Lancet Regional Health-Europe最新文献

{"title":"Emerging data on SGLT2 benefits in acute coronary syndromes","authors":"","doi":"10.1016/j.lanepe.2024.101085","DOIUrl":"10.1016/j.lanepe.2024.101085","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666776224002527/pdfft?md5=09e81064915a8c58a71ecd67b1d12d25&pid=1-s2.0-S2666776224002527-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood-based biomarkers in the oldest old: towards Alzheimer's disease detection in primary care","authors":"","doi":"10.1016/j.lanepe.2024.101077","DOIUrl":"10.1016/j.lanepe.2024.101077","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666776224002448/pdfft?md5=9366f8cb802717eb778cfbf2b1bd76c7&pid=1-s2.0-S2666776224002448-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-processed foods and type 2 diabetes: more fundamental research is needed","authors":"","doi":"10.1016/j.lanepe.2024.101084","DOIUrl":"10.1016/j.lanepe.2024.101084","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666776224002515/pdfft?md5=fb2c4817668d269938f48caab1370d8a&pid=1-s2.0-S2666776224002515-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Getting to the heart of it: sex and gender considerations in the management of cardiovascular disease","authors":"","doi":"10.1016/j.lanepe.2024.101076","DOIUrl":"10.1016/j.lanepe.2024.101076","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666776224002436/pdfft?md5=3ca55856641c0e48e142c847130913fe&pid=1-s2.0-S2666776224002436-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood microRNA testing in participants with suspicious low-dose CT findings: follow-up of the BioMILD lung cancer screening trial","authors":"","doi":"10.1016/j.lanepe.2024.101070","DOIUrl":"10.1016/j.lanepe.2024.101070","url":null,"abstract":"<div><h3>Background</h3><p>The proper management of suspicious radiologic findings is crucial to optimize the effectiveness of low-dose computed tomography (LDCT) lung cancer screening trials. In the BioMILD study, we evaluated the utility of combining a plasma 24-microRNA signature classifier (MSC) and LDCT to define the individual risk and personalize screening strategies. Here we aim to assess the utility of repeated MSC testing during annual screening rounds in 1024 participants with suspicious LDCT findings.</p></div><div><h3>Methods</h3><p>The primary outcome was two-year lung cancer incidence in relation to MSC test results, reported as relative risk (RR) with 95% confidence interval (CI). Lung cancer incidence and mortality were estimated using extended Cox models for time-dependent covariates, yielding the respective hazard ratios (HR). <span><span>Clinicaltrials.gov</span><svg><path></path></svg></span> ID: <span><span>NCT02247453</span><svg><path></path></svg></span>.</p></div><div><h3>Findings</h3><p>With a median follow-up of 8.5 years, the full study set included 1403 indeterminate LDCT (CTind) and 584 positive LDCT (CT+) results. A lung cancer RR increase in MSC+ compared to MSC- participants was observed in both the CTind (RR: 2.5; 95% CI: 1.4–4.32) and CT+ (RR: 2.6; 95% CI: 1.81–3.74) groups and was maintained when considering stage I or resectable tumors only. A 98% negative predictive value in CTind/MSC− and a 30% positive predictive value in CT+/MSC+ lesions were recorded. At seven years’ follow-up, MSC+ participants had a cumulative HR of 4.4 (95% CI: 3.0–6.4) for lung cancer incidence and of 8.1 (95% CI: 2.7–24.5) for lung cancer mortality.</p></div><div><h3>Interpretation</h3><p>Our study shows that MSC can be reliably performed during LDCT screening rounds to increase the accuracy of lung cancer risk and mortality prediction and supports its clinical utility in the management of LDCT findings of uncertain malignancy.</p></div><div><h3>Funding</h3><p>Italian Association for <span>Cancer Research</span>; <span>Italian Ministry of Health</span>; <span>Horizon2020</span>; <span>National Cancer Institute</span> (NCI); <span>Gensignia LifeScience</span>.