Biomarkers in Neuropsychiatry最新文献

Fatty acids as potential biomarkers of stearoyl-CoA desaturase inhibition: Variation in healthy subjects and Parkinson's disease patients 脂肪酸作为硬脂酰辅酶a去饱和酶抑制的潜在生物标志物：健康受试者和帕金森病患者的差异

Biomarkers in Neuropsychiatry Pub Date : 2025-06-14 DOI: 10.1016/j.bionps.2025.100132

Pepijn P.N.M. Eijsvogel , Andriy A. Gorbenko , Dan F. Tardiff , Michelle Skupien , Ken Rhodes , Robert H. Scannevin , Yalcin Yavuz , Emilie M.J. van Brummelen , Brigitte Robertson , Philip H.C. Kremer , Geert Jan Groeneveld

{"title":"Fatty acids as potential biomarkers of stearoyl-CoA desaturase inhibition: Variation in healthy subjects and Parkinson's disease patients","authors":"Pepijn P.N.M. Eijsvogel , Andriy A. Gorbenko , Dan F. Tardiff , Michelle Skupien , Ken Rhodes , Robert H. Scannevin , Yalcin Yavuz , Emilie M.J. van Brummelen , Brigitte Robertson , Philip H.C. Kremer , Geert Jan Groeneveld","doi":"10.1016/j.bionps.2025.100132","DOIUrl":"10.1016/j.bionps.2025.100132","url":null,"abstract":"<div><div>This study aimed to assess the naturally occurring variation in plasma fatty acids in healthy subjects and Parkinson’s disease (PD) patients. Alpha-synuclein (aSyn) plays a major role in Parkinson’s disease. Inhibition of stearoyl-CoA desaturase (SCD) reduces levels of mono-unsaturated C16 and C18 fatty acids, which are involved in aSyn toxicity in vitro and in vivo. The ratio of mono-unsaturated to saturated fatty acids (fatty acid desaturase index (FA-DI)) in plasma after SCD-inhibition correlates with effects on brain FA-DI. However, the FA-DI normal values and the inter- and intra-day variation in PD-patients and healthy subjects is unknown. Ten PD-patients (54 –73 years) and ten age-matched healthy subjects were included. On three consecutive days, fatty acids fractions and concentrations were measured throughout the day. Outcomes are expressed as estimated mean, and the coefficient of variation (CV%) in percentage. For C16 FA-DI, the inter-subject CV% was 20.7 % in healthy subjects, and 37.7 % in PD-patients. The intra-subject CV% over days was 14.0 % in healthy subjects, and 14.2 % in PD-patients, and within days 5.1 % in healthy subjects, and 5.9 % in PD-patients. For C18 FA-DI, the inter-subject CV% was 14.8 % in healthy subjects, and 16.0 % in PD-patients. The intra-subject CV% over days was 11.0 % in healthy subjects, and 8.6 % in PD-patients, and within days 8.4 % in healthy subjects, and 6.7 % in PD-patients. The observed extent of variability in healthy subjects and PD-patients support C16 and C18 FA-DI as suitable biomarkers to demonstrate target engagement in plasma, of for example SCD-inhibitors, in both healthy subjects and PD-patients.</div></div>","PeriodicalId":52767,"journal":{"name":"Biomarkers in Neuropsychiatry","volume":"13 ","pages":"Article 100132"},"PeriodicalIF":0.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Corrigendum to “Football-related concussions and head impacts are associated with changes in retinal structure and signaling” [Biomark. Neuropsychiatry 10 (2024) 100091] “与足球有关的脑震荡和头部撞击与视网膜结构和信号的变化有关”[生物标记]的勘误表。神经精神病学10 (2024)100091]

Biomarkers in Neuropsychiatry Pub Date : 2025-06-01 DOI: 10.1016/j.bionps.2024.100118

Steven M. Silverstein , Jason Atlas , Mia Young , Lyvia Bertolace , Iwona Juskiewicz , Kian Merchant-Borna , Sarah Dermady , Yonatan Abrham , Kyle Green , Jeff Bazarian , Rajeev S. Ramchandran , Brian P. Keane

