Retinal Cases and Brief Reports最新文献_第7页

Isolated vitritis as the presenting feature of disseminated Mycobacterium chelonae subspecies gwanakae, a novel subspecies. 分离性玻璃体炎是一种播散性龟分枝杆菌亚种，一种新的亚种。

Retinal Cases and Brief Reports Pub Date : 2025-02-12 DOI: 10.1097/ICB.0000000000001733

Samantha S Massenzio, Ajay E Kuriyan, Tatyana Milman, Nicole D Pecora, Matthew A Pettengill, John J Zurlo, Jordan D Deaner

{"title":"Isolated vitritis as the presenting feature of disseminated Mycobacterium chelonae subspecies gwanakae, a novel subspecies.","authors":"Samantha S Massenzio, Ajay E Kuriyan, Tatyana Milman, Nicole D Pecora, Matthew A Pettengill, John J Zurlo, Jordan D Deaner","doi":"10.1097/ICB.0000000000001733","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001733","url":null,"abstract":"Purpose: To report a case of isolated vitritis as the presenting feature of a disseminated infection with Mycobacterium chelonae subspecies gwanakae, a novel subspecies.Methods: Case report.Results: A 66-year-old male who presented with progressive floaters and blurred vision was found to have isolated vitritis of the left eye. Diagnostic vitrectomy revealed acid-fast bacilli in the vitreous. Whole genome sequencing identified the organism as Mycobacterium chelonae subspecies gwanakae, a recently identified novel subspecies. The patient was admitted for further evaluation and treatment. Punch biopsies of the numerous ulcerative skin lesions revealed acid-fast bacilli. Magnetic resonance imaging revealed osteomyelitis underlying the soft tissue infections, requiring incision and drainage. Biopsy of the bone also revealed acid-fast bacilli. He was treated with weekly intravitreal amikacin and empiric intravenous azithromycin, imipenem, and tobramycin. His ocular infection responded well to treatment with resolution of the vitritis and improvement in visual acuity. Unfortunately, his systemic condition deteriorated, and he declined further intervention, ultimately succumbing to his systemic infection 12 weeks after presentation.Conclusion: Isolated vitritis can be the presenting feature of a severe disseminated Mycobacterium chelonae subspecies gwanakae infection.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ciliary Neurotrophic Factor Implant in Geographic Atrophy from Age-related Macular Degeneration: A Long-Term Case Study. 睫状神经营养因子植入治疗老年性黄斑变性导致的地理萎缩：一项长期病例研究。

Retinal Cases and Brief Reports Pub Date : 2025-02-06 DOI: 10.1097/ICB.0000000000001725

Sakshi Shiromani, Donna Leef, Nieraj Jain, Jiong Yan

{"title":"Ciliary Neurotrophic Factor Implant in Geographic Atrophy from Age-related Macular Degeneration: A Long-Term Case Study.","authors":"Sakshi Shiromani, Donna Leef, Nieraj Jain, Jiong Yan","doi":"10.1097/ICB.0000000000001725","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001725","url":null,"abstract":"Purpose: To report a case of thirteen-year long progression of geographic atrophy (GA) from dry age-related macular degeneration (AMD) with ciliary neurotrophic factor (CNTF) implant, NT-501, in one eye, compared to the untreated contralateral eye.Methods: Using sequential images from 2012 to 2024, the macular GA and peripapillary atrophy was identified as areas of definitely decreased autofluorescence on fundus autofluorescence (FAF) and clearly delineated areas of hyperreflectivity on near infrared reflectance (NIR-R). Optical coherence tomography B scans confirmed areas of complete retinal pigment epithelium and outer retinal atrophy to support FAF grading.Results: A 76-year-old male received the CNTF implant in the right eye in August 2011. Macular GA area on short wavelength FAF exhibited growth from 4.51 mm2 (8/2012) to 14.46 mm2 (6/2020), in the treated right eye, and from 3.2 mm2 to 14.92 mm2 in the untreated left eye. The linearized growth rates were 0.21 mm/y (right) and 0.26 mm/y (left), showing a 16.3% difference. A similar pattern was seen on green laser FAF from 2018 to 2024, with peripapillary atrophy progression rates of 0.2 mm2/y (right) and 1.03 mm2/y (left).Conclusions: Notably, the implanted eye, exhibited less progression of macular GA and peripapillary atrophy. While acknowledging the limitations of a single case, we highlight the potential benefits of using the CNTF implant, a one-time surgical procedure, in reducing the treatment burden for atrophic AMD patients. We hope to see further reports from other sites that participated in this compassionate use protocol for NT-501 in atrophic AMD.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Choroidal Synphlebia in a Patient with Central Serous Chorioretinopathy. 中枢性浆液性脉络膜视网膜病变患者的脉络膜综合征。

