Translational Medicine at UniSa最新文献

{"title":"Endovascular Treatment with Drug-Eluting Balloon for Severe Subclavian Artery Stenosis Involving the Origin of the Vertebral Artery.","authors":"E Dinoto,&nbsp;F Pecoraro,&nbsp;D Mirabella,&nbsp;F Ferlito,&nbsp;A Farina,&nbsp;N Lo Biundo,&nbsp;P Conti,&nbsp;G Bajardi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The first line approach for subclavian steal syndrome is PTA-stenting of subclavian artery. When the ipsilateral vertebral artery origin is involved or in closed proximity of the atherosclerotic lesion in the subclavian artery PTA-stenting is at risk of ipsilateral vertebral artery coverage. Herein we report our experience with DEB to address lesions involving the subclavian artery and the origin of the ipsilateral vertebral artery. From January 2017 to February 2019, patients presenting subclavian artery lesion involving the origin of the ipsilateral vertebral artery and treated using primary DEB, were included. Three patients, with left subclavian steal syndrome, were identified. The perioperative mortality and morbidity were outcomes evaluated. Freedom from occlusion, secondary patency, amputation rate was registered. A total of 3 (2 female) patients were included in the study. No complication, symptoms recurrence, restenosis or occlusion were reported at duplex scan during 12-month follow-up. Indication for stenting was arterial dissection. In our limited experience, the use of DEB in association to embolic protection device in the treatment of atherosclerotic subclavian lesion involving the origin of the vertebral artery was safe and technically feasible.</p>","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"21 ","pages":"35-37"},"PeriodicalIF":1.5,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37698819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Health Technologies: a challenge to tackle in NETWORK","authors":"Maddalena Ilario, V. D. Luca, Umberto Bracale, Giancarlo Bracale","doi":"10.14273/UNISA-2812","DOIUrl":"https://doi.org/10.14273/UNISA-2812","url":null,"abstract":"Health and social challenges require the adoption of new approaches to prevention, diagnostics and care, which pose important sustainability and equity issues to the different healthcare systems of Italian regions. It is therefore essential to set up sustainable models, as part of an overall health innovation process, where ongoing structural reforms are able to increase the effectiveness and resilience of health systems. The participation of citizens, patients, formal and informal caregivers in the planning, set-up and evaluation of these new solutions is pivotal to overcome those current approaches which are no longer fulfilling the provision of integrated social and health services. Digital transformation of health and care provides tools capable to support the modernization of social and health systems, and their adaptation to challenges such as the progressive population ageing, especially in a framework of shared resources and skills, that bring the citizen at the center of the healthcare politics, addressing health needs at individual and community level. The adoption of advanced technologies for diagnostics and therapy, and the digitization of services and care, represent an opportunity to be seized to set a virtuous circuit connecting needs, innovation and investments, through the adoption of transparent procedures. The collaborative approach to the provision of health services through network models allows the multidisciplinary management of the innovative tools that are progressively adopted, while supporting operators training, citizen empowerment and outcomes monitoring, also through rationalization and centralized management of financial resources. With these premises, on 1st October 2018 MeFAVS, the Mediterranean Federation for Advancing of Vascular Surgery was founded, willing to connect University Professors, heads of Vascular Departments and consultant surgeons for ongoing scientific, educational and clinical cooperation amongst the Mediterranean basin countries, such as Italy, France, Spain, Portugal, Greece, Morocco, Algeria, Tunisia, Egypt, Lebanon, Emirates, Albania, Croatia and Turkey, among others. Its activities, some currently and actively ongoing, have been a series of verbal information exchanges, meetings and surveys based on common topics of vascular pathology, epidemiology, new treatments and materials for Vascular Surgery. This project was born in collaboration with the “Federico II” University of Naples and the Campania Region which, according to the European Community directives and regulations, aimed to include MeFAVS in the Pro.M.I.S. (“Progetto Mattone Internazionale” Italian Ministry of Health Programme for Internationalization of Regional Health Systems) linked to the Horizon 2020 cycle to gain access to European Community funds managed by the Regional Governance. During a two-days meeting held in Pozzuoli (Naples) between the 19th and 20th of June 2019, collaborative networking approaches to innovative serv","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"21 