Lancet Regional Health-Europe最新文献

筛选
英文 中文
Equity and cardiovascular disease: time to take it seriously 公平与心血管疾病:是时候认真对待它了
IF 13
Lancet Regional Health-Europe Pub Date : 2025-08-21 DOI: 10.1016/j.lanepe.2025.101405
Manuel Martínez-Sellés
{"title":"Equity and cardiovascular disease: time to take it seriously","authors":"Manuel Martínez-Sellés","doi":"10.1016/j.lanepe.2025.101405","DOIUrl":"10.1016/j.lanepe.2025.101405","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"56 ","pages":"Article 101405"},"PeriodicalIF":13.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reducing inequalities in cardiovascular disease: focus on marginalized populations considering ethnicity and race 减少心血管疾病方面的不平等:考虑到族裔和种族,重点关注边缘化人群
IF 13
Lancet Regional Health-Europe Pub Date : 2025-08-21 DOI: 10.1016/j.lanepe.2025.101371
Sonia S. Anand , Sujane Kandasamy , Miles Marchand , Maryam Kavousi , Martha Gulati , John Deanfield , Arshed A. Quyyumi
{"title":"Reducing inequalities in cardiovascular disease: focus on marginalized populations considering ethnicity and race","authors":"Sonia S. Anand ,&nbsp;Sujane Kandasamy ,&nbsp;Miles Marchand ,&nbsp;Maryam Kavousi ,&nbsp;Martha Gulati ,&nbsp;John Deanfield ,&nbsp;Arshed A. Quyyumi","doi":"10.1016/j.lanepe.2025.101371","DOIUrl":"10.1016/j.lanepe.2025.101371","url":null,"abstract":"<div><div>Cardiovascular disease (CVD) and its risk factors are more prevalent among traditionally marginalized racial, ethnic, and Indigenous groups. These populations also often face greater barriers to accessing cardiovascular health care, further contributing to the health equity gap. To address the challenge of inequalities and disparities in cardiovascular health outcomes, the Lancet Regional Health—Europe convened experts to evaluate the current state of knowledge on inequalities and disparities in cardiovascular health among marginalized populations and propose recommendations to address these disparities. This Series paper aims to review disparities in CVD referring to coronary heart disease and stroke, based on race, ethnicity, ancestry, and Indigeneity emphasizing the intersection of these factors with sex, gender, and socioeconomic status (SES) across Europe and North America. These regions were chosen as they have well established health-care systems, with persistent, and in some regions widening, disparities in cardiovascular health and outcomes. Ethnicity and race should be measured in a standardized manner in health-care administrative databases to identify high risk groups who might need focused programmes to improve health-care access and to address bias and inequities in care. Strategies that policymakers, health-care professionals, and advocacy groups can use to advance cardiovascular health equity include improving access to health-care systems and research for high-risk communities, fostering trust between these communities and public health providers, and enhancing the delivery of evidence-based therapies for the prevention and treatment of CVD.</div></div>","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"56 ","pages":"Article 101371"},"PeriodicalIF":13.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mental health disorders and their impact on cardiovascular health disparities 精神健康障碍及其对心血管健康差异的影响
IF 13
Lancet Regional Health-Europe Pub Date : 2025-08-21 DOI: 10.1016/j.lanepe.2025.101373
Viola Vaccarino , Eva Prescott , Amit J. Shah , J. Douglas Bremner , Paolo Raggi , Olivija Dobiliene , Chris P. Gale , Raffaele Bugiardini