Retinal Cases and Brief Reports Pub Date : 2025-02-06 DOI: 10.1097/ICB.0000000000001728

Amirreza Naderi, Richard Spaide

{"title":"Choroidal Synphlebia in a Patient with Central Serous Chorioretinopathy.","authors":"Amirreza Naderi, Richard Spaide","doi":"10.1097/ICB.0000000000001728","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001728","url":null,"abstract":"Purpose: To describe the choroidal vascular abnormality of conjoined choroidal vessels, synphlebia, in a patient with central serous chorioretinopathy (CSC).Methods: A patient initially referred for pigmentary retinal dystrophy later developed central serous retinopathy and underwent a comprehensive examination with multimodal imaging.Results: A 30-year-old man had an undiagnosed pigmentary retinopathy and nyctalopia was found to have a DHDDS mutation, confirming a retinitis pigmentosa diagnosis. A year later, he presented with bilateral central serous chorioretinopathy. During the venous phase of indocyanine green angiography individual vessels could not be differentiated in the posterior pole. Swept-source optical coherence tomography revealed an abnormally thick choroid with enormous vascular channels that did not appear to have separation into individual tubular structures. These abnormal vessels nearly occupied the entire thickness of the choroid in the macular region. There was little sign of any intermediate-sized choroidal vessels in the posterior pole. A review of other patients with DHDDS mutation showed no similar choroidal vascular changes.Conclusion: Large, conjoined veins, which we termed synphlebia, were seen in an eye with CSC. Loading of the choriocapillaris from these enlarged vascular channels may have contributed to hyperpermeability and formation of serous fluid. Observation of this choroidal vascular pattern suggests that a CSC phenotype may develop through more than one pathway.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellulosimicrobium spp. - A novel cause of endogenous endophthalmitis diagnosed on DNA sequencing. 纤维素微生物——DNA测序诊断的内源性眼内炎的新病因。

Retinal Cases and Brief Reports Pub Date : 2025-02-06 DOI: 10.1097/ICB.0000000000001732

Manoj P Shettigar, Esther Sheba, Joveeta Joseph, Vivek Pravin Dave

{"title":"Cellulosimicrobium spp. - A novel cause of endogenous endophthalmitis diagnosed on DNA sequencing.","authors":"Manoj P Shettigar, Esther Sheba, Joveeta Joseph, Vivek Pravin Dave","doi":"10.1097/ICB.0000000000001732","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001732","url":null,"abstract":"Purpose: To report two cases of Cellulosimicrobium. spp - A novel cause of endogenous endophthalmitis diagnosed on DNA sequencing.Methods: Our non-comparative retrospective descriptive case series included two clinically diagnosed cases of endogenous endophthalmitis. We noted the clinical presentations, management outcomes, and microbiological workup. The patients underwent pars plana vitrectomy with intravitreal empirical antibiotics and microbiological investigation of the vitreous sample. The vitreous biopsy samples from both cases underwent routine microbiological evaluation, PCR, and DNA sequencing, which played a crucial role in the diagnosis.Results: Both cases were of young males aged 12 and 13 years, respectively, who presented with painful diminution in vision and redness. The mode of infection was deemed endogenous, given the spontaneous occurrence of endophthalmitis. Both patients underwent pars plana vitrectomy followed by intravitreal empirical antibiotics injection (Vancomycin and Ceftazidime). Vitreous biopsy demonstrated thick Gram-positive beaded bacilli. DNA sequencing revealed Cellulosimicrobium spp. The organism was found to be multi-drug resistant but was susceptible to Vancomycin. Post vitrectomy, a rhegmatogenous retinal detachment was noted. Both patients underwent silicone oil injections and, over the next month, showed complete resolution of endophthalmitis. Snellen's best-corrected visual acuity in Case 1 remained at counting fingers close to face due to a recurrent retinal detachment, while in Case 2, it improved to 20/50 from baseline.Conclusion: Cellulosimicrobium spp. can cause endogenous endophthalmitis, and the infection can be multi-drug-resistant. Organism identification may be elusive using routine smear culture techniques but can be confirmed by DNA sequencing.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enormous Bilateral Optic Disc Drusen Presenting as a Central Retinal Vein and Cilioretinal Artery Occlusion. 巨大的双侧视盘囊肿表现为视网膜中央静脉和睫状体视网膜动脉阻塞。

