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Highlights From the Recent AASLD/IDSA Guideline on Hepatitis B Virus Management. 最近AASLD/IDSA关于乙型肝炎病毒管理指南的亮点。
Gastroenterology and Hepatology Pub Date : 2026-07-01
Mindie H Nguyen
{"title":"Highlights From the Recent AASLD/IDSA Guideline on Hepatitis B Virus Management.","authors":"Mindie H Nguyen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":52498,"journal":{"name":"Gastroenterology and Hepatology","volume":"22 7","pages":"381-384"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13552440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleep and Disorders of Gut-Brain Interaction. 睡眠与肠脑相互作用障碍。
Gastroenterology and Hepatology Pub Date : 2026-07-01
Brian E Lacy, Jessica C Petrov, Pablo R Castillo
{"title":"Sleep and Disorders of Gut-Brain Interaction.","authors":"Brian E Lacy, Jessica C Petrov, Pablo R Castillo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sleep plays a critical role in maintaining good physical and emotional health. Sleep and circadian rhythms are fundamental regulators of human physiology, influencing most biological processes from the cellular to the organ-system level. Sleep disorders are common with a prevalence of 30% in adults. Impaired sleep reduces patients' quality of life and has a significant negative economic impact on the health care system. Sleep deprivation can affect the brain and alter normal circadian rhythms. These disturbances influence the brain-gut axis and subsequently affect both symptom development and symptom expression in patients with disorders of gut-brain interaction (DGBIs), including functional dyspepsia and irritable bowel syndrome. DGBIs are highly prevalent with at least 40% of adults worldwide meeting criteria for at least 1 DGBI. This article reviews the prevalence and impact of disordered sleep, discusses the basics of normal and abnormal sleep, examines the role of diagnostic testing for sleep disorders, and evaluates the role of disordered sleep in common DGBIs. Practical tips to evaluate and treat patients with DGBIs and disordered sleep are also discussed.</p>","PeriodicalId":52498,"journal":{"name":"Gastroenterology and Hepatology","volume":"22 7","pages":"362-370"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13552402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Update on Pregnancy in Inflammatory Bowel Disease. 炎症性肠病妊娠的最新进展
Gastroenterology and Hepatology Pub Date : 2026-07-01
Taylor Boyd, Sunanda Kane
{"title":"Update on Pregnancy in Inflammatory Bowel Disease.","authors":"Taylor Boyd, Sunanda Kane","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Ongoing clinical and population health research continues to inform evidence-based management of patients with inflammatory bowel disease during pregnancy. Advances in noninvasive tools for disease monitoring highlight the expanding role of intestinal ultra-sound for point-of-care assessments throughout pregnancy. Updates in medical management include recent data demonstrating the association between thiopurines and intrahepatic cholestasis of pregnancy, the role of low-dose aspirin in preventing hypertensive disorders of pregnancy, and guidance related to Janus kinase inhibitor safety. Evolving pharmacologic data inform the safety and increasing use of biosimilars during pregnancy, the emergence of newer targeted therapies such as selective interleukin-23p19 inhibitors, and emerging evidence to support the safety of rotavirus vaccination in infants exposed to biologics in utero. This article summarizes several key updates on diagnostics, treatment, and preventative care strategies aimed at improving maternal and fetal health.</p>","PeriodicalId":52498,"journal":{"name":"Gastroenterology and Hepatology","volume":"22 6","pages":"303-312"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13322327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic Approaches for Disorