{"title":"A novel rat model for studying bilateral cavernous nerve damage in vivo: exploring the potential of chitosan-blended membranes for nerve regeneration post-radical prostatectomy.","authors":"Federica Fregnan, Luisa Muratori, Alessandro Crosio, Federica Zen, Cristian Fiori, Ilaria Tonazzini, Giovanna Gambarotta, Antonello Martinelli, Juliette Meziere, Stefania Raimondo, Matteo Manfredi, Luca Scaccini, Stefano Geuna, Francesco Porpiglia","doi":"10.23736/S2724-6051.25.06169-5","DOIUrl":"https://doi.org/10.23736/S2724-6051.25.06169-5","url":null,"abstract":"<p><strong>Background: </strong>The primary treatment for localized prostate cancer involves radical prostatectomy (RP) often resulting in iatrogenic damage to the periprostatic neurovascular bundles (NVB), leading to erectile dysfunction. The current study devised an experimental model involving bilateral cavernous nerve (CN) lesions in rats to replicate nerve damage close to the injury of the NVB in humans following radical prostatectomy.</p><p><strong>Methods: </strong>Fifteen adult male Wistar rats were divided as follows: control rats without surgery (CTRL group); rats underwent bilateral resection of 2 mm of CN repaired with a glycerol-blended chitosan membranes (CS-MEM group); rats underwent a total resection of both CN and major pelvic ganglion (RES group). Two months after surgery, membranes with regenerated nerves were analyzed morphologically, and for gene and protein expression for the evaluation of nerve regeneration and vascularization. Rat penises were assessed for smooth muscle content, morphology, and tissue arrangement. Primary sensory neuron cultures and DRG explants were cultured on micro-grooved chitosan-blended membranes, to evaluate axonal orientation on different topographies.</p><p><strong>Results: </strong>Regenerated nerve fibers and newly formed vessels colonized the whole CS-membrane. The regenerative process was also confirmed by gene and protein expression analyses. The target organ exhibited remodeling of smooth muscle tissue around sinusoidal spaces, indicating potential restoration of cavernous tissue. The quantitative analyses of α-actin smooth muscle (α-SMA) expression in CS-MEM groups displayed α-SMA protein signals comparable to controls. In-vitro experiments on micro-patterned membranes displayed oriented axonal growth, showing valuable insights into the ways in which topographical features can be considered for a more effective performance in vivo.</p><p><strong>Conclusions: </strong>Chitosan-blended membranes promote nerve fiber regeneration in an in-vivo model of nerve lesion that resembles the damage to the NVB occurring in men after radical prostatectomy. These results highlight the promising potential of this device in the clinical urological field, thus suggesting that the application of orientated micro-patterned membranes could further improve nerve regeneration.</p>","PeriodicalId":53228,"journal":{"name":"Minerva Urology and Nephrology","volume":"77 1","pages":"91-110"},"PeriodicalIF":4.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alberto Artiles Medina, José D Subiela, Ana Tagalos Muñoz, Marta Tato Díez, César Mínguez Ojeda, David López Curtis, Álvaro Sánchez González, Jennifer Brasero Burgos, Alejandra Serna-Céspedes, Victoria Gómez Dos Santos, Miguel Á Jiménez Cidre, Francisco J Burgos Revilla
{"title":"Clinical outcomes of BCG infections in patients undergoing intravesical immunotherapy for non-muscle-invasive bladder cancer: a systematic review and meta-analysis.","authors":"Alberto Artiles Medina, José D Subiela, Ana Tagalos Muñoz, Marta Tato Díez, César Mínguez Ojeda, David López Curtis, Álvaro Sánchez González, Jennifer Brasero Burgos, Alejandra Serna-Céspedes, Victoria Gómez Dos Santos, Miguel Á Jiménez Cidre, Francisco J Burgos Revilla","doi":"10.23736/S2724-6051.24.05910-X","DOIUrl":"https://doi.org/10.23736/S2724-6051.24.05910-X","url":null,"abstract":"<p><strong>Introduction: </strong>Intravesical bacillus Calmette-Guérin (BCG) is the standard treatment for high- and intermediate-risk non-muscle-invasive bladder cancer (NMIBC). Despite its 50-year history of use, there remains a paucity of data regarding infections associated with intravesical BCG immunotherapy in real-world clinical practice. Thus, this study aimed to assess the clinical outcomes of BCG infections in a high-volume center and systematically review the literature on the topic.