IJU Case Reports最新文献

{"title":"Rapidly Progressive Retroperitoneal Dissemination of Plasmacytoid Urothelial Carcinoma Presenting With Multiorgan Obstruction After Radical Cystectomy: A Case Report","authors":"Mahito Atsuta,&nbsp;Naoki Uchida,&nbsp;Hirokazu Kagawa,&nbsp;Naoya Tomomasa,&nbsp;Shun Saito,&nbsp;Kazuhiro Takahashi,&nbsp;Kosuke Iwatani,&nbsp;Shun Sato,&nbsp;Takahiro Kimura,&nbsp;Jun Miki","doi":"10.1002/iju5.70249","DOIUrl":"https://doi.org/10.1002/iju5.70249","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Plasmacytoid urothelial carcinoma (PUC) is a rare, aggressive subtype of bladder cancer characterized by diffuse infiltrative growth and a propensity for peritoneal and retroperitoneal dissemination.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A patient with muscle-invasive bladder cancer (cT3N1M0) was diagnosed with conventional high-grade urothelial carcinoma without subtype histology on transurethral resection. After neoadjuvant gemcitabine–cisplatin chemotherapy, robot-assisted radical cystectomy with intracorporeal neobladder reconstruction was performed. Final pathological examination revealed PUC (pT4aN2). Within weeks after surgery, the patient developed sequential retroperitoneal fluid accumulation, bilateral hydronephrosis, duodenal obstruction, and biliary obstruction, suggesting rapid diffuse retroperitoneal progression. Enfortumab vedotin plus pembrolizumab was initiated; however, the disease progressed aggressively, and the patient died on postoperative day 80.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>PUC may evade detection on initial TUR and can progress rapidly through diffuse retroperitoneal dissemination even after radical cystectomy. Early postoperative, unexplained multiorgan obstructive findings should raise suspicion of occult progression and prompt timely initiation of systemic therapy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 5","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70249","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148783542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Follicular Lymphoma Arising in an Ileal Neobladder Presenting as a Large Pelvic Mass","authors":"Ken Fujita,&nbsp;Takato Nishino,&nbsp;Masaki Shimbo,&nbsp;Shinya Yamanaka,&nbsp;Tomohiko Oguchi,&nbsp;Kazutaka Narimoto,&nbsp;Kazunori Hattori,&nbsp;Naoki Kanomata,&nbsp;Shinichiro Mori,&nbsp;Fumiyasu Endo","doi":"10.1002/iju5.70250","DOIUrl":"10.1002/iju5.70250","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Secondary malignancies arising in intestinal segments used for urinary diversion are rare, and reports of malignant lymphoma are extremely limited. We report a rare case of follicular lymphoma arising in an ileal neobladder 20 years after radical cystectomy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>An 81-year-old man had undergone radical cystectomy with ileal neobladder reconstruction for muscle-invasive bladder cancer (pT2bN0M0) 20 years earlier and had remained recurrence-free. Follow-up imaging incidentally revealed a large pelvic mass contiguous with the neobladder and multiple enlarged lymph nodes. Transurethral resection led to a diagnosis of follicular lymphoma. Treatment with bendamustine plus rituximab achieved marked tumor reduction without severe adverse events.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Malignant lymphoma arising in urinary diversion organs is extremely rare. This case highlights the potential for late-onset lymphoid malignancies following urinary diversion and emphasizes the need for long-term clinical awareness of secondary malignancies in such patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 5","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13462665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148725568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorescent Ureteral Catheter-Assisted Retroperitoneoscopic Biopsy for Periureteral IgG4-Related Disease Mimicking Upper Tract Urothelial Carcinoma","authors":"Takeshi Yoshida,&nbsp;Takaomi Sugi,&nbsp;Kentaro Tanigawa,&nbsp;Shogo Fujii,&nbsp;Kohei Yasuda,&nbsp;Atsushi Fukuda,&nbsp;Kiyotaka Iihara,&nbsp;Keisuke Kuretake,&nbsp;Katsuyoshi Higashijima,&nbsp;Shuji Harada","doi":"10.1002/iju5.70246","DOIUrl":"10.1002/iju5.70246","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Periureteral IgG4-related disease (IgG4-RD) is rare and can mimic upper tract urothelial carcinoma (UTUC), sometimes leading to unnecessary nephroureterectomy. Diagnosis is challenging when endoscopic biopsy is inconclusive and percutaneous biopsy is unsafe.