-57"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142142042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscribers' Page","authors":"","doi":"10.1016/S2451-9022(24)00362-8","DOIUrl":"10.1016/S2451-9022(24)00362-8","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Page A2"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143164484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging Distributed Brain Signal at Rest to Predict Internalizing Symptoms in Youth: Deriving a Polyneuro Risk Score From the ABCD Study Cohort","authors":"Dakota Kliamovich ,&nbsp;Oscar Miranda-Dominguez ,&nbsp;Nora Byington ,&nbsp;Abigail V. Espinoza ,&nbsp;Arturo Lopez Flores ,&nbsp;Damien A. Fair ,&nbsp;Bonnie J. Nagel","doi":"10.1016/j.bpsc.2024.07.026","DOIUrl":"10.1016/j.bpsc.2024.07.026","url":null,"abstract":"<div><h3>Background</h3><div>The prevalence of internalizing psychopathology rises precipitously from early to mid-adolescence, yet the underlying neural phenotypes that give rise to depression and anxiety during this developmental period remain unclear.</div></div><div><h3>Methods</h3><div>Youths from the Adolescent Brain Cognitive Development (ABCD) Study (ages 9–10 years at baseline) with a resting-state functional magnetic resonance imaging scan and mental health data were eligible for inclusion. Internalizing subscale scores from the Brief Problem Monitor-Youth Form were combined across 2 years of follow-up to generate a cumulative measure of internalizing symptoms. The total sample (<em>N</em> = 6521) was split into a large discovery dataset and a smaller validation dataset. Brain-behavior associations of resting-state functional connectivity with internalizing symptoms were estimated in the discovery dataset. The weighted contributions of each functional connection were aggregated using multivariate statistics to generate a polyneuro risk score (PNRS). The predictive power of the PNRS was evaluated in the validation dataset.</div></div><div><h3>Results</h3><div>The PNRS explained 10.73% of the observed variance in internalizing symptom scores in the validation dataset. Model performance peaked when the top 2% functional connections identified in the discovery dataset (ranked by absolute <em>β</em> weight) were retained. The resting-state functional connectivity networks that were implicated most prominently were the default mode, dorsal attention, and cingulo-parietal networks. These findings were significant (<em>p</em> &lt; 1 × 10⁻⁶) as accounted for by permutation testing (<em>n</em> = 7000).</div></div><div><h3>Conclusions</h3><div>These results suggest that the neural phenotype associated with internalizing symptoms during adolescence is functionally distributed. The PNRS approach is a novel method for capturing relationships between resting-state functional connectivity and behavior.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages 58-67"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}