Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis最新文献_第5页

Molecular toxicology and carcinogenesis of fumonisins: a review. 伏马菌素的分子毒理学和致癌性研究进展。

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2021-01-01 Epub Date: 2021-02-07 DOI: 10.1080/26896583.2020.1867449

Ruth Nabwire Wangia-Dixon, Kizito Nishimwe

引用次数: 10

Effect of fluoride on bone and growth plate cartilage. 氟化物对骨骼和生长板软骨的影响。

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2021-01-01 Epub Date: 2021-08-23 DOI: 10.1080/26896583.2021.1963606

Mercedes Lombarte, Brenda L Fina, Lucas R Brun, Stella Maris Roma, Alfredo Rigalli, Di Loreto V E

{"title":"Effect of fluoride on bone and growth plate cartilage.","authors":"Mercedes Lombarte, Brenda L Fina, Lucas R Brun, Stella Maris Roma, Alfredo Rigalli, Di Loreto V E","doi":"10.1080/26896583.2021.1963606","DOIUrl":"https://doi.org/10.1080/26896583.2021.1963606","url":null,"abstract":"The use of fluoride (F) for therapeutic purposes is controversial and its toxicity is a health problem. The aim of this study was to evaluate the effect of F on endochondral ossification in growing rats. Twenty-four rats of 21 days were divided into 4 groups which received 0, 20, 40 or 80 μmol F/100 g body weight/day for 30 days, through an orogastric tube. Histological evaluation of growth plate cartilage (GPC) and primary and secondary bone were analyzed on sections of the metaphysis of tibias. Total thickness of the GPC (GPC.Th), thickness of resting zone (RZ.Th), proliferative zone (PZ.Th) and hypertrophic zone (HZ.Th); bone volume (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), trabecular separation (Tb.Sp), and apoptosis by the TUNEL were measured. A hyperplasia of the proliferative zone and a significant increase in PZ.Th with 40 and 80 μmol F without changes in GPC.Th were found. In the secondary trabecular bone, presence of immature trabeculae, peritrabecular inflammatory foci and sinusoidal dilatation were observed. A significant decrease in BV/TV was also found due to a decrease in Tb.Th and a progressive increase was observed in the number of apoptotic nuclei as the dose of F increased. In conclusion, results suggest that prolonged administration (30 days) of F negatively affect the endochondral ossification with increased chondrocyte proliferation and delayed maturity of new bone, causing inflammatory damage, edema, and increased apoptotic bone cells.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"39 4","pages":"388-399"},"PeriodicalIF":2.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40550930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Metabolism of carcinogenic pyrrolizidine alkaloids and pyrrolizidine alkaloid N-oxides by rat primary hepatocytes generate the same characteristic DHP-DNA adducts. 大鼠原代肝细胞代谢致癌吡咯利西啶生物碱和吡咯利西啶生物碱n -氧化物产生相同的DHP-DNA加合物。

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2021-01-01 Epub Date: 2021-08-23 DOI: 10.1080/26896583.2021.1954460

Xiaobo He, Qingsu Xia, Qiang Shi, Peter P Fu

{"title":"Metabolism of carcinogenic pyrrolizidine alkaloids and pyrrolizidine alkaloid N-oxides by rat primary hepatocytes generate the same characteristic DHP-DNA adducts.","authors":"Xiaobo He, Qingsu Xia, Qiang Shi, Peter P Fu","doi":"10.1080/26896583.2021.1954460","DOIUrl":"https://doi.org/10.1080/26896583.2021.1954460","url":null,"abstract":"We recently established a genotoxic mechanism mediated by a set of (±)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-DNA adducts, which lead to pyrrolizidine alkaloid (PA)-induced liver tumor initiation. This mechanism is involved in the metabolism of a series of carcinogenic PAs and PA N-oxides in rats in vivo and in vitro. There is a correlation between the order of liver tumor potency and the level of DHP-DNA adduct formation. Thus, these DHP-DNA adducts can be potential biomarkers of PA and PA N-oxide exposure and liver tumor initiation. To establish the generality of this mechanism, in the present study, we examined the metabolism of 13 potential carcinogenic PAs, 1 non-carcinogenic PA, and 5 PA N-oxides by male rat primary hepatocytes. With the exception of the nontoxic PA and vehicle control, all treated groups produced identical set of DHP-DNA adducts. These results support a general genotoxic mechanism mediated by the formation of characteristic DHP-DNA adducts leading to PA-induced liver tumor initiation.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"39 4","pages":"357-372"},"PeriodicalIF":2.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40566689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Protective role of Spirulina platensis against glyphosate induced toxicity in marine mussel Mytilus galloprovincialis. 平螺旋藻对草甘膦致褐贻贝毒性的保护作用。

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2021-01-01 Epub Date: 2021-08-04 DOI: 10.1080/26896583.2021.1954833