</p><p><strong>Evidence acquisition: </strong>We retrospectively reviewed the records of patients who had experienced BCG infections following intravesical immunotherapy for NMIBC at our institution between 2001 and 2022, and systematically reviewed the literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) (PROSPERO registration: CRD42024497171). The PubMed, EMBASE and Scopus databases were searched in December 2023. Endpoints were: overall incidence of BCG infections, incidence of disseminated infection and mortality.</p><p><strong>Evidence synthesis: </strong>Twelve eligible references were identified through the search strategy (n=306 patients), while our series comprised 18 patients. A total of 324 patients were thus included for evidence synthesis. Meta-analysis results showed that the pooled incidence of BCG infection among patients treated with intravesical immunotherapy was 2% (95% CI 1-2%). The pooled mean age was 71.19 years (95% CI 65.89-76.50). The pooled mean duration of intravesical therapy until the diagnosis of BCG infection was 11.67 months (95% CI 4.62-18.71), and a low rate of urine culture positivity was observed (pooled rate of 23% [95% CI 13-34%]). Disseminated disease was present in 61% of cases (95% CI 45-77%), while the pooled rate of local (genitourinary) involvement was 32% (95% CI 17-50%). The proportion of deaths among these patients was 5% (95% CI 2-10%).</p><p><strong>Conclusions: </strong>BCG infections following intravesical immunotherapy are a rare condition (2%). While more than half of those who experience this complication present with a disseminated pattern, the associated mortality appears to be low (5%).</p>","PeriodicalId":53228,"journal":{"name":"Minerva Urology and Nephrology","volume":"77 1","pages":"13-24"},"PeriodicalIF":4.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fabrizio Dal Moro, Simonetta Fracalanza, Fabio Zattoni, Giacomo Novara, Mario Gardi
{"title":"Robot-assisted retroperitoneoscopic kidney surgery with Versius®.","authors":"Fabrizio Dal Moro, Simonetta Fracalanza, Fabio Zattoni, Giacomo Novara, Mario Gardi","doi":"10.23736/S2724-6051.24.06122-6","DOIUrl":"10.23736/S2724-6051.24.06122-6","url":null,"abstract":"","PeriodicalId":53228,"journal":{"name":"Minerva Urology and Nephrology","volume":" ","pages":"142-144"},"PeriodicalIF":4.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Juan Justo Quintas, Esther García Rojo, Borja García Gómez, Fernando Lista Mateos, Renan J Otta Oshiro, Elena Peña Vallejo, Celeste Manfredi, Giorgio Bozzini, Alfredo Rodríguez Antolín, Javier Romero-Otero
{"title":"Aquablation vs. holmium laser enucleation of the prostate for benign prostatic hyperplasia: a 150-patients prospective comparative multicenter study.","authors":"Juan Justo Quintas, Esther García Rojo, Borja García Gómez, Fernando Lista Mateos, Renan J Otta Oshiro, Elena Peña Vallejo, Celeste Manfredi, Giorgio Bozzini, Alfredo Rodríguez Antolín, Javier Romero-Otero","doi":"10.23736/S2724-6051.24.05871-3","DOIUrl":"10.23736/S2724-6051.24.05871-3","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to compare the efficacy and safety of Aquablation<sup>®</sup> with those of holmium laser enucleation of the prostate (HoLEP) for the treatment of patients with benign prostatic hyperplasia (BPH).</p><p><strong>Methods: </strong>Prospective comparative non-randomized multicenter study conducted between July 2021 and July 2023, consecutive patients undergoing BPH surgery were enrolled to each group. Patients had moderate to severe lower urinary tract symptoms (LUTS), International Prostate Symptom Score (IPSS) ≥8, maximum urinary flow rate (Qmax) ≤15 mL/s, prostate volume ≥30 mL ≤120 mL, and BPH medical therapy failure. Primary outcome was short-term efficacy measured by IPSS, IPSS-QoL, Qmax, post-void residual volume (PVR), prostate-specific antigen (PSA); secondary outcome was safety (intra and post-operative complications, ejaculatory dysfunction, continence, blood transfusions). A six-month follow-up was performed.