Savio D Pandolfo, Fabio Crocerossa, Celeste Manfredi, Matteo Ferro, Giuseppe Lucarelli, Francesco Lasorsa, Pierluigi Russo, Zhenije Wu, Riccardo Autorino, Daniele Amparore
{"title":"Cytology's sunset: is it time to embrace new biomarkers for upper tract urothelial carcinoma?","authors":"Savio D Pandolfo, Fabio Crocerossa, Celeste Manfredi, Matteo Ferro, Giuseppe Lucarelli, Francesco Lasorsa, Pierluigi Russo, Zhenije Wu, Riccardo Autorino, Daniele Amparore","doi":"10.23736/S2724-6051.24.06265-7","DOIUrl":"https://doi.org/10.23736/S2724-6051.24.06265-7","url":null,"abstract":"","PeriodicalId":53228,"journal":{"name":"Minerva Urology and Nephrology","volume":"76 6","pages":"806-807"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Water vapor thermal therapy (Rezūm System) in patients with large prostates: results from a prospective comparative study.","authors":"Raffaele Balsamo, Simone Tammaro, Massimiliano Trivellato, Felice Crocetto, Biagio Barone, Ferdinando Fusco, Davide Arcaniolo, Celeste Manfredi, Luca Cindolo, Raffaele Ranavolo, Francesco Uricchio","doi":"10.23736/S2724-6051.24.05883-X","DOIUrl":"10.23736/S2724-6051.24.05883-X","url":null,"abstract":"<p><strong>Background: </strong>Rezūm is a novel minimally invasive surgical technique (MIST) useful for BPH patients with medium-sized prostate (30-80 cm<sup>3</sup>) refractory to medical treatment. The aim of this study was to evaluate the efficacy and safety of Rezūm as a treatment option in large-sized prostates (>80 cm<sup>3</sup>).</p><p><strong>Methods: </strong>We performed a prospective, comparative, single-center study from June 2022 to June 2023, including consecutive patients undergoing surgery with the Rezūm System. Enrolled men were classified into two subgroups based on prostate size: medium prostate (MP) (30-80 cm<sup>3</sup>) and large prostate (LP) (≥80 cm<sup>3</sup>). Inclusion criteria included an International Prostate Symptom Score (IPSS) Total score of ≥ 8 points. International Prostate Symptom Score (IPSS), maximum urinary flow rate (Qmax), post-void residual (PVR), and International Index of Erectile Function 5-item version (IIEF-5) were collected at baseline and at three, six, and 12 months post-procedure. Ejaculation presence was assessed at 3 months. Post-operative complications were described using the Clavien-Dindo (CD) classification. The primary outcome was the IPSS-Total score, with intraoperative and postoperative CD grade ≥III complications as secondary outcomes.</p><p><strong>Results: </strong>One hundred and twenty-one patients (PV 78.2±32.1 mL) were included in the study, 51 large prostate (LP) and 70 medium prostate (MP). The IPSS-Total score and Q<inf>max</inf> showed a statistically significant (P<0.0001) improvement at 3, 6, and 12 months respectively. PVR decreased at 3, 6, and 12 months; however, only at 3 months this variation was statistically significant (P<0.0001). At 3-month follow-up, anejaculation was detected in (3; 5.8% and 1; 1.4%) patients in LP and MP group respectively (P=0.86). IIEF-5 significantly improved 3 months after surgery in the LP subgroup (P<0.0001).</p><p><strong>Conclusions: </strong>Rezūm water vapor therapy appears to be effective for treating BPH in larger prostates. Additionally, it demonstrates a low risk of impairing sexual function, indicating a favorable safety profile.</p>","PeriodicalId":53228,"journal":{"name":"Minerva Urology and Nephrology","volume":" ","pages":"759-767"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Olga Katzendorn, Frank Schiefelbein, Georg Schoen, Clemens Wiesinger, Jacob Pfuner, Burkhard Ubrig, Simon Gloger, Daniar Osmonov, Ahmed Eraky, Christian Wagner, Abdirahman Ayanle, Mulham Al-Nadar, Claudia Kesch, Boris A Hadaschik, Pouriya Faraj Tabrizi, Mathias Wolters, Markus A Kuczyk, Stefan Siemer, Michael Stoeckle, Philip Zeuschner, Nina N Harke
