Multimodal Brain Age Indicators of Internalizing Problems in Early Adolescence: A Longitudinal Investigation

IF 5.7 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging Pub Date : 2025-05-01 DOI:10.1016/j.bpsc.2024.11.003

Niamh MacSweeney , Dani Beck , Lucy Whitmore , Kathryn L. Mills , Lars T. Westlye , Tilmann von Soest , Lia Ferschmann , Christian K. Tamnes

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引用次数: 0

Abstract

Background

Adolescence is a time of increased risk for the onset of internalizing problems, particularly in females. However, how individual differences in brain maturation are related to the increased vulnerability for internalizing problems in adolescence remains poorly understood due to a scarcity of longitudinal studies.

Methods

Using ABCD (Adolescent Brain Cognitive Development) Study data, we examined longitudinal associations between multimodal brain age and youth internalizing problems. Brain age models were trained, validated, and tested independently on T1-weighted imaging (n = 9523), diffusion tensor imaging (n = 8834), and resting-state functional magnetic resonance imaging (n = 8233) data at baseline (mean_age = 9.9 years) and 2-year follow-up (mean_age = 11.9 years). Self-reported internalizing problems were measured at 3-year follow-up (mean_age = 12.9 years) using the Brief Problem Monitor.

Results

Latent change score models demonstrated that although brain age gap (BAG) at baseline was not related to later internalizing problems, an increase in BAG between time points was positively associated with internalizing problems at 3-year follow-up in females but not males. This association between an increasing BAG and higher internalizing problems was observed in the T1-weighted imaging (β = 0.067, SE = 0.050, false discovery rate [FDR]–corrected p = .020) and resting-state functional magnetic resonance imaging (β = 0.090, SE = 0.025, p_FDR = .007) models but not diffusion tensor imaging (β = −0.002, SE = 0.053, p_FDR = .932) and remained significant when accounting for earlier internalizing problems.

Conclusions

A greater increase in BAG in early adolescence may reflect the heightened vulnerability shown by female youth to internalizing problems. Longitudinal research is necessary to understand whether this increasing BAG signifies accelerated brain development and its relationship to the trajectory of internalizing problems throughout adolescence.

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青少年早期内化问题的多模态脑龄指标：纵向调查

背景：青春期是内化问题发病风险增加的时期，尤其是女性。然而，由于缺乏纵向研究，人们对大脑成熟过程中的个体差异与青春期内化问题易发性之间的关系仍然知之甚少：方法：我们利用青少年脑认知发展（ABCD）研究数据，研究了多模态脑年龄与青少年内化问题之间的纵向联系。在基线（Mage=9.9岁）和2年随访（Mage=11.9岁）时，对T1加权（T1；N=9523）、弥散张量（DTI；N=8834）和静息态功能（rs-fMRI；N=8233）磁共振成像数据对脑年龄模型进行了独立训练、验证和测试。在 3 年随访（年龄= 12.9 岁）期间，使用简明问题监测表测量了自我报告的内化问题：潜在变化得分模型显示，虽然基线时的脑龄差距（BAG）与后来的内化问题无关，但在3年的随访中，女性脑龄差距的增加与内化问题呈正相关，而男性则不然。在T1（β=0.067，SE=0.050，pFDR=0.020）和rs-fMRI（β=0.090，SE=0.025，pFDR=0.007）模型中观察到了BAG增加与内化问题增加之间的关系，但在DTI（β=-0.002，SE=0.053，pFDR=0.932）模型中没有观察到这种关系：结论：BAG在青春期早期增幅较大，这可能反映出女性青少年更容易出现内化问题。有必要进行纵向研究，以了解 BAG 的增加是否意味着大脑发育的加速，及其与整个青春期内化问题轨迹的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging Neuroscience-Biological Psychiatry

CiteScore

10.40

自引率

1.70%

发文量

247

审稿时长

30 days

期刊介绍： Biological Psychiatry: Cognitive Neuroscience and Neuroimaging is an official journal of the Society for Biological Psychiatry, whose purpose is to promote excellence in scientific research and education in fields that investigate the nature, causes, mechanisms, and treatments of disorders of thought, emotion, or behavior. In accord with this mission, this peer-reviewed, rapid-publication, international journal focuses on studies using the tools and constructs of cognitive neuroscience, including the full range of non-invasive neuroimaging and human extra- and intracranial physiological recording methodologies. It publishes both basic and clinical studies, including those that incorporate genetic data, pharmacological challenges, and computational modeling approaches. The journal publishes novel results of original research which represent an important new lead or significant impact on the field. Reviews and commentaries that focus on topics of current research and interest are also encouraged.