</p><p><strong>Results: </strong>Of 150 patients (75:75) enrolled, both groups showed improvements (P<0.05) in IPSS, IPSS-QoL, Qmax, and PVR at six months. No significant differences were observed between HoLEP and Aquablation<sup>®</sup> in IPSS (7.6±6.9 vs. 5.05±4.9 points, P=0.11), IPSS-QoL (1.7±1.6 vs. 1.3±1.6 points, P=0.16), Qmax (28.6±8.8 vs. 23.8±9.3 mL/sec, P=0.12), and PVR (7.2±8.2 vs. 20.3±22.6 mL, P=0.19) at six months. No intraoperative complications occurred. Postoperative hemoglobin drop was higher in Aquablation<sup>®</sup> group (2.6±1.33 vs. 0.4±0.67 g/dL, P<0.001), with no statistically significant differences in transfusion rate (1.3 vs. 1.3%, P=0.31). Ejaculatory dysfunction rate was significantly lower in Aquablation<sup>®</sup> (6,6%) than HoLEP (89.3%, P<0.001). Mean prostate volume was (mean±SD) 81.8±37.4 and 71.9±34.8 mL (P=0.08) in HoLEP and Aquablation<sup>®</sup> groups, respectively. Holep demonstrated a smaller prostate volume after treatment (18.1±6.5 vs. 46.5±25.02 mL P<0.001) as well as a significantly greater reduction and lower levels of PSA (1.2±1.4 vs. 2.65±2.8 ng/mL, P<0.001). Aquablation<sup>®</sup> demonstrated significantly shorter tissue removal time (5.5±2.4 vs. 22.4±9.8 min, P<0.001), but no difference in total operative time (49.1±15 vs. 43.9±26.8 min, P=0.052).</p><p><strong>Conclusions: </strong>HoLEP and Aquablation<sup>®</sup> show similar effectiveness and safety for BPH-related-LUTS at 6 months. Aquablation<sup>®</sup> has lower ejaculatory dysfunction rates. Larger randomized trials and with longer follow-up time are needed for validation.</p>","PeriodicalId":53228,"journal":{"name":"Minerva Urology and Nephrology","volume":" ","pages":"111-119"},"PeriodicalIF":4.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roberto Miano, Giovanni Gambaro, Corrado Vitale, Giuseppe Vezzoli, Michele Talso, Stefania Ferretti, Michele Raguso, Pietro M Ferraro
{"title":"Management of genetically determined kidney stone disease: consensus from a panel of urologists and nephrologists.","authors":"Roberto Miano, Giovanni Gambaro, Corrado Vitale, Giuseppe Vezzoli, Michele Talso, Stefania Ferretti, Michele Raguso, Pietro M Ferraro","doi":"10.23736/S2724-6051.24.05875-0","DOIUrl":"10.23736/S2724-6051.24.05875-0","url":null,"abstract":"<p><strong>Background: </strong>Available evidence suggests that monogenic causes of kidney stones are likely under-diagnosed, particularly in young adults, needing expert multidisciplinary recommendations to improve diagnosis, management and therapeutic outcomes. To increase the awareness among the medical community on the recognition of the signs and symptoms of genetically determined kidney stone disease in adult patients, with a special focus on primary hyperoxaluria (PH), a group of nephrologists and urologists started a consensus process through the Delphi method.</p><p><strong>Methods: </strong>A list of 40 statements (23 regarding genetically determined stone disease and 17 regarding primary hyperoxaluria) was defined by the authors and included in an online Delphi survey, which was sent to 16 urologists and 22 nephrologists with expertise in managing patients with kidney stone disease. An agreement threshold of 75% was established for consensus.</p><p><strong>Results: </strong>After two rounds of Delphi voting, consensus was reached for 33 statements, 18 regarding genetically determined stone disease and 15 regarding PH.</p><p><strong>Conclusions: </strong>The Delphi process highlighted several areas of agreement with regard to the characteristic or anamnestic data suggesting diagnostic investigation, optimal diagnostic patterns, treatment strategies and management of patients with genetically determined nephrolithiasis. The process also highlighted some grey areas, which deserve further investigation and highlight the need for educational initiatives focused on rare diseases in the field of kidney stones.</p>","PeriodicalId":53228,"journal":{"name":"Minerva Urology and Nephrology","volume":" ","pages":"130-136"},"PeriodicalIF":4.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fabrizio Di Maida, Antonio A Grosso, Andrea Mari, Andrea Minervini