</p></div>","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666776224002370/pdfft?md5=80bf92de5915924fb0056eb8a035384e&pid=1-s2.0-S2666776224002370-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early intervention for obstructive sleep apnoea in Down syndrome – making a difference?","authors":"","doi":"10.1016/j.lanepe.2024.101074","DOIUrl":"10.1016/j.lanepe.2024.101074","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666776224002412/pdfft?md5=9f4c1c34cf72629f5a424149fe87a449&pid=1-s2.0-S2666776224002412-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142228740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional dependence following intensive care unit-treated sepsis: three-year follow-up results from the prospective Mid-German Sepsis Cohort (MSC)","authors":"","doi":"10.1016/j.lanepe.2024.101066","DOIUrl":"10.1016/j.lanepe.2024.101066","url":null,"abstract":"<div><h3>Background</h3><p>Surviving sepsis can lead to chronic physical, psychological and cognitive impairments, which affect millions of patients worldwide, including survivors after COVID-19 viral sepsis. We aimed to characterize the magnitude and trajectory of functional dependence and new impairments post-sepsis.</p></div><div><h3>Methods</h3><p>We conducted a prospective cohort study including sepsis survivors who had been discharged from five German intensive care units (ICUs), until 36 months post-discharge. Primary outcome was functional dependence, defined as ≥1 impaired activity of daily living (ADL; 10-item ADL score &lt;100), self-reported nursing care dependence or nursing care level. Secondary outcome was post-sepsis morbidity in the physical, psychological or cognitive domain. We used a multistate, competing risk model to address competing events in the course of dependence, and conducted multiple linear regression analyses to identify predictors associated with the ADL score.</p></div><div><h3>Findings</h3><p>Of 3210 sepsis patients screened, 1968 survived the ICU treatment (61.3%). A total of 753 were included in the follow-up assessments of the Mid-German Sepsis cohort. Patients had a median age of 65 (Q1–Q3 56–74) years, 64.8% (488/753) were male and 76.1% (573/753) had a septic shock. Considering competing risk modelling, the probability of still being functional dependent was about 25%, while about 30% regained functional independence and 45% died within the three years post-sepsis. Patients reported a high burden of new and often overlapping impairments until three years post-sepsis. In the subgroup of three-year survivors (n = 330), new physical impairments affected 91.2% (n = 301) while new cognitive and psychological impairments were reported by 57.9% (n = 191) and 40.9% (n = 135), respectively. Patients with pre-existing functional limitations and higher age were at risk for low ADL scores three years after sepsis.</p></div><div><h3>Interpretation</h3><p>Sepsis survivorship was associated with a broad range of new impairments and led to functional dependence in around one quarter of patients. Targeted measures are needed to mitigate the burden of this Post-Sepsis-Syndrome and increase the proportion of patients that achieve functional improvements.</p></div><div><h3>Funding</h3><p>This work was supported by the <span>Integrated Research and Treatment Center</span>, <span>Center for Sepsis Control and Care</span> (CSCC) at the <span>Jena University Hospital</span> funded by the German <span>Ministry of Education and Research</span> and by the Rudolf Presl GmbH &amp; Co, Kreischa, Germany.</p></div>","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666776224002333/pdfft?md5=1cee67b34dc818cab85aab45e5f07faa&pid=1-s2.0-S2666776224002333-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142172983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Protecting infants against RSV disease: an impact and cost-effectiveness comparison of long-acting monoclonal antibodies and maternal vaccination” [The Lancet Regional Health – Europe 38 (2024) 100829]","authors":"","doi":"10.1016/j.lanepe.2024.101073","DOIUrl":"10.1016/j.lanepe.2024.101073","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666776224002400/pdfft?md5=7cc8e529861b59997135016ec0de715f&pid=1-s2.0-S2666776224002400-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"More or less “modest” versus significant excess mortality due to COVID-19 deaths in Europe","authors":"","doi":"10.1016/j.lanepe.2024.101060","DOIUrl":"10.1016/j.lanepe.2024.101060","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666776224002278/pdfft?md5=dc8848415539f39d5d3f891ccbfa7e2e&pid=1-s2.0-S2666776224002278-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time to enhance COVID-19 vaccination in women of reproductive age","authors":"","doi":"10.1016/j.lanepe.2024.101069","DOIUrl":"10.1016/j.lanepe.2024.101069","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666776224002369/pdfft?md5=42ec4ffa56377b36eb84b3344bc92593&pid=1-s2.0-S2666776224002369-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142164730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}