{"title":"Conversions in robot-assisted partial nephrectomy: a multicentric analysis of 2549 cases.","authors":"Olga Katzendorn, Frank Schiefelbein, Georg Schoen, Clemens Wiesinger, Jacob Pfuner, Burkhard Ubrig, Simon Gloger, Daniar Osmonov, Ahmed Eraky, Christian Wagner, Abdirahman Ayanle, Mulham Al-Nadar, Claudia Kesch, Boris A Hadaschik, Pouriya Faraj Tabrizi, Mathias Wolters, Markus A Kuczyk, Stefan Siemer, Michael Stoeckle, Philip Zeuschner, Nina N Harke","doi":"10.23736/S2724-6051.24.06018-X","DOIUrl":"10.23736/S2724-6051.24.06018-X","url":null,"abstract":"<p><strong>Background: </strong>Conversion in partial nephrectomy to radical nephrectomy occurs in 1-5%. This analysis assessed predictors for conversions in robot-assisted partial nephrectomies.</p><p><strong>Methods: </strong>Two thousand five hundred forty-nine patients at eight robotic centers for robot-assisted partial nephrectomy were retrospectively analyzed. Intervention was performed by 25 surgeons with varying expertise. Conversion was defined as change from robot-assisted partial nephrectomy to open partial, open radical or robot-assisted radical nephrectomy. Comparative analyses between converted and non-converted cases and within subgroups as well as multivariate regression analyses for predictors for conversion were performed.</p><p><strong>Results: </strong>Eighty-eight (3.5%) conversions were documented (17% open nephrectomy, 53% open partial nephrectomy, 30% robot-assisted nephrectomy). In case of conversion, patients were significantly older (P<0.001) with a higher Body Mass Index (BMI; P=0.029), larger tumor size (P<0.001), multiple tumors (P<0.001) and higher PADUA scores (P<0.001). Converting surgeons had a significantly lower experience in RAPN (median EXP 64 vs. 29, P<0.001). The main reasons to convert were unfavorable anatomic features (69%). Radical nephrectomy occurred more frequently in tumors with higher PADUA Score (P<0.001). Experienced surgeons in open renal surgery performed more often open partial nephrectomy in case of open conversion (P<0.001). Patients' age, BMI, surgeon's expertise, number of tumors, tumor size and PADUA Score were independent predictors for conversion (P<0.001). Limitations are the retrospective study design and short-term follow-up.</p><p><strong>Conclusions: </strong>Conversions in robot-assisted partial nephrectomy are predominantly determined by patient- and tumor-related factors, but also surgical experience. Intensified surgical training might reduce the risk of conversions with an increased chance for nephron-sparing surgery in converted cases.</p>","PeriodicalId":53228,"journal":{"name":"Minerva Urology and Nephrology","volume":" ","pages":"708-716"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Selcuk Erdem, Laura Marandino, Eduard Roussel, Chiara Ciccarese, Daniele Amparore, Riccardo Campi
{"title":"YAU renal cancer spotlight: how should cost-effectiveness affect decision-making regarding adjuvant pembrolizumab for clear cell renal cell carcinoma?","authors":"Selcuk Erdem, Laura Marandino, Eduard Roussel, Chiara Ciccarese, Daniele Amparore, Riccardo Campi","doi":"10.23736/S2724-6051.24.06268-2","DOIUrl":"https://doi.org/10.23736/S2724-6051.24.06268-2","url":null,"abstract":"","PeriodicalId":53228,"journal":{"name":"Minerva Urology and Nephrology","volume":"76 6","pages":"797-801"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Humphrey Robin, Stessy Kutchukian, Pierre Bigot, Marc Françot, Stéphane de Vergie, Jérôme Rigaud, Mathilde Chapuis, Laurent Brureau, Camille Jousseaume, Omar Karray, Fares T Kosseifi, Aurélien Descazeaud, Harrison-Junior Asare, Maxime Gaullier, Baptiste Poussot, Thibault Tricard, Shahed Borojeni, Bastien Gondran-Tellier, Michael Baboudjian, Éric Lechevallier, Pierre-Olivier Delpech, Elias Ayoub, Héloïse Ducousso, Simon Bernardeau, Aurélien Dinh, Franck Bruyère, Maxime Vallée
{"title":"Impact of antibiotic treatment duration for preoperative asymptomatic bacteriuria, during urological surgery, on postoperative infectious complications: results from the multicentric TOCUS cohort.","authors":"Humphrey Robin, Stessy Kutchukian, Pierre Bigot, Marc Françot, Stéphane de Vergie, Jérôme Rigaud, Mathilde Chapuis, Laurent Brureau, Camille Jousseaume, Omar Karray, Fares T Kosseifi, Aurélien Descazeaud, Harrison-Junior Asare, Maxime Gaullier, Baptiste Poussot, Thibault Tricard, Shahed Borojeni, Bastien Gondran-Tellier, Michael Baboudjian, Éric Lechevallier, Pierre-Olivier Delpech, Elias Ayoub, Héloïse Ducousso, Simon Bernardeau, Aurélien Dinh, Franck Bruyère, Maxime Vallée","doi":"10.23736/S2724-6051.24.05725-2","DOIUrl":"https://doi.org/10.23736/S2724-6051.24.05725-2","url":null,"abstract":"<p><strong>Background: </strong>According to the European guidelines, any urological surgery breaching the mucosa requires preoperative screening and antibiotic treatment of any asymptomatic bacteriuria (ABU).