Biological Psychiatry-Cognitive Neuroscience and Neuroimaging最新文献

{"title":"Peak Alpha Frequency in Schizophrenia, Bipolar Disorder, and Healthy Volunteers: Associations With Visual Information Processing and Cognition","authors":"","doi":"10.1016/j.bpsc.2024.06.004","DOIUrl":"10.1016/j.bpsc.2024.06.004","url":null,"abstract":"<div><h3>Background</h3><div>Schizophrenia (SCZ) and bipolar disorder (BD) are associated with information processing abnormalities, including visual perceptual and cognitive impairments, that impact daily functioning. Recent work with healthy samples suggests that peak alpha frequency (PAF) is an electrophysiological index of visual information processing speed that is correlated with cognitive ability. There is evidence that PAF is slowed in SCZ, but it remains unclear whether PAF is reduced in BD or whether slower PAF is associated with impaired visual perception and cognition in these clinical disorders.</div></div><div><h3>Methods</h3><div>We recorded resting-state brain activity (both eyes open and closed) with electroencephalography in 90 participants with SCZ, 62 participants with BD, and 69 healthy control participants. Most participants also performed a visual perception task (backward masking) and cognitive testing (MATRICS Concensus Cognitive Battery).</div></div><div><h3>Results</h3><div>We replicated previous findings of reduced PAF in patients with SCZ compared with healthy control participants. In contrast, PAF in patients with BD did not differ significantly from that in healthy control participants. Furthermore, PAF was significantly correlated with performance on the perceptual and cognitive measures in SCZ but not BD. PAF was also correlated with visual perception in the healthy control group and showed a trend-level correlation with cognition.</div></div><div><h3>Conclusions</h3><div>Together, these results suggest that PAF deficits characterize SCZ, but not BD, and that individual differences in PAF are related to abnormalities in visual information processing and cognition in SCZ.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 11","pages":"Pages 1132-1140"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S2451-9022(24)00290-8","DOIUrl":"10.1016/S2451-9022(24)00290-8","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 11","pages":"Pages A5-A10"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peak Alpha Frequency, Visual Perception, and Cognition in Schizophrenia","authors":"Victor J. Pokorny","doi":"10.1016/j.bpsc.2024.09.007","DOIUrl":"10.1016/j.bpsc.2024.09.007","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 11","pages":"Pages 1077-1078"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macrostructural Brain Morphology as Moderator of the Relationship Between Pandemic-Related Stress and Internalizing Symptomology During COVID-19 in High-Risk Adolescents","authors":"McKinley Pawlak ,&nbsp;Jennifer Kemp ,&nbsp;Signe Bray ,&nbsp;Sneha Chenji ,&nbsp;Melanie Noel ,&nbsp;Kathryn A. Birnie ,&nbsp;Frank P. MacMaster ,&nbsp;Jillian Vinall Miller ,&nbsp;Daniel C. Kopala-Sibley","doi":"10.1016/j.bpsc.2024.07.002","DOIUrl":"10.1016/j.bpsc.2024.07.002","url":null,"abstract":"<div><h3>Background</h3><div>According to person-by-environment models, individual differences in traits may moderate the association between stressors and the development of psychopathology; however, findings in the literature have been inconsistent and little literature has examined adolescent brain structure as a moderator of the effects of stress on adolescent internalizing symptoms. The COVID-19 pandemic presented a unique opportunity to examine the associations between stress, brain structure, and psychopathology. Given links of cortical morphology with adolescent depression and anxiety, the current study investigated whether cortical morphology moderated the relationship between stress from the COVID-19 pandemic and the development of internalizing symptoms in familial high-risk adolescents.</div></div><div><h3>Methods</h3><div>Prior to the COVID-19 pandemic, 72 adolescents (27 male) completed a measure of depressive and anxiety symptoms and underwent magnetic resonance imaging. T1-weighted images were acquired to assess cortical thickness and surface area. Approximately 6 to 8 months after COVID-19 was declared a global pandemic, adolescents reported their depressive and anxiety symptoms and pandemic-related stress.</div></div><div><h3>Results</h3><div>Adjusting for pre-pandemic depressive and anxiety symptoms and stress, increased pandemic-related stress was associated with increased depressive but not anxiety symptoms. This relationship was moderated by cortical thickness and surface area in the anterior cingulate and cortical thickness in the medial orbitofrontal cortex such that increased stress was only associated with increased depressive and anxiety symptoms among adolescents with lower cortical surface area and higher cortical thickness in these regions.</div></div><div><h3>Conclusions</h3><div>Results further our understanding of neural vulnerabilities to the associations between stress and internalizing symptoms in general and during the COVID-19 pandemic in particular.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 11","pages":"Pages 1141-1177"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141636124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural Correlates of Metacognition Impairment in Opioid Addiction","authors":"Scott J. Moeller ,&nbsp;Sameera Abeykoon ,&nbsp;Pari Dhayagude ,&nbsp;Benjamin Varnas ,&nbsp;Jodi J. Weinstein ,&nbsp;Greg Perlman ,&nbsp;Roberto Gil ,&nbsp;Stephen M. Fleming ,&nbsp;Anissa Abi-Dargham","doi":"10.1016/j.bpsc.2024.07.014","DOIUrl":"10.1016/j.bpsc.2024.07.014","url":null,"abstract":"<div><h3>Background</h3><div>Individuals with substance use disorder show impaired self-awareness of ongoing behavior. This deficit suggests problems with metacognition, which has been operationalized in the cognitive neuroscience literature as the ability to monitor and evaluate the success of one’s own cognition and behavior. However, the neural mechanisms of metacognition have not been characterized in a population with drug addiction.</div></div><div><h3>Methods</h3><div>Community samples of participants with opioid use disorder (OUD) (<em>n</em> = 27) and healthy control participants (<em>n</em> = 29) performed a previously validated functional magnetic resonance imaging metacognition task (perceptual decision-making task along with confidence ratings of performance). Measures of recent drug use and addiction severity were also acquired.</div></div><div><h3>Results</h3><div>Individuals with OUD had lower metacognitive sensitivity (i.e., disconnection between task performance and task-related confidence) than control individuals. Trial-by-trial analyses showed that this overall group difference was driven by (suboptimally) low confidence in participants with OUD during correct trials. In functional magnetic resonance imaging analyses, the task engaged an expected network of brain regions (e.g., rostrolateral prefrontal cortex and dorsal anterior cingulate/supplementary motor area, both previously linked to metacognition); group differences emerged in a large ventral anterior cluster that included the medial and lateral orbitofrontal cortex and striatum (higher activation in OUD). Trial-by-trial functional magnetic resonance imaging analyses showed group differences in rostrolateral prefrontal cortex activation, which further correlated with metacognitive behavior across all participants. Exploratory analyses suggested that the behavioral and neural group differences were exacerbated by recent illicit opioid use and unexplained by general cognition.</div></div><div><h3>Conclusions</h3><div>With confirmation and extension of these findings, metacognition and its associated neural circuits could become new, promising therapeutic targets in addiction.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 11","pages":"Pages 1211-1221"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141768229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Keeping an Eye Out for Change: Anxiety Disrupts Adaptive Resolution of Policy Uncertainty","authors":"Amrita Lamba ,&nbsp;Michael J. Frank ,&nbsp;Oriel FeldmanHall","doi":"10.1016/j.bpsc.2024.07.015","DOIUrl":"10.1016/j.bpsc.2024.07.015","url":null,"abstract":"<div><h3>Background</h3><div>Human learning unfolds under uncertainty. Uncertainty is heterogeneous with different forms exerting distinct influences on learning. While one can be uncertain about what to do to maximize rewarding outcomes, known as policy uncertainty, one can also be uncertain about general world knowledge, known as epistemic uncertainty (EU). In complex and naturalistic environments such as the social world, adaptive learning may hinge on striking a balance between attending to and resolving each type of uncertainty. Prior work illustrates that people with anxiety—those with increased threat and uncertainty sensitivity—learn less from aversive outcomes, particularly as outcomes become more uncertain. How does a learner adaptively trade-off between attending to these distinct sources of uncertainty to successfully learn about their social environment?</div></div><div><h3>Methods</h3><div>We developed a novel eye-tracking method to capture highly granular estimates of policy uncertainty and EU based on gaze patterns and pupil diameter (a physiological estimate of arousal).</div></div><div><h3>Results</h3><div>These empirically derived uncertainty measures revealed that humans (<em>N</em> = 94) flexibly switched between resolving policy uncertainty and EU to adaptively learn about which individuals can be trusted and which should be avoided. However, those with increased anxiety (<em>n</em> = 49) did not flexibly switch between resolving policy uncertainty and EU and instead expressed less uncertainty overall.