1","pages":"1 - 3"},"PeriodicalIF":1.5,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47738675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Double-Microcatheter Technique through Tortuous Anatomy for Coil Embolization of a Saccular $plenic Aneurysm: a Technical Report.","authors":"M Panagrosso,&nbsp;C De Gregorio,&nbsp;A Peluso,&nbsp;P Venetucci,&nbsp;G Buono,&nbsp;U M Bracale","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We report on a case of an asymptomatic splenic artery aneurysm (SAA) with a large neck in a 53-year-old female with an extreme vessel tortuosity which was treated with a Double Microcatheter Technique. This endovascular procedure consists of embolization of the aneurysm using detachable coils with no application of any glue, stent or balloon. At the end of procedure, no complications occurred. At the three-month follow-up an MRI showed the aneurysm's complete exclusion and patency of the splenic artery.</p>","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"21 ","pages":"31-34"},"PeriodicalIF":1.5,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37698713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to Repair Non-Atheromatous Carotid Lesions.","authors":"N M Bouayed, L A Bouziane","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Non-atheromatous surgical lesions are estimated to represent at most 10% of all carotid procedures, most of which involve atheromatous lesions. Isolated tortuosity of the carotid vessels is sometimes treated surgically. The pathologies most frequently studied are extra-cranial carotid aneurysms, dissections, and fibromuscular dysplasia. Behcet's disease only rarely affects the carotid trunk, but in view of its prevalence in our country of Algeria a short section will be devoted to it. A series of 57 patients treated for non-atheromatous carotid lesions is presented article. These cases were treated using both endovascular and conventional surgical techniques. A review of the literature shows that endovascular treatment is now replacing conventional surgery for most indications except carotid paraganglioma.</p>","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"21 ","pages":"24-26"},"PeriodicalIF":1.5,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37698816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Way we were: Technology will Change the Profession of Vascular Surgery.","authors":"A Stella","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"21 ","pages":"52-58"},"PeriodicalIF":1.5,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37698717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Health Technologies: a challenge to tackle in NETWORK.","authors":"M Illario, V De Luca, U M Bracale, G Bracale","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"21 ","pages":"1-3"},"PeriodicalIF":1.5,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37698811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Diabetes Mellitus on the Outcome of Superficial Femoral Artery Recanalization is Debatable.","authors":"L Rizzo,&nbsp;A D'Andrea,&nbsp;N Stella,&nbsp;P Orlando,&nbsp;M Taurino","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Notwithstanding technological improvements in endovascular devices treatment of steno-obstructive lesions of the superficial femoral artery (SFA) remains a challenge for today's vascular surgeon. Current opinion dictates that the diabetic population may have worse outcome after revascularization of the lower extremities. Herein we examine the effects of endovascular treatment on steno-obstructive lesions of the SFA in diabetic and non-diabetic patients.</p><p><strong>Methods: </strong>A retrospective analysis was carried out on 110 patients who had undergone endovascular treatment of the SFA from 2010 to 2017 comparing outcomes in diabetic (DM) <i>vs</i> non-diabetic patients (nDM).</p><p><strong>Results: </strong>56 (50.9%) of the patients were diabetic and 54 were non-diabetic (49.1%). 52.7% (62.7% DM vs 35.2% nDM, p = 0.0003) were patients with critical limb ischemia. SFA occlusion was present in 65.5% (60.7% DM vs 70.4% nDM, p = 0.29) of all patients. All had undergone PTA of the SFA and 40.9% had received adjunctive stenting (44.6% DM vs 37.0% nDM, p = 0.41). A multilevel treatment was executed in 39.1% (51.8% DM vs 25.9% nDM) of the cases whereas an infra-popliteal procedure was associated in 27.3% (37.5% DM vs 16.7% nDM). In both groups the presence of diabetes was significantly associated (p = 0.005 e p = 0.014, respectively). Reintervention rate was 22.7%; 13 in the diabetic group (23.2%) and 12 in the non-diabetic group (22.2%). Of those who had had reintervention (p = 0.77); 9 patients (8.2%) had undergone an open surgical operation, 6 of whom had diabetes (p = 0.32). 5 patients (4.5%) had had major amputation, 4 of whom were diabetic (p = 0.20). Curves assessing freedom from target lesion restenosis were substantially overlapping between the two groups.