IJU Case Reports最新文献

{"title":"Clear Cell Papillary Renal Cell Carcinoma Incidentally Discovered in a Patient With Normal Renal Function: A Case Report","authors":"Toru Inoue,&nbsp;Masahiro Fuse,&nbsp;Satoki Abe,&nbsp;Shinya Sejiyama,&nbsp;Kazuhiro Kawamura,&nbsp;Yuzo Oyama,&nbsp;Tadasuke Ando,&nbsp;Toshitaka Shin","doi":"10.1002/iju5.70050","DOIUrl":"https://doi.org/10.1002/iju5.70050","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Clear cell papillary renal cell carcinoma is a distinct histopathological entity first characterized in patients with end-stage renal disease. Although increasingly reported in patients with normal renal function, it remains relatively unfamiliar in routine clinical practice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 75-year-old male with normal renal function presented with an incidentally discovered left renal mass. Radiological evaluation revealed a mass with a distinct enhancement pattern. Considering the patient's preference for surgical management, robot-assisted partial nephrectomy was performed, confirming clear cell papillary renal cell carcinoma, with immunohistochemistry demonstrating diffuse cytokeratin 7-positivity, alpha-methylacyl-CoA racemase-negativity, and cup-shaped carbonic anhydrase IX staining.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This case demonstrated the characteristic features of clear cell papillary renal cell carcinoma in a patient with normal renal function. Nephron-sparing surgery and rigorous follow-up protocols are crucial management strategies. Future studies with larger cohorts are needed to define the natural history and optimal management of clear cell papillary renal cell carcinoma.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"8 4","pages":"394-397"},"PeriodicalIF":0.0,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urethral Stricture Associated With an Artificial Urethral Sphincter: A Case Report","authors":"Akira Tachibana,&nbsp;Kazumasa Torimoto,&nbsp;Daisuke Gotoh,&nbsp;Kenta Onishi,&nbsp;Shunta Hori,&nbsp;Yosuke Morizawa,&nbsp;Yasushi Nakai,&nbsp;Makito Miyake,&nbsp;Nobumichi Tanaka,&nbsp;Kiyohide Fujimoto","doi":"10.1002/iju5.70049","DOIUrl":"https://doi.org/10.1002/iju5.70049","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Artificial urinary sphincter implantation is the standard treatment for moderate-to-severe stress urinary incontinence in men. We report a case of urethral stricture associated with an artificial urinary sphincter in a patient who underwent urethroplasty and subsequent replacement of the implant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 64-year-old man who had undergone radical retropubic prostatectomy presented to our department for stress urinary incontinence. An artificial urinary sphincter was implanted, and the incontinence resolved. Eleven years later, the patient returned because of voiding symptoms. Urethroscopy and retrograde urethrography revealed a pendulous urethral stricture, measuring approximately 2 mm in length. The patient underwent implant removal and non-transecting anastomotic urethroplasty. Postoperative urethroscopy confirmed resolution of the stricture. Artificial urinary sphincter reimplantation was performed 6 months later, restoring continence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Non-transecting urethroplasty to treat short urethral strictures associated with an artificial urinary sphincter may increase the success of artificial sphincter replacement.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"8 4","pages":"390-393"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment on “Zinner Syndrome Presenting With Chronic Pelvic Pain and Ejaculatory Dysfunction” From Dr. Sourav and Dr. Tweheyo","authors":"Sourav Sudan,&nbsp;Tweheyo Ronald","doi":"10.1002/iju5.70046","DOIUrl":"https://doi.org/10.1002/iju5.70046","url":null,"abstract":"<p>We read with great interest the case report by Patil et al., and this instructive case of Zinner syndrome thoughtfully navigates the diagnostic pathway using magnetic resonance imaging (MRI) to delineate anatomical anomalies [<span>1</span>]; however, it also opens the door for deeper reflection on emerging embryological correlations. While the authors appropriately attributed the pathology to mesonephric duct maldevelopment, the literature now suggests that coexisting anomalies such as Müllerian duct remnants or aberrant mesonephric-Müllerian fusion defects may occasionally coexist in patients with cysts exceeding 2.5 cm [<span>2, 3</span>]. The cyst dimensions in this case could serve as an opportunity to consider subtle embryological overlaps, which may have functional implications.