A. Habibelahi, N. Bahrami, Farnoush Mohammadi, Sarvin Sarmadi, Mohammad Hosein Amirzade-Iranaq, Masoume Farhangiyan, M. Bayat
{"title":"The registry of congenital Cleft lip and cleft palate in Iran: Three-years pilot results and learned lessons","authors":"A. Habibelahi, N. Bahrami, Farnoush Mohammadi, Sarvin Sarmadi, Mohammad Hosein Amirzade-Iranaq, Masoume Farhangiyan, M. Bayat","doi":"10.18502/jcr.v8i3.8837","DOIUrl":"https://doi.org/10.18502/jcr.v8i3.8837","url":null,"abstract":"Introduction: Cleft lip and cleft palate are the most common maxillofacial congenital defects leading to facial deformity and complications in nutrition, respiration, and social interaction. The current study aims to report early findings of the pilot registry for congenital Cleft lip and cleft palate in Iran and discuss limitations and further goals to collect and implicate information of cleft newborn patients. \u0000Methods: A 3-year hospital-based multicenter prospective cohort study of The Congenital Cleft lip and cleft palate Registry was performed in various hospitals in Iran from 2018 to 2020. Newborns with oral clefts were included, and The type of cleft, location, geographical place, and gender of each patient were recorded. The descriptive statistics were reported as means and percentages analyzed with Fisher exact test using SPSS software ver. 22 (IBM, Chicago, US). The P-value < 0.05 considered as significant. \u0000Results: From 336 registered newborns with Cleft lip and cleft palate, 40.1% were females, while 59.9% were males. The prevalence of lip cleft was 31.5%, while 17.6% have palate cleft. Also, 50.9% suffer from both cleft lip and palate simultaneously. (P-value<0.05) The frequent location of clefts were bilateral Cleft lip and cleft palate with 50% of the cases (P-value<0.05). Also, 28.2% and 21.8% had right-side and left side unilateral Cleft lip and cleft palate, respectively. Tabriz, Mashhad, Tehran were the most frequent location of clefts. \u0000Conclusion: Despite the primary statistics and trends presented in this study, the data quality could improve through some limited modifications. Also, the provinces with a high prevalence of congenital deformities need critical attention and provide adequate healthcare.","PeriodicalId":52622,"journal":{"name":"Journal of Craniomaxillofacial Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48962895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Feizbakhsh, S. Razavi, V. Hajhashemi, M. Mortazavi
{"title":"Effects of FGF on tooth movement and root resorption","authors":"M. Feizbakhsh, S. Razavi, V. Hajhashemi, M. Mortazavi","doi":"10.18502/jcr.v8i3.8838","DOIUrl":"https://doi.org/10.18502/jcr.v8i3.8838","url":null,"abstract":"Introduction: Basic fibroblast growth factor (bFGF) is an effective cytokine in angiogenesis and bone remodeling. The aim of this study was to determine the effect of locally injected bFGF on movement rate and root resorption during orthodontic force application in dogs. \u0000Material and Methods: In this experimental animal study, four 10-12 months male dogs were selected and were randomly allocated into two groups. A week following insertion of closing coil spring between the canines and second premolars, 50 µg of bFGF was injected to the case group and phosphate saline to the control group once per month. One month after second injection, the distance between the mentioned teeth were measured. Also, root resorption percentage were analyzed on the second premolars. \u0000Results: Average maxillary tooth movement rate in case and control groups were found 2.53and 1.35mm/month respectively. The correspondent mandibular measures were 2.23mm and 1.15mm. These differences were statistically significant (P<0.0001). In respect to root resorption, the differences were found statistically significant (P<0.01) for coronal region in maxilla, which was higher in control group. Regarding the apical and middle regions of both jaws as well as coronal region of mandible the differences were insignificant. \u0000Conclusion: The results of the study showed that the local injection of bFGF can increase tooth movement rate and has the potential to decrease root resorption during orthodontic tooth movement in dogs.","PeriodicalId":52622,"journal":{"name":"Journal of Craniomaxillofacial Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43750013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Izzati Nabilah Ismail, Mohammad Aizuddin Abu Bakar, Khairul Fikri Hairul Anuar, Mohamad Arif Mohd Ramlee