Retinal Cases and Brief Reports Pub Date : 2025-02-06 DOI: 10.1097/ICB.0000000000001727

Amirreza Naderi, Richard Spaide

{"title":"Enormous Bilateral Optic Disc Drusen Presenting as a Central Retinal Vein and Cilioretinal Artery Occlusion.","authors":"Amirreza Naderi, Richard Spaide","doi":"10.1097/ICB.0000000000001727","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001727","url":null,"abstract":"Purpose: To report a case of combined cilioretinal artery and central retinal vein occlusion in a patient with extremely large, asymptomatic optic disc drusen.Methods: A patient with sudden vision loss underwent a comprehensive examination, including multimodal imaging.Results: A 45-year-old man with no previous visual symptoms presented with a combined cilioretinal artery and central retinal vein occlusion in the right eye. The optic nerve in the right eye was slightly hyperemic and the nerve appeared normal in the left eye. His optic nerves did not have a nodular appearance but showed subtle hyperautofluorescence. A hematological and clotting work-up was unrevealing. Optical coherence tomography revealed an exceptionally large, deeply embedded optic disc druse (1604 x 1390 μm) that almost spanned the width of the optic canal, starting from 464 μm beneath the optic disc surface extending to below any visible lamina cribrosa. The right eye demonstrated a paracentral scotoma, while a minimal visual field defect was observed in the left eye despite the presence of a large-sized (1125 x 803 μm) druse.Conclusion: While optic disc drusen are typically small nodular aggregates in the prelaminar optic nerve head, this patient had an enormous buried solitary druse of the optic nerve in each eye. The unexpected size and location of the drusen, along with the lack of preceding symptoms, suggest that they may not be detected in routine evaluations, thus necessitating multimodal imaging. The redundancy of nerve fibers in the optic nerve may allow significant asymptomatic damage prior to vascular occlusion.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Presumed Mitomycin C-Induced Retinal Toxicity Following Combined Cataract and Xen Gel Stent Surgery. 推测丝裂霉素c在白内障和Xen凝胶支架联合手术后引起视网膜毒性。

Retinal Cases and Brief Reports Pub Date : 2025-02-05 DOI: 10.1097/ICB.0000000000001729

Jared J Tuttle, Shannon D Scarboro, John C Fitzpatrick, C Armitage Harper

引用次数: 0

Infusion-Induced Macular Holes in Pars Plana Vitrectomy: A Case Series of Six Patients. 玻璃体部分切除术中输液引起的黄斑孔洞：附6例病例分析。

Retinal Cases and Brief Reports Pub Date : 2025-02-05 DOI: 10.1097/ICB.0000000000001731

Hannah Shuman, Vichar Trivedi, Dhir Patwa, Patrick Sy Lee, David V Tran, Jacob Im, Rao Me, Jack Komro, Chinwenwa Okeagu, Kim Le, Xihui Lin

{"title":"Infusion-Induced Macular Holes in Pars Plana Vitrectomy: A Case Series of Six Patients.","authors":"Hannah Shuman, Vichar Trivedi, Dhir Patwa, Patrick Sy Lee, David V Tran, Jacob Im, Rao Me, Jack Komro, Chinwenwa Okeagu, Kim Le, Xihui Lin","doi":"10.1097/ICB.0000000000001731","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001731","url":null,"abstract":"Purpose: To describe a series of six cases in which iatrogenic macular holes were induced by the infusion fluid flow of a 25-gauge pars plana vitrectomy (PPV) system.Methods: This is a retrospective case series of six patients treated at Kresge Eye Institute between 2018 and 2024.Results: Iatrogenic macular holes caused by infusion fluid flow are a rare complication of PPV. In this series, five out of six patients had a history of diabetes mellitus and proliferative diabetic retinopathy. The majority of these patients were undergoing repair of tractional retinal detachments when the complication occurred. The average patient age was 47 years (range: 32-66 years). Four patients were pseudophakic, and only one had undergone prior vitrectomy. Preoperative visual acuity ranged from 20/50 to hand motion, while postoperative visual acuity ranged from 20/80 to hand motion. Two patients experienced an improvement in visual acuity postoperatively.Conclusion: This case series highlights the potential risk of macular hole formation due to infusion fluid dynamics during pars plana vitrectomy. In diabetic patients with tractional retinal detachments or significant macular ischemia, we recommend positioning the infusion cannula away from the posterior pole to mitigate the risk of this complication.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of Bartonella Neuroretinitis Presenting with Concomitant Frosted Branch Angiitis on long-term follow-up. 巴尔通体神经视网膜炎1例，长期随访，并发霜状支血管炎。

