Lancet Regional Health-Europe最新文献

{"title":"Is the field of multiple sclerosis ready for a biologically driven continuum framework?","authors":"The Lancet Regional Health – Europe","doi":"10.1016/j.lanepe.2024.101054","DOIUrl":"10.1016/j.lanepe.2024.101054","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"44 ","pages":"Article 101054"},"PeriodicalIF":13.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666776224002217/pdfft?md5=c09e5f79fed037940466298153b54e92&pid=1-s2.0-S2666776224002217-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142122508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional association between inflammatory bowel disease and type 1 diabetes: a nationwide matched cohort and case-control study","authors":"Jiangwei Sun ,&nbsp;Jialu Yao ,&nbsp;Ola Olén ,&nbsp;Jonas Halfvarsson ,&nbsp;David Bergman ,&nbsp;Fahim Ebrahimi ,&nbsp;Sofia Carlsson ,&nbsp;Johnny Ludvigsson ,&nbsp;Jonas F. Ludvigsson","doi":"10.1016/j.lanepe.2024.101056","DOIUrl":"10.1016/j.lanepe.2024.101056","url":null,"abstract":"<div><h3>Background</h3><p>Co-occurrence of inflammatory bowel disease (IBD) and type 1 diabetes (T1D) has been linked to poor clinical outcomes, but evidence on their bidirectional associations remain scarce. This study aims to investigate their bidirectional associations.</p></div><div><h3>Methods</h3><p>A nationwide matched cohort and case–control study with IBD patients identified between 1987 and 2017. The cohort study included 20,314 IBD patients (≤28 years; Crohn’s disease [CD, n = 7277], ulcerative colitis [UC, n = 10,112], and IBD-unclassified [IBD-U, n = 2925]) and 99,200 individually matched reference individuals, with a follow-up until December 2021. The case–control study enrolled 87,001 IBD patients (no age restriction) and 431,054 matched controls. We estimated adjusted hazard ratio (aHR) of incident T1D in the cohort study with flexible parametric survival model and adjusted odds ratio (aOR) of having a prior T1D in the case–control study with conditional logistic regression model, with 95% confidence intervals (CI).</p></div><div><h3>Findings</h3><p>During a median follow-up of 14 years, 116 IBD patients and 353 reference individuals developed T1D. Patients with IBD had a higher hazard of developing T1D (aHR = 1.58 [95% CI = 1.27–1.95]). The hazard was increased in UC (aHR = 2.02 [1.51–2.70]) but not in CD or IBD-U. In the case–control study, a total of 1018 (1.2%) IBD patients and 3496 (0.8%) controls had been previously diagnosed with T1D. IBD patients had higher odds of having prior T1D (aOR = 1.36 [1.26–1.46]). Such positive association was observed in all IBD subtypes. The sibling comparison analyses showed similar associations between IBD and T1D (aHR = 1.44 [0.97–2.15] and aOR = 1.32 [1.18–1.49]).</p></div><div><h3>Interpretation</h3><p>Patients with IBD had a moderately increased hazard of developing T1D and higher odds of having prior T1D. Their bidirectional associations may be partially independent of shared familial factors.</p></div><div><h3>Funding</h3><p><span>European Crohn’s and Colitis Organisation</span>, <span>Stiftelsen Professor Nanna Svartz Fond</span>, <span>SSMF</span> (project#: <span><span>PG-23-0315-H-02</span></span>), <span>Ruth and Richard Julin Foundation</span>; and <span>FORTE</span> (project#: <span><span>2016-00424</span></span>).</p></div>","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"46 ","pages":"Article 101056"},"PeriodicalIF":13.6,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666776224002230/pdfft?md5=8c9d1f189177cc2c92a59b38439810d5&pid=1-s2.0-S2666776224002230-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142097951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond one size fits all: tailoring healthcare to the realities of migration","authors":"Giancarlo Ceccarelli ,&nbsp;Francesco Branda ,&nbsp;Marta Giovanetti ,&nbsp;Gabriella d’Ettorre ,&nbsp;Fabio Scarpa ,&nbsp;Massimo Ciccozzi","doi":"10.1016/j.lanepe.2024.101058","DOIUrl":"10.1016/j.lanepe.2024.101058","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"45 ","pages":"Article 101058"},"PeriodicalIF":13.6,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666776224002254/pdfft?md5=33fa19dfbd417f5bff34fca41edb94ff&pid=1-s2.0-S2666776224002254-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142099056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding excess mortality