</p><p>Furthermore, the report offers an excellent depiction of structural anomalies; however, functional correlates remain an evolving area in such syndromes. For instance, compensatory hyperfunction of the solitary kidney, often seen in unilateral renal agenesis, might benefit from noninvasive evaluation using serum cystatin C or differential renal scintigraphy, which are increasingly being adopted in urological surveillance [<span>4</span>].</p><p>Additionally, while semen analysis revealing oligospermia adds an important reproductive dimension, future case discussions should consider incorporating baseline endocrine profiles and scrotal ultrasonography to offer a more holistic reproductive assessment. Such adjuncts, when included, can inform long-term fertility planning and personalize follow-up decisions. This case adds meaningful value to the literature and invites further exploration of how structural clarity can be enriched by functional parameters, especially in a condition where both fertility and renal preservation are central to patient outcomes.</p><p>The authors have nothing to report.</p><p>The authors have nothing to report.</p><p>The authors declare no conflicts of interest.</p>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"8 4","pages":"328-329"},"PeriodicalIF":0.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144524561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Second Renal Transplantation With Simultaneous Ileal Conduit Creation Following Transplant Nephroureterectomy and Native Cystectomy","authors":"Ayato Ito,&nbsp;Takehiro Ohyama,&nbsp;Kyoko Minamisono,&nbsp;Sho Nishida,&nbsp;Daiki Iwami","doi":"10.1002/iju5.70044","DOIUrl":"https://doi.org/10.1002/iju5.70044","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Postrenal transplant urothelial carcinoma necessitates multidisciplinary treatment. We here report the first case of a patient with transplant ureteral and bladder cancer who underwent transplant nephroureterectomy and cystectomy, followed by a second living donor renal transplantation and ileal conduit creation after a cancer recurrence-free period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 78-year-old female with end-stage renal disease who had previously undergone living donor renal transplantation presented with gross hematuria. She was diagnosed with transplant ureteral and bladder cancer and subsequently underwent transplant nephroureterectomy and cystectomy. She was immediately reintroduced to hemodialysis. After a 2-year cancer-free period, a second living donor renal transplantation with simultaneous ileal conduit surgery was successfully performed. Currently, the patient remains cancer-free for 2 years following the second renal transplantation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Second renal transplantation and simultaneous ileal conduit creation are alternatives following curative transplant nephrouretero-cystectomy for post-transplant urothelial carcinoma.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"8 4","pages":"377-381"},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144524949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mixed Epithelial and Stromal Tumor of the Kidney in a Patient With Mental Retardation: A Case Report","authors":"Kazuki Sato,&nbsp;Kotaro Hirai,&nbsp;Yumiko Yokomizo,&nbsp;Azumi Fujioka,&nbsp;Yuki Ito,&nbsp;Sawako Chiba,&nbsp;Junichi Murayama","doi":"10.1002/iju5.70043","DOIUrl":"https://doi.org/10.1002/iju5.70043","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Mixed epithelial and stromal tumors are rare renal neoplasms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 55-year-old woman with mental retardation presented with a giant renal tumor with abdominal pain. After a renal biopsy with a definitive diagnosis, an open total nephrectomy was performed. There was no recurrence for the following year.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Discussion</h3>\u0000 \u0000 <p>Since a definitive diagnosis of MEST cannot be made through imaging alone, surgery is the preferred diagnostic treatment. To our knowledge, renal biopsy has only been reported in three cases. There are only two reports of nonsurgical treatment of benign MEST and no reports of malignant transformation or exacerbation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>If the biopsy findings are suggestive of a benign tumor, follow-up is an option. We look forward to reporting the long-term outcomes of the conservative management of MEST.