{"title":"Mental health disorders and their impact on cardiovascular health disparities","authors":"Viola Vaccarino ,&nbsp;Eva Prescott ,&nbsp;Amit J. Shah ,&nbsp;J. Douglas Bremner ,&nbsp;Paolo Raggi ,&nbsp;Olivija Dobiliene ,&nbsp;Chris P. Gale ,&nbsp;Raffaele Bugiardini","doi":"10.1016/j.lanepe.2025.101373","DOIUrl":"10.1016/j.lanepe.2025.101373","url":null,"abstract":"<div><div>Mental health disorders are highly prevalent and are associated with significant morbidity, disability, and reduced life expectancy. A key contributor to this disparity is the increased risk of cardiovascular disease (CVD), which is partially driven by inequalities in social determinants of health, healthcare access, and quality of care. To address this challenge, The Lancet Regional Health—Europe convened experts to evaluate the current state of knowledge on inequalities and disparities in cardiovascular health among people with mental health disorders and propose recommendations to address these disparities. This Series paper aims to raise awareness of the disparities in CVD and health-care quality faced by individuals with common mental health conditions such as major depression, anxiety disorders, schizophrenia, bipolar disorder, and posttraumatic stress disorder. There is an urgent need for increased investment, intervention, and research to address the burden of CVD in these populations. Effective management of the comorbidity between mental health disorders and CVD requires an integrated and holistic approach to clinical care that addresses shared risk factors and the complex interactions between physical and mental health.</div></div>","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"56 ","pages":"Article 101373"},"PeriodicalIF":13.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tolerating cardiovascular health disparities is a failure of science and society 容忍心血管健康差异是科学和社会的失败
IF 13
Lancet Regional Health-Europe Pub Date : 2025-08-21 DOI: 10.1016/j.lanepe.2025.101445
The Lancet Regional Health – Europe
{"title":"Tolerating cardiovascular health disparities is a failure of science and society","authors":"The Lancet Regional Health – Europe","doi":"10.1016/j.lanepe.2025.101445","DOIUrl":"10.1016/j.lanepe.2025.101445","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"56 ","pages":"Article 101445"},"PeriodicalIF":13.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges in the prevention, treatment and management of cardiovascular disease among older adults 老年人心血管疾病预防、治疗和管理的挑战
IF 13
Lancet Regional Health-Europe Pub Date : 2025-08-21 DOI: 10.1016/j.lanepe.2025.101372
Nick Townsend , Adam Timmis , Andrejs Erglis , Davor Miličić , Pasquale Perrone-Filardi , Franz Weidinger , Tomasz Guzik , Chris P. Gale
{"title":"Challenges in the prevention, treatment and management of cardiovascular disease among older adults","authors":"Nick Townsend ,&nbsp;Adam Timmis ,&nbsp;Andrejs Erglis ,&nbsp;Davor Miličić ,&nbsp;Pasquale Perrone-Filardi ,&nbsp;Franz Weidinger ,&nbsp;Tomasz Guzik ,&nbsp;Chris P. Gale","doi":"10.1016/j.lanepe.2025.101372","DOIUrl":"10.1016/j.lanepe.2025.101372","url":null,"abstract":"<div><div>The ageing population in Europe is contributing to a growing proportion of older people affected by cardiovascular disease (CVD). Older adults account for most of the CVD burden and face unique challenges, complicated by age-related physiological changes and comorbidities. Older patients are underrepresented in clinical trials, leading to scientific and clinical equipoise, and inequities in care. Managing CVD in this age group is complex. Despite the availability of guideline-directed therapies, older adults often do not receive optimal treatment due to the complexity of their conditions and are at higher risk of complications. Strategies for the treatment and management of CVD in older individuals should be driven by patient centred outcomes relating to functional capacity and quality of life. Social and economic factors, such as financial limitations and isolation, further exacerbate age-related CVD inequalities and highlight the need for a holistic approach to care. To address this challenge, The Lancet Regional Health–Europe convened experts to evaluate the current state of knowledge on inequalities and disparities in cardiovascular health among older adults and propose recommendations to address these disparities. This Series paper aims to explore inequalities in, and the escalating burden of, CVD for older adults, with a focus on treatment, prevention, and strategies to support their physical and mental well-being.</div></div>","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"56 ","pages":"Article 101372"},"PeriodicalIF":13.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk factors for dementia and cognitive impairment within 5 years after stroke: a prospective multicentre cohort study 脑卒中后5年内痴呆和认知障碍的危险因素:一项前瞻性多中心队列研究