Retinal Cases and Brief Reports Pub Date : 2025-02-05 DOI: 10.1097/ICB.0000000000001730

Wenjing Zhang, Cong Chen, Yanping Song, Ming Yan

引用次数: 0

Endophthalmitis Following Delayed Gore-Tex Suture Rotation: A Lesson in Suture Management. 延迟Gore-Tex缝线旋转后的眼内炎：缝线管理的一个教训。

Retinal Cases and Brief Reports Pub Date : 2025-02-03 DOI: 10.1097/ICB.0000000000001724

Amin A Karadaghy, Ajay Singh

{"title":"Endophthalmitis Following Delayed Gore-Tex Suture Rotation: A Lesson in Suture Management.","authors":"Amin A Karadaghy, Ajay Singh","doi":"10.1097/ICB.0000000000001724","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001724","url":null,"abstract":"Purpose: To highlight occurrence and management of an important surgical complication.Methods: Retrospective case review.Results: A 35-year-old Caucasian female with a history of crystalline lens dislocation secondary to Marfan Syndrome was referred for management of chronically exposed Gore-Tex suture knots following AKREOS 4-point fixation six years prior. The initial surgery was reportedly complicated by hypotony leading to multiple attempted wound revisions. Ultimately, the patient remained with chronically exposed suture knots. Upon referral to our practice, the knots of the left eye were rotated into the eye, leading to endophthalmitis refractory to two rounds of intravitreal antibiotics. Infection was controlled only after removal of all preexisting hardware, suggesting colonization of the suture material. In the other eye, the decision was made to remove all preexisting sutures and re-fixate the initial lens using new suture. The patient achieved 20/20 vision in both eyes with implantation of a new secondary IOL in one eye and with removal of all preexisting sutures in the other eye.Conclusion: This report highlights a case of endophthalmitis following delayed rotation of exposed suture. Based on the outcome of this case, the importance of avoiding suture exposure is highlighted, and options to manage chronically exposed suture are discussed.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Deficits Associated with Dark Without Pressure. 与无压力黑暗有关的功能缺陷。

Retinal Cases and Brief Reports Pub Date : 2025-02-03 DOI: 10.1097/ICB.0000000000001723

Lucy V Cobbs, Jacques Bijon, K Bailey Freund

{"title":"Functional Deficits Associated with Dark Without Pressure.","authors":"Lucy V Cobbs, Jacques Bijon, K Bailey Freund","doi":"10.1097/ICB.0000000000001723","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001723","url":null,"abstract":"Purpose: To describe a patient with progressive visual symptoms and reduced retinal sensitivity corresponding to dark without pressure (DWP).Methods: Retrospective chart review of a single patient. Comprehensive ophthalmic examinations and multimodal imaging techniques, including optical coherence tomography (OCT), OCT-angiography, and microperimetry, were analyzed.Results: A 23-year-old male presented with progressive peripheral areas of blurred vision superiorly in his right eye and temporally in his left eye. These disturbances corresponded with dark areas of retina inferiorly in his right eye and nasally in his left eye having characteristic features of DWP on multimodal imaging. Although Humphrey visual field (HVF) 24-2 testing was normal, microperimetry showed decreased retinal sensitivity in areas of DWP relative to adjacent areas without DWP.Conclusion: Prior descriptions of DWP have described it as a benign retinal finding showing no functional deficits. We demonstrate that DWP can be associated with progressive visual complaints showing decreased retinal sensitivity on microperimetry and undetected with HVF 24-2 testing.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0