Advances in Medicine最新文献_第10页

CYP4F2 (rs2108622) Gene Polymorphism Association with Age-Related Macular Degeneration. CYP4F2 (rs2108622)基因多态性与年龄相关性黄斑变性的关系

Advances in Medicine Pub Date : 2016-01-01 Epub Date: 2016-08-29 DOI: 10.1155/2016/3917916

Ruta Sakiene, Alvita Vilkeviciute, Loresa Kriauciuniene, Vilma Jurate Balciuniene, Dovile Buteikiene, Goda Miniauskiene, Rasa Liutkeviciene

{"title":"CYP4F2 (rs2108622) Gene Polymorphism Association with Age-Related Macular Degeneration.","authors":"Ruta Sakiene, Alvita Vilkeviciute, Loresa Kriauciuniene, Vilma Jurate Balciuniene, Dovile Buteikiene, Goda Miniauskiene, Rasa Liutkeviciene","doi":"10.1155/2016/3917916","DOIUrl":"https://doi.org/10.1155/2016/3917916","url":null,"abstract":"Background. Age-related macular degeneration is the leading cause of blindness in elderly individuals where aetiology and pathophysiology of age-related macular degeneration are not absolutely clear. Purpose. To determine the frequency of the genotype of rs2108622 in patients with early and exudative age-related macular degeneration. Methods. The study enrolled 190 patients with early age-related macular degeneration, 181 patients with exudative age-related macular degeneration (eAMD), and a random sample of 210 subjects from the general population (control group). The genotyping of rs2108622 was carried out using the real-time polymerase chain reaction method. Results. The analysis of rs2108622 gene polymorphism did not reveal any differences in the distribution of C/C, C/T, and T/T genotypes between the early AMD group, the eAMD group, and the control group. The CYP4F2 (1347C>T) T/T genotype was more frequent in males with eAMD compared to females (10.2% versus 0.8%; p = 0.0052); also T/T genotype was less frequently present in eAMD females compared to healthy control females (0.8% versus 6.2%; p = 0.027). Conclusion. Rs2108622 gene polymorphism had no predominant effect on the development of early AMD and eAMD. The T/T genotype was more frequent in males with eAMD compared to females and less frequently present in eAMD females compared to healthy females. ","PeriodicalId":53309,"journal":{"name":"Advances in Medicine","volume":" ","pages":"3917916"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/3917916","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39977849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Intestinal Parasite Profile in the Stool of HIV Positive Patients in relation to Immune Status and Comparison of Various Diagnostic Techniques with Special Reference to Cryptosporidium at a Tertiary Care Hospital in South India. 南印度一家三级医院HIV阳性患者粪便中肠道寄生虫与免疫状态的关系及各种诊断技术的比较，特别参考隐孢子虫。

Advances in Medicine Pub Date : 2016-01-01 Epub Date: 2016-07-17 DOI: 10.1155/2016/3564359

Vishnu Kaniyarakkal, Nizamuddin Mundangalam, Anitha Puduvail Moorkoth, Sheela Mathew

{"title":"Intestinal Parasite Profile in the Stool of HIV Positive Patients in relation to Immune Status and Comparison of Various Diagnostic Techniques with Special Reference to Cryptosporidium at a Tertiary Care Hospital in South India.","authors":"Vishnu Kaniyarakkal, Nizamuddin Mundangalam, Anitha Puduvail Moorkoth, Sheela Mathew","doi":"10.1155/2016/3564359","DOIUrl":"https://doi.org/10.1155/2016/3564359","url":null,"abstract":"Acquired immunodeficiency syndrome and related opportunistic infections are a significant cause of morbidity and mortality in susceptible population. This study aims to negate the paucity of data regarding the relation between CD4 levels, prevalence of enteric parasites, and the outcome of treatment with HAART (highly active antiretroviral therapy) and Cotrimoxazole in Kerala, India. Multiple stool samples from 200 patients in a cross-sectional study were subjected to microscopy and Cryptosporidium stool antigen ELISA. Parasites were identified in 18 samples (9%). Cystoisospora and Cryptosporidium spp. were seen in 9 cases (4.5%) and 5 cases (2.5%), respectively. Microsporidium spores and Chilomastix mesnili cysts were identified in 1 case each (0.5% each). Seven cases of Cystoisospora diarrhoea recovered after treatment with Cotrimoxazole. Diarrhoea due to Cryptosporidium spp. in all 5 cases subsided after immune reconstitution with HAART. This study concludes that a positive association was seen between low CD4 count (<200 cells/μL) and overall parasite positivity (P value < 0.01). ELISA is a more sensitive modality for the diagnosis of Cryptosporidium diarrhoea. Chilomastix mesnili, generally considered a nonpathogen, may be a cause of diarrhoeal disease in AIDS. Immune reconstitution and Cotrimoxazole prophylaxis remain to be the best therapeutic approach in AIDS-related diarrhoea. ","PeriodicalId":53309,"journal":{"name":"Advances in Medicine","volume":"2016 ","pages":"3564359"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/3564359","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34344342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