IF 13
Lancet Regional Health-Europe Pub Date : 2025-08-19 DOI: 10.1016/j.lanepe.2025.101428
Jule Filler , Marios K. Georgakis , Daniel Janowitz , Marco Duering , Rong Fang , Anna Dewenter , Felix J. Bode , Sebastian Stoesser , Christine Kindler , Peter Hermann , Christian H. Nolte , Thomas G. Liman , Lucia Kerti , Kathleen Bernkopf , Benno Ikenberg , Wenzel Glanz , Michael Wagner , Annika Spottke , Karin Waegemann , Michael Goertler , Oliver Speck
{"title":"Risk factors for dementia and cognitive impairment within 5 years after stroke: a prospective multicentre cohort study","authors":"Jule Filler ,&nbsp;Marios K. Georgakis ,&nbsp;Daniel Janowitz ,&nbsp;Marco Duering ,&nbsp;Rong Fang ,&nbsp;Anna Dewenter ,&nbsp;Felix J. Bode ,&nbsp;Sebastian Stoesser ,&nbsp;Christine Kindler ,&nbsp;Peter Hermann ,&nbsp;Christian H. Nolte ,&nbsp;Thomas G. Liman ,&nbsp;Lucia Kerti ,&nbsp;Kathleen Bernkopf ,&nbsp;Benno Ikenberg ,&nbsp;Wenzel Glanz ,&nbsp;Michael Wagner ,&nbsp;Annika Spottke ,&nbsp;Karin Waegemann ,&nbsp;Michael Goertler ,&nbsp;Oliver Speck","doi":"10.1016/j.lanepe.2025.101428","DOIUrl":"10.1016/j.lanepe.2025.101428","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Stroke survivors frequently experience subsequent cognitive impairment or dementia. We aimed to identify risk factors for post-stroke dementia (PSD) and cognitive impairment (PSCI) within 5 years after stroke.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;The DEMDAS (German Center for Neurological Diseases (DZNE) mechanisms of dementia after stroke) study is a prospective cohort of stroke patients admitted to six German tertiary stroke centres between May 1, 2011 and January 31, 2019. Eligible dementia-free patients with ischaemic or haemorrhagic stroke underwent baseline examinations and regular clinical, neuropsychological, and neuroimaging follow-ups over 5 years, with the last follow-ups completed in January 2024. PSD was the primary outcome, determined by comprehensive cognitive testing, patient and informant interviews, and review of medical records. The secondary outcomes were early-onset PSD (3–6 months), delayed-onset PSD (&gt;6 months), and PSCI. Associations between baseline risk factors and PSD were assessed using Cox regression models adjusted for age, sex, education, and stroke severity.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Findings&lt;/h3&gt;&lt;div&gt;Of 736 patients (245 [33%] female, mean age 68·0 years [SD 11·2], median admission National Institutes of Health Stroke Scale (NIHSS) 3 [IQR 1–5]), 557 (76%) were followed up until death or the end of the study, and 706 (96%) contributed to the PSD analysis. During a median of 5·0 years [IQR 3·3–5·1] of follow-up, 55 new dementia cases were diagnosed (6-month incidence: 3·1% [1·8–4·5], 5-year incidence: 8·8% [6·5–11·1]), of which 21 (38%) were classified as early-onset PSD. The 5-year risk of PSD was associated with older age (HR 1·13 [95% CI 1·08–1·18] per year), higher stroke severity (1·08 [1·03–1·13] per point on NIHSS), lower educational attainment (1·16 [1·05–1·28] per year), acute phase cognitive impairment (5·86 [2·21–15·58]), lower Barthel Index (1·10 [1·05–1·16] per 5 points less), atrial fibrillation (1·91 [1·10–3·30]), metabolic syndrome (MetS, 2·05 [1·15–3·64]), particularly reduced high-density lipoprotein cholesterol (HDL-C, 2·61 [1·50–4·52]) and pre-/diabetes mellitus (2·13 [1·13–4·00]), imaging markers of small vessel disease, and stroke recurrence during follow-up (2·36 [1·16–4·83]). Patients who received acute reperfusion treatment had a 65% lower risk of PSD than those who did not (0·35 [0·16–0·77]). While factors related to the severity of the index stroke were more strongly associated with early-onset PSD, MetS showed a stronger association with delayed-onset PSD. The association between MetS and PSD was independent of stroke recurrence and consistent across age subgroups, with 5-year cumulative incidence ranging from 1·7% (0·0–4·0) in patients ≤65 years without MetS to 24·5% (14·3–33·4) in patients ≥74 years with MetS.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Interpretation&lt;/h3&gt;&lt;div&gt;The risk of dementia after stroke is multifactorial, with differing risk profiles for early-onset and delayed","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"56 ","pages":"Article 101428"},"PeriodicalIF":13.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144867313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uptake, positivity, and equity of online postal self-sampling for chlamydia testing in England: a retrospective cohort study 英国衣原体检测的在线邮政自我抽样的吸收、积极性和公平性:一项回顾性队列研究
IF 13
Lancet Regional Health-Europe Pub Date : 2025-08-15 DOI: 10.1016/j.lanepe.2025.101412
Alison Howarth , Ana Harb , Hamish Mohammed , Fiona Burns , Claudia Estcourt , Sonja C.M. Bloch , Andrew Copas , Jonathan O'Sullivan , Tamilore Sonubi , Oliver Stirrup , Anna Tostevin , John Saunders , Jo Gibbs
{"title":"Uptake, positivity, and equity of online postal self-sampling for chlamydia testing in England: a retrospective cohort study","authors":"Alison Howarth ,&nbsp;Ana Harb ,&nbsp;Hamish Mohammed ,&nbsp;Fiona Burns ,&nbsp;Claudia Estcourt ,&nbsp;Sonja C.M. Bloch ,&nbsp;Andrew Copas ,&nbsp;Jonathan O'Sullivan ,&nbsp;Tamilore Sonubi ,&nbsp;Oliver Stirrup ,&nbsp;Anna Tostevin ,&nbsp;John Saunders ,&nbsp;Jo Gibbs","doi":"10.1016/j.lanepe.2025.101412","DOIUrl":"10.1016/j.lanepe.2025.101412","url":null,"abstract":"<div><h3>Background</h3><div>Chlamydia is the most commonly reported sexually transmitted infection (STI) in Europe and untreated chlamydia is associated with poor health outcomes. Online postal self-sampling enables people to test for STIs including chlamydia without having to visit a health-care provider, but the extent to which the addition of this mode of testing in England has impacted access to testing in different populations is unclear. In England, there is national-level surveillance data enabling identification of the factors associated with use of online postal self-sampling (OPSS) for chlamydia testing. The aim of this analysis was to determine the change in chlamydia testing, chlamydia positivity, and test location as a result of the introduction of OPSS, and to determine socio-demographic factors associated with uptake of OPSS services compared to testing in-person.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study analysing data on all publicly funded chlamydia tests between 01/01/2015 and 31/12/2022 in England using two pseudonymised national surveillance systems (GUMCAD STI Surveillance System and CTAD Chlamydia Surveillance System) for STIs. We conducted a descriptive analysis of 25,171,919 chlamydia tests to establish the uptake and positivity of chlamydia tests by testing mode and gender over time. We used bivariate and multivariable logistic regression to examine associations of uptake of testing and positivity of tests with sociodemographic characteristics and testing by OPSS or a different mode.</div></div><div><h3>Findings</h3><div>The overall number of chlamydia tests/quarter (OPSS and in-person) gradually increased over time until 2019 (884,843 tests/quarter in quarter 1) and then declined in early 2020 (376,118 in quarter 2) and had not returned to 2019 levels by the end of 2022 (715,166 in quarter 4). During this time, the proportion of OPSS testing completed through OPSS increased from 2.6% (88,144/3,433,987) in 2015 to 38.4% (1,168,828/2,972,226) in 2022. Women were less likely than men to use OPSS compared to all available in-person testing (aOR = 0.75, 95% CI 0.75–0.75)). Those aged 20–24 were more likely to use OPSS than 15–19-year-olds (aOR = 1.55, 95% CI 1.55–1.56) and use of OPSS then decreased with increasing age. People in the most deprived areas were the least likely to use OPSS (aORs 1.18–1.28 for index of multiple deprivation quintile groups 2–5 vs 1). People were less likely to test positive using OPSS compared to in-person testing (aOR = 0.87, 95% CI 0.87–0.88). Between 2015 and 2022 OPSS chlamydia test-positivity decreased from 9.3% (2551/27,557) to 7.5% (34,050/454,596) in men and 7.4% (4458/60,367) to 6.1% (43,088/702,867) in women. During the same period, chlamydia test-positivity in sexual health services increased from 8.2% (57,139/692,873) to 10.6% (43,061/406,161) in men and 6.4% (51,080/797,143) to 7.9% (33,292/420,760) in women.