in Europe during the COVID-19 pandemic","authors":"Lasse S. Vestergaard ,&nbsp;Richard G. Pebody","doi":"10.1016/j.lanepe.2024.101053","DOIUrl":"10.1016/j.lanepe.2024.101053","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"45 ","pages":"Article 101053"},"PeriodicalIF":13.6,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666776224002205/pdfft?md5=0b3830bbac12151f294fcb63d5ae48ed&pid=1-s2.0-S2666776224002205-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142098421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex and gender bias in chronic coronary syndromes research: analysis of studies used to inform the 2019 European Society of Cardiology guidelines","authors":"Kathleen Bastian-Pétrel ,&nbsp;Jessica L. Rohmann ,&nbsp;Sabine Oertelt-Prigione ,&nbsp;Marco Piccininni ,&nbsp;Katja Gayraud ,&nbsp;Michelle Kelly-Irving ,&nbsp;Nathalie Bajos","doi":"10.1016/j.lanepe.2024.101041","DOIUrl":"10.1016/j.lanepe.2024.101041","url":null,"abstract":"<div><h3>Background</h3><p>Sex and gender inequalities in ischemic heart diseases persist. Although ischemic heart disease is less common in women, they experience worse clinical outcomes and are less likely to receive guideline-recommended treatments. The primary scientific literature from which clinical guideline recommendations are derived may not have considered potential sex- and gender biases. This study aims to determine whether the literature cited in recent cardiovascular guidelines’ clinical recommendations contain sex and gender biases.</p></div><div><h3>Methods</h3><p>We analysed publications cited in the 2019 European Society of Cardiology (ESC) guideline recommendations on chronic coronary syndromes, using a checklist to guide data extraction and evaluate the individual studies for sex- and gender-related aspects, such as inclusion/exclusion criteria, outcome measures, and demographic data reporting. To assess representation over time, the proportion of women participants in each study was computed and analysed using a beta regression model. We also examined the associations between women’s representation, journal impact factor and author gender.</p></div><div><h3>Findings</h3><p>Among the 20 ESC recommendations on chronic coronary syndromes, four contained sex-related statements; we did not identify any gender-specific suggestions. The referenced literature upon which these recommendations were based consisted of 108 articles published between 1991 and 2019, encompassing more than 1.6 million study participants (26.8%; 432,284 women). Only three studies incorporated sex-sensitive designs; none were gender-specific. The term “gender” did not occur in 84% (n = 91/108) of the publications; when used, it was exclusively to denote biological sex. The proportion of women (assumed by investigators) among study participants fluctuated over time. Having a woman as first (odds ratio (OR) = 1.68, 95% CI: 1.19–2.39) or last author (OR = 2.28, 95% CI: 1.31–3.97), was significantly associated with having more women participants in the study.</p></div><div><h3>Interpretation</h3><p>The data underlying ESC guideline recommendations largely lack reporting of possible sex- and gender-specific aspects, and women are distinctly underrepresented. To what extent these recommendations apply to members of specific population groups who are not well-represented in the underlying evidence base remains unknown.</p></div><div><h3>Funding</h3><p>This study is part of the <span>Gender and Health Inequalities</span> (GENDHI) project, <span><span>ERC-2019-SyG</span></span>. This project has received funding from the <span>European Research Council</span> (ERC).</p></div>","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"45 ","pages":"Article 101041"},"PeriodicalIF":13.6,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666776224002084/pdfft?md5=2f0d0fccd37dfc81bbc18d5031f952e5&pid=1-s2.0-S2666776224002084-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142099054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The contribution of avoidable mortality to life expectancy differences and lifespan disparities in the European Union: a population-based study","authors":"Rok Hrzic ,&nbsp;Tobias Vogt","doi":"10.1016/j.lanepe.2024.101042","DOIUrl":"10.1016/j.lanepe.2024.101042","url":null,"abstract":"<div><h3>Background</h3><p>Twenty years after the 2004 European Union (EU) enlargement, life expectancy differences between established (EMS) and new member states (NMS) remain large. Contributing to this gap are deaths that can be avoided through preventive services or adequate medical treatment. We estimate the impact of reducing avoidable mortality on life expectancy and lifespan disparities in the enlarged EU.