An Optimized Injectable Hydrogel Scaffold Supports Human Dental Pulp Stem Cell Viability and Spreading. 一种优化的可注射水凝胶支架支持人牙髓干细胞的生存和扩散。

Advances in Medicine Pub Date : 2016-01-01 Epub Date: 2016-05-16 DOI: 10.1155/2016/7363579

T D Jones, A Kefi, S Sun, M Cho, S B Alapati

{"title":"An Optimized Injectable Hydrogel Scaffold Supports Human Dental Pulp Stem Cell Viability and Spreading.","authors":"T D Jones, A Kefi, S Sun, M Cho, S B Alapati","doi":"10.1155/2016/7363579","DOIUrl":"https://doi.org/10.1155/2016/7363579","url":null,"abstract":"Introduction. HyStem-C™ is a commercially available injectable hydrogel composed of polyethylene glycol diacrylate (PEGDA), hyaluronan (HA), and gelatin (Gn). These components can be mechanically tuned to enhance cell viability and spreading. Methods. The concentration of PEGDA with an added disulfide bond (PEGSSDA) was varied from 0.5 to 8.0% (w/v) to determine the optimal concentration for injectable clinical application. We evaluated the cell viability of human dental pulp stem cells (hDPSCs) embedded in 2% (w/v) PEGSSDA-HA-Gn hydrogels. Volume ratios of HA : Gn from 100 : 0 to 25 : 75 were varied to encourage hDPSC spreading. Fibronectin (Fn) was added to our model to determine the effect of extracellular matrix protein concentration on hDPSC behavior. Results. Our preliminary data suggests that the hydrogel gelation time decreased as the PEGSSDA cross-linker concentration increased. The PEGSSDA-HA-Gn was biocompatible with hDPSCs, and increased ratios of HA : Gn enhanced cell viability for 14 days. Additionally, cell proliferation with added fibronectin increased significantly over time at concentrations of 1.0 and 10.0 μg/mL in PEGDA-HA-Gn hydrogels, while cell spreading significantly increased at Fn concentrations of 0.1 μg/mL. Conclusions. This study demonstrates that PEG-based injectable hydrogels maintain hDPSC viability and facilitate cell spreading, mainly in the presence of extracellular matrix (ECM) proteins. ","PeriodicalId":53309,"journal":{"name":"Advances in Medicine","volume":"2016 ","pages":"7363579"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/7363579","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34571428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Impact of a Core Ferrule Design on Fracture Resistance of Teeth Restored with Cast Post and Core. 核箍设计对铸造桩核修复牙抗断裂性能的影响。

Advances in Medicine Pub Date : 2016-01-01 Epub Date: 2016-06-22 DOI: 10.1155/2016/5073459

Loubna Shamseddine, Farid Chaaban

{"title":"Impact of a Core Ferrule Design on Fracture Resistance of Teeth Restored with Cast Post and Core.","authors":"Loubna Shamseddine, Farid Chaaban","doi":"10.1155/2016/5073459","DOIUrl":"https://doi.org/10.1155/2016/5073459","url":null,"abstract":"Objectives. To investigate the influence of a contra bevel on the fracture resistance of teeth restored with cast post and core. Materials and Methods. Sixty plastic analogues of an upper incisor were endodontically treated and prepared with 6° internal taper and 2 mm of ferrule in order to receive a cast post and core. The prepared samples were divided into two groups (n = 30); the first group serves as control while the second group was prepared with an external 30° bevel on the buccal and lingual walls. All samples crowned were exposed to a compressive load at 130° to their long axis until fractures occurred. Fracture resistance loads were recorded and failure modes were also observed. Mann-Whitney test was carried out to compare the two groups. Results. Mean failure loads for the groups were, respectively, 1038.69 N (SD ±243.52 N) and 1078.89 N (SD ±352.21 N). Statistically, there was no significant difference between the two groups (P = 0.7675 > 0.05). Conclusion. In the presence of a ferrule and a crown in the anterior teeth, adding a secondary ferrule to the cast post and core will not increase the resistance to fracture. ","PeriodicalId":53309,"journal":{"name":"Advances in Medicine","volume":"2016 ","pages":"5073459"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/5073459","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34561399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Prevalence of Schistosoma mansoni Infection in Four Health Areas of Kisantu Health Zone, Democratic Republic of the Congo. 刚果民主共和国基桑图卫生区四个卫生区曼氏血吸虫感染流行情况

