南印度一家三级医院HIV阳性患者粪便中肠道寄生虫与免疫状态的关系及各种诊断技术的比较,特别参考隐孢子虫。

Advances in Medicine Pub Date : 2016-01-01 Epub Date: 2016-07-17 DOI:10.1155/2016/3564359
Vishnu Kaniyarakkal, Nizamuddin Mundangalam, Anitha Puduvail Moorkoth, Sheela Mathew
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引用次数: 18

摘要

获得性免疫缺陷综合征和相关的机会性感染是易感人群发病和死亡的重要原因。本研究旨在否定印度喀拉拉邦CD4水平、肠道寄生虫患病率与HAART(高活性抗逆转录病毒治疗)和复方新诺明治疗结果之间关系的数据缺乏。在一项横断面研究中,对200名患者的多个粪便样本进行了显微镜检查和隐孢子虫粪便抗原ELISA检测。18份样本(9%)检出寄生虫。检出囊异孢子虫9例(4.5%),隐孢子虫5例(2.5%)。检出小孢子虫孢子1例,小孢子虫包囊0.5%。7例囊异孢子虫腹泻经复方新诺明治疗后恢复。5例隐孢子虫引起的腹泻均在HAART免疫重建后消退。该研究得出结论,CD4细胞计数低(
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Intestinal Parasite Profile in the Stool of HIV Positive Patients in relation to Immune Status and Comparison of Various Diagnostic Techniques with Special Reference to Cryptosporidium at a Tertiary Care Hospital in South India.

Intestinal Parasite Profile in the Stool of HIV Positive Patients in relation to Immune Status and Comparison of Various Diagnostic Techniques with Special Reference to Cryptosporidium at a Tertiary Care Hospital in South India.

Intestinal Parasite Profile in the Stool of HIV Positive Patients in relation to Immune Status and Comparison of Various Diagnostic Techniques with Special Reference to Cryptosporidium at a Tertiary Care Hospital in South India.

Intestinal Parasite Profile in the Stool of HIV Positive Patients in relation to Immune Status and Comparison of Various Diagnostic Techniques with Special Reference to Cryptosporidium at a Tertiary Care Hospital in South India.

Acquired immunodeficiency syndrome and related opportunistic infections are a significant cause of morbidity and mortality in susceptible population. This study aims to negate the paucity of data regarding the relation between CD4 levels, prevalence of enteric parasites, and the outcome of treatment with HAART (highly active antiretroviral therapy) and Cotrimoxazole in Kerala, India. Multiple stool samples from 200 patients in a cross-sectional study were subjected to microscopy and Cryptosporidium stool antigen ELISA. Parasites were identified in 18 samples (9%). Cystoisospora and Cryptosporidium spp. were seen in 9 cases (4.5%) and 5 cases (2.5%), respectively. Microsporidium spores and Chilomastix mesnili cysts were identified in 1 case each (0.5% each). Seven cases of Cystoisospora diarrhoea recovered after treatment with Cotrimoxazole. Diarrhoea due to Cryptosporidium spp. in all 5 cases subsided after immune reconstitution with HAART. This study concludes that a positive association was seen between low CD4 count (<200 cells/μL) and overall parasite positivity (P value < 0.01). ELISA is a more sensitive modality for the diagnosis of Cryptosporidium diarrhoea. Chilomastix mesnili, generally considered a nonpathogen, may be a cause of diarrhoeal disease in AIDS. Immune reconstitution and Cotrimoxazole prophylaxis remain to be the best therapeutic approach in AIDS-related diarrhoea.

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