{"title":"Accuracy of Cone Beam CT Measurements for Assessment of Posterior Mandible: A Cadaver Study","authors":"Izzati Nabilah Ismail, Mohammad Aizuddin Abu Bakar, Khairul Fikri Hairul Anuar, Mohamad Arif Mohd Ramlee","doi":"10.18502/jcr.v8i2.7642","DOIUrl":"https://doi.org/10.18502/jcr.v8i2.7642","url":null,"abstract":"Objectives: This study is aimed at analysing the accuracy and reliability of the cone beam CT (CBCT) measurements and direct physical measurements of the posterior mandible. \u0000Materials and methods: Eighteen cadaveric hemi-mandibles were dissected from the soft tissues and the CBCT images of the mandibles were taken. Direct physical and cone beam CT measurements of six landmarks which includes height of ramus (R), distance of lingula to sigmoid notch (LS), distance of lingula to inferior border (LI), position of lingula in relation to occlusal plane (L-OP), ramus thickness at crestal level (RT-C), and ramus thickness at midway between sigmoid notch and lingula (RT-M) were determined. Accuracy and reliability of the measurements were tested. \u0000Results: Four landmarks showed high accuracy when measuring the posterior mandible, while two landmarks, LI and RT-M, showed statistically significant weaker accuracy (p<0.05). Inter-reliability were good for all landmarks when measured directly physically on mandibles (ICC>0.7 and p>0.05), but were low on two landmarks, LI and RT-C, on CBCT measurement (ICC<0.5 and p<0.05). \u0000Conclusion: A generally strong accuracy between direct physical and CBCT measurements for most landmarks on posterior mandible were found. Reliability between two researchers were high on direct physical measurements. Meanwhile, two landmarks on CBCT which include LI and RT-C showed low inter-reliability. Hence, CBCT measurements proved to be a good tool for pre-operative assessment, since high inter-reliability and strong accuracy corresponding to direct physical were recorded.","PeriodicalId":52622,"journal":{"name":"Journal of Craniomaxillofacial Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47125503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdollah Farhadi Nasab, Malihe Roozbakhsh, N. Bahrami
{"title":"Comparative efficacy of haloperidol and placebo for treatment of delirium induced by biperiden and LPS in adult male rats based on their learning style and change in their short-term spatial memory","authors":"Abdollah Farhadi Nasab, Malihe Roozbakhsh, N. Bahrami","doi":"10.18502/jcr.v8i2.7643","DOIUrl":"https://doi.org/10.18502/jcr.v8i2.7643","url":null,"abstract":"Background and Objectives: Delirium refers to acute loss of consciousness and is characterized by confused thinking and impaired orientation. It is a life-threatening, but reversible syndrome manifested by cognitive impairment, abnormal psychomotor activity and sleep disturbances. Due to high prevalence in hospitalized patients and high rate of morbidity and mortality, delirium significantly decreases the prognosis of hospitalized patients. \u0000Materials and Methods: This experimental animal study evaluated 54 adult male Wistar rats over 2 months of age that weighed 200 to 230 g. Of all, 24 rats received biperiden (40 mg/kg) while the remaining 24 received 50 µg/kg LPS. Induction of delirium was ensured using a Y-maze after 3 hours. The control group included 6 rats The efficacy of different doses of haloperidol for treatment of delirium was assessed 3 h after injection using the Y-maze . Data were compared using one-way ANOVA followed by Tukey’s post-hoc test via GraphPad Prism. \u0000Results: Haloperidol at 0.1, 0.2 and 0.5 mg/kg dosage significantly increased the percentage of spontaneous alternation and improved the memory, consciousness and learning compared with biperiden and LPS groups (P<0.01). No significant difference was noted between the haloperidol groups regarding efficacy (P>0.05). \u0000Conclusion: Delirium is characterized by attention deficit, impaired orientation, changes in memory, consciousness, perception and mood, and psychotic symptoms. Detection of the complete spectrum of delirium signs and symptoms in an animal that cannot talk (rat) is obviously difficult .using of Y-maze can facilitate this problem .","PeriodicalId":52622,"journal":{"name":"Journal of Craniomaxillofacial Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68130035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effect of using pineapple fresh juice to improve post-surgical pain, ecchymosis and swelling in maxillofacial region","authors":"Dr. Bayad Jaza Mahmood","doi":"10.18502/jcr.v8i2.7644","DOIUrl":"https://doi.org/10.18502/jcr.v8i2.7644","url":null,"abstract":"\u0000 \u0000 \u0000Background: Facial plastic surgeries are usually associated with various post-surgical unde- sirable symptoms, particularly pain, Swelling, and ecchymosis. Depending on the nature of the procedures, these symptoms could last for days, sometimes over a week or more. Considering the optimal efficacy of Bromelain, this study is used to justify the benefits of pre-operative use of Bro- melain found in pineapple using fresh pineapple juice to reduce such complications. \u0000Materials and Methods: A randomized clinical study was performed among 100 patients undergoing various facial surgical operations; the patients were randomly divided into two groups; fifty patients received the pre-operative fresh pineapple juice (350ml glass) twice every day, a week before and continued for seven days after surgery. The pain level was determined using a visual an- alog scale, Swelling, and ecchymosis judged by visual inspection. Average scores for all symptoms were added to obtain the clinical sum score