{"title":"Stress fractures of the lower extremity in methotrexate-induced osteopathy: A case report","authors":"Shuji Nagata MD, PhD , Miyuki Sawano MD , Yuki Shouji MD , Takuma Koga MD, PhD , Shuichi Tanoue MD, PhD","doi":"10.1016/j.radcr.2025.08.080","DOIUrl":"10.1016/j.radcr.2025.08.080","url":null,"abstract":"<div><div>We report a case of metachronous stress fractures in the bilateral lower extremities associated with methotrexate (MTX)-induced osteopathy in a 61-year-old woman. She had been treated with low-dose MTX for 4 years for rheumatoid arthritis (RA) and acute lymphoblastic leukemia (ALL). She presented with a 2-month history of right ankle pain and swelling without trauma. Magnetic resonance imaging revealed stress fractures in the distal tibial metaphysis, calcaneus, and talus. The tibial lesion appeared meander-shaped along the growth plates, hypointense on T1-weighted images, with surrounding bone marrow edema hyperintense on fat-suppressed T2-weighted images. The patient received nonweight bearing therapy while continuing low-dose MTX for maintenance of remission in ALL. Twelve months later, pain developed in the contralateral ankle, and MRI demonstrated a stress fracture in the left distal tibial metaphysis. We diagnosed metachronous stress fractures due to MTX-induced osteopathy. Although rare, clinicians and radiologists should be aware of the potential for stress fractures in the lower extremities, particularly the distal tibial metaphysis, in patients receiving low-dose MTX who present with ankle pain.</div></div>","PeriodicalId":53472,"journal":{"name":"Radiology Case Reports","volume":"20 12","pages":"Pages 5984-5988"},"PeriodicalIF":0.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145061157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pulmonary calcinosis in renal failure","authors":"Anas Douami, Mohamed Labied, Chorouk Mountassir, Ghizlane Lembarki, Mouna Sabiri, Samira Lezar","doi":"10.1016/j.radcr.2025.08.019","DOIUrl":"10.1016/j.radcr.2025.08.019","url":null,"abstract":"<div><div>Metastatic pulmonary calcification (MPC), also known as pulmonary calcinosis, is a metabolic lung disease characterized by the deposition of calcium in lung tissue due to hypercalcemia. MPC is often a long-term complication of chronic renal failure. The pathological process is marked by the interstitial deposition of calcium salts, primarily within the alveolar epithelial basement membranes. Although histological changes indicative of MPC are observed in 60%-75% of hemodialysis patients at autopsy, it is infrequently diagnosed before death. While the condition is typically asymptomatic, it can progress to respiratory failure in some cases. Computed tomography (CT) has been shown to be more sensitive than conventional radiography in detecting MPC, with the most common CT finding being multiple calcified pulmonary nodules. We present a case of metastatic pulmonary calcification in a 50-year-old male patient undergoing treatment for chronic renal failure.</div></div>","PeriodicalId":53472,"journal":{"name":"Radiology Case Reports","volume":"20 12","pages":"Pages 5968-5973"},"PeriodicalIF":0.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145061154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Orlando Diaz MD , Jochen Gerstner Saucedo MD , Isabel Carmona MD , Alan B. Lumsden MD , Balazs C. Lengyel MD
{"title":"Intravascular lithotripsy-assisted carotid artery stenting in heavily calcified lesions: A case series","authors":"Orlando Diaz MD , Jochen Gerstner Saucedo MD , Isabel Carmona MD , Alan B. Lumsden MD , Balazs C. Lengyel MD","doi":"10.1016/j.radcr.2025.08.087","DOIUrl":"10.1016/j.radcr.2025.08.087","url":null,"abstract":"<div><div>Intravascular lithotripsy (IVL), although considered off-label for carotid interventions, has proven to be beneficial for the treatment of heavily calcified lesions and may improve outcomes in select patients unsuitable for open repair. We present 3 consecutive cases of IVL-assisted carotid artery stenting (CAS) performed via transfemoral and transradial approaches in patients with severe internal carotid artery calcification. All patients were considered poor candidates for carotid endarterectomy (CEA). Technical success was achieved in all cases, with no neurological complications noted during the perioperative period, 30-day follow-up (with 6-month follow-up in 2 patients since 1 was lost to follow-up). All procedures were performed using distal filter protection alone without flow reversal, in contrast to most published series. IVL may broaden CAS applicability for patients with circumferential calcification and combined high anatomic/physiologic surgical risk who are not candidates for CEA. Further studies are warranted to evaluate long-term outcomes and optimal patient selection.</div></div>","PeriodicalId":53472,"journal":{"name":"Radiology Case Reports","volume":"20 12","pages":"Pages 5977-5983"},"PeriodicalIF":0.