Revista Peruana de Medicina de Experimental y Salud Publica最新文献_第9页

Molecular detection of the natural infection by trypanosomatid parasites in Didelphis marsupialis from a rural area in northern Colombia. 对哥伦比亚北部农村地区Didelphis marsupialis锥虫自然感染的分子检测。

Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2023-01-01 Epub Date: 2023-06-23 DOI: 10.17843/rpmesp.2023.401.11573

Marlon M Ardila, Yoselin Villadiego, Leidi Herrera, Wendy Zabala-Monterroza, Alveiro Pérez-Doria

{"title":"Molecular detection of the natural infection by trypanosomatid parasites in Didelphis marsupialis from a rural area in northern Colombia.","authors":"Marlon M Ardila, Yoselin Villadiego, Leidi Herrera, Wendy Zabala-Monterroza, Alveiro Pérez-Doria","doi":"10.17843/rpmesp.2023.401.11573","DOIUrl":"10.17843/rpmesp.2023.401.11573","url":null,"abstract":"We studied the prevalence of infection by trypanosomatid parasites in Didelphis marsupialis and its relationship with morphological/age aspects in a rural area of El Carmen de Bolivar, Colombia. Five visits were made to the Vereda El Alférez; each of which lasted three consecutive nights. During these visits, Tomahawk® traps were installed in the peridomestic and wild ecotopes of the Vereda El Alférez. Body measurements, sex and age were determined from the collected animals. Blood was extracted by cardiopuncture, after sedation, in order to obtain total deoxyribonucleic acid (DNA) and amplify the conserved region of the kinetoplast minicircle DNA (kDNA) of parasitic trypanosomatids. The association between morphological parameters of didelphids and their frequency of infection by parasitic trypanosomatids was determined by binomial regression. Thirty D. marsupialis specimens (60.0% females and 40.0% males/66.7% adults and 33.3% juveniles) were collected. Molecular diagnosis revealed a frequency of trypanosomatid parasite infection of 46.7%. Stage (p=0.024) was a determinant for infection. We discuss the role of D. marsupialis as a potential reservoir of parasitic trypanosomatids in the Vereda El Alférez.","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":"40 1","pages":"79-85"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10953644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9748650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent laryngeal papillomatosis with pulmonary involvement: case report. 复发性喉乳头状瘤病伴肺部受累：病例报告。

Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2023-01-01 Epub Date: 2023-06-23 DOI: 10.17843/rpmesp.2023.401.12169

Enrique Zumaeta-Saavedra, Christian Chiara-Chilet, Julio Maquera-Afaray, Medalit Luna-Vilchez

引用次数: 0

Diagnostic performance of the time to positivity of blood cultures to distinguish true bacteremia from contaminants based on an automated system. 基于自动系统的血液培养阳性时间诊断性能，以区分真正的菌血症和污染物。

Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2023-01-01 DOI: 10.17843/rpmesp.2023.404.12724

Aracely Laque-Ale, Miguel Hueda-Zavaleta, Juan Carlos Gómez de la Torre, Luis Alvarado, José Alonso Cáceres Del Águila

{"title":"Diagnostic performance of the time to positivity of blood cultures to distinguish true bacteremia from contaminants based on an automated system.","authors":"Aracely Laque-Ale, Miguel Hueda-Zavaleta, Juan Carlos Gómez de la Torre, Luis Alvarado, José Alonso Cáceres Del Águila","doi":"10.17843/rpmesp.2023.404.12724","DOIUrl":"10.17843/rpmesp.2023.404.12724","url":null,"abstract":"Objective.: To determine the diagnostic performance of blood culture positivity times for distinguishing true bacteremia from contaminants in the automated \"BACT/ALERT®\" system.Materials and methods.: A cross-sectional, diagnostic test-type study was conducted from a database of blood culture samples processed between January 2016 and August 2021. All blood culture samples from patients with suspected bacteremia were included; blood culture samples were entered into the \"BACT/ALERT®\" system to differentiate true bacteremia from contaminants.Results.: We obtained 33,951 blood cultures samples, of which 3875 were positive. Of the total number of positive blood cultures, 75.2% (n=2913) were true bacteremia and 24.8% (n=962) were contaminants. The median time to positivity in blood cultures with true bacteremia was significantly shorter (16.3 hours; IQR: 11.2 - 24.9) than the median time to positivity of blood cultures with contaminants (22.5 hours; IQR: 18.4 - 31.8; p<0.001). The positivity time showed the capacity to differentiate true bacteremia from contaminants, with an AUC-ROC of 0.73 (95%CI: 0.71 - 0.75), with 85% and 63% sensitivity and specificity respectively for the diagnosis of contaminants when the positivity time exceeds 16.5 hours. The use of antibiotics prior to sampling delayed the time to positivity, while having fever before sampling shortened the time to positivity.Conclusions.: Our results show good diagnostic performance of blood culture positivity times to differentiate true bacteremia from contaminants using the \"BACT/ALERT®\" system when the positivity time was longer than 16.5 hours.","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":"40 4","pages":"451-458"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11138833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adaptation of food guideline messages for the visually impaired in Lima, Peru: a validation experience. 为秘鲁利马的视障人士改编食品指南信息：验证经验。

Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2023-01-01 DOI: 10.17843/rpmesp.2023.404.12973

Mirko Lázaro-Serrano, César Domínguez-Curi

引用次数: 0

Medication use in pediatric patients with covid-19 hospitalized in a referral hospital in Lima, Peru, 2020 - 2022. 2020-2022年在秘鲁利马一家转诊医院住院的19型霍乱小儿患者的用药情况。

Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2023-01-01 Epub Date: 2023-06-23 DOI: 10.17843/rpmesp.2023.401.12326

Medalit Luna-Vilchez, Jhonatan R Mejia, Zhamanda N Ortiz-Benique, Mitsi Santiago-Abal, Alvaro Taype-Rondan

引用次数: 0

Prevalence and factors associated with admission to the intensive care unit in children hospitalized for community-acquired pneumonia. 因社区获得性肺炎住院的儿童入住重症监护室的患病率及相关因素。

Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2023-01-01 DOI: 10.17843/rpmesp.2023.404.12872

Melany Mosquera-Rojas, Jenny Rondón-Saldaña, Patricia Llaque-Quiroz

{"title":"Prevalence and factors associated with admission to the intensive care unit in children hospitalized for community-acquired pneumonia.","authors":"Melany Mosquera-Rojas, Jenny Rondón-Saldaña, Patricia Llaque-Quiroz","doi":"10.17843/rpmesp.2023.404.12872","DOIUrl":"10.17843/rpmesp.2023.404.12872","url":null,"abstract":"Objective.: To determine the prevalence and factors associated with intensive care unit admission in children and adolescents with community-acquired pneumonia.Materials and methods.: Analytical cross-sectional observational study at the Instituto Nacional de Salud del Niño San Borja in 2019. The sample consisted of children older than one month and younger than 18 years who were admitted to emergency diagnosed with community-acquired pneumonia. We used Poisson regression to assess association.Results.: We evaluated 166 patients diagnosed with pneumonia, 94 (56.6%) were male and the median age was 24 months (IQR: 11 - 48). Most patients had a mild modified PIRO score of 136 (81.9%); 31 (18.7%) patients had complicated pneumonia and 24 (14.5%) were admitted to intensive care. The higher the age, the lower the prevalence of admission to ICU (PR=0.99, 95%CI: 0.98-0.99). The severity assessed with the modified PIRO score (PR=3.40, 95%CI: 1.46-7.93) and the presence of complicated pneumonia (PR: 5.88, 95%CI: 2.46-14.06) were associated with admission to intensive care.Conclusions.: The prevalence of admission to intensive care in children with community-acquired pneumonia was 14.5%. Younger patients with pneumonia, with greater severity assessed with the modified PIRO score and with complicated pneumonia have a higher prevalence of admission to intensive care.","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":"40 4","pages":"406-412"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11138820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of fat sources on liver characteristics and intestinal morphometry in an early-life animal model. 脂肪来源对早期动物模型肝脏特征和肠道形态的影响

Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2023-01-01 DOI: 10.17843/rpmesp.2023.404.12804

Ivonne M Gutiérrez Zorrilla, Nataly D Bernuy-Osorio, Otto Zea Mendoza, Emilio Fredy Yabar Villanueva, Carlos Vílchez-Perales

{"title":"Effects of fat sources on liver characteristics and intestinal morphometry in an early-life animal model.","authors":"Ivonne M Gutiérrez Zorrilla, Nataly D Bernuy-Osorio, Otto Zea Mendoza, Emilio Fredy Yabar Villanueva, Carlos Vílchez-Perales","doi":"10.17843/rpmesp.2023.404.12804","DOIUrl":"10.17843/rpmesp.2023.404.12804","url":null,"abstract":"Motivation for the study. There is little evidence on whether the consumption of fat sources containing different proportions of fatty acids has an effect on the characteristics of the liver and small intestine at an early age. Main findings. We found that the intake of fat sources containing unsaturated fatty acids contributes to maintaining the characteristics of both organs; whereas, consumption of sources containing saturated fatty acids favors inflammation in the liver and small intestine. Implications. The consumption of quinoa oil constitutes an alternative to protect these noble organs in an animal model at an early age. We aimed to determine the effect of the consumption of three sources of fatty acids on the relative weight, macroscopic and microscopic characteristics of the liver, and intestinal morphometry in an early-life animal model. Seventy-six randomly distributed chicks received one of the diets (T1: 97.0% basal diet (BD) + 3.0% inert material, T2: 97.0% BD + 3.0% partially hydrogenated vegetable shortening, T3: 97.0% BD + 3.0% quinoa oil, and T4: 97.0% BD + 3.0% fish oil) until the seventh day of life; samples were then extracted in order to be analyzed. We found that the animals that consumed quinoa oil (T3) or fish oil (T4) had favorable results associated to lower liver weight and better absorption of nutrients at intestinal level due to higher values in the hair length and crypt depth ratio, in comparison to partially hydrogenated vegetable shortening (T2). In conclusion, quinoa oil constitutes a healthy option for consumption and an alternative source to fish oil.","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":"40 4","pages":"459-465"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11139498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140868899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between pre-bronchoscopy time of illness and post-bronchoscopy discharge time in pediatric patients with foreign body aspiration: retrospective cohort study in a Peruvian referral center, 2014-2019. 2014-2019年秘鲁一家转诊中心对异物吸入儿科患者进行的回顾性队列研究：支气管镜检查前发病时间与支气管镜检查后出院时间之间的关系。

Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2023-01-01 DOI: 10.17843/rpmesp.2023.404.12977

Esteban Andrés Huarhua Jimenez, Alejandro Kruchinsky Lozada, Marcelo Galdos Bejar, Nilton Yhuri Carreazo

{"title":"Association between pre-bronchoscopy time of illness and post-bronchoscopy discharge time in pediatric patients with foreign body aspiration: retrospective cohort study in a Peruvian referral center, 2014-2019.","authors":"Esteban Andrés Huarhua Jimenez, Alejandro Kruchinsky Lozada, Marcelo Galdos Bejar, Nilton Yhuri Carreazo","doi":"10.17843/rpmesp.2023.404.12977","DOIUrl":"10.17843/rpmesp.2023.404.12977","url":null,"abstract":"Objective.: To determine the association between pre-bronchoscopy time of illness and post-bronchoscopy discharge time in pediatric patients with foreign body aspiration.Materials and methods.: Retrospective cohort study. Medical records were studied and reviewed at the Pediatric Emergency Hospital of Lima, Peru. We reviewed 324 medical records, and selected 183 because they had the diagnosis of foreign body aspiration and complete data. Fisher's exact test and Mann Whitney U test were used for the bivariate analysis, while Poisson regression was used to calculate the Relative Risk (RR) and its 95% confidence interval (CI).Results.: We included 183 patients, of whom 65.6% were men with a mean age of 2.4 years. The most frequent location of the foreign body was the right bronchial tree and most of them were made of organic material. The majority (72.7%) of patients were discharged before 24 hours. We found an association between the time of illness prior to bronchoscopy and post-bronchoscopy discharge time (RR: 2.94, 95%CI: 1.72 - 5.01).Conclusions.: The time of illness prior to bronchoscopy and the length of hospital stay after removal of the foreign body were significantly associated when adjusted for age, sex, type of foreign body and mouth sweep maneuver as a rescue measure. Our findings are relevant because they highlight the importance of early care, timely diagnosis and early management of pediatric patients.","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":"40 4","pages":"423-431"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11139497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of adverse events to hydroxychloroquine, ivermectin, azithromycin and tocilizumab in patients hospitalized due to COVID-19 in a Peruvian Social Health Insurance hospital. 秘鲁一家社会医疗保险医院中因 COVID-19 而住院的患者对羟氯喹、伊维菌素、阿奇霉素和托珠单抗的不良反应特征。

Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2023-01-01 Epub Date: 2023-06-23 DOI: 10.17843/rpmesp.2023.401.11563

L Yesenia Rodríguez-Tanta, Enrique Cachay Rojas, Fabián Fiestas Saldarriaga, Guisela Alva Lozada, Paola Fernández-Rojas, Raquel Delgado-Escalante