</p><p><strong>Methods: </strong>The aim of this study was to determine whether the preoperative antibiotic treatment duration of ABU in urological surgery impact postoperative infectious complications. National multicenter, retrospective study including all consecutive patients screened for ABU before urologic surgery in 10 centers from 1<sup>st</sup> April 2019 to April 2023. The primary endpoint was all postoperative infectious complications occurring within 30 days after surgery. Short antibiotic treatment (SAT) of ABU was defined by 5- day regimen or less. Long antibiotic treatment (LAT) was defined by duration longer than 5 days.</p><p><strong>Results: </strong>Among the 2389 patients included, 839 (35.1%) patients had positive urine culture (UC), of whom 546 (65%) had positive mono or bimicrobial UC and 292 (34.8%) polymicrobial UC. There were 106 (4.4%) postoperative infectious complications occurring within 30 days including 62 (58.5%) in the positive UC group. In the positive UC group, 336 (40%) had received SAT, 261 (31.1%) LAT and 231 (27.5%) had not received any treatment. The 30-day surgery-related infection rates were 8.3%, 6.1% and 7.36% respectively. There was no statistical difference between SAT versus LAT in the univariate analysis (P=0.6) or in the multivariate analysis OR 1.97 [0.37, 1.86] (P=0.06).</p><p><strong>Conclusions: </strong>Our results found no association between antibiotic treatment duration and urinary infectious complication among patients with preoperative ABU who undergo urological surgery. These results need a RCT to be confirmed.</p>","PeriodicalId":53228,"journal":{"name":"Minerva Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhenyu Li, Silu Chen, Yicong DU, Zhihua Li, Shubo Fan, Shengwei Xiong, Xiang Wang, Xinfei Li, Liqun Zhou, Kunlin Yang, Xuesong Li
{"title":"Modified robot-assisted laparoscopic dismembered pyeloplasty for adult patients with horseshoe kidney: techniques and medium-term outcomes.","authors":"Zhenyu Li, Silu Chen, Yicong DU, Zhihua Li, Shubo Fan, Shengwei Xiong, Xiang Wang, Xinfei Li, Liqun Zhou, Kunlin Yang, Xuesong Li","doi":"10.23736/S2724-6051.24.06024-5","DOIUrl":"https://doi.org/10.23736/S2724-6051.24.06024-5","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to report our technique and medium-term outcomes of modified robot-assisted laparoscopic dismembered pyeloplasty (RALDP) in the Lithotomy Trendelenburg position for treating adult ureteropelvic junction obstruction (UPJO) with horseshoe kidney (HSK).</p><p><strong>Methods: </strong>Between March 2021 and March 2023, 11 adult patients with UPJO and HSK underwent modified RALDP in the lithotomy Trendelenburg position. Patient demographic characteristics, perioperative parameters, and follow-up outcomes were collected prospectively and analyzed. A detailed description of the technique and medium-term outcomes were reported.</p><p><strong>Results: </strong>The median (range) age was 33 (23-50) years. The mean preoperative serum creatinine and preoperative estimated glomerular filtration rate (eGFR) were 74.72±16.20 μmol/L and 100.4±16.5 mL/min/1.73 m<sup>2</sup>, respectively. One patient (9.1%) required an additional right pyelolithotomy. The mean operative duration was 208±70 min. The median (range) estimated blood loss was 20 (20-100) mL. The median (range) drainage-tube removal time was 3 (2-4) days postoperatively. The median (range) postoperative hospitalization period was 5 (3-6) days. No open conversions or intraoperative complications occurred. Postoperative urinary tract infections (Clavien-Dindo grade II) occurred in two patients, managed with oral antibiotics. The median (range) follow-up of 25 (12-36) months achieved an overall success rate of 100%. The mean postoperative serum creatinine and postoperative eGFR were 74.96±17.43 μmol/L and 98.14±18.39 mL/min/1.73 m<sup>2</sup>, respectively.</p><p><strong>Conclusions: </strong>Our medium-term outcomes indicate that the modified RALDP in the Lithotomy Trendelenburg position was safe and feasible for adult HSK patients. Further prospective studies of larger sample sizes and randomized controlled trials are warranted.</p>","PeriodicalId":53228,"journal":{"name":"Minerva Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mateusz Czajkowski, Bartosz Małkiewicz, Katarzyna Czajkowska, Piotr M Wierzbicki, Adrian Poterek, Roman Sosnowski, Małgorzata Sokołowska-Wojdyło, Tomasz Szydełko, Marzena Kogut-Wierzbicka, Marcin Matuszewski
