Journal of Affective Disorders Reports最新文献

{"title":"Individual differences in anxious apprehension and anxious arousal alter resting-state network structure and connectivity","authors":"Stacie L. Warren ,&nbsp;Whitney N. Geller ,&nbsp;Brian Droncheff ,&nbsp;Kevin Liu","doi":"10.1016/j.jadr.2025.100895","DOIUrl":"10.1016/j.jadr.2025.100895","url":null,"abstract":"<div><h3>Background</h3><div>Pathological anxiety is commonly treated as a unitary construct, manifesting as various clinical subtypes. However, there is a growing consensus that anxiety has at least two unique dimensions, anxious arousal and anxious apprehension. Nevertheless, their distinguishable neurobiological mechanisms are unclear. Here, we take a transdiagnostic approach to disentangle network-level functional and structural disturbances at rest, a state when some anxiety symptoms may be most apparent.</div></div><div><h3>Methods</h3><div>53 adults experiencing a range of anxiety and/or depressive symptoms completed resting-state fMRI. Resting-state networks were identified by independent components analysis. Dual-regression tested anxious arousal and anxious apprehension derived within-network connectivity differences while controlling for depression. FSLNets tested differences in between-network functional connectivity.</div></div><div><h3>Results</h3><div>Anxious apprehension was associated with expansion of the default and somatomotor networks, while anxious arousal was associated with hyperconnectivity in the salience, limbic, frontoparietal, and default networks. Anxious apprehension was also associated with increased connectivity between the default and salience networks as well as decreased connectivity between the dorsal attention and limbic networks.</div></div><div><h3>Limitations</h3><div>Evaluating a larger sample size and longer resting-state scans can better ensure reproducibility of results. The cross-sectional design limits conclusions about the temporal dynamics of anxious apprehension and anxious arousal and functional connectivity alterations observed in the present study.</div></div><div><h3>Conclusions</h3><div>Results suggest that anxious apprehension and anxious arousal have distinguishable neurobiological mechanisms that contribute to maladaptive differences in threat evaluation, stress response, and self-referential thought. These findings enhance our understanding of anxiety's nosology and pathophysiology, informing potential mechanisms for intervention.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100895"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are amygdala and insula consistently hyperresponsive to aversive stimuli in PTSD? Comment on Bastos et al. 2022","authors":"Aline Rodrigues Cardoso ,&nbsp;Aline Furtado Bastos ,&nbsp;José Magalhães Oliveira ,&nbsp;João Ricardo Sato ,&nbsp;Liana Catarina Lima Portugal ,&nbsp;Mirtes Garcia Pereira ,&nbsp;Leticia de Oliveira ,&nbsp;Eliane Volchan ,&nbsp;Fátima Smith Erthal","doi":"10.1016/j.jadr.2025.100897","DOIUrl":"10.1016/j.jadr.2025.100897","url":null,"abstract":"<div><h3>Background</h3><div>A recurring theme in fMRI studies is the inconsistent findings in amygdala and insula hyperreactivity among patients with PTSD vs. trauma-exposed controls. This study reanalyzed data from Bastos et al. (2022) investigating group effects to aversive stimuli in those regions.</div></div><div><h3>Methods</h3><div>Patients with PTSD (<em>n</em> = 20) and trauma-exposed controls (<em>n</em> = 23) briefly viewed neutral and mutilation pictures. Amygdala and insula ROIs were analyzed for valence and group effects. Subsequently, regressor duration was extended to determine whether a longer regressor would capture a lasting valence effect beyond picture presentation.</div></div><div><h3>Results</h3><div>Significant main effects of valence were observed in the amygdala and insula ROIs, for both regressor durations. In both regions there were no significant main effects for group. Further no interactions between valence and group were found, indicating lack of consistent hyperresponsivity in patients with PTSD.</div></div><div><h3>Conclusions</h3><div>Our results help to challenge hyperreactivity as a proxy of PTSD. In fact, multiple traumatic experiences and/or childhood maltreatment were shown to be associated with hyporeactivity in PTSD. If this is not taken into consideration, the average pattern of reactivity recorded from a mixed sample with both hypo and hyper responders can be indistinguishable from controls.