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Erratum regarding missing disclosure statements of previously published articles 关于先前发表的文章缺少披露声明的勘误

Biomarkers in Neuropsychiatry Pub Date : 2025-06-01 DOI: 10.1016/j.bionps.2025.100127

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Multidimensional perspectives on (bio)markers: Linking clinical and biological insights across psychiatric disorders, supporting a transdiagnostic model （生物）标记物的多维视角：将精神疾病的临床和生物学见解联系起来，支持跨诊断模型

Biomarkers in Neuropsychiatry Pub Date : 2025-05-20 DOI: 10.1016/j.bionps.2025.100129

Dusan Hirjak

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Dimensions of psychosis in delirious and catatonic trauma critically Ill patients 精神错乱和紧张性创伤危重病人的精神病维度

Biomarkers in Neuropsychiatry Pub Date : 2025-05-08 DOI: 10.1016/j.bionps.2025.100128

Ming-Ray Xu , Trey W. McGonigle , Jinyuan Liu , Robert S. Dittus , Stephan Heckers , Pratik P. Pandharipande , Shawniqua Williams Roberson , Mayur B. Patel , E. Wesley Ely , Jo Ellen Wilson

{"title":"Dimensions of psychosis in delirious and catatonic trauma critically Ill patients","authors":"Ming-Ray Xu , Trey W. McGonigle , Jinyuan Liu , Robert S. Dittus , Stephan Heckers , Pratik P. Pandharipande , Shawniqua Williams Roberson , Mayur B. Patel , E. Wesley Ely , Jo Ellen Wilson","doi":"10.1016/j.bionps.2025.100128","DOIUrl":"10.1016/j.bionps.2025.100128","url":null,"abstract":"<div><h3>Objective</h3><div>We examined the effect of delirium and catatonia on psychosis symptom presentation in trauma intensive care unit (TICU) patients without previous history of serious psychiatric illness.</div></div><div><h3>Design</h3><div>Prospective observational cohort study at a single academic medical center TICU, enrolling adult patients with critical illness secondary to traumatic injury excluding patients with significant psychiatric history. ICU patients received once-daily DSM-5 delirium and catatonia evaluations, and Clinician-Related Dimensions of Psychosis Severity Scale (CRDPSS) assessment. Patients were grouped by delirium and/or catatonia diagnosis with Kruskal-Wallis and Pearson’s Chi-square testing of differences between groups in CRDPSS scores.</div></div><div><h3>Main Results</h3><div>74 patients were sorted into delirium and/or catatonia groups for the dimensions of psychosis analysis. Catatonia was common in this critically ill trauma population with 26 % prevalence. Patients with delirium and/or catatonia diagnoses had differing severities of psychosis symptoms from those with neither condition. CRDPSS total scores were significantly different between the groups (p = 0.011).</div></div><div><h3>Conclusions</h3><div>Further investigation is needed to explore commonalities in the mechanisms underpinning ICU psychosis and to identify specific psychotic symptom manifestations suggestive of delirium versus catatonia.</div></div>","PeriodicalId":52767,"journal":{"name":"Biomarkers in Neuropsychiatry","volume":"12 ","pages":"Article 100128"},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Genetic predictors of attempted suicide among South Indian adolescents and young adults: A case-control study 南印度青少年和年轻人自杀未遂的遗传预测因素：一项病例对照研究

Biomarkers in Neuropsychiatry Pub Date : 2025-03-26 DOI: 10.1016/j.bionps.2025.100126

Anju Mathew , Ann Mary Alex , Chathathayil Mohammedali Shafeeque , Saboora Beegum Muthubeevi , Vijayakumar Krishnapillai , Moinak Banerjee

{"title":"Genetic predictors of attempted suicide among South Indian adolescents and young adults: A case-control study","authors":"Anju Mathew , Ann Mary Alex , Chathathayil Mohammedali Shafeeque , Saboora Beegum Muthubeevi , Vijayakumar Krishnapillai , Moinak Banerjee","doi":"10.1016/j.bionps.2025.100126","DOIUrl":"10.1016/j.bionps.2025.100126","url":null,"abstract":"<div><h3>Background</h3><div>Suicide among adolescents and young adults is an alarming public health issue globally. Though studies suggest the link between genetic factors and suicidal behavior, there is a paucity of studies of specific genetic variants in adolescents and young adults. Hence this study explored the genetic predictors for attempted suicide among adolescents and young adults, by studying the genetic basis of serotonin and dopamine synthesis, transport, and degradation machinery.</div></div><div><h3>Methods</h3><div>A Case-control association study was conducted comprising individuals with attempted suicide (cases n = 80), 13–29 years of age, belonging to Malayalam speaking Dravidian population, and attending a tertiary care center in South India. Age, sex, and ethnicity matched controls (n = 267) with no history of attempted suicide were also considered from the same ethnic population. Genotyping was performed for functionally critical SNP in serotonin receptor, Tryptophan hydroxylase, Tyrosine hydroxylase, and Catechol-o-methyl transferase. Statistical significance for allelic and genotypic comparisons and their odds ratios were computed.</div></div><div><h3>Results</h3><div>The Tyrosine Hydroxylase THrs2070762 and Tryptophan Hydroxylase TPH1rs211105 genetic variants showed a statistically significant association with attempted suicide phenotype.</div></div><div><h3>Conclusion</h3><div>The study suggests that the genetic variants in Tyrosine Hydroxylase and Tryptophan Hydroxylase are predictive of attempted suicide among adolescents and young adults. Understanding the genetic variations will help in identifying and managing high-risk individuals.</div></div>","PeriodicalId":52767,"journal":{"name":"Biomarkers in Neuropsychiatry","volume":"12 ","pages":"Article 100126"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Is low-grade inflammation related to cognitive performance during a sustained attention task in depression? – A case-control study 轻度炎症是否与抑郁症患者持续注意力任务中的认知表现有关？-病例对照研究

Biomarkers in Neuropsychiatry Pub Date : 2025-02-06 DOI: 10.1016/j.bionps.2025.100121

Bruno Pedraz-Petrozzi , Eva Kathrin Lamadé , Nils Mischa Hübner , Jil Zippelius , Elena Neumann , Gebhard Sammer

{"title":"Is low-grade inflammation related to cognitive performance during a sustained attention task in depression? – A case-control study","authors":"Bruno Pedraz-Petrozzi , Eva Kathrin Lamadé , Nils Mischa Hübner , Jil Zippelius , Elena Neumann , Gebhard Sammer","doi":"10.1016/j.bionps.2025.100121","DOIUrl":"10.1016/j.bionps.2025.100121","url":null,"abstract":"<div><div>This study aimed to investigate the associations between inflammatory cytokines and cognitive performance in individuals with depression compared to healthy controls, while accounting for variables, such as perceived fatigue, BMI, and age. Individuals diagnosed with depression (n = 23) and healthy controls (n = 31) were included in the study. A 15-minute sustained attention task (subtest of the Test Battery for Attention, version 2.3.1) was administered with concurrent electroencephalographic recordings to evaluate P300 amplitude and latency. Peripheral inflammation was assessed by measuring IL-6, IL-1β, and TNF-α levels. Perceived fatigue was assessed using the German version of the Fatigue Impact Scale. Generalized linear models (GLM) were used to evaluate the main aims of the study. Results indicated that depression was associated with reduced P300 amplitudes (p = 0.011), and age was significantly associated with P300 amplitude, with older participants showing reductions (p = 0.016). However, no significant effects of inflammatory markers on P300 components were found. While no group differences were observed in the total number of hits, both perceived fatigue (p = 0.033) and TNF-α (p = 0.007) were significantly associated with hit accuracy. A post-hoc mediation analysis explored that perceived fatigue mediates the relationship between depression and number of hits. These findings suggest that low-grade inflammation may not directly influence P300 components, though inflammation and fatigue appear linked to accuracy deficits. Finally, the impact of depression on the number of hits is primarily mediated by perceived fatigue, suggesting that fatigue is a crucial factor in how depression affects cognition.</div></div>","PeriodicalId":52767,"journal":{"name":"Biomarkers in Neuropsychiatry","volume":"12 ","pages":"Article 100121"},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Advancing transdiagnostic data analytics using knowledge graphs 利用知识图谱推进跨诊断数据分析