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 58-year-old man presented with right-sided hydronephrosis. Imaging suggested right renal pelvic or ureteral carcinoma; however, ureteroscopic biopsy was nondiagnostic despite weak IgG4 positivity. Serum IgG4 was elevated to 684 mg/dL. Because percutaneous biopsy was unsafe owing to proximity to major vessels, retroperitoneoscopic biopsy was performed after placement of a fluorescent ureteral catheter. Near-infrared imaging identified the ureteral course, enabling safe biopsy. Frozen sections showed no malignancy, and histopathology revealed abundant IgG4-positive plasma cells, establishing IgG4-RD. Steroid therapy was initiated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Intraoperative frozen-section analysis ruled out malignancy and was the decisive factor in avoiding nephroureterectomy; the fluorescent ureteral catheter served as intraoperative navigation, enabling safe sampling of the periureteral lesion without ureteral injury.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 5","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148714668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Dilation of Ileal Conduit Stenosis 47 Years After Construction: The Longest Reported Interval in the Literature","authors":"Ayaka Igarashi,&nbsp;Seiji Arai,&nbsp;Sho Watanuki,&nbsp;Yusaku Shimizu,&nbsp;Tatsuhiro Sawada,&nbsp;Akira Ohtsu,&nbsp;Yuji Fujizuka,&nbsp;Yoshitaka Sekine,&nbsp;Hidekazu Koike,&nbsp;Kazuhiro Suzuki","doi":"10.1002/iju5.70247","DOIUrl":"10.1002/iju5.70247","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Ileal conduit diversion is commonly performed after cystectomy and is considered the gold standard. However, late complications can occur.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 74-year-old woman had undergone cystectomy with ileal conduit diversion for neurogenic bladder dysfunction 47 years earlier. She presented with recurrent urinary tract infections and bilateral hydroureteronephrosis. Imaging revealed conduit stenosis and impaired bilateral renal function. Endoscopy of ileal conduit revealed a pinhole-like stenosis on the proximal side. A 10-Fr catheter was advanced across the stenotic segment, resulting in pyelonephritis resolution and renal function improvement. After 1 month, the catheter was upsized to 16-Fr. Five months later, the catheter was spontaneously expelled, and good urine flow was maintained, with no recurrence over 2 years of follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Ileal conduit stenosis can occur even decades after urinary diversion and can be managed effectively by stepwise dilation. The present case highlights the need for lifelong surveillance in ileal conduit patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 5","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13460026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148714641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penile Metastasis From Castration-Resistant Prostate Cancer: A Case Report","authors":"Satoshi Asakura,&nbsp;Yoshihiro Nakagami,&nbsp;Tatsuki Inoue,&nbsp;Yuki Matsui,&nbsp;Kazuhiko Oshinomi,&nbsp;Masakazu Nagata,&nbsp;Takashi Fukagai,&nbsp;Yasuyuki Ohira,&nbsp;Yoshiko Yamochi","doi":"10.1002/iju5.70244","DOIUrl":"10.1002/iju5.70244","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Penile metastasis from prostate cancer—generally associated with a poor prognosis—is rare and underreported. We report one relevant case.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>The patient was a 65-year-old male with metastatic hormone-sensitive prostate cancer (prostate-specific antigen [PSA]: 500 ng/mL) and lung, bone, and lymph node metastases. The patient received luteinizing hormone-releasing hormone agonist monotherapy. The patient developed castration-resistant prostate cancer and received androgen receptor signal inhibitor therapy and chemotherapy. As the disease progressed, a mass formed on his penis; biopsy revealed prostate cancer penile metastasis. The patient died 5 months later.