</div></div><div><h3>Conclusions</h3><div>Combining modeling and eye-tracking techniques, we show that altered learning in people with anxiety emerged from an insensitivity to policy uncertainty and rigid choice policies, leading to maladaptive behaviors with untrustworthy people.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 11","pages":"Pages 1188-1198"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metacognition and Addiction: A New Look Inside","authors":"Charles W. Bradberry","doi":"10.1016/j.bpsc.2024.09.004","DOIUrl":"10.1016/j.bpsc.2024.09.004","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 11","pages":"Pages 1081-1082"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2451-9022(24)00286-6","DOIUrl":"10.1016/S2451-9022(24)00286-6","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 11","pages":"Page A1"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Neurophysiological Effects of Theta Burst Stimulation as Measured by Electroencephalography: A Systematic Review","authors":"Bridgette E. Speranza ,&nbsp;Aron T. Hill ,&nbsp;Michael Do ,&nbsp;Andris Cerins ,&nbsp;Peter H. Donaldson ,&nbsp;Pushpal Desarker ,&nbsp;Lindsay M. Oberman ,&nbsp;Sushmit Das ,&nbsp;Peter G. Enticott ,&nbsp;Melissa Kirkovski","doi":"10.1016/j.bpsc.2024.07.018","DOIUrl":"10.1016/j.bpsc.2024.07.018","url":null,"abstract":"<div><div>Theta burst stimulation (TBS) is a noninvasive brain stimulation technique that can modulate neural activity. The effect of TBS on regions beyond the motor cortex remains unclear. With increased interest in applying TBS to nonmotor regions for research and clinical purposes, these effects must be understood and characterized. We synthesized the electrophysiological effects of a single session of TBS, as indexed by electroencephalography (EEG) and concurrent transcranial magnetic stimulation and EEG, in nonclinical participants. We reviewed 79 studies that administered either continuous TBS or intermittent TBS protocols. Broadly, continuous TBS suppressed and intermittent TBS facilitated evoked response component amplitudes. Response to TBS as measured by spectral power and connectivity was much more variable. Variability increased in the presence of task stimuli. There was a large degree of heterogeneity in the research methodology across studies. Additionally, the effect of individual differences on TBS response has been insufficiently investigated. Future research investigating the effects of TBS as measured by EEG must consider methodological and individual factors that may affect TBS outcomes.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 11","pages":"Pages 1083-1120"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psilocybin and 2C-B at Encoding Distort Episodic Familiarity","authors":"","doi":"10.1016/j.bpsc.2024.06.008","DOIUrl":"10.1016/j.bpsc.2024.06.008","url":null,"abstract":"<div><h3>Background</h3><div>As research on psychedelics (hallucinogenic serotonin receptor 2A agonists) progresses, it is important to delineate the reliability of supposedly unique effects across this drug class. One such effect is how psychedelics impair the formation (i.e., encoding) of hippocampal-dependent recollections (retrieval of specific details) while potentially enhancing the encoding of cortical-dependent familiarity (a feeling of knowing that a stimulus has been previously experienced).</div></div><div><h3>Methods</h3><div>In a double-blind, placebo-controlled, within-participants study (<em>N</em> = 20), we tested the acute effects of 2 distinct psychedelics, psilocybin and 2C-B, on the encoding of emotional episodic memories. During acute drug effects, participants viewed negative, neutral, and positive pictures. The following day (while sober), participants completed 2 separate memory tests for these pictures.</div></div><div><h3>Results</h3><div>Using computational models of memory confidence, we found trends for psilocybin and 2C-B at encoding to impair estimates of recollection that were supported by other measures/analyses. Surprisingly, psilocybin and 2C-B at encoding impaired estimates of familiarity, but these impairments were likely due to a misattribution of heightened familiarity, because both drugs at encoding selectively increased familiarity-based false alarms, especially for negative and positive stimuli. Psilocybin and 2C-B at encoding also tended to impair estimates of metamemory (understanding one’s own memory) for negative and neutral memories but enhanced estimates of metamemory for positive memories, although these effects were less reliable in additional analyses.</div></div><div><h3>Conclusions</h3><div>Despite differences in their chemistry, pharmacology, and subjective effects, both psilocybin and 2C-B distorted episodic familiarity, suggesting a common neurocognitive mechanism across psychedelics that may drive other phenomena.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 10","pages":"Pages 1048-1057"},"PeriodicalIF":5.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141473484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}