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"8 4","pages":"373-376"},"PeriodicalIF":0.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144524551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Delayed Refractory Mycobacterium mageritense Abdominal Wall Abscess in a Kidney Transplant Recipient","authors":"Hisashi Sakurai,&nbsp;Teppei Okamoto,&nbsp;Tomoko Hamaya,&nbsp;Hirotake Kodama,&nbsp;Naoki Fujita,&nbsp;Hayato Yamamoto,&nbsp;Kazuyuki Mori,&nbsp;Takeshi Fujita,&nbsp;Atushi Imai,&nbsp;Reiichi Murakami,&nbsp;Hirofumi Tomita,&nbsp;Shingo Hatakeyama","doi":"10.1002/iju5.70042","DOIUrl":"https://doi.org/10.1002/iju5.70042","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p><i>Mycobacterium mageritense</i> (<i>M. mageritense</i>), a rare non-tuberculous mycobacterium (NTM), can cause infections in immunocompromised patients, including kidney transplant recipients. We present a case of an abdominal wall abscess caused by <i>M. mageritense</i> following a living donor kidney transplant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 58-year-old woman, post-ABO-incompatible kidney transplant, developed an abscess at the site of a removed peritoneal dialysis catheter. Initial antibiotics were ineffective, and pus cultures identified <i>M. mageritense</i>. Surgical drainage and levofloxacin-linezolid therapy controlled the infection temporarily. Despite clinical improvement, the abscess recurred 30 days post-discharge, which required repeated antibiotic use and adjustments to immunosuppression. Reducing mycophenolate mofetil while maintaining tacrolimus stabilized the infection, and prophylactic levofloxacin was continued post-discharge to prevent relapse.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Effective infection control requires careful immunosuppressive adjustment and long-term antibiotic use to balance graft preservation with infection risk.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"8 4","pages":"369-372"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144524534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internal High Echoes Can Suggest the Possible Resection of Ovarian Vein Leiomyosarcoma: A Case Report","authors":"Sohei Iwagami,&nbsp;Shoji Oura,&nbsp;Masaya Nishihata","doi":"10.1002/iju5.70025","DOIUrl":"https://doi.org/10.1002/iju5.70025","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Leiomyosarcomas of ovarian veins often affect the IVC, the duodenum, and kidneys. Therefore, the resectability of the leiomyosarcomas highly depends on the presence or extent of their invasion to the surrounding organs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 55-year-old woman with a retroperitoneal mass on CT was referred to our hospital. CT and MRI showed a lobulated large mass with broad contact with the duodenum. EUS showed focal internal high echoes in the tumor areas adjacent to the duodenum. After obtaining the pathological diagnosis of leiomyosarcoma, the tumor was successfully removed without duodenum resection. Post-operative pathological findings confirmed the absence of direct leiomyosarcoma invasion to the duodenum and the sparse atypical cells with edematous background in the high internal echo areas.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Surgeons should note that internal high echoes in the tumor areas adjacent to the duodenum can be an important predictor of possible resection of the retroperitoneal tumors.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"8 4","pages":"315-318"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144524536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robot-Assisted Laparoscopic Radical Nephrectomy in a Renal Cell Carcinoma Patient With Severe Scoliosis: A Case Report","authors":"Tatsuya Kawamura,&nbsp;Daiki Ikarashi,&nbsp;Ayato Ito,&nbsp;Ei Shiomi,&nbsp;Shigekatsu Maekawa,&nbsp;Renpei Kato,&nbsp;Mitsugu Kanehira,&nbsp;Ryo Takata,&nbsp;Wataru Obara","doi":"10.1002/iju5.70037","DOIUrl":"https://doi.org/10.1002/iju5.70037","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Laparoscopic nephrectomy in patients with severe scoliosis presents significant challenges due to altered anatomy and limited space. This case report discusses using robot-assisted laparoscopic radical nephrectomy in such a scenario.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 68-year-old man with severe right convex scoliosis was diagnosed with cT3aN0M0 right locally advanced renal cell carcinoma. Given the anatomical distortions caused by scoliosis, traditional laparoscopic techniques posed difficulties. We opted for robot-assisted laparoscopic radical nephrectomy, carefully planning the port placement and surgical approach to accommodate the patient's unique anatomical features.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This is the first reported instance of robot-assisted laparoscopic radical nephrectomy in a patient with severe scoliosis. The successful outcome demonstrates the feasibility and benefits of robotic assistance in overcoming the technical difficulties associated with scoliosis, offering a viable surgical option for similar cases.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"8 4","pages":"352-355"},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144524524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leuprorelin-Induced Thrombocytopenia Successfully Treated With Surgical Resection of the Injection Site","authors":"Ryota Mori,&nbsp;Satoru Taguchi,&nbsp;Masahiro Yamamoto,&nbsp;Yuta Inoue,&nbsp;Koichiro Kanazawa,&nbsp;Yoichi Fujii,&nbsp;Haesu Lee,&nbsp;Kiichi Furuse,&nbsp;Hiroaki Maki,&nbsp;Jun Kamei,&nbsp;Shigenori Kakutani,&nbsp;Yuta Yamada,&nbsp;Aya Niimi,&nbsp;Daisuke Yamada,&nbsp;Aya Shinozaki-Ushiku,&nbsp;Tetsuo Ushiku,&nbsp;Mineo Kurokawa,&nbsp;Mutsumi Okazaki,&nbsp;Haruki Kume","doi":"10.1002/iju5.70041","DOIUrl":"https://doi.org/10.1002/iju5.70041","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Drug-induced thrombocytopenia (DITP) can be caused by many kinds of drugs. Its treatment generally involves discontinuation of the responsible drug.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 70-year-old man received a subcutaneous injection of long-acting (24-week) leuprorelin depot as androgen deprivation therapy for prostate cancer. Four days after the injection, he presented with gingival bleeding and his platelet count was remarkably decreased (&lt; 1000/μL). There was no sign of malignancy but the presence of megakaryocytes on bone-marrow examinations. Considering immune and/or DITP, he started immunoglobulin and steroid therapy while stopping all suspected medications. However, even a month later, his platelet count did not recover with the need for frequent platelet transfusions. Therefore, he eventually underwent surgical resection of the leuprorelin injection site. After the surgery, his platelet count drastically recovered and platelet transfusion became unnecessary.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We report a case of leuprorelin-induced thrombocytopenia that was successfully treated with surgical resection of the injection site.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"8 4","pages":"365-368"},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enfortumab Vedotin–Induced Toxic Epidermal Necrolysis in Metastatic Urothelial Carcinoma Complicated by Severe Gastrointestinal Bleeding","authors":"Aika Matsuyama,&nbsp;Takashi Kato,&nbsp;Rion Kawase,&nbsp;Mikinori Kobayashi,&nbsp;Ayako Momota,&nbsp;Yukiko Tsunoda,&nbsp;Asaomi Yamaguchi,&nbsp;Hiroki Hirabayashi,&nbsp;Shoji Suzuki,&nbsp;Masashi Kato","doi":"10.1002/iju5.70036","DOIUrl":"https://doi.org/10.1002/iju5.70036","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Enfortumab vedotin (EV) has been reported to cause skin toxicity in some patients. We report a rare case of toxic epidermal necrolysis (TEN) induced by EV and complicated by severe gastrointestinal (GI) bleeding.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 70-year-old man with recurrent urothelial carcinoma developed a trunk rash at 16 days after EV administration. He presented to the emergency department with loss of consciousness and was diagnosed with TEN and septic shock. Although pulse steroid therapy improved his skin lesions, his abdominal symptoms progressively worsened. On Day 27, he developed massive GI bleeding. Despite intensive interventions, he died of multiple organ failure on Day 30.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This case highlights that Stevens–Johnson syndrome/TEN induced by EV can develop shortly after treatment, with delayed and potentially fatal GI manifestations. Given the challenges in managing established TEN, close monitoring for adverse events is essential.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"8 4","pages":"348-351"},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144524526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}