{"title":"Characterization of adverse events to hydroxychloroquine, ivermectin, azithromycin and tocilizumab in patients hospitalized due to COVID-19 in a Peruvian Social Health Insurance hospital.","authors":"L Yesenia Rodríguez-Tanta, Enrique Cachay Rojas, Fabián Fiestas Saldarriaga, Guisela Alva Lozada, Paola Fernández-Rojas, Raquel Delgado-Escalante","doi":"10.17843/rpmesp.2023.401.11563","DOIUrl":"10.17843/rpmesp.2023.401.11563","url":null,"abstract":"Objective.: To characterize the adverse events (AEs) related to the off-label use of hydroxychloroquine (HQ), azithromycin (AZI), tocilizumab (TOB) and ivermectin (IVM) for the treatment of COVID-19 in hospitalized patients.Materials and methods.: We conducted a secondary cross-sectional analysis of the Peruvian Social Health Insurance (EsSalud) pharmacovigilance system database of AE notifications to HQ, AZI, TOB and IVM in the Edgardo Rebagliati Martins National Hospital from April to October 2020. Information was collected from digital medical records. We estimated AE reporting rates and evaluated their characteristics by drug type, time of occurrence, type by the affected organ-system, severity and causality.Results.: We identified 154 notifications describing a total of 183 AE possibly related to HQ, AZI, TOB and IVM; the reporting rate was 8%. The median time of AE occurrence was 3 days (IQR: 2-5). Most were cardiovascular events; prolongation of the QT interval was the most frequent. Hepatobiliary AEs were mainly associated with TOB. Most cases were moderate, however, 10.4% were severe.Conclusions.: We found AEs potentially associated with the use of HQ, AZI, TOB and IVM against COVID-19; cardiovascular events were the most frequent. Although AZI, HQ and IVM have known safety profiles, their use against COVID-19 could increase the occurrence of AE due to the risk factors inherent to this infection. Surveillance systems must be improved, especially those for TOB.","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":"40 1","pages":"16-24"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10953645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9695445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myths and beliefs about insulin therapy in patients with diabetes mellitus and their family caregivers from a hospital in northern Peru, 2020. 2020 年秘鲁北部一家医院的糖尿病患者及其家庭护理人员对胰岛素治疗的误解和看法。

Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2023-01-01 Epub Date: 2023-06-23 DOI: 10.17843/rpmesp.2023.401.12210

Jhoana Lorena Vera Ubillús, Blanca Katiuska Loayza Enríquez, Rosa Elizabeth Guarníz Lozano, Franco Ernesto León Jiménez

{"title":"Myths and beliefs about insulin therapy in patients with diabetes mellitus and their family caregivers from a hospital in northern Peru, 2020.","authors":"Jhoana Lorena Vera Ubillús, Blanca Katiuska Loayza Enríquez, Rosa Elizabeth Guarníz Lozano, Franco Ernesto León Jiménez","doi":"10.17843/rpmesp.2023.401.12210","DOIUrl":"10.17843/rpmesp.2023.401.12210","url":null,"abstract":"Objective.: To analyze and explore the myths and beliefs about insulin therapy in patients with diabetes mellitus and their family caregivers from a general hospital in northern Peru in 2020.Materials and methods.: This qualitative study used a thematic analysis model, following the interpretative paradigm. Sociodemographic and clinical data were obtained from medical records. Patients with diabetes that used some type of insulin for at least three months prior to the study were interviewed, as well as their family caregivers. Patients participated in a focus group and in-depth interviews; family caregivers participated only in in-depth interviews.Results.: Twelve patients with diabetes (11 with type 2 diabetes mellitus) were included; six in the focus group and six in the in-depth interviews. Seven family caregivers were included. After analysis, we obtained four categories: 1) beliefs related to starting insulin treatment: treatment of choice after failure of other drugs, cures diabetes, regulates sugar, fear of injectables; 2) beliefs related to treatment adherence: decompensation for not using insulin, insulin is necessary to live; 3) beliefs related to alternative therapies and cost: use of alternative therapies, high cost of insulin; and 4) myths related to the use of insulin: generates dependence, dependence for insulin administration, negative effects of insulin.Conclusions.: The beliefs and myths of patients treated with insulin arise from the beginning of treatment, remain throughout the course of treatment, and are often reinforced by the worldview of family members.","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":"40 1","pages":"42-50"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10953673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9748647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0