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Penile metastasis is rare and typically observed in advanced prostate cancer stages. Awareness may aid in early recognition, guide palliative management, and support patient counseling.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 5","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13453427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Cytokine Release Syndrome (CRS) Related to Treatment With Lenvatinib Plus Pembrolizumab for Metastatic Clear Cell Renal Cell Carcinoma","authors":"Kei Nagase,&nbsp;Hiroaki Kakinoki,&nbsp;Kazuki Nakamura,&nbsp;Yukako Yamaguchi,&nbsp;Shuhei Kusano,&nbsp;Yuka Kakinoki,&nbsp;Maki Kawasaki,&nbsp;Kazuma Udo,&nbsp;Shohei Tobu,&nbsp;Mitsuru Noguchi","doi":"10.1002/iju5.70228","DOIUrl":"10.1002/iju5.70228","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Cytokine release syndrome (CRS) is a systemic inflammatory response triggered by various factors, including infection and immunotherapy. Due to its nonspecific presentation, distinguishing CRS from other life-threatening conditions remains challenging.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 79-year-old male receiving lenvatinib plus pembrolizumab for metastatic renal cell carcinoma presented with high-grade fever, altered mental status, and respiratory failure on day 4 of treatment. After excluding infectious etiologies and endocrine dysfunction, CRS was suspected and confirmed by elevated interleukin-6 levels. Lenvatinib and pembrolizumab were discontinued, and the patient was treated with tocilizumab and dexamethasone. Clinical improvement was achieved by day 7.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>CRS should be considered a potential cause of unexplained shock in patients receiving immune checkpoint inhibitors. Early diagnostic consideration is vital for timely intervention.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 5","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13451156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urethral Metastasis of Therapy-Induced Neuroendocrine Prostate Cancer Successfully Managed With Chemoradiotherapy: A Case Report","authors":"Toshiaki Kayaba,&nbsp;Satoshi Washino,&nbsp;Takanori Hayase,&nbsp;Kai Yazaki,&nbsp;Kimitoshi Saito,&nbsp;Tomoaki Miyagawa","doi":"10.1002/iju5.70234","DOIUrl":"10.1002/iju5.70234","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Urethral metastasis of prostate cancer is exceptionally rare, particularly in castration-resistant disease. Therapy-induced neuroendocrine prostate cancer (t-NEPC) is an aggressive variant with limited treatment options.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 72-year-old man, 14 years after diagnosis of prostate adenocarcinoma treated with androgen deprivation therapy, presented with hematuria and dysuria. Prostate-specific antigen was 2.05 ng/mL and neuron-specific enolase was 28.0 ng/mL. Urethroscopy revealed papillary tumors in the pendulous urethra. Histology showed high-grade adenocarcinoma with a small cell carcinoma component, positive for synaptophysin and prostate-specific antigen. Genomic profiling demonstrated PTEN loss, TP53 mutation, and androgen receptor amplification. Platinum-based chemotherapy with external-beam radiotherapy achieved durable urethral local control despite later distant progression; the patient survived 2 years 10 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Platinum-based chemoradiotherapy may provide durable local control of urethral metastasis from t-NEPC.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 5","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13448509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncocytoma Arising From an Accessory Adrenal Gland: A Case Report","authors":"Yuki Seki,&nbsp;Kento Morozumi,&nbsp;Naomi Sato,&nbsp;Masaaki Oikawa,&nbsp;Hiroki Kusumoto,&nbsp;Nao Iwamoto,&nbsp;Naoki Kawamorita,&nbsp;Takayuki Yamada,&nbsp;Yasuhiro Nakamura,&nbsp;Yasuhiro Kaiho","doi":"10.1002/iju5.70245","DOIUrl":"10.1002/iju5.70245","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Accessory adrenal oncocytomas are rare. Consequently, the clinical characteristics and management of this entity remain poorly