{"title":"Urinary tract infections in obstetrics and gynaecology: diagnosis, management and recurrence prevention","authors":"Zainab Al-Jawahiri, Priyanka Krishnaswamy, Maya Basu","doi":"10.1016/j.ogrm.2025.07.009","DOIUrl":"10.1016/j.ogrm.2025.07.009","url":null,"abstract":"<div><div>Urinary tract infections (UTIs) are among the most common bacterial infections in adults, with significant clinical implications. Acute uncomplicated UTIs, typically caused by <em>Escherichia coli</em>, present with classic symptoms such as dysuria, frequency, and urgency, and are most often managed with antibiotics. However, recurrent UTIs, defined as two or more infections within six months or three or more within a year, pose a greater challenge in clinical management due to their multifactorial nature. Risk factors for recurrent UTIs include anatomical abnormalities, sexual activity, use of spermicides, postmenopausal status, and a history of prior infections. This review aims to examine the pathophysiology, diagnosis, and treatment strategies for both acute and recurrent UTIs in women, trans men and non-binary people. Understanding the complexities of these infections is essential for improving patient outcomes, preventing unnecessary antimicrobial use, and guiding evidence-based management strategies.</div></div>","PeriodicalId":53410,"journal":{"name":"Obstetrics, Gynaecology and Reproductive Medicine","volume":"35 11","pages":"Pages 325-331"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145448924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ovarian hyperstimulation syndrome","authors":"Zohra Amin, Nikolas Tsampras, Raj Mathur","doi":"10.1016/j.ogrm.2025.07.008","DOIUrl":"10.1016/j.ogrm.2025.07.008","url":null,"abstract":"<div><div>Ovarian hyperstimulation syndrome (OHSS) is a serious iatrogenic complication of ovarian stimulation with gonadotropins. It is characterized by enlarged ovaries along with fluid shift from intravascular compartment to the extravascular space. Clinical features include abdominal distension, discomfort, ascites, and pleural effusion. There is a risk of thromboembolism, and renal and respiratory dysfunction. Presence of polycystic ovaries, raised Antral Follicle Count, high Anti-Mullerian hormone, and occurrence of pregnancy in the treatment cycle are risk factors. GnRH antagonist protocol, individualized FSH dose, GnRH agonist trigger, elective cryopreservation of all embryos and dopamine agonists are important preventative measures. All women at risk of OHSS should have adequate information and access to 24-hour care. Women presenting with possible OHSS should be assessed and investigated to confirm the diagnosis and classify severity. Mild and moderate OHSS can be managed on an outpatient basis, while severe OHSS often needs in-patient care. Principles of management are maintaining intravascular hydration by encouraging fluid intake guided by thirst, close monitoring of fluid balance, prevention of thromboembolic complications, drainage of ascites in selected cases and symptom relief. If conception occurs in the treatment cycle, the course of OHSS is likely to be more severe and protracted.</div></div>","PeriodicalId":53410,"journal":{"name":"Obstetrics, Gynaecology and Reproductive Medicine","volume":"35 11","pages":"Pages 320-324"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145448925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Li Yan Chow, Emma E Williams, Deena-Shefali Patel, Cheryl Battersby
{"title":"Perinatal optimisation: the role of the multi-disciplinary team","authors":"Li Yan Chow, Emma E Williams, Deena-Shefali Patel, Cheryl Battersby","doi":"10.1016/j.ogrm.2025.07.007","DOIUrl":"10.1016/j.ogrm.2025.07.007","url":null,"abstract":"<div><div>Premature birth is associated with high risk of neonatal morbidity and mortality. There has been focus therefore on improving awareness and prediction of preterm birth, involving primary and secondary care providers, so that modifiable risk factors can be addressed early. Antenatal and peripartum optimisation measures aim to reduce neonatal morbidity associated with being born prematurely. Such optimisation pathways involve collaborative working within and between large multi-disciplinary teams and institutions, with shared goals, joint coordination of care and delivery of evidence based best practice within the perinatal period to improve outcomes for mother and infant.</div></div>","PeriodicalId":53410,"journal":{"name":"Obstetrics, Gynaecology and Reproductive Medicine","volume":"35 11","pages":"Pages 312-319"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145448926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Grace Buckingham, Natalie Edwards, Elizabeth Maronge, Kate F Walker
{"title":"Pain relief and anaesthesia in maternity care and the role of the obstetric anaesthetist","authors":"Grace Buckingham, Natalie Edwards, Elizabeth Maronge, Kate F Walker","doi":"10.1016/j.ogrm.2025.07.006","DOIUrl":"10.1016/j.ogrm.2025.07.006","url":null,"abstract":"<div><div>Pain is a common and treatable symptom in all stages of pregnancy. All agents must be prescribed considering the perceived benefits whilst acknowledging the potential fetal adverse effects. Oral agents can be safe and effective antenatally, and management must be tailored for each individual. Intrapartum analgesia should be multi-modal with consideration for complimentary therapies including continuous labour support and water immersion. Epidural anaesthesia is the gold standard for pain management in labour, with inhalation anaesthetic offering excellent adjunct analgesia. A combined spinal/epidural anaesthesia acts rapidly compared to traditional epidural. Pudendal nerve blocks are effective methods of analgesia with decreasing popularity. TAP blocks and wound infiltration of local anaesthetic reduces post-operative requirement for opioids. The obstetric anaesthetist plays a significant role in the multidisciplinary team in identifying and planning care for high-risk individuals. Furthermore, anaesthetic intervention at the time of delivery is not infrequent and can be optimized.</div></div>","PeriodicalId":53410,"journal":{"name":"Obstetrics, Gynaecology and Reproductive Medicine","volume":"35 11","pages":"Pages 307-311"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145448927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tian Wang, Sarah Prewett, Sarah Smith, Simon L Duke