{"title":"The role of open surgery in shaping the urologists of tomorrow: necessity or redundancy?","authors":"Fabrizio Di Maida, Antonio A Grosso, Andrea Mari, Andrea Minervini","doi":"10.23736/S2724-6051.25.06424-9","DOIUrl":"https://doi.org/10.23736/S2724-6051.25.06424-9","url":null,"abstract":"","PeriodicalId":53228,"journal":{"name":"Minerva Urology and Nephrology","volume":"77 1","pages":"3-5"},"PeriodicalIF":4.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Robot-assisted redo ureteral reimplantation in adults after failed primary surgery: technique and outcomes from two centers.","authors":"Liqing Xu, Xinfei Li, Fangzhou Zhao, Zhihua Li, Guanpeng Han, Wencong Han, Yaming Gu, Bing Wang, Peng Zhang, Wenzhi Gao, Liang Cui, Liqun Zhou, Kunlin Yang, Xuesong Li","doi":"10.23736/S2724-6051.24.06009-9","DOIUrl":"10.23736/S2724-6051.24.06009-9","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to report our technical experience and mid-term outcomes of robot-assisted redo ureteral reimplantation in adults following failed primary ureteral reimplantation.</p><p><strong>Methods: </strong>Twelve patients underwent robot-assisted redo ureteral reimplantation from December 2020 to May 2022 at double centers. Surgical procedures included anti-reflux dismembered submucosal tunnel reimplantation, anti-reflux dismembered nipple reimplantation, and anti-reflux non-dismembered submucosal tunnel reimplantation. The perioperative variables were prospectively collected, and the outcomes were assessed.</p><p><strong>Results: </strong>Twelve patients underwent 13 robot-assisted redo ureteral reimplantations. Anastomotic stenosis was the primary cause of redo surgery, accounting for 83.3% of cases. Additionally, 83.3% of patients had received balloon dilation, stent placement, and other urological treatments after primary surgery. All patients successfully underwent robot-assisted redo ureteral reimplantation without conversion to open or laparoscopic surgery. All patients underwent anti-reflux technique, with 9 patients undergoing submucosal tunnel reimplantation (75%) and 3 nipple reimplantation (25%). Psoas hitch was required in eight patients (66.7%). The mean operative time was 129.3±29.0 minutes. The median postoperative hospitalization time was 3.0 (IQR, 3.0, 3.0) days. At a mean follow-up of 15.7±5.9 months, all patients achieved complete success with no severe complication. Two patients (16.7%) still experienced vesicoureteral reflux related symptoms postoperatively, which improved compared to preoperatively.</p><p><strong>Conclusions: </strong>Robotic redo ureteral reimplantation is safe and effective. The success of redo surgery is attributed to preoperative nephrostomy, clearing the fibrous scar surrounding the ureter, appropriate selection of anti-reflux technique, and psoas hitch when needed.</p>","PeriodicalId":53228,"journal":{"name":"Minerva Urology and Nephrology","volume":" ","pages":"69-78"},"PeriodicalIF":4.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Angelo Cormio, Matteo Mantovan, Vanessa Palantrani, Mattia Beltrami, Demetra Fuligni, Valerio Passarella, Vanessa Cammarata, Carlo Brocca, Bhaskar K Somani, Vineet Gauhar, Giuseppe Carrieri, Luigi Cormio, Andrea B Galosi, Daniele Castellani
{"title":"A narrative review on extracorporeal shock wave lithotripsy, ureterolithotripsy, and percutaneous nephrolithotripsy in patients with anomalous kidneys.","authors":"Angelo Cormio, Matteo Mantovan, Vanessa Palantrani, Mattia Beltrami, Demetra Fuligni, Valerio Passarella, Vanessa Cammarata, Carlo Brocca, Bhaskar K Somani, Vineet Gauhar, Giuseppe Carrieri, Luigi Cormio, Andrea B Galosi, Daniele Castellani","doi":"10.23736/S2724-6051.25.06001-X","DOIUrl":"https://doi.org/10.23736/S2724-6051.25.06001-X","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this paper was to review the outcomes of shock wave lithotripsy (SWL), ureteroscopy, and percutaneous nephrolithotripsy (PCNL) in kidney stone patients with Congenital Anomalies of the Kidney and Urinary Tract (CAKUT).</p><p><strong>Evidence acquisition: </strong>A literature search was performed on 15th November 2023 and updated on 18<sup>th</sup> October 2024 using Cochrane Central Register of Controlled Trials, PubMed, Scopus and Google Scholar with no date limit. Preclinical and animal studies, reviews, letters to editor, case reports, pediatric studies were excluded. Only English papers were included.