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100897"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting preventative effects of cognitive control training in remitted depressed individuals: A machine learning approach","authors":"Yannick Vander Zwalmen ,&nbsp;Ernst H.W. Koster ,&nbsp;David Demeester ,&nbsp;Chris Baeken ,&nbsp;Nick Verhaeghe ,&nbsp;Kristof Hoorelbeke","doi":"10.1016/j.jadr.2025.100894","DOIUrl":"10.1016/j.jadr.2025.100894","url":null,"abstract":"<div><h3>Background</h3><div>Residual cognitive complaints are frequently observed in remitted depressed individuals (RMD), which can impair full recovery and increase the likelihood of recurrent episodes of depression. Cognitive control training (CCT) has shown potential as a preventative intervention in RMD with small to moderate effect sizes, but substantial heterogeneity in effects between individuals exists.</div></div><div><h3>Objective</h3><div>This study aimed to identify individual characteristics associated with CCT treatment response in RMD participants using machine learning (ML) models.</div></div><div><h3>Methods</h3><div>227 RMD underwent a CCT regimen of at least 10 sessions. Three machine-learning models were evaluated: logistic regression, random forest, and XGBoost, alongside one random classifier benchmark. Performance metrics (accuracy, precision, recall, F1-score, and AUC-ROC) were computed. Feature importance was assessed using SHAP values.</div></div><div><h3>Result</h3><div>All models demonstrated low performance, regardless of ML methodology. The logistic regression model obtained the highest performance, although this was still considered low (accuracy: 0.54; AUC-ROC: 0.49). Exploratory feature importance analysis revealed that age, sense of well-being, and life satisfaction were important variables in the models, while current use of psychotherapy, number of prior depressive episodes, and history of inpatient treatment were not.</div></div><div><h3>Conclusion</h3><div>All models performed poorly, indicating that baseline characteristics did not confidently predict CCT treatment effects in this RMD sample. Exploratory feature analysis indicates that some clinical variables may increase the likelihood of benefiting from CCT, while most demographical variables did not seem to affect treatment effectiveness. However, due to low model performance, confidence in feature importance was low and additional research using larger samples is required.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100894"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of neurophysiological signatures of bipolar disorder by resting-state EEG microstate analysis","authors":"Keita Taniguchi ,&nbsp;Naotsugu Kaneko ,&nbsp;Masataka Wada ,&nbsp;Mayuko Takano ,&nbsp;Sotato Moriyama ,&nbsp;Yu Mimura ,&nbsp;Hiroyuki Uchida ,&nbsp;Shinichiro Nakajima ,&nbsp;Yoshihiro Noda","doi":"10.1016/j.jadr.2025.100891","DOIUrl":"10.1016/j.jadr.2025.100891","url":null,"abstract":"<div><h3>Background</h3><div>This investigation probed the neurophysiological disparities between patients with bipolar disorder (BD) and healthy controls (HC) utilizing resting-state electroencephalography (rs-EEG) microstate (MS) analysis. The study, conducted at Keio University Hospital from 2017 to 2023, sought to differentiate BD from HC for early detection.</div></div><div><h3>Methods</h3><div>The study included 36 BD (average age: 48.3 years) and 36 age- and sex-matched HC (average age: 47.8 years). Participants underwent a 5-min rs-EEG recording with eyes closed. MS analysis focused on the duration, occurrence, and coverage of MS (<em>A</em> − <em>E</em>) transitions. Comparisons were executed using Mann-Whitney U tests, and a logistic regression model distinguished the groups based on these MS indices.</div></div><div><h3>Results</h3><div>Patients with BD exhibited a shorter MS-D duration (<em>p</em> &lt; 0.001) and longer MS-C (<em>p</em> = 0.027) and MS-E (<em>p</em> = 0.020) durations compared to HC. The occurrence and coverage of MS-D were significantly lower in BD (<em>p</em> &lt; 0.001 for both). The logistic regression model accurately classified 84.7% of cases (χ2(3)=42.03, <em>p</em> &lt; 0.001).</div></div><div><h3>Limitations</h3><div>Limitations include the potential influence of medication on MS dynamics and the cross-sectional design, which prevents causal conclusions. Longitudinal studies are required to comprehend the relationship between MS alterations and BD symptoms.</div></div><div><h3>Conclusion</h3><div>Decreased MS-D indices, along with increased MS-C and MS-E indices in BD, imply dysfunction in the frontoparietal network and impairments in the default mode and salience networks. The altered temporal dynamics of rs-EEG MSs provide a unique neurophysiological profile of BD, suggesting that MS indices could potentially serve as neurophysiological markers for BD diagnosis.