for each visit. \u0000Results: Pre-operative use of fresh pineapple juice was significantly reduced post-surgical pain, swelling, and ecchymosis with statistically significant results (p<0.005) in each pineapple groups. \u0000Conclusion: Bromelain found in pineapple fruit can be used as a successful therapy before var- ious facial surgical procedures to minimize and provide faster recovery from undesirable post-op- erative symptoms. \u0000 \u0000 \u0000","PeriodicalId":52622,"journal":{"name":"Journal of Craniomaxillofacial Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42394339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reference point and confirming points two important guides in treatment of panfacial fractures of panfacial Fx: A case report","authors":"Mehrnoush Momeni Roochi, Narges Hajiani, Sayna Nezaminia","doi":"10.18502/jcr.v8i2.7646","DOIUrl":"https://doi.org/10.18502/jcr.v8i2.7646","url":null,"abstract":"\u0000 \u0000 \u0000A therapeutic challenge to maxillofacial surgeons is management of panfacial fractures, especially when treating multiple comminuted bone fractures. One of the most important goals in these fractures is achieve and stablish a correct occlusal relationship of the mandibular-maxillary unit in parallel with the proper positioning of the jaws with the skull base and other facial units. Also, it is important to prevent long-term sequelae such as facial asymmetry, enophthalmos, and mal- occlusion that could be caused by inadequate correction. To achieve all these goals some usual guides of management are proposed as follow: “Bottom to up”, “Top to down”, “outside to inside,” or “inside to outside”. We present 3 cases of Panfacial fracture and the proposed methods were based on different sequences of management with introducing “reference point” as the most intact area to determine the management concept & “confirming point” as the areas that should be reduced and fixed completely. These points act as an orientation aid during surgery and aid to successfully restore the entire face contour and maxillomandibular occlusion and also to improves surgical procedure. \u0000 \u0000 \u0000","PeriodicalId":52622,"journal":{"name":"Journal of Craniomaxillofacial Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43023400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ultrasound-guided FNA Efficiency in Diagnosing of Metastatic Nodes of Oral Squamous Cell Carcinoma; Article Review","authors":"Sona Rafieyan, Yousef Kananizadeh, Elahe Reyhani","doi":"10.18502/jcr.v8i2.7641","DOIUrl":"https://doi.org/10.18502/jcr.v8i2.7641","url":null,"abstract":"Oral cancer comprises a group of neoplasms affecting any fields of the oral cavity, pharyngeal regions and salivary glands. However, this term tends to be used interchangeably with oral squamous cell carcinoma (OSCC), which represents the most common of all oral neoplasms. It is estimated that more than 90% of all oral neoplasms are OSCC. Oral SCC prefers to spread through the lymphatic system than the bloodstream, and in this region tongue tumors have the greatest potential for neck metastases.Primary tumor’s histopathologic features like depth of invasion, thickness, growth pattern, differentiation, lymphovascular or vascular invasion have a limited prognostic value for nodal disease. cervical lymph node status accurate assessment in HNSCC patients is critical issue because of its influences on prognosis and treatment decisions, USgFNAC proved widely accepted not only because of safety and availability in diagnosis but also it is repeatable, minimally invasive and cost-effectiveness.","PeriodicalId":52622,"journal":{"name":"Journal of Craniomaxillofacial Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49147507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of light-emitting diode phototherapy on pain and trismus following surgical extraction of impacted mandibular third molars","authors":"G. Shirani, M. Reshadi","doi":"10.18502/jcr.v8i2.7645","DOIUrl":"https://doi.org/10.18502/jcr.v8i2.7645","url":null,"abstract":"\u0000 \u0000 \u0000Purpose: This study aimed to assess the effect of light-emitting diode (LED) phototherapy on pain and trismus following surgical extraction of impacted mandibular third molars. \u0000Materials and Methods: This double-blind randomized controlled clinical trial evaluated 50 patients between 20 to 35 years requiring extraction of their impacted mandibular third molars. The patients were randomized into two groups of LED phototherapy and control by flipping a coin. Patients in the LED group underwent LED phototherapy immediately after surgery with red light at 618nm wavelength, 20 mW/cm2 power density and 4 J/cm2 energy density in continuous-wave mode (irradiated area: 3.15cm×1.5cm=4.725cm2). The LED device was used in off mode in the control group (as placebo). The level of postoperative pain was measured by the numerical rating scale, and trismus of patients was evaluated by measuring the maximum mouth opening (MMO). The two groups were compared by the Mann-Whitney and NPar tests. \u0000Results: The mean difference in MMO postoperatively, compared with baseline, was lower in the LED group than the placebo group but not significantly (P=0.465). The two groups were not significantly different regarding the level of pain. \u0000Conclusion: LED phototherapy with the parameters applied in this study failed to significantly decrease the level of pain and trismus following surgical extraction of impacted mandibular third molars. \u0000 \u0000 \u0000","PeriodicalId":52622,"journal":{"name":"Journal of Craniomaxillofacial Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47255074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Manifar, S. Najafi, M. Koopaie, A. Tafakhori, Diba Farmanbordar
{"title":"Assessment of oral health status in chronic headache patients and its comparison with healthy control","authors":"S. Manifar, S. Najafi, M. Koopaie, A. Tafakhori, Diba Farmanbordar","doi":"10.18502/jcr.v8i1.7153","DOIUrl":"https://doi.org/10.18502/jcr.v8i1.7153","url":null,"abstract":"Introduction: Headache is a common problem with intense side effects on quality of life. Dental and maxillofacial problems, including dental infections and temporomandibular disorders may trigger the onset of headache or have direct impact on the intensity of headache. The purpose of this paper is assessment of oral health indexes in chronic headache patients and compare it with a healthy control group. \u0000Material & Methods: Thirty chronic headache patients based on diagnosis by a neurologist were enrolled in our study and thirty healthy volunteers were recruited into the control group. Dental and periodontal examination were carried out in order to evaluate of the decayed, missing and filled teeth (DMFT) index, the assessment of community periodontal index of treatment needs (CPITN) index and determination of tooth wear status and oral health status. Statistical analysis was done using SPSS statistical package (version 20, IBM). \u0000Results: Mean age, educational level, tooth brushing, using dental floss and DMFT index was not statistically different between chronic headache patients and control group. There was no statistically significant difference in CPITN index between cases and control group (p-value=0.538). \u0000Conclusion: This study suggest that chronic headache patients have an acceptable oral hygiene which may be attribute to their attempts to omit pain from head and oral region. Considering high prevalence of chronic headache, planning a protocol for oral hygiene instruction is necessary. In this regard, coordination between neurologists and oral medicine specialists can be very effective.","PeriodicalId":52622,"journal":{"name":"Journal of Craniomaxillofacial Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46829043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdollah Farhadi Nasab, Safoura Raoufi, N. Bahrami
{"title":"Ascorbic Acid Effect on Morphine Withdrawal Symptoms in Rats","authors":"Abdollah Farhadi Nasab, Safoura Raoufi, N. Bahrami","doi":"10.18502/jcr.v8i1.7154","DOIUrl":"https://doi.org/10.18502/jcr.v8i1.7154","url":null,"abstract":"Introduction: Today, drug addiction is an important healthcare issue. Any helps to drug withdrawal may decrease its prevalence in the society. Ascorbic acid is a component, which can affect neurotransmitter systems as a regulator along with its cofactor role. Noradrenergic and dopaminergic systems are two important neurotransmitter systems in the opiate withdrawal syndrome. It seems that ascorbic acid can decrease the symptoms of opiate withdrawal through regulating the related systems. In this regard, the current study aimed to evaluate the effect of ascorbic acid on the symptoms of morphine withdrawal in Syrian mice. \u0000Materials and Methods: Male Syrian mice in eight experimental groups received incremental doses of morphine as 10, 20, 30 and 40 mg/kg within the first, second, third, and fourth days of the experiment, respectively, through intraperitoneal injection, twice a day, and the control group received and equal amount of saline. On the fifth day, six groups of morphine addicts received ascorbic acid with six doses of 10, 50, 100, 200,400 and 800 mg/kg through intraperitoneal injection. Then, naloxone 2 mg/kg was injected to all groups including morphine alone and morphine with acute does of ascorbic acid. Then, withdrawal symptoms were evaluated for 30 minutes. \u0000Results: Administration of an acute dose of ascorbic acid reduced dose dependent withdrawal symptoms in such a way that 10, 50, and 100 mg/kg doses of ascorbic acid reduced “writhing” symptom, 200 mg/kg reduced “jumping” symptom, and 400 and 800 mg/kg reduced “climbing, jumping, and standing” symptoms. \u0000Conclusion: It seems that ascorbic acid administration can improve the symptoms of opiate withdrawal syndrome. More studies on human population can also indicate the therapeutic effect of ascorbic acid on drug withdrawal.","PeriodicalId":52622,"journal":{"name":"Journal of Craniomaxillofacial Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48667209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}