</p><p><strong>Evidence synthesis: </strong>Forty-one articles were accepted. Seventeen studies focused on horse-shoe kidney (HSK). Among these, 3 papers focused on RIRS, 9 on PCNL, 5 compared RIRS vs PCNL. The remaining ones explored SWL, RIRS, PCNL in ectopic, malrotated and medullary sponge kidney and caliceal diverticulum stones. HSK, caliceal diverticulum and malrotated kidneys stones treated with SWL have poor stone-free rate, while the best choices are PCNL and ureteroscopy. In ectopic kidneys the best choice is ureteroscopy, SWL has poor stone-free rate, while PCNL is less safe for higher bowel injury risk. In medullary sponge kidneys regardless of the treatment used, stone-free rate is low, with a higher rate of retreatment.</p><p><strong>Conclusions: </strong>SWL has lower stone-free rate and higher retreatment in all types of CAKUT but has the lowest rate of complications. PCNL has the best stone-free rate in large stone burdens and RIRS is effective procedure although higher reintervention rate and need of pre-stenting in some cases.</p>","PeriodicalId":53228,"journal":{"name":"Minerva Urology and Nephrology","volume":"77 1","pages":"43-51"},"PeriodicalIF":4.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qinglong Yang, Hanyuan Lin, Xuan Zhang, Haoxian Tang, Jingtao Huang, Nan Luo, Qingtao Yang
{"title":"Life's Essential 8 and kidney stones in US adults: mediating roles of HDL and insulin resistance.","authors":"Qinglong Yang, Hanyuan Lin, Xuan Zhang, Haoxian Tang, Jingtao Huang, Nan Luo, Qingtao Yang","doi":"10.23736/S2724-6051.24.05774-4","DOIUrl":"10.23736/S2724-6051.24.05774-4","url":null,"abstract":"<p><strong>Background: </strong>The rising incidence of kidney stones underscores the imperative to devise effective preventive measures. While a robust association between cardiovascular disease (CVD) and kidney stones exists, the current research landscape lacks investigations between cardiovascular health (CVH) and kidney stones. This study aims to explore the association between CVH, assessed by Life's Essential 8 (LE8), and kidney stones, with the role of blood lipids and insulin resistance in this relationship.</p><p><strong>Methods: </strong>The study included 19,942 adults aged ≥20 from the National Health and Nutrition Examination Survey of the US from 2007 to 2018. LE8, measuring CVH, includes four behavior and four factor metrics. Participants were categorized into high, moderate, and low CVH levels according to LE8 Scores: 80-100, 50-79, and 0-49, respectively. Kidney stones cases were identified through interviews and self-reported records. Weighted multivariate linear regressions, weighted logistic regressions, restricted cubic spline (RCS) analysis, mediation analyses, and sensitivity analyses were conducted.</p><p><strong>Results: </strong>In the fully adjusted logistic model, 10-point increase in LE8 Score exhibited a significant 19% reduction in kidney stones prevalence (OR=0.81, 95% CI: 0.77-0.85). The RCS confirmed the nonlinear association between LE8 Score and kidney stones (P for non-linearity: 0.004). Mediation analyses showed the mediation proportions of 19.62%, 24.26%, and 27.82% for high-density lipoprotein (HDL), insulin resistance (HOMA-IR), and serum insulin, respectively. The mediation proportions of the HOMA-IR-HDL and serum insulin-HDL pathways were 6.62% and 5.96%, respectively.</p><p><strong>Conclusions: </strong>This study illuminates a negative association between CVH and kidney stones, providing an effective strategy for kidney stones prevention.</p>","PeriodicalId":53228,"journal":{"name":"Minerva Urology and Nephrology","volume":" ","pages":"120-129"},"PeriodicalIF":4.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Riccardo Bertolo, Francesco Cianflone, Riccardo Negrelli, Giovanni Corghi, Michele Boldini, Francesco Ditonno, Luca Roggero, Antonio B Porcaro, Alessandro Veccia, Elena Marastoni, Stefano Gobbo, Matteo Brunelli, Mirko D'Onofrio, Alessandro Antonelli
{"title":"Giant cell inflammatory reaction to hemostatic cellulose matrix mimicking renal cell carcinoma recurrence.","authors":"Riccardo Bertolo, Francesco Cianflone, Riccardo Negrelli, Giovanni Corghi, Michele Boldini, Francesco Ditonno, Luca Roggero, Antonio B Porcaro, Alessandro Veccia, Elena Marastoni, Stefano Gobbo, Matteo Brunelli, Mirko D'Onofrio, Alessandro Antonelli","doi":"10.23736/S2724-6051.24.06210-4","DOIUrl":"10.23736/S2724-6051.24.06210-4","url":null,"abstract":"","PeriodicalId":53228,"journal":{"name":"Minerva Urology and Nephrology","volume":" ","pages":"6-12"},"PeriodicalIF":4.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}