Biological Psychiatry-Cognitive Neuroscience and Neuroimaging最新文献

{"title":"Aperiodic (1/f) Neural Activity Robustly Tracks Symptom Severity Changes in Treatment-Resistant Depression","authors":"Carl Hacker ,&nbsp;Madaline M. Mocchi ,&nbsp;Jiayang Xiao ,&nbsp;Brian Metzger ,&nbsp;Joshua Adkinson ,&nbsp;Bailey Pascuzzi ,&nbsp;Raissa Mathura ,&nbsp;Denise Oswalt ,&nbsp;Andrew Watrous ,&nbsp;Eleonora Bartoli ,&nbsp;Anusha Allawala ,&nbsp;Victoria Pirtle ,&nbsp;Xiaoxu Fan ,&nbsp;Isabel Danstrom ,&nbsp;Ben Shofty ,&nbsp;Garrett Banks ,&nbsp;Yue Zhang ,&nbsp;Michelle Armenta-Salas ,&nbsp;Koorosh Mirpour ,&nbsp;Nicole Provenza ,&nbsp;Kelly R. Bijanki","doi":"10.1016/j.bpsc.2024.10.019","DOIUrl":"10.1016/j.bpsc.2024.10.019","url":null,"abstract":"<div><h3>Background</h3><div>A reliable physiological biomarker for major depressive disorder is essential for developing and optimizing neuromodulatory treatment paradigms. In this study, we investigated a passive electrophysiologic biomarker that tracks changes in depressive symptom severity on the order of minutes to hours.</div></div><div><h3>Methods</h3><div>We analyzed brief recordings from intracranial electrodes implanted deep in the brain during a clinical trial of deep brain stimulation for treatment-resistant depression in 5 human participants (<em>n</em>_female = 3, <em>n</em>_male = 2). This surgical setting allowed for precise temporal and spatial sensitivity in the ventromedial prefrontal cortex, a challenging area to measure. We focused on the aperiodic slope of the power spectral density, a metric that reflects the balance of activity across all frequency bands and may serve as a proxy for excitatory/inhibitory balance in the brain.</div></div><div><h3>Results</h3><div>Our findings demonstrated that shifts in aperiodic slope correlated with depression severity, with flatter (less negative) slopes indicating reduced depression severity. This significant correlation was observed in all 5 participants, particularly in the ventromedial prefrontal cortex.</div></div><div><h3>Conclusions</h3><div>This biomarker offers a new way to track patient responses to major depressive disorder treatment, thus paving the way for individualized therapies in both intracranial and noninvasive monitoring contexts.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 2","pages":"Pages 186-194"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Effective Connectivity During Threat Anticipation in Individuals With Alcohol Use Disorder","authors":"Milena Radoman ,&nbsp;K. Luan Phan ,&nbsp;Olusola A. Ajilore ,&nbsp;Stephanie M. Gorka","doi":"10.1016/j.bpsc.2024.07.023","DOIUrl":"10.1016/j.bpsc.2024.07.023","url":null,"abstract":"<div><h3>Background</h3><div>A developing theory and recent research suggest that heightened reactivity to uncertain stressors or threats may be an important individual difference factor that facilitates excessive drinking as a means of avoidance-based coping and characterizes individuals with current and past alcohol use disorder (AUD). Neuroimaging studies of unpredictable threat processing have repeatedly demonstrated activation of the anterior insula, anteromedial thalamus, and dorsal anterior cingulate cortex. In the current study, we aimed to understand how these 3 regions function as a network during anticipation of unpredictable threat (and predictable threat).</div></div><div><h3>Methods</h3><div>Participants were 43 adults (ages 21–30) with AUD and 26 healthy control participants. Functional magnetic resonance imaging and dynamic causal modeling were used to study interregional effective connectivities and predictable and unpredictable threat-related modulations thereof within this network. Parametric empirical Bayesian modeling was used to conduct between-group comparisons in effective connectivities.</div></div><div><h3>Results</h3><div>During unpredictable threat trials, the increased projection from the right anteromedial thalamus to the right anterior insula was significantly present only in the AUD group. This directional influence was stronger among individuals who consumed more drinks per week on average. As expected, we found no group differences in modulatory changes to effective connectivities during predictable threat trials.</div></div><div><h3>Conclusions</h3><div>To our knowledge, this is the first study to examine directional interactions between key frontolimbic regions during anticipation of unpredictable and predictable threat and demonstrate the importance of bottom-up thalamic-insular projections during unpredictable threat processing in AUD. Prospective studies are warranted to determine whether this association is causal.