</div></div><div><h3>Interpretation</h","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"56 ","pages":"Article 101412"},"PeriodicalIF":13.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144842101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatio-temporal trends and socio-environmental determinants of suicides in England (2002–2022): an ecological population-based study 英国自杀的时空趋势和社会环境决定因素(2002-2022):一项基于生态人口的研究
IF 13
Lancet Regional Health-Europe Pub Date : 2025-08-14 DOI: 10.1016/j.lanepe.2025.101386
Connor Gascoigne , Annie Jeffery , Ioannis Rotous , Xuewen Yu , Sara Geneletti , Bethan Davies , Gianluca Baio , James B. Kirkbride , Alexandra Pitman , Marta Blangiardo
{"title":"Spatio-temporal trends and socio-environmental determinants of suicides in England (2002–2022): an ecological population-based study","authors":"Connor Gascoigne ,&nbsp;Annie Jeffery ,&nbsp;Ioannis Rotous ,&nbsp;Xuewen Yu ,&nbsp;Sara Geneletti ,&nbsp;Bethan Davies ,&nbsp;Gianluca Baio ,&nbsp;James B. Kirkbride ,&nbsp;Alexandra Pitman ,&nbsp;Marta Blangiardo","doi":"10.1016/j.lanepe.2025.101386","DOIUrl":"10.1016/j.lanepe.2025.101386","url":null,"abstract":"<div><h3>Background</h3><div>Over the last two decades of suicide prevention strategy implementation, suicide rates in England have shown a fluctuating pattern, declining from the early 2000s (10.3 deaths per 100,000 in 2002) until around 2010 (9.0 deaths per 100,000 in 2007), then gradually increasing (10.7 deaths per 100,000 in 2022). It remains unclear whether the pattern varies by local area, the influence of the socio-environmental factors or a combination of both. Our aim was to evaluate spatio-temporal trends of suicides in England from 2002 to 2022 whilst examining the role of socio-environmental characteristics.</div></div><div><h3>Methods</h3><div>In this ecological study, we analysed Office for National Statistics data on deaths by suicide, exploring spatial and temporal patterns in England (2002–2022). Using a Hurdle Poisson model fit within a Bayesian hierarchical framework, we assessed the effects of local area level deprivation, ethnic density, population density, light pollution, railway and road network densities and greenspace composition on suicide risk.</div></div><div><h3>Findings</h3><div>From 2002 to 2022, suicide risk across England showed no substantial change overall (−4.26%; 95% Credible Interval (CrI): −8.95%, 0.72%). The difference between the regions with the lowest (London) and highest (North East) risk was 39.2% (95% CrI: 34.1%, 44.3%). We found that for one standard deviation change in each covariate, suicide risk increased with deprivation (20.06%; 95% CrI: 18.48%, 21.65%), railway network density (1.37%; 95% CrI: 0.32%, 2.46%), and road network density (5.16%; 95% CrI: 3.12%, 7.46%) while risk decreased with ethnic density (−7.47%; 95% CrI: −8.91%, −6.00%), population density (−5.42%; 95% CrI: −7.34%, −3.25%), light pollution (−4.20%; 95% CrI: −5.71%, −2.72%), and greenspace composition (−6.43%; 95% CrI: −7.94%, −4.99%).</div></div><div><h3>Interpretation</h3><div>We did not find evidence to support a decline in suicide rates in England over the last 20 years and our findings highlight the community profiles, characterised by greater deprivation, isolation, and access to road/rail networks, where suicide risk was highest. This should help focus future research to understand these as drivers of suicide risk, leading to the development of effective area-level interventions and targeted investment in those approaches where most needed.</div></div><div><h3>Funding</h3><div><span>Wellcome Trust</span>, <span>UKHSA</span>, <span>MRC</span>, <span>NIHR</span> through its <span>HPRU</span>, <span>HDRUK</span>, <span>NIHR University College Hospital London (UCLH) Biomedical Research Centre (BRC)</span>.</div></div>","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"56 ","pages":"Article 101386"},"PeriodicalIF":13.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends over 48 years in a one-number index of survival for all cancers combined, England and Wales (1971–2018): a population-based registry study 英格兰和威尔士(1971-2018)48年来所有癌症综合生存指数的趋势:一项基于人群的登记研究