Biomarkers in Neuropsychiatry Pub Date : 2025-02-01 DOI: 10.1016/j.bionps.2025.100122

Fiona Klaassen , Emanuel Schwarz

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Biomarkers in alcohol use disorder - The promise and pitfalls of neuroimaging drug cue reactivity 酒精使用障碍的生物标志物——神经成像药物线索反应的前景和缺陷

Biomarkers in Neuropsychiatry Pub Date : 2025-01-29 DOI: 10.1016/j.bionps.2025.100119

Marlen Pfisterer , Sina Zimmermann , Judith Zaiser , Sarah Gerhardt , Sabine Vollstädt-Klein , Falk Kiefer , Patrick Bach

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Developing non-invasive molecular markers for early risk assessment of Alzheimer's disease 开发用于阿尔茨海默病早期风险评估的非侵入性分子标记

Biomarkers in Neuropsychiatry Pub Date : 2025-01-28 DOI: 10.1016/j.bionps.2025.100120

Tapas K. Sur , Tanmoy Mondal , Zarish Noreen , Jheannelle Johnson , Gail Nunlee-Bland , Christopher A. Loffredo , Brent E. Korba , Vijay Chandra , Siddhartha S. Jana , Bernard Kwabi-Addo , Sumit Sarkar , Somiranjan Ghosh

{"title":"Developing non-invasive molecular markers for early risk assessment of Alzheimer's disease","authors":"Tapas K. Sur , Tanmoy Mondal , Zarish Noreen , Jheannelle Johnson , Gail Nunlee-Bland , Christopher A. Loffredo , Brent E. Korba , Vijay Chandra , Siddhartha S. Jana , Bernard Kwabi-Addo , Sumit Sarkar , Somiranjan Ghosh","doi":"10.1016/j.bionps.2025.100120","DOIUrl":"10.1016/j.bionps.2025.100120","url":null,"abstract":"<div><div>Alzheimer's disease (AD) is a heterogeneous neurodegenerative disease, with no standard biomarker(s) to detect or confirm its risk at an early stage. The prevalence of AD increases exponentially worldwide in people of ages over 65 and older. Current improvements have unveiled the disease's pathophysiology and clinical diagnostic tests, targeting the neurological changes (neurodegeneration, amyloid precursor protein metabolism and tangle pathology) with precise PET/MRI imaging and xMAP/SIMOA (Multiplex simultaneous detection/single molecule array) to identify and quantify β-amyloids (Aβ40, Aβ42), total tau (T-tau) and phosphorylated tau (P-tau) proteins in the brain and cerebrospinal fluid (CSF) of patients. However, their utility for diagnosis in routine clinical practice is still challenging because of cost, accessibility, standardization, procedural limitation, and regulatory approval. Further research is needed to establish affordable, patient-friendly, easy, quick, and robust biomarkers for early AD detection, progression, and therapeutic management. Research on blood-based preclinical diagnosis and clinical practice for AD has advanced significantly in the last decade. Emerging literature supports the importance of new molecular biomarkers and signature genes from blood to detect and predict AD in advance. This review examines the potential applications of these blood-based target biomarkers for early disease detection, co-morbid condition risk prediction, and treatment management of AD.</div></div>","PeriodicalId":52767,"journal":{"name":"Biomarkers in Neuropsychiatry","volume":"12 ","pages":"Article 100120"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143352413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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