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 2","pages":"Pages 213-221"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opposite-Direction Spatial Working Memory Biases in People With Schizophrenia and Healthy Control Participants","authors":"James M. Gold ,&nbsp;Sonia Bansal ,&nbsp;Benjamin Robinson ,&nbsp;Alan Anticevic ,&nbsp;Steven J. Luck","doi":"10.1016/j.bpsc.2024.09.008","DOIUrl":"10.1016/j.bpsc.2024.09.008","url":null,"abstract":"<div><h3>Background</h3><div>People with schizophrenia (PSZ) show impaired accuracy in spatial working memory (sWM), which is thought to reflect abnormalities in the sustained firing of feature selective neurons that are critical for successful encoding and maintenance processes. Recent research has documented a new source of variance in the accuracy of sWM: In healthy adults, sWM representations are unconsciously biased by previous trials such that current-trial responses are attracted to previous-trial responses (serial dependence). This opens a new window to examine how schizophrenia impacts both the sustained neural firing representing the current-trial target and the longer-term synaptic plasticity that stores previous-trial information.</div></div><div><h3>Methods</h3><div>We examined response accuracy in a single-item sWM test with delay intervals of 0, 2, 4, or 8 seconds in 41 PSZ and 32 demographically similar healthy control participants. Our main dependent variable was the bias index, which quantifies the extent to which the current-trial responses were biased toward or away from the previous-trial target.</div></div><div><h3>Results</h3><div>PSZ showed opposite-direction serial dependence bias effects: Healthy control participants showed an attractive bias that increased over increasing delays whereas PSZ showed a repulsion bias that increased over delays. In PSZ, the magnitude of the repulsion bias negatively correlated with broad measures of cognitive ability and WM capacity.</div></div><div><h3>Conclusions</h3><div>PSZ show opposite-direction effects of previous trials on WM. Such qualitatively distinct differences in performance are extremely rare in psychopathology and may index a fundamental alteration in neural processing that could serve as a valuable biomarker for pathophysiology and treatment development research.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 2","pages":"Pages 167-174"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2451-9022(25)00003-5","DOIUrl":"10.1016/S2451-9022(25)00003-5","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 2","pages":"Page A1"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143167042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the Neurocognitive Effects of Right Unilateral Ultra-Brief Pulse Electroconvulsive Therapy and Magnetic Seizure Therapy for the Treatment of Major Depressive Episode","authors":"Shawn M. McClintock ,&nbsp;Zhi-De Deng ,&nbsp;Mustafa M. Husain ,&nbsp;Vishal J. Thakkar ,&nbsp;Elisabeth Bernhardt ,&nbsp;Richard D. Weiner ,&nbsp;Bruce Luber ,&nbsp;Sarah H. Lisanby","doi":"10.1016/j.bpsc.2024.10.016","DOIUrl":"10.1016/j.bpsc.2024.10.016","url":null,"abstract":"<div><h3>Background</h3><div>Magnetic seizure therapy (MST) is under investigation as a treatment for adults with major depression. Previous research has suggested that MST has antidepressant efficacy comparable to that of electroconvulsive therapy (ECT), but with greater cognitive safety. The objective of the study was to compare the neurocognitive outcomes of patients receiving an acute course of MST with the outcomes of those receiving ECT for the treatment of major depressive episode.</div></div><div><h3>Methods</h3><div>This was a between-subjects, double-masked, randomized, multicenter clinical trial. Seventy-three participants with a severe major depressive episode were enrolled and randomly assigned to treatment with MST (<em>n</em> = 35) or ultra-brief pulse right unilateral ECT (<em>n</em> = 38). The main outcome was change in performance from baseline to the end of acute treatment on multiple neurocognitive measures.