{"title":"Partial penectomy with reconstruction using a split-thickness skin graft: a multicenter experience.","authors":"Mateusz Czajkowski, Bartosz Małkiewicz, Katarzyna Czajkowska, Piotr M Wierzbicki, Adrian Poterek, Roman Sosnowski, Małgorzata Sokołowska-Wojdyło, Tomasz Szydełko, Marzena Kogut-Wierzbicka, Marcin Matuszewski","doi":"10.23736/S2724-6051.24.05924-X","DOIUrl":"https://doi.org/10.23736/S2724-6051.24.05924-X","url":null,"abstract":"<p><strong>Background: </strong>Penile cancer is a relatively rare neoplasm in developed countries, with the majority of newly diagnosed cases presenting as organ-confined, with a 5-year survival rate of 90%. Therefore, it is crucial to consider the impact of penile tumor resection on sexual and urinary function. Regrettably, the literature is devoid of comprehensive, step-by-step video instructions for the surgical procedure of partial penectomy with reconstruction using a split-thickness skin graft (0.3 mm). This study aimed to demonstrate a step-by-step video of the partial penectomy technique with reconstruction using a split-thickness skin graft and to present the outcomes of this procedure.</p><p><strong>Methods: </strong>This multicenter study was initiated in April 2019 and completed in February 2023, enrolling 54 male patients who underwent partial penectomy and reconstruction using a split-thickness skin graft (0.3 mm). The study collected data on the local recurrence rates, overall survival, sexual and voiding functions and complications.</p><p><strong>Results: </strong>The average patient age was 61.26 years old (range: 26-82 years). Following penile-sparing surgery, a substantial proportion of patients exhibited favorable results. Among the 54 patients, 37 (68.5%) were classified as sexually active and 50 (92.6%) demonstrated good voiding function. Excellent cosmetic outcomes were achieved in 52 patients (96.3%), and the average size of the negative resection margins was 4.75±4.162 mm (range: 0.5 to 20 mm). Notably, no positive margins were observed. Patient outcomes depend on the tumor stage and histologic grade rather than the size of the surgical margin.</p><p><strong>Conclusions: </strong>Partial penectomy with reconstruction using a split-thickness skin graft has excellent oncological, functional, and cosmetic outcomes.</p>","PeriodicalId":53228,"journal":{"name":"Minerva Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Angelo Porreca, Stefania Zovato, Marco Rinaldi, Luca DI Gianfrancesco, Isabella Mammi, Filippo Marino, Gianluca Giannarini, Alessandro Crestani
{"title":"The association between MET c.3328G>A p.Val1110Ile mutation and renal cell carcinomas in a specific population: data on histology, focality, onset and the need for surgery from a monocentric study.","authors":"Angelo Porreca, Stefania Zovato, Marco Rinaldi, Luca DI Gianfrancesco, Isabella Mammi, Filippo Marino, Gianluca Giannarini, Alessandro Crestani","doi":"10.23736/S2724-6051.24.05998-6","DOIUrl":"https://doi.org/10.23736/S2724-6051.24.05998-6","url":null,"abstract":"","PeriodicalId":53228,"journal":{"name":"Minerva Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Letizia M Jannello, Mario DE Angelis, Carolin Siech, Francesco DI Bello, Natali Rodriguez Peñaranda, Zhe Tian, Jordan A Goyal, Stefano Luzzago, Francesco A Mistretta, Marco Tozzi, Fred Saad, Felix K Chun, Alberto Briganti, Stefano Puliatti, Nicola Longo, Ottavio DE Cobelli, Gennaro Musi, Pierre I Karakiewicz