Ouarghi Wided, Khazri Abdelhafidh, Mezni Ali, Samir Touaylia

{"title":"Protective role of Spirulina platensis against glyphosate induced toxicity in marine mussel Mytilus galloprovincialis.","authors":"Ouarghi Wided, Khazri Abdelhafidh, Mezni Ali, Samir Touaylia","doi":"10.1080/26896583.2021.1954833","DOIUrl":"https://doi.org/10.1080/26896583.2021.1954833","url":null,"abstract":"Glyphosate is a toxic environmental pollutant that has the ability to induce biochemical and physiological alterations in living organisms. Several studies have focused on the research of protective techniques against the stress induced by this contaminant. In this context, we studied the protective effect of Spirulina against the disturbances induced by glyphosate. A biomarker approach was adopted to determine the impact of glyphosate, Spirulina and their mixture, during two time slots (4 and 7 days), on Mytilus galloprovincialis. Glyphosate treated mussels revealed significantly increased malondialdehyde and decreased acetylcholinesterase (AChE) levels. Spirulina normalized catalase (CAT), glutathione-S-transferase (GST), and AChE activities. Furthermore, it reduced glyphosate-induced malondialdehyde (MDA) levels. The current study suggests a protective effect of Spirulina against glyphosate-induced oxidative stress by strengthening the antioxidant system, sequestering ROS and inhibiting cellular damage.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"39 4","pages":"373-387"},"PeriodicalIF":2.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40566688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Applications of electron spin resonance spectroscopy in photoinduced nanomaterial charge separation and reactive oxygen species generation. 电子自旋共振光谱在光致纳米材料电荷分离和活性氧生成中的应用。

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2021-01-01 Epub Date: 2021-09-01 DOI: 10.1080/26896583.2021.1971477

Xiumei Jiang, Mary D Boudreau, Peter P Fu, Jun-Jie Yin

引用次数: 3

Glyphosate disrupts sperm quality and induced DNA damage of rainbow trout (Oncorhynchus mykiss) sperm. 草甘膦破坏虹鳟精子质量，引起虹鳟精子DNA损伤。

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2021-01-01 Epub Date: 2021-09-01 DOI: 10.1080/26896583.2021.1969180

Ayşe Akça, Mehmet Kocabaş, Filiz Kutluyer

引用次数: 2

Short-term metabolic disruptions in urine of mouse models following exposure to low doses of oxygen ion radiation. 暴露于低剂量氧离子辐射后小鼠模型尿液中的短期代谢紊乱。

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2021-01-01 DOI: 10.1080/26896583.2020.1868866

Michael Girgis, Yaoxiang Li, Meth Jayatilake, Kirandeep Gill, Sirao Wang, Kepher Makambi, Vijayalakshmi Sridharan, Amrita K Cheema

{"title":"Short-term metabolic disruptions in urine of mouse models following exposure to low doses of oxygen ion radiation.","authors":"Michael Girgis, Yaoxiang Li, Meth Jayatilake, Kirandeep Gill, Sirao Wang, Kepher Makambi, Vijayalakshmi Sridharan, Amrita K Cheema","doi":"10.1080/26896583.2020.1868866","DOIUrl":"https://doi.org/10.1080/26896583.2020.1868866","url":null,"abstract":"Molecular alterations as a result of exposure to low doses of high linear energy transfer (LET) radiation can have deleterious short- and long-term consequences on crew members embarking on long distance space missions. Oxygen ions (16O) are among the high LET charged particles that make up the radiation environment inside a vehicle in deep space. We used mass spectrometry-based metabolomics to characterize urinary metabolic profiles of male C57BL/6J mice exposed to a single dose of 0.1, 0.25 and 1.0 Gy of 16O (600 MeV/n) at 10 and 30 days post-exposure to delineate radiation-induced metabolic alterations. We recognized a significant down regulation of several classes of metabolites including cresols and tryptophan metabolites, ketoacids and their derivatives upon exposure to 0.1 and 0.25 Gy after 10 days. While some of these changes reverted to near normal by 30 days, some metabolites including p-Cresol sulfate, oxalosuccinic acid, and indoxylsulfate remained dysregulated at 30 days, suggesting long term prognosis on metabolism. Pathway analysis revealed a long-term dysregulation in multiple pathways including tryptophan and porphyrin metabolism. These results suggest that low doses of high-LET charged particle irradiation may have long-term implications on metabolic imbalance.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"39 2","pages":"234-249"},"PeriodicalIF":2.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/26896583.2020.1868866","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10365016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Longitudinal metabolic alterations in plasma of rats exposed to low doses of high linear energy transfer radiation. 受低剂量高线性能量转移辐射照射的大鼠血浆中的纵向代谢变化。

IF 1.2 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2021-01-01 DOI: 10.1080/26896583.2020.1865027

Tixieanna Dissmore, Andrew G DeMarco, Meth Jayatilake, Michael Girgis, Shivani Bansal, Yaoxiang Li, Khyati Mehta, Vijayalakshmi Sridharan, Kirandeep Gill, Sunil Bansal, John B Tyburski, Amrita K Cheema