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100891"},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143465375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in inflammatory markers in bipolar disorder","authors":"Yanlin Liu ,&nbsp;Hui Xin Ng ,&nbsp;Ashley Sutherland ,&nbsp;Soohyun Joe ,&nbsp;Benchawanna Soontornniyomkij ,&nbsp;Federica Klaus ,&nbsp;Lisa T. Eyler","doi":"10.1016/j.jadr.2025.100892","DOIUrl":"10.1016/j.jadr.2025.100892","url":null,"abstract":"<div><h3>Background</h3><div>Chronic peripheral and brain inflammatory processes contribute to mood disorders. Elevated inflammation may serve as a biomarker for bipolar disorder (BD). Studies have noted sex differences in inflammatory marker levels in the general population, primarily focusing on the effects of surgeries or infections. We explored differences between men and women in serum levels of four inflammatory markers – IL-6, TNF-α, CCL-11, and CRP – among individuals with BD and healthy comparison (HC) participants and compared sex differences between groups.</div></div><div><h3>Methods</h3><div>Data from 156 participants (HC: 49 women, 45 men; BD: 38 women, 24 men) were averaged over three baseline visits of a longitudinal study on inflammation and cognitive aging in BD. Blood samples were collected every week during a two-week period and assessed for biomarker levels using electrochemiluminescence assays. General linear models were applied to examine the main effects of sex, diagnostic group, and sex x diagnostic group for IL-6, TNF-α, CCL-11, and CRP, with smoking, BMI, and age included as covariates.</div></div><div><h3>Results</h3><div>Participants with BD showed higher levels of IL-6 than HC. Sex, diagnostic group, and their interaction showed effects in TNF-α, with higher levels in men with BD and lower levels in HC women. CCL-11 was higher in men than women. CRP levels were higher in BD men than HC men.</div></div><div><h3>Conclusions</h3><div>Men had higher TNF-α serum levels than women; this difference was more pronounced in BD than HC. CRP was elevated in BD compared to HC men. Future anti-inflammatory treatments should consider possible sex differences in BD.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100892"},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative analytics from stakeholder perspective describes the biopsychosocial model for patient-centred approach to managing psychiatric ailments","authors":"Abhishek Cukkemane ,&nbsp;Rene Hurlemann ,&nbsp;Veralia Gabriela Sanchez","doi":"10.1016/j.jadr.2025.100893","DOIUrl":"10.1016/j.jadr.2025.100893","url":null,"abstract":"<div><div>Chronic mental illnesses (CMIs) such as schizophrenia, schizoaffective disorder, bipolar disorder, major depressive disorders, to name a few are psychiatric disorders poses significant burden to both patients and healthcare systems. The public policy and management of such complex set of spectral disorders often includes procedures and regulations, pharmacological treatments, psychotherapy, and social support. However, these approaches frequently fail to fully address patient requirements, leading to inadequate care and poor outcomes. Therefore, by conducting interviews and synthesizing insights from various stakeholders, including clinicians, researchers, and healthcare professionals, the study investigates the multi-dimensional challenges in CMI management. This report of qualitative analysis explores a patient-centric approach towards three main themes in managing CMIs such as, tasks related to diagnosis, challenges with current procedures, and expectations from newer diagnostic methodologies. Key themes emerged revolving around requirements for emotional care, trust, complexity, and the integration of technology in treatment. Our findings highlight the need for personalized care strategies that encompass biological, psychological, and social dimensions with emphasis on effective communication and resource management. The study underscores the potential of a holistic, patient-centred framework, which serendipitously parallels George Engel's biopsychosocial model to improve outcomes and address the multifaceted nature of spectral psychiatric disorders. In the light of newer emerging technologies and the demands for psychometric intervention, perhaps, we suggest revisiting the model for a comprehensive approach in policy-making, health care management and patient-centric support to address these challenges effectively</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100893"},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of olfactory training on depressive symptoms and olfactory function in patients with olfactory dysfunction – A prospective observational pilot study","authors":"Emilie Keusters ,&nbsp;Marnick Clijsters ,&nbsp;Kristof Vansteelandt ,&nbsp;Laura Van Gerven ,&nbsp;Filip Bouckaert","doi":"10.1016/j.jadr.2025.100887","DOIUrl":"10.1016/j.jadr.2025.100887","url":null,"abstract":"<div><h3>Introduction</h3><div>Olfaction plays an important role in different aspects of our daily functioning and there is a positive correlation between olfactory dysfunction (OD) and depressive symptoms. Multiple parts of the brain are involved in both olfaction and the origin of depressive symptoms, e.g. amygdala and hippocampus. Olfactory training (OT) is one of the main therapeutic options in the management of OD. The objective of our study is to look at the prevalence of depressive symptoms in patients with olfactory disorders and to examine the effect of OT on mood in patients who present with OD.