{"title":"Principles of non-surgical cancer therapies for the obstetrician and gynaecologist","authors":"Tian Wang, Sarah Prewett, Sarah Smith, Simon L Duke","doi":"10.1016/j.ogrm.2025.07.002","DOIUrl":"10.1016/j.ogrm.2025.07.002","url":null,"abstract":"<div><div>The current management of all gynaecological malignancy requires multidisciplinary investigation and discussion, frequently leading to multi-modality treatment. This article outlines the principles of non-surgical cancer treatment with radiotherapy and systemic anti-cancer therapies. These treatments have different aims depending on the type of cancer, clinical context and patient wishes – the review uses the standard treatments for common cancer sites such as endometrial, ovarian, cervical and vulvar cancer to highlight where the underlying principles apply across these sites. Areas of current research and future clinical promise are also highlighted. The article concludes with a special section on anti-cancer therapies in pregnancy.</div></div>","PeriodicalId":53410,"journal":{"name":"Obstetrics, Gynaecology and Reproductive Medicine","volume":"35 10","pages":"Pages 282-289"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145236472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Demystifying long-acting reversible contraception (LARC): a low-maintenance guide for low-maintenance contraception","authors":"Kajal Radia, Charlotte Gatenby, Ulrike Sauer","doi":"10.1016/j.ogrm.2025.07.003","DOIUrl":"10.1016/j.ogrm.2025.07.003","url":null,"abstract":"<div><div>Long-acting reversible contraception (LARC) comprises the most effective forms of contraception available and significantly reduce user error causing contraceptive failure. Despite having high user acceptability, usage of LARC methods have decreased in the UK. A key barrier to LARC usage can be clinician's knowledge and education. This review provides an overview of the four LARC methods available in the UK; Progestogen-only implant and injectable, Levonorgestrel-containing and copper intrauterine devices. Whilst all constitute good options, differences in method of insertion and removal, side effects, non-contraceptive benefits and effects on bleeding patterns differ significantly. Here, we compare key factors which can determine patient preference and suitability, to help clinicians feel more confident in discussing and offering LARC methods.</div></div>","PeriodicalId":53410,"journal":{"name":"Obstetrics, Gynaecology and Reproductive Medicine","volume":"35 10","pages":"Pages 290-298"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145236473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"When delay is deadly: ectopic pregnancy, the leading cause of first-trimester death","authors":"Camilla Gangoo","doi":"10.1016/j.ogrm.2025.07.001","DOIUrl":"10.1016/j.ogrm.2025.07.001","url":null,"abstract":"<div><div>Despite ectopic pregnancy being a well recognized complication within emergency gynaecology, women still die from this condition in the developed world. It accounts for 1% of all pregnancies and the majority are located within the fallopian tube. Women can display symptoms ranging from irregular bleeding to severe abdominal pain or gastrointestinal upset. Ultrasound is the key diagnostic tool to locate the ectopic pregnancy. Ectopic pregnancies can be conservatively managed if a woman is medically stable however systemic Methotrexate or surgical management are alternative treatments. Ultimately, a personalized approach of care is required as women may have a complex fertility history which will impact on options offered. More awareness in the public domain is needed to help women get diagnosed in a timely manner.</div></div>","PeriodicalId":53410,"journal":{"name":"Obstetrics, Gynaecology and Reproductive Medicine","volume":"35 10","pages":"Pages 275-281"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145236471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preterm prelabour rupture of membranes (PPROM) before 23 weeks' gestation: key points for counselling and management","authors":"Laura Goodfellow, Angharad Care","doi":"10.1016/j.ogrm.2025.07.004","DOIUrl":"10.1016/j.ogrm.2025.07.004","url":null,"abstract":"<div><div>Preterm prelabour rupture of membranes (PPROM) before 23 weeks' gestation is a rare but high-risk complication. A UK-wide prospective study using the UK Obstetric Surveillance System (UKOSS) identified 364 women with PPROM between 16<sup>+0</sup> and 22<sup>+6</sup> weeks' gestation. Of these, 32% had a termination and 68% had expectant management. Sepsis occurred in 14% of women and there were two maternal deaths. There was a high rate of birth in the immediate period after PPROM; only 38% of women remained pregnant at 28 days. Among women who continued their pregnancies, 44% had live births and 26% had babies that survived to discharge, with 70% of survivors avoiding severe morbidity. These findings highlight the importance of sepsis vigilance, early multidisciplinary counselling, and psychological support. Outcomes vary depending on gestation at rupture and timing of delivery. As no formal guidelines currently exist, this study provides a foundation for future research and supports balanced, individualised management of early PPROM in clinical practice.</div></div>","PeriodicalId":53410,"journal":{"name":"Obstetrics, Gynaecology and Reproductive Medicine","volume":"35 10","pages":"Pages 299-302"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145236474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}