{"title":"Longitudinal metabolic alterations in plasma of rats exposed to low doses of high linear energy transfer radiation.","authors":"Tixieanna Dissmore, Andrew G DeMarco, Meth Jayatilake, Michael Girgis, Shivani Bansal, Yaoxiang Li, Khyati Mehta, Vijayalakshmi Sridharan, Kirandeep Gill, Sunil Bansal, John B Tyburski, Amrita K Cheema","doi":"10.1080/26896583.2020.1865027","DOIUrl":"10.1080/26896583.2020.1865027","url":null,"abstract":"Astronauts embarking on deep space missions are at high risk of long-term exposure to low doses of high linear energy transfer (LET) radiation, which can contribute to the development of cancer and multiple degenerative diseases. However, long term effects of exposure to low doses of high LET radiation in plasma metabolite profiles have not been elucidated. We utilized an untargeted metabolomics and lipidomics approach to analyze plasma obtained from adult male Long Evans rats to determine the longitudinal effects of low-dose proton and low-dose oxygen ion whole-body irradiation on metabolic pathways. Our findings reveal that radiation exposure induced modest changes in the metabolic profiles in plasma, 7 months after exposure. Furthermore, we identified some common metabolite dysregulations between protons and oxygen ions, which may indicate a similar mechanism of action for both radiation types.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"39 2","pages":"219-233"},"PeriodicalIF":1.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896584/pdf/nihms-1858535.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9206371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A descriptor-based analysis to highlight the mechanistic rationale of mutagenicity. 基于描述符的分析，强调致突变性的机制原理。

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2021-01-01 Epub Date: 2021-05-06 DOI: 10.1080/26896583.2021.1883964

Domenico Gadaleta, Emilio Benfenati

{"title":"A descriptor-based analysis to highlight the mechanistic rationale of mutagenicity.","authors":"Domenico Gadaleta, Emilio Benfenati","doi":"10.1080/26896583.2021.1883964","DOIUrl":"https://doi.org/10.1080/26896583.2021.1883964","url":null,"abstract":"Cancer is a main concern for human health and there is a need of alternative methodologies to rapidly screen large quantitative of compounds that may represent a toxicological risk. Here a statistical analyses is performed on a benchmark database of experimental Ames data to identify chemical descriptors discriminating mutagens and non-mutagens. A total of 53 activating and deactivating modulators are identified, that flagged respectively a percentage of mutagen and non-mutagen up to 87%. Modulators are further combined to form synergistic cross-terms, accounting for the effect that combined properties may have on the final toxicity. Exclusion rules are defined as exception to the modulators. Synergistic cross-terms and exclusion rules improve the enrichment of mutagens/non-mutagens with respect of the original abundance in the dataset to values higher than 95%. The external predictivity of modulators and cross-terms reach balanced accuracy up to 0.775 that is analogous to other mutagenicity models from the literature, confirming the suitability of the rules to real-life screening of chemicals. Modulators are discussed for their mechanistic link to mutagenicity. This analysis confirms the key role of some properties (polarizability, shape, mass, presence of reactive functional groups or unsaturated planar systems) as driving elements for the initiation of the mutagenicity.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"39 3","pages":"269-292"},"PeriodicalIF":2.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/26896583.2021.1883964","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38955327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Trace elements exposure and risk in age-related eye diseases: a systematic review of epidemiological evidence. 微量元素暴露与老年性眼病风险:流行病学证据系统综述

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2021-01-01 Epub Date: 2021-06-11 DOI: 10.1080/26896583.2021.1916331

Onyinyechi Bede-Ojimadu, Chinna N Orish, Beatrice Bocca, Flavia Ruggieri, Chiara Frazzoli, Orish E Orisakwe

{"title":"Trace elements exposure and risk in age-related eye diseases: a systematic review of epidemiological evidence.","authors":"Onyinyechi Bede-Ojimadu, Chinna N Orish, Beatrice Bocca, Flavia Ruggieri, Chiara Frazzoli, Orish E Orisakwe","doi":"10.1080/26896583.2021.1916331","DOIUrl":"https://doi.org/10.1080/26896583.2021.1916331","url":null,"abstract":"This systematic review aimed to evaluate existing evidence on the associations between trace elements exposure and age-related eye diseases. PubMed and Google scholar databases were searched for epidemiological and postmortem studies on the relationship between exposure to trace elements and Age-related eye diseases such as age-related macular degeneration (AMD), cataract, glaucoma and diabetic retinopathy (DR), in population groups aged 40 years and above. Available evidence suggests that cadmium (Cd) exposure may be positively associated with the risks of AMD and cataract. There is also evidence that exposure to lead (Pb) may be positively associated with higher risk of cataract and glaucoma. There is limited number of relevant studies and lack of prospective studies for most of the investigated associations. Evidence for other trace elements is weak and inconsistent, and the number of available studies is small. Likewise, there are very few relevant studies on the role of trace elements in DR. Chemical elements that affect the distribution and absorption of other trace elements have never been investigated. The suggestive but limited evidence motivates large and quality prospective studies to fully characterize the impact of exposure to trace (toxic and essential) elements on age-related eye diseases.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"39 3","pages":"293-339"},"PeriodicalIF":2.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/26896583.2021.1916331","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39082419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4