</div></div><div><h3>Methods</h3><div>We included patients who presented at the Ears-Nose-Throat outpatient clinic with subjective OD and were eligible for OT. At baseline and follow-up (3 to 6 months) olfactory function and depression were assessed respectively by a Sniffin’ Sticks test and the Quick Inventory of Depressive Symptoms questionnaire.</div></div><div><h3>Results</h3><div>Our study revealed that 57 % of participants had mild to severe depressive symptoms at baseline. There was no correlation between the depressive symptoms and OD at baseline. From baseline to follow-up, there was a significant decline in depressive symptoms, but no significant changes in the olfactory function. In addition, there was no correlation between change in depression and change in olfactory function.</div></div><div><h3>Limitations</h3><div>These results should be interpreted with caution because this is an observational pilot study with no placebo-controlled group and a small sample size. Further investigation is warranted.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100887"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genetic overlap between major depressive disorder, white blood cell counts and interleukin 6","authors":"Erik D Wiström ,&nbsp;Kevin S O'Connell ,&nbsp;Elise Koch ,&nbsp;Piotr Jaholkowski ,&nbsp;Guy F.L. Hindley ,&nbsp;Nils Eiel Steen ,&nbsp;Pravesh Parekh ,&nbsp;Charge Consortium, Oleksandr Frei ,&nbsp;Nadine Parker ,&nbsp;Alexey Shadrin ,&nbsp;Srdjan Djurovic ,&nbsp;Anders Dale ,&nbsp;Ole A Andreassen ,&nbsp;Olav B Smeland","doi":"10.1016/j.jadr.2025.100889","DOIUrl":"10.1016/j.jadr.2025.100889","url":null,"abstract":"<div><h3>Background</h3><div>Immune dysregulation may contribute to the pathophysiology of major depressive disorder (MDD). Here we aimed to identify genetic architecture jointly associated with MDD, white blood cell (WBC) count and interleukin 6 (IL-6) levels.</div></div><div><h3>Methods</h3><div>Using genome-wide association studies summary statistics on MDD (330,173 cases and 727,595 controls), WBC counts (<em>n_max</em> = 563,946) and IL-6 (<em>n</em> = 52,654), we performed linkage disequilibrium (LD) score regression, bivariate causal mixture model (MiXeR), conjunctional false discovery rate (conjFDR) and Mendelian randomization (MR) analyses. Additionally, we used an independent MDD dataset (9,582 cases and 84,670 controls) from the Norwegian Mother, Father and Child Cohort Study for polygenic risk score (PRS) analyses.</div></div><div><h3>Findings</h3><div>We found a significant positive genetic correlation (rg = 0.22) between MDD and IL-6. MiXeR estimates indicated substantial differences in the polygenicity of MDD (13.7K variants), WBC subgroups (0.8K-1.8K variants), and IL-6 (0.2K variants), with 10.1 %-31.4 % of the variants influencing WBC subgroups overlapping with MDD. We identified MDD risk loci shared with basophils (8), eosinophils (17), lymphocytes (23), monocytes (14), neutrophils (20), and total WBC counts (20), as well as two loci shared between MDD and IL-6, at conjFDR &lt;0.05. PRS analysis showed a weak, but significantly increased risk for MDD dependent on monocyte count.</div></div><div><h3>Limitations</h3><div>The analyses only included European ancestry samples, and the causal genes associated with the identified genetic loci were not experimentally validated.</div></div><div><h3>Conclusions</h3><div>MDD shares genetic underpinnings with immune system components, which implicates immune-mediated pathways in the pathophysiology of MDD. However, this connection may only be relevant for a minority of patients.</div></div><div><h3>Abbreviations</h3><div>MDD, major depressive disorder; White blood cell, WBC; MiXeR<strong>,</strong> bivariate causal mixture model; conjFDR, conjunctional false discovery rate; condFDR, conditional FDR; LD linkage disequilibrium; PRS, polygenic risk score; MoBa, Norwegian Mother, Father and Child Cohort Study</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100889"},"PeriodicalIF":0.0,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143428750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of mental health and psychosocial concerns among South African student-athletes","authors":"Ankebé Kruger","doi":"10.1016/j.jadr.2025.100888","DOIUrl":"10.1016/j.jadr.2025.100888","url":null,"abstract":"<div><h3>Purpose</h3><div>This investigation aimed to identify the prevalence of mental health and psychosocial concerns in a group of South African student-athletes.