Advances in Medicine Pub Date : 2016-01-01 Epub Date: 2016-08-07 DOI: 10.1155/2016/6596095

R Khonde Kumbu, K Mbanzulu Makola, Lu Bin

{"title":"Prevalence of Schistosoma mansoni Infection in Four Health Areas of Kisantu Health Zone, Democratic Republic of the Congo.","authors":"R Khonde Kumbu, K Mbanzulu Makola, Lu Bin","doi":"10.1155/2016/6596095","DOIUrl":"https://doi.org/10.1155/2016/6596095","url":null,"abstract":"Background. Schistosomiasis is a public health problem in Democratic Republic of the Congo but estimates of its prevalence vary widely. The aim of this study was to determine prevalence of Schistosoma mansoni infection and associated risk factors among children in 4 health areas of Kisantu health zone. Methods. A cross-sectional study was carried out in 4 health areas of Kisantu health zone. 388 children randomly selected were screened for S. mansoni using Kato Katz technique and the sociodemographic data was collected. Data were entered and encoded using software EpiData version 3.1. Analysis was performed using SPSS version 21 software. Results. The prevalence of S. mansoni was 26.5% (103); almost two-thirds (63) (61.2%) had light infection intensity. A significant association was found between S. mansoni infection and age (p = 0.005), educational level (p = 0.001), and practices of swimming/bathing (p < 0.001) and using water from river/lake/stream for domestic use (p < 0.001). Kipasa health area had high prevalence of schistosomiasis (64.6%) (64/99; 95% CI 54.4-74.0) compared to other health areas. Conclusion. Schistosoma mansoni infection still remains a public health problem in these areas. There is a need to promote health education and promote behavioral changes in children towards schistosomiasis. ","PeriodicalId":53309,"journal":{"name":"Advances in Medicine","volume":"2016 ","pages":"6596095"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/6596095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34351321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Safety and Complications of Medical Thoracoscopy. 医用胸腔镜的安全性和并发症。

Advances in Medicine Pub Date : 2016-01-01 Epub Date: 2016-06-19 DOI: 10.1155/2016/3794791

Shimaa Nour Moursi Ahmed, Hideo Saka, Hamdy Ali Mohammadien, Ola Alkady, Masahide Oki, Yoshimasa Tanikawa, Rie Tsuboi, Masahiro Aoyama, Keiji Sugiyama

{"title":"Safety and Complications of Medical Thoracoscopy.","authors":"Shimaa Nour Moursi Ahmed, Hideo Saka, Hamdy Ali Mohammadien, Ola Alkady, Masahide Oki, Yoshimasa Tanikawa, Rie Tsuboi, Masahiro Aoyama, Keiji Sugiyama","doi":"10.1155/2016/3794791","DOIUrl":"https://doi.org/10.1155/2016/3794791","url":null,"abstract":"Objectives. To highlight the possible complications of medical thoracoscopy (MT) and how to avoid them. Methods. A retrospective and prospective analysis of 127 patients undergoing MT in Nagoya Medical Center (NMC) and Toyota Kosei Hospital. The data about complications was obtained from the patients, notes on the computer system, and radiographs. Results. The median age was 71.0 (range, 33.0-92.0) years and 101 (79.5%) were males. The median time with chest drain after procedure was 7.0 (range, 0.0-47.0) days and cases with talc poudrage were 30 (23.6%). Malignant histology was reported in 69 (54.3%), including primary lung cancer in 35 (27.5), mesothelioma in 18 (14.2), and metastasis in 16 (12.6). 58 (45.7%) revealed benign pleural diseases and TB was diagnosed in 15 (11.8%). 21 (16.5%) patients suffered from complications including lung laceration in 3 (2.4%), fever in 5 (3.9%) (due to hospital acquired infection (HAI) in 2, talc poudrage in 2, and malignancy in 1), HAI in 2 (1.6%), prolonged air-leak in 14 (11.0%), and subcutaneous emphysema in 1 (0.8%). Conclusions. MT is generally a safe procedure. Lung laceration is the most serious complication and should be managed well. HAI is of low risk and can be controlled by medical treatment. ","PeriodicalId":53309,"journal":{"name":"Advances in Medicine","volume":"2016 ","pages":"3794791"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/3794791","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34730093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Molecular Analysis of Vancomycin-Resistant Enterococci Isolated from Regional Hospitals in Trinidad and Tobago. 特立尼达和多巴哥地区医院分离的万古霉素耐药肠球菌的分子分析