defined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 65-year-old man presented with a retroperitoneal mass. Imaging revealed a 103 × 96 mm tumor adjacent to the left kidney. Hormonal evaluation indicated the tumor was nonfunctioning; however, dehydroepiandrosterone sulfate and neuron-specific enolase levels were elevated, and malignancy could not be excluded. The tumor was resected laparoscopically. Histopathological examination revealed oncocytic features, and immunohistochemistry demonstrated positivity for steroidogenic factor 1. The tumor was anatomically separate from the normal adrenal gland, supporting the diagnosis of an accessory adrenal oncocytoma. Based on the Lin–Weiss–Bisceglia criteria, the tumor was classified as borderline malignant potential. No recurrence has been observed during 2 years of follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Accessory adrenal oncocytomas are rare entities, and their accurate diagnosis requires a comprehensive, integrated approach incorporating clinical findings, imaging studies, and detailed pathological evaluation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 5","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13451159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upper Urinary Tract Carcinoma With Primary Small Cell Neuroendocrine Cancer—Case Report and Review of Literature","authors":"Siddhant Kumar,&nbsp;Sunil Pillai Bhaskara,&nbsp;A. V. B. Krishnakanth,&nbsp;Abhijit Shah,&nbsp;Siddalingeshwara Chandragouda Doddamani,&nbsp;Padmaraj hegde,&nbsp;Arun Chawla","doi":"10.1002/iju5.70071","DOIUrl":"10.1002/iju5.70071","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Upper Urinary Tract Small Cell Neuroendocrine Ca are extremely rare carcinomas with less than 40 reported cases in literature.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case</h3>\u0000 \u0000 <p>92 years old male with left flank pain and diagnosed to have an enhancing renal pelvic mass, which on histopathological examination was noted to have a predominant small cell carcinoma component.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This case report attempts to shed a light on the patients with small cell neuroendocrine carcinoma of the upper tract with its silent and aggressive nature.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 5","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13443127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148686517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deferred Cytoreductive Nephrectomy With Partial Hepatectomy for Giant Renal Cell Carcinoma of the Right Kidney With Extensive Hepatic Invasion: A Case Report in the Era of Systemic Immune Checkpoint Inhibitors and Tyrosine Kinase Inhibitors","authors":"Yuki Hiroshi,&nbsp;Takamitsu Inoue,&nbsp;Takuya Minagawa,&nbsp;Masaki Takahashi,&nbsp;Akinobu Katami,&nbsp;Mizuki Onozawa,&nbsp;Masahiro Shinoda,&nbsp;Osamu Itano,&nbsp;Jun Miyazaki","doi":"10.1002/iju5.70209","DOIUrl":"10.1002/iju5.70209","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Deferred cytoreductive nephrectomy may improve the prognosis of patients with metastatic renal cell carcinoma (RCC). However, reports of combined hepatic resection for RCC with liver invasion are limited, and treatment strategies remain insufficiently established.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 75-year-old man presented with right RCC with liver invasion, lung metastases, and an inferior vena cava (IVC) tumor thrombus. Nivolumab plus cabozantinib reduced the lung metastases but not the primary tumor or thrombus. Three months after starting systemic therapy, he underwent open right nephrectomy, partial hepatectomy of segments 5, 6, 7, and part of 8, and tumor thrombus resection. Pathology revealed pT4, Grade 4 clear cell carcinoma. Although lung metastases recurred postoperatively, systemic therapy was resumed on day 51, resulting in complete remission.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Appropriately early cytoreductive nephrectomy with partial hepatectomy after systemic therapy may have contributed to this favorable outcome.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 5","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13439213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}