IF 13
Lancet Regional Health-Europe Pub Date : 2025-08-13 DOI: 10.1016/j.lanepe.2025.101385
Michel P. Coleman , Melissa Matz , Pamela Minicozzi , Veronica Di Carlo , Dyfed Huws , Stephanie Smits , Jon Shelton , Claudia Allemani
{"title":"Trends over 48 years in a one-number index of survival for all cancers combined, England and Wales (1971–2018): a population-based registry study","authors":"Michel P. Coleman ,&nbsp;Melissa Matz ,&nbsp;Pamela Minicozzi ,&nbsp;Veronica Di Carlo ,&nbsp;Dyfed Huws ,&nbsp;Stephanie Smits ,&nbsp;Jon Shelton ,&nbsp;Claudia Allemani","doi":"10.1016/j.lanepe.2025.101385","DOIUrl":"10.1016/j.lanepe.2025.101385","url":null,"abstract":"<div><h3>Background</h3><div>Trends in cancer survival are a key indicator of progress in the effectiveness of the health system in managing cancer. We aimed to provide long-term trends in a one-number index of survival for all cancers combined, to support national cancer policy.</div></div><div><h3>Methods</h3><div>We examined long-term trends in a one-number index of net survival (Cancer Survival Index) for all cancers combined in adults in England and Wales. Net survival includes all cancer patients, regardless of whether cancer was the cause of their death. We estimated net survival up to 10 years after diagnosis for 10,769,854 adults diagnosed with a first, primary, invasive cancer during 1971–2018 and followed up to 2019, using anonymised individual records from the National Disease Registration Service for England and the Welsh Cancer Intelligence and Surveillance Unit. We examined trends in the Cancer Survival Index (CSI) at one, five, seven and 10 years after diagnosis, using the entire data set. We present results for selected periods: 1971–72, 1980–81, 1990–91, 2000–01, 2005–06, 2010–11 and 2018.</div></div><div><h3>Findings</h3><div>During the 48 years 1971–2018, the CSI for England and Wales rose substantially, at all intervals up to 10 years after diagnosis. For patients diagnosed in 1971–72, the CSI was 46.5% at 1 year after diagnosis. For patients diagnosed in 2018, the index is 49.8% at 10 years after diagnosis. The CSI has remained about 10% higher for women than men since the early 1970s. The speed of improvement has slowed down: between 2000–01 and 2005–06, the 10-year CSI rose by 4.0%. Ten years later, the increase between 2010–11 and 2015–16 was only 1.4%.</div></div><div><h3>Interpretation</h3><div>The slow-down since 2010 of long-term trends in the CSI for all cancers combined in England and Wales is likely to be at least partly explained by longer waits for diagnosis and treatment. A long-term national cancer plan to bring cancer survival trends back towards the best in the world is essential.</div></div><div><h3>Funding</h3><div>Cancer Research UK.</div></div>","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"56 ","pages":"Article 101385"},"PeriodicalIF":13.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The pre-implantation biopsy story is not over yet 植入前活检的故事还没有结束
IF 13
Lancet Regional Health-Europe Pub Date : 2025-08-13 DOI: 10.1016/j.lanepe.2025.101441
Alden Doyle, Sarthak Virmani
{"title":"The pre-implantation biopsy story is not over yet","authors":"Alden Doyle,&nbsp;Sarthak Virmani","doi":"10.1016/j.lanepe.2025.101441","DOIUrl":"10.1016/j.lanepe.2025.101441","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"56 ","pages":"Article 101441"},"PeriodicalIF":13.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144829786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信