Advances in Medicine Pub Date : 2016-01-01 Epub Date: 2016-05-19 DOI: 10.1155/2016/8762691

Patrick E Akpaka, Shivnarine Kissoon, Padman Jayaratne

{"title":"Molecular Analysis of Vancomycin-Resistant Enterococci Isolated from Regional Hospitals in Trinidad and Tobago.","authors":"Patrick E Akpaka, Shivnarine Kissoon, Padman Jayaratne","doi":"10.1155/2016/8762691","DOIUrl":"https://doi.org/10.1155/2016/8762691","url":null,"abstract":"Geographic spread of vancomycin-resistant enterococci (VRE) clones in cities, countries, or even continents has been identified by molecular techniques. This study aimed at characterizing virulent genes and determining genetic relatedness of 45 VRE isolates from Trinidad and Tobago using molecular tools, including polymerase chain reaction, pulsed-field gel electrophoresis (PFGE), and Random Amplification Polymorphic DNA (RAPD). The majority (84%) of the isolates were Enterococcus faecium possessing vanA gene while the rest (16%) were Enterococcus faecalis possessing vanB. The esp gene was found in all 45 VRE isolates while hyl genes were found only in E. faecium species. The E. faecium species expressed five distinct PFGE patterns. The predominant clones with similar or common patterns belonged to clones one and three, and each had 11 (29%) of the VRE isolates. Plasmid content was identified in representative isolates from each clonal group. By contrast, the E. faecalis species had one PFGE pattern suggesting the presence of an occult and limited clonal spread. The emergence of VRE in the country seems to be related to intra/interhospital dissemination of an epidemic clone carrying the vanA element. Therefore, infection control measures will be warranted to prevent any potential outbreak and spread of VRE in the country. ","PeriodicalId":53309,"journal":{"name":"Advances in Medicine","volume":"2016 ","pages":"8762691"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/8762691","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34576551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Morphological Spectrum of Orbitoocular Diseases in a Tertiary Health Centre in Keffi, North Central Nigeria 尼日利亚中北部Keffi三级保健中心眼窝疾病的形态学谱

Advances in Medicine Pub Date : 2015-10-20 DOI: 10.1155/2015/619414

I. M. Onwubuya, Tunde Mark Owoyele, O. Olaofe, K. Ezike

{"title":"Morphological Spectrum of Orbitoocular Diseases in a Tertiary Health Centre in Keffi, North Central Nigeria","authors":"I. M. Onwubuya, Tunde Mark Owoyele, O. Olaofe, K. Ezike","doi":"10.1155/2015/619414","DOIUrl":"https://doi.org/10.1155/2015/619414","url":null,"abstract":"Aim. The aim of this study was to carry out a retrospective clinicopathological analysis of the ocular lesions requiring biopsy seen in the Department of Histopathology, Federal Medical Centre (FMC), Keffi, in North Central Nigeria. Materials and Method. A retrospective review of the clinicopathologic profile of orbitoocular lesions diagnosed at the FMC, Keffi, was done. Clinical and pathological data were obtained from the patients' clinical records and original biopsy reports, respectively. Results. Sixty-six cases of orbitoocular lesions were reviewed for this study. Of the 54 cases investigated, 28 were HIV negative while 26 were HIV positive (37.1% of all cases). There were 30 cases of Ocular Surface Squamous Neoplasia (OSSN) with a male-to-female ratio of 0.9 : 1. Squamous cell carcinoma (SCC) was the most frequent OSSN with 17 cases. The mean age of cases of SCC is 37.1 ± 7.6 SD (years). The mean age of carcinoma in situ is 35.8 ± 11.4 years. Conclusion. There was no significant difference in the sex distribution of patients with OSSN. It is probable that a diagnosis of squamous cell carcinoma may be encountered in about a year after diagnosis of a carcinoma in situ especially if the in situ carcinoma is left untreated or improperly treated.","PeriodicalId":53309,"journal":{"name":"Advances in Medicine","volume":"98 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74592015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