</div></div><div><h3>Results</h3><div>Compared with patients who received ECT, patients who received MST had superior cognitive outcomes up to 72 hours posttreatment. Specifically, following MST treatment, there was significant improvement in fine motor dexterity (<em>p</em> = .017) and no significant change in cognitive domains of attention, verbal fluency, executive function, or verbal learning and memory. In contrast, following treatment with ECT, patients demonstrated significantly worse performance on measures of verbal fluency (<em>p</em> &lt; .001), executive function (<em>p</em> = .038), and verbal memory retention (<em>p</em> &lt; .001). Autobiographical memory consistency decreased significantly following treatment with both ECT (<em>p</em> &lt; .001) and MST, although the magnitude of change was greater for ECT.</div></div><div><h3>Conclusions</h3><div>The study findings confirm previous work and provide new evidence supporting the enhanced cognitive safety of MST relative to ECT. Future research on MST is warranted to optimize its application to individuals with neuropsychiatric illnesses across the life span.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 2","pages":"Pages 175-185"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aperiodic Neural Activity as an Index of Depression Severity","authors":"Kirill V. Nourski","doi":"10.1016/j.bpsc.2024.12.007","DOIUrl":"10.1016/j.bpsc.2024.12.007","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 2","pages":"Pages 123-124"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143167351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscribers' Page","authors":"","doi":"10.1016/S2451-9022(25)00004-7","DOIUrl":"10.1016/S2451-9022(25)00004-7","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 2","pages":"Page A2"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143167043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Reward Positivity As a Predictor of First-Lifetime Onsets of Depression, Anxiety, and Suicidal Ideation in High-Risk Adolescents","authors":"Gia-Huy L. Hoang ,&nbsp;Kent G. Hecker ,&nbsp;Connor Maxey ,&nbsp;Ford Burles ,&nbsp;Olave E. Krigolson ,&nbsp;Daniel C. Kopala-Sibley","doi":"10.1016/j.bpsc.2024.10.017","DOIUrl":"10.1016/j.bpsc.2024.10.017","url":null,"abstract":"<div><h3>Background</h3><div>Reduced reward positivity (RewP), an electroencephalography marker elicited by feedback indicating reward, has been associated with an increased risk for depression during adolescence. However, the ability of the RewP to predict the first-lifetime onset of depressive disorders, as opposed to anxiety and suicidal ideation in high-risk populations, has not been thoroughly investigated. In this study, we examined whether the RewP predicts the first-lifetime onset of depression, anxiety, and suicidal ideation over 18 months in familial high-risk adolescents.</div></div><div><h3>Methods</h3><div>The sample included 145 adolescents (64.8% female), ages 11 to 17 years, who had at least 1 parent with a history of mood or anxiety disorders and completed baseline and at least 1 follow-up measurement. At baseline, the RewP was measured using a simple gambling task; current internalizing symptoms were assessed using self-report questionnaires; and the adolescent’s psychiatric diagnoses were evaluated with diagnostic interviews. The same interview was administered to the adolescents again 9 months and 18 months later.</div></div><div><h3>Results</h3><div>Logistic regression models showed that higher RewP scores significantly predicted a lower likelihood of developing a first onset of major depressive disorder over 18 months, even after controlling for sex, age, and baseline internalizing symptoms. In contrast, the RewP did not significantly predict the first onset of anxiety disorders or suicidal ideation.</div></div><div><h3>Conclusions</h3><div>A reduced RewP precedes the first onset of depression in high-risk adolescents, highlighting the RewP’s predictive capability for depression risk in predisposed populations. A blunted RewP could complement self-reported symptoms in screening and prevention.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 2","pages":"Pages 148-157"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S2451-9022(25)00007-2","DOIUrl":"10.1016/S2451-9022(25)00007-2","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 2","pages":"Pages A5-A10"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143167046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Womb to Brain: Rethinking Maternal Immune Activation and Its Long-Term Impact","authors":"Ashley F.P. Sanders","doi":"10.1016/j.bpsc.2024.12.012","DOIUrl":"10.1016/j.bpsc.2024.12.012","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 2","pages":"Pages 125-126"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143167350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}