</p><p><strong>Conclusion: </strong>No statistical associations between diabetes and reintervention or amputation rates were found. Indication to treat the SFA were not influenced by the presence of diabetes but further investigation is required to verify our hypothesis.</p>","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"21 ","pages":"10-18"},"PeriodicalIF":1.5,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37698814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Strategy for a High Tumour Burden Region: The Campania Oncological Network","authors":"S. De Placido, U. Bracale, R. Pacelli, M. Sodo, G. Merola, V. Silvestri, F. Corcione","doi":"10.14273/UNISA-2799","DOIUrl":"https://doi.org/10.14273/UNISA-2799","url":null,"abstract":"59 Università degli Studi di Salerno In the period from 2006 to 2019 the Italian Association of Medical Oncology (AIOM) reported a tumour burden with a prevalence in cancer cases rising from 225,000 to 346,000 1. One of the major issues of oncological disease in Italy today is its geographical distribution, with an increasing incidence disparity from north (4%) to south (14%). For instance, today in Italy 63% of women and 54% of men with colon cancer are alive 5 years after diagnosis however, if assessed as a whole, Italy’s survival rate for colon cancer is equal to or higher than the European average. However, these statistics are not homogenous amongst all region as the southern Italian regions report a lower survival rate than the rest of the country. This data may not only be due to different lifestyle habits and educational and cultural levels throughout Italy, but perhaps also to adherence to locally available screening programs by southern Italian patients. The Italian National Institute of Health (INIH) reports that each year in the southern Italian region of Campania (consisting of Naples, the third largest city in Italy, Salerno and the provincial capitals of Caserta, Avellino, Benevento and Nola) 398 new cases of cancer per 100,000 inhabitants were reported for the male sex versus a national rate of 336 per 100,000 inhabitants . An analysis of the number of surgical procedures for the first three most frequent oncological diseases (colorectal, breast and prostate cancer) reveals that almost 7000 major procedures were performed in the year 2016 in the Campania Region. Despite the impressive number of patients, and the fully technologically equipped hospitals available, over the last ten years a notable “health migration” to access northern Italian health care facilities was prevalent. The ARSAN (Regional Agency for Health), during the 2007-2013 period, registered a high rate of “health migration” from the Campania Region to northern regions for the cure of patients affected, for example, with colon cancer. In the district of Caserta, 44-45% of colo-rectal cancer procedures diagnosed locally were performed outside the region. Moreover, during the year 2012, 7 online cancer registries were set up in Campania, although today only three are currently working. In this scenario, three causes have been identified: • Low compliance to screening programs • Difficulties in accessing hospitals • Division of diagnostic and therapeutic pathways between hospitals Based upon these issues the Campania Region Health Committee decided to set up an oncological network (CON) based on the latest evidence of best practices for oncology. In particular, the first aim of the network was to properly channel the flow of patients for colorectal, breast and uterine cancer 3 with the intent of keeping them in the region and not seeking recourse elsewhere. The oncological network is based on four pillars: Epidemiology, Guidelines and Screening, Qualified Hospitals an","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"21 1","pages":"59 - 60"},"PeriodicalIF":1.5,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45822169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Deep Vein Thrombosis and Pulmonary Embolism: is the Thromboaspiration Device an Appropriate Choice?","authors":"C Setacci, D Benevento, G de Donato, G Galzerano, U M Bracale, F Setacci, G Palasciano","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Nowadays patients affected by deep vein thrombosis (DVT) and pulmonary embolism (PE) are studied widely but the challenge for physicians is when and how they are to be treated. Most patients present serious comorbidities that can potentially make treatment difficult. An increasing cohort of patients cannot be treated with systemic fibrinolysis but fortunately today, physicians can utilize a number of different instruments to resolve acute DVT and PE.</p>","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"21 ","pages":"38-46"},"PeriodicalIF":1.5,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37698714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence on the Need for an Integrated Approach to the Management of Diabetes: The Diagnostic Perspective if Osteomyelitis is Suspected.","authors":"B R Saleem","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"21 ","pages":"19-20"},"PeriodicalIF":1.5,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37698815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}