{"title":"Validation of lymphovascular invasion as a predictor of lymph-node invasion in squamous cell carcinoma of the penis.","authors":"Letizia M Jannello, Mario DE Angelis, Carolin Siech, Francesco DI Bello, Natali Rodriguez Peñaranda, Zhe Tian, Jordan A Goyal, Stefano Luzzago, Francesco A Mistretta, Marco Tozzi, Fred Saad, Felix K Chun, Alberto Briganti, Stefano Puliatti, Nicola Longo, Ottavio DE Cobelli, Gennaro Musi, Pierre I Karakiewicz","doi":"10.23736/S2724-6051.24.05938-X","DOIUrl":"https://doi.org/10.23736/S2724-6051.24.05938-X","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to validate lymphovascular invasion (LVI) as a predictor of lymph-node invasion (LNI) in squamous cell carcinoma of the penis (SCCP).</p><p><strong>Methods: </strong>Within the Surveillance, Epidemiology, and End Results database (2010-2020), we identified SCCP patients who underwent lymphadenectomy with known LVI status. Univariable logistic regression models (LRMs) addressed LNI. Harrell's concordance index (c-index) quantified accuracy after 2000 bootstrap resamples for internal validation. Multivariable LRMs included the most informative, statistically significant predictors. Subgroup analyses were repeated in organ-confined (T1b-T2) and non-organ confined (T3-T4) stages.</p><p><strong>Results: </strong>Of 586 SCCP patients, 219 (37%) had LVI. LVI was associated with higher rate of LNI (66 vs. 43%; P<0.001). Positive predictive value of LVI was 66 vs. 57% for negative predictive value. In multivariable LRMs, LVI independently predicted LNI (Odds ratio [OR]: 2.41; P<0.001). Bootstrap-adjusted c-index of multivariable model was 0.570 without LVI vs. 0.639 with LVI. In subgroup analyses, LVI independently predicted LNI in organ-confined (OR: 2.23; P<0.001) and in non-organ confined stages (OR: 3.10; P<0.001). In subgroup analyses, addition of LVI increased c-index from 0.530 to 0.595 in organ-confined and from 0.599 to 0.682 in non-organ confined.</p><p><strong>Conclusions: </strong>The current study validates LVI as an independent predictor of LNI in SCCP. LVI increases the accuracy of LNI predictions in the overall cohort as well as in organ-confined and non-organ confined stages. However, stage and grade even with the added consideration of LVI are not accurate enough to provide LNI prediction in individual patients.</p>","PeriodicalId":53228,"journal":{"name":"Minerva Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlos Delgado-Miguel, Virginia Amesty, Susana Rivas, Roberto Lobato, María J Martínez-Urrutia, Pedro López-Pereira
{"title":"Augmentation cystoplasty in children with neuropathic bladder: long-term outcomes after 30 years experience.","authors":"Carlos Delgado-Miguel, Virginia Amesty, Susana Rivas, Roberto Lobato, María J Martínez-Urrutia, Pedro López-Pereira","doi":"10.23736/S2724-6051.24.05919-6","DOIUrl":"https://doi.org/10.23736/S2724-6051.24.05919-6","url":null,"abstract":"<p><strong>Background: </strong>Augmentation cystoplasty (AC) is a useful alternative for the treatment of neuropathic bladder, although there are few studies reporting long-term results. We assess our experience over the last 30-years.</p><p><strong>Methods: </strong>A retrospective study was conducted in patients with neuropathic bladder in whom AC was performed in our institution between 1990-2020. Demographic variables, pre- and post- AC urodynamic studies, long-term outcomes and postoperative complications were collected.</p><p><strong>Results: </strong>Eighty-six patients (43 males and 43 females) underwent AC surgery with a median age of 12.8 years (interquartile range 9.6-15.1). Bladder augmentation was performed with ileum in 49 cases (57%), sigma in 32 cases (37.2%) and ureter in 5 cases (5.8%). In 27 patients an artificial urinary sphincter (AUS) was placed at the same intervention. The mean preoperative bladder capacity was 117 mL (SD 40), which was increased to 430 mL (SD 64) one year after surgery, this difference being statistically significant (P<0.001). Median follow-up was 24.5 years (interquartile range 17.5-26). Vesico-ureteral reflux improved after AC in 78.9% with no other surgical interventions. Seven mechanical complications associated with AUS were reported. Bladder lithiasis was reported in 9 patients. No bladder perforations were described. One patient developed bladder squamous cell carcinoma 16 years after AC, requiring radical cystectomy and Hautmann neobladder.</p><p><strong>Conclusions: </strong>Long-term results of this study demonstrate that AC is an effective surgical treatment in patients with neuropathic bladder patients without proper response to medical treatment. The risk of developing complications long after bladder augmentation makes close clinical follow-up of these patients essential.</p>","PeriodicalId":53228,"journal":{"name":"Minerva Urology and Nephrology","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}