</p></div><div><h3>Methods</h3><p>Using World Health Organization mortality database data, we analysed the potential of reducing avoidable mortality, as defined by Eurostat and the Organisation for Economic Cooperation and Development, to close the mortality gap between NMS and EMS. We decomposed the changes in life expectancy and lifespan disparity by age and cause using linear integral decomposition.</p></div><div><h3>Findings</h3><p>Averting all avoidable deaths across the EU from 2005 to 2019 would decrease the average life expectancy gap from 5.8 to 2.4 years in men and 3.3–2 years in women and eliminate the lifespan disparity gap. Had NMS achieved the average EMS avoidable mortality rates during the same period, the average life expectancy gap would have been reduced to 1.8 years in men and 1.6 years in women, and the lifespan disparities gap would have been reversed. Avoidable circulatory and injury-related deaths in middle and older age drove the observed mortality changes.</p></div><div><h3>Interpretation</h3><p>Our results suggest that the gap in life expectancy and lifespan disparity across the EU could be reduced by strengthening health systems and investing in averting circulatory and injury-related deaths in middle and older age in NMS.</p></div><div><h3>Funding</h3><p>None.</p></div>","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"46 ","pages":"Article 101042"},"PeriodicalIF":13.6,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666776224002096/pdfft?md5=4c25cd71fdd9e84850dda13e6bfbe918&pid=1-s2.0-S2666776224002096-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142097952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The third generation modified vaccinia Ankara vaccine is effective in preventing the transmission of mpox","authors":"Mingwang Shen ,&nbsp;Lei Zhang","doi":"10.1016/j.lanepe.2024.101052","DOIUrl":"10.1016/j.lanepe.2024.101052","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"45 ","pages":"Article 101052"},"PeriodicalIF":13.6,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666776224002199/pdfft?md5=8bddce77fb8a2130b95597b133c5ca78&pid=1-s2.0-S2666776224002199-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142099055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental findings in NIPT show potential for detecting hematological malignancies","authors":"Folkert J. van Kemenade","doi":"10.1016/j.lanepe.2024.101045","DOIUrl":"10.1016/j.lanepe.2024.101045","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"45 ","pages":"Article 101045"},"PeriodicalIF":13.6,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666776224002126/pdfft?md5=79142be2581c9976e883adb5b508ef0f&pid=1-s2.0-S2666776224002126-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142098422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Europe needs to urgently implement an outward looking Global Health Strategy","authors":"Astrid Berner-Rodoreda ,&nbsp;Quique Bassat ,&nbsp;Alberto Rocamora ,&nbsp;Mario Raviglione ,&nbsp;Ana B. Abecasis ,&nbsp;Kerstin Klipstein-Grobusch ,&nbsp;Jolene Skordis ,&nbsp;Nora Anton ,&nbsp;Till Bärnighausen","doi":"10.1016/j.lanepe.2024.101046","DOIUrl":"10.1016/j.lanepe.2024.101046","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"45 ","pages":"Article 101046"},"PeriodicalIF":13.6,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666776224002138/pdfft?md5=b287452dbc9bef14b9473cad97333817&pid=1-s2.0-S2666776224002138-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142076964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is childcare good or bad for children’s socio-emotional development? Context matters","authors":"Ruben Fukkink","doi":"10.1016/j.lanepe.2024.101044","DOIUrl":"10.1016/j.lanepe.2024.101044","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"45 ","pages":"Article 101044"},"PeriodicalIF":13.6,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666776224002114/pdfft?md5=3d507bdacda8996607ea13357d6f8469&pid=1-s2.0-S2666776224002114-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142058129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}