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145061158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multiseptate gallbladder with gallstones in a pediatric patient","authors":"Taku Yamamichi MD, PhD , Ryo Tsukada MD, PhD , Shun Iwasaki MD, PhD , Rika Omote MD, PhD , Ryuta Saka MD, PhD","doi":"10.1016/j.radcr.2025.08.079","DOIUrl":"10.1016/j.radcr.2025.08.079","url":null,"abstract":"<div><div>Multiseptate gallbladder is a rare congenital anomaly characterized by multiple intraluminal septa. While often asymptomatic, it can present with abdominal pain or complications, such as gallstones. Cases of multiseptate gallbladder with gallstones have been rarely reported. We describe the case of a 15-year-old girl with multiseptate gallbladder complicated by cholelithiasis. No other biliary ductal anomalies were identified. Laparoscopic cholecystectomy was performed and the gallstones were identified as bilirubin stones. Complete symptom relief was achieved postoperatively. This case highlights that multiseptate gallbladder may contribute to bile stasis and pigment stone formation, even in the absence of other congenital anomalies. Early imaging is essential to confirm the diagnosis and guide management. Magnetic resonance cholangiopancreatography enabled exclusion of associated anomalies, guiding management.</div></div>","PeriodicalId":53472,"journal":{"name":"Radiology Case Reports","volume":"20 12","pages":"Pages 5989-5993"},"PeriodicalIF":0.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145061165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cameron Nosrat BS, Kevin Sweetwood MD, Daria Motamedi MD
{"title":"Parosteal lipoma of the proximal humerus mimicking atypical lipomatous tumor: A diagnostic challenge","authors":"Cameron Nosrat BS, Kevin Sweetwood MD, Daria Motamedi MD","doi":"10.1016/j.radcr.2025.08.083","DOIUrl":"10.1016/j.radcr.2025.08.083","url":null,"abstract":"<div><div>Parosteal lipomas are a rare benign fat-containing neoplasm that originates from mature adipose tissue near the bone periosteum that can often be difficult to differentiate from malignant tumors. We present the case of a 75-year-old female presenting with several months of a growing, uncomfortable right shoulder mass without neurological or motor deficits. Computerized tomography (CT) demonstrated a well-defined mass located deep to the deltoid along the proximal humerus with peripheral fat attenuation while follow-up magnetic resonance imaging (MRI) demonstrated internal central enhancement and thin fibrous septae. Such findings were most consistent with a parosteal lipoma, and given the indolent nature of the mass, absence of aggressive features, and stable size over a 5-month period, conservative management with observation and interval imaging was recommended. This case emphasizes that while histological confirmation remains the gold standard, magnetic resonance imaging (MRI) is currently the most valuable tool in differentiating parosteal lipoma from atypical lipomatous tumors and other fat-containing lesions and guiding management decisions.</div></div>","PeriodicalId":53472,"journal":{"name":"Radiology Case Reports","volume":"20 12","pages":"Pages 5974-5976"},"PeriodicalIF":0.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145061166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Beyond bladder clots: Unmasking nutcracker syndrome in refractory hematuria: A case report","authors":"Asem Afana MD, Mostafa Amro MD, Yasmin Dahabreh MD, Mohammed AbuBaha MD, Hossam Salameh MD, Leena Amer Owaisi MD, Nour Aldeen Imad Abdeen MD, Nour Amjad Hamad MD, Rahaf Fares MD","doi":"10.1016/j.radcr.2025.08.074","DOIUrl":"10.1016/j.radcr.2025.08.074","url":null,"abstract":"<div><div>Nutcracker syndrome (NCS) is a rare cause of unexplained hematuria and flank pain. We report a 28-year-old woman with recurrent gross hematuria misdiagnosed as a urinary tract infection. Imaging revealed left renal vein compression from a narrow aortomesenteric angle. Stenting failed due to complications, and she improved with conservative management. This case highlights the importance of vascular imaging in cases of persistent hematuria and underscores the role of nonsurgical management when intervention is not feasible.</div></div>","PeriodicalId":53472,"journal":{"name":"Radiology Case Reports","volume":"20 12","pages":"Pages 6011-6015"},"PeriodicalIF":0.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145061155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Charles K. Crawford BS , Hajra Arshad MD , John M. Gross MD , Elliot K. Fishman MD
{"title":"Conventional chondrosarcoma of the sternum presenting as a chest wall mass with multilobulated intra- and extra-thoracic extension","authors":"Charles K. Crawford BS , Hajra Arshad MD , John M. Gross MD , Elliot K. Fishman MD","doi":"10.1016/j.radcr.2025.08.043","DOIUrl":"10.1016/j.radcr.2025.08.043","url":null,"abstract":"<div><div>Chondrosarcomas are rare malignant tumors, comprising 20% of all primary bone tumors. They are classified as primary or secondary based on their origin and as conventional or nonconventional based on histology. While conventional chondrosarcomas are the most common form, their occurrence in the chest, and more specifically in the sternocostal joints, is extremely infrequent. We present a case of a 61-year-old female with a longstanding history of a small stable-appearing anterior chest chondrosarcoma for well over a decade, which required surgical intervention after rapid and spontaneous growth. The unique growth pattern extending both extra-thoracically and intra-thoracically is a rare occurrence. Common radiological findings of chondrosarcomas that were appreciated in this case includes lytic lesions with matrix calcifications, endosteal scalloping, and soft tissue masses. Modern imaging techniques, like computed tomography (CT), are excellent for identifying and preoperative planning of chondrosarcomas, however, histology remains the gold standard for confirming the diagnosis.</div></div>","PeriodicalId":53472,"journal":{"name":"Radiology Case Reports","volume":"20 12","pages":"Pages 6016-6020"},"PeriodicalIF":0.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145061156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saad Bouchlarhem MD , Mohammed Amine Rabhi MD , Charaf Eddine Mohammed Chatar MD , Achraf Amine Sbai MD , Drissia Benfadil MD , Azeddine Lachkar MD , Fahd El Ayoubi El Idrissi MD
{"title":"“Hard palate adenoid cystic carcinoma: surgical resection, radiotherapeutic strategy, and long-term surveillance”","authors":"Saad Bouchlarhem MD , Mohammed Amine Rabhi MD , Charaf Eddine Mohammed Chatar MD , Achraf Amine Sbai MD , Drissia Benfadil MD , Azeddine Lachkar MD , Fahd El Ayoubi El Idrissi MD","doi":"10.1016/j.radcr.2025.08.044","DOIUrl":"10.1016/j.radcr.2025.08.044","url":null,"abstract":"<div><div>Adenoid cystic carcinoma (ACC) of the palate is a rare malignant tumor arising from minor salivary glands, characterized by slow but infiltrative growth, frequent perineural invasion, and a high risk of late recurrence and metastasis. We report the case of a 42-year-old male who presented with a progressively enlarging hard–soft palate mass over 5 years, associated with dyspnea, dysphagia, and mild hemipalatal paresthesia. Magnetic resonance imaging revealed a large, well-circumscribed, heterogeneously enhancing mass with extension toward the oropharyngeal lumen and suspected perineural spread. Histopathological examination confirmed ACC, solid subtype, with a Ki-67 index of XX% and perineural invasion (Szanto grade III). The patient underwent complete transoral resection followed by reconstruction using a local palatal flap and adjuvant intensity-modulated radiotherapy (66 Gy/6 weeks). At 12 months, follow-up MRI demonstrated no recurrence or metastasis. This case underscores the crucial role of multimodal imaging in defining tumor extent, guiding surgical margins, and detecting perineural spread, which directly influence treatment planning and long-term surveillance. Early diagnosis and a multidisciplinary approach are essential to optimize outcomes in palatal ACC.</div></div>","PeriodicalId":53472,"journal":{"name":"Radiology Case Reports","volume":"20 12","pages":"Pages 5954-5960"},"PeriodicalIF":0.0,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145046701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Benign or malignant: FDG-avid splenic lesion in a patient with melanoma","authors":"Aakanksha Sriwastwa MD , Sajel Dutt MD , Sandeep Sharma MD","doi":"10.1016/j.radcr.2025.08.038","DOIUrl":"10.1016/j.radcr.2025.08.038","url":null,"abstract":"<div><div>Though hypermetabolic metastatic splenic lesions have been reported in patients with melanoma on fluorine 18-fluorodeoxyglucose (FDG) PET-CT, FDG-avid benign splenic lesions in known cases of melanoma are exceedingly rare. These lesions can cause diagnostic confusion and potentially lead to inadvertent interventional or surgical procedures. An 82-year-old patient with a history of scalp melanoma was found to have an isolated FDG-avid splenic lesion. While it was initially diagnosed as splenic metastases on a PET-CT, it was later confirmed to be a splenic infarct secondary to an episode of bacterial endocarditis. The objective of this case report is to highlight the diagnostic dilemma posed by hypermetabolic splenic lesions in the setting of a known malignancy. This case reports emphasizes the importance of carefully considering patients’ clinical history, laboratory findings, and other noteworthy differentials for hypermetabolic lesions before undertaking invasive procedures.</div></div>","PeriodicalId":53472,"journal":{"name":"Radiology Case Reports","volume":"20 12","pages":"Pages 5949-5953"},"PeriodicalIF":0.0,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145046707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David A. Lizarazo MD , Angela Guarnizo MD , Jairo Lizarazo MD
{"title":"Rare central-variant of posterior reversible encephalopathy syndrome: Pons and middle cerebellar peduncles involvement","authors":"David A. Lizarazo MD , Angela Guarnizo MD , Jairo Lizarazo MD","doi":"10.1016/j.radcr.2025.08.060","DOIUrl":"10.1016/j.radcr.2025.08.060","url":null,"abstract":"<div><div>Central variant of posterior reversible encephalopathy syndrome is an atypical clinical-radiological condition. We report an unusual case of a 37-year old woman with history of chronic renal insufficiency and hypertension. The patient presented with headache, dysarthria, dizziness and balance disturbance. Imaging findings include vasogenic edema of the pons and the middle cerebellar peduncles without supratentorial involvement. After treatment with antihypertensives and dialysis, her blood pressure and physical exam returned to normal and neurological symptoms resolved. Follow-up imaging showed improvement. It is import to identify this entity to enact appropriate treatment.</div></div>","PeriodicalId":53472,"journal":{"name":"Radiology Case Reports","volume":"20 12","pages":"Pages 5946-5948"},"PeriodicalIF":0.0,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145046706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}