An Association between Single Nucleotide Polymorphisms of Lys751Gln ERCC2 Gene and Ovarian Cancer in Polish Women 波兰妇女Lys751Gln ERCC2基因单核苷酸多态性与卵巢癌的关系

Advances in Medicine Pub Date : 2015-10-07 DOI: 10.1155/2015/109593

M. Michalska, D. Samulak, H. Romanowicz, M. Sobkowski, B. Smolarz

{"title":"An Association between Single Nucleotide Polymorphisms of Lys751Gln ERCC2 Gene and Ovarian Cancer in Polish Women","authors":"M. Michalska, D. Samulak, H. Romanowicz, M. Sobkowski, B. Smolarz","doi":"10.1155/2015/109593","DOIUrl":"https://doi.org/10.1155/2015/109593","url":null,"abstract":"Aim. The aim of this study was to evaluate the role of the Lys751Gln (rs13181) ERCC2 gene polymorphism in clinical parameters and the risk for development of ovarian cancer. Material and Methods. The study consisted of 430 patients with ovarian cancer (mean age: 53.2 ± 10.11) and 430 healthy subjects (mean age: 50.31 ± 18.21). Analysis of the gene polymorphisms was performed using the PCR-based restriction fragment length polymorphism (PCR-RFLP). The odds ratios (ORs) and 95% confidence intervals (CIs) for each genotype and allele were calculated. Results. The results obtained indicate that the genotype Gln/Gln is associated with an increased risk of ovarian cancer (OR 5.01; 95% CI 3.37–7.43; p < 0.0001). Association of Lys751Gln polymorphism with histological grading showed increased ERCC2 Gln/Gln (OR = 6.96; 95% CI 3.41–14.21; p < 0.0001) genotype in grading 1 as well as Gln allele overrepresentation (OR = 4.98; 95% CI 3.37–7.40; p < 0.0001) in G1 ovarian patients. Finally, with clinical FIGO staging under evaluation, an increase in ERCC2 Gln/Gln homozygote frequencies in staging I and Gln allele frequencies in SI were observed. Conclusion. On the basis of these results, we conclude that ERCC2 gene polymorphism Lys751Gln may be associated with an increased risk of ovarian carcinoma.","PeriodicalId":53309,"journal":{"name":"Advances in Medicine","volume":"2008 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86226990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Use of Virtual Reality Tools for Vestibular Disorders Rehabilitation: A Comprehensive Analysis 虚拟现实工具在前庭功能障碍康复中的应用:综合分析

Advances in Medicine Pub Date : 2015-04-30 DOI: 10.1155/2015/916735

Mathieu Bergeron, C. Lortie, M. Guitton

{"title":"Use of Virtual Reality Tools for Vestibular Disorders Rehabilitation: A Comprehensive Analysis","authors":"Mathieu Bergeron, C. Lortie, M. Guitton","doi":"10.1155/2015/916735","DOIUrl":"https://doi.org/10.1155/2015/916735","url":null,"abstract":"Classical peripheral vestibular disorders rehabilitation is a long and costly process. While virtual reality settings have been repeatedly suggested to represent possible tools to help the rehabilitation process, no systematic study had been conducted so far. We systematically reviewed the current literature to analyze the published protocols documenting the use of virtual reality settings for peripheral vestibular disorders rehabilitation. There is an important diversity of settings and protocols involving virtual reality settings for the treatment of this pathology. Evaluation of the symptoms is often not standardized. However, our results unveil a clear effect of virtual reality settings-based rehabilitation of the patients' symptoms, assessed by objectives tools such as the DHI (mean decrease of 27 points), changing symptoms handicap perception from moderate to mild impact on life. Furthermore, we detected a relationship between the duration of the exposure to virtual reality environments and the magnitude of the therapeutic effects, suggesting that virtual reality treatments should last at least 150 minutes of cumulated exposure to ensure positive outcomes. Virtual reality offers a pleasant and safe environment for the patient. Future studies should standardize evaluation tools, document putative side effects further, compare virtual reality to conventional physical therapy, and evaluate economical costs/benefits of such strategies.","PeriodicalId":53309,"journal":{"name":"Advances in Medicine","volume":"367 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82581041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 80