</div></div><div><h3>Procedure</h3><div>A cross-sectional research design, following a quantitative research approach, was used with a convenient sample. Two hundred (n=200) student-athletes representing various South African universities, with an average age of 20.45 years, avail their data for research purposes, 72 males and 128 females. Data was collected during service delivery in clinical practice using a psychological test battery yielding information on depression, anxiety, and stress (DASS-21), sleep behaviour (PROMIS scale), alcohol consumption (AUDIT-C), eating behaviour (BEDA-Q) and smoking behaviour.</div></div><div><h3>Findings</h3><div>Frequencies indicated that 6.5% showed extremely severe levels of depression, while 4.5% indicated severe and 13.0% moderate levels of depression. Fifteen percent of the athletes noted experiencing extremely severe levels of anxiety, 6.5 % severe and 23.5% moderate levels of anxiety. One percent of the athletes displayed extremely severe levels of distress, 6% had severe levels of distress, and 14% had moderate distress levels. Thirty-five percent indicated mild disturbed sleeping behaviours, with 20% reporting moderate and 15% severe symptoms of disturbed sleeping behaviour. Twenty-nine percent of the athletes noted adverse alcohol use, while 75% indicated the presence of adverse eating behaviour. Twelve percent of the athletes indicated that they smoke.</div></div><div><h3>Conclusion</h3><div>Student-athletes exhibit elevated levels of mental health challenges and psychosocial stressors, which warrant significant attention and intervention. The findings furthermore highlight the significance of implementing a system to facilitate the early identification of athletes experiencing mental health symptoms. This will encourage athletes who require assistance to seek help from a registered health professional, and it will make it easier for athletes to proceed with further assessment and treatment, if necessary. Also, early detection and intervention may help prevent the escalation of symptoms and the development of a mental health disorder. Tertiary institutions should use this information to inform policy changes to improve mental health support structures for athletes. Understanding the prevalence of mental health issues allows for developing strategies to support the student-athlete's well-being, overall health and, ultimately, their sports performance.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100888"},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma BDNF in burnout-related depressive disorders: The mediating role of perceived social isolation and the biopsychological effect of a multimodal inpatient treatment","authors":"Roberto La Marca ,&nbsp;Monika Scheiwiller ,&nbsp;Michael Pfaff ,&nbsp;Pearl La Marca-Ghaemmaghami ,&nbsp;Heinz Böker","doi":"10.1016/j.jadr.2025.100880","DOIUrl":"10.1016/j.jadr.2025.100880","url":null,"abstract":"<div><h3>Background</h3><div>The neurotrophic hypothesis of depression assumes that a reduced expression of BDNF may partially explain the development of depression, and that antidepressants increase BDNF levels and mood. In this study, we aimed at comparing plasma BDNF levels in inpatients with a burnout-related depressive disorder to those of healthy controls and explore the effects of a multimodal inpatient treatment. Moreover, we examined the mediating role of BDNF and perceived social isolation in predicting depression severity.</div></div><div><h3>Methods</h3><div>Thirty-five inpatients treated at a specialized burnout clinic and 21 matched healthy controls participated in this study. The inpatients responded to self-report questionnaires measuring depression severity, burnout, loneliness, and social isolation as well as a clinician-administered depression questionnaire (HAMD-17) after clinic admission (T1) and before clinic discharge (T2). Plasma BDNF concentrations were determined at the same time points. Inpatients reported on depression severity again at 6 months follow-up (T3). In healthy controls, psychological data and blood samples were collected only once.</div></div><div><h3>Results</h3><div>Inpatients exhibited lower BDNF levels than controls (U = 267.00, <em>p</em>=.045). The treatment led to a significant increase in BDNF levels (<em>z</em>=-1.974, <em>p</em>=.024), whereby the change in BDNF levels and in depression severity were inversely related (HAMD-17: rs=0.30, <em>p</em>=.042). Finally, this association was significantly mediated by perceived social isolation.</div></div><div><h3>Conclusions</h3><div>The findings support the assumptions within the neurotrophic hypothesis and a mediating role of perceived social isolation. Prevention and treatment of clinically relevant burnout and depression should consider perceived social isolation and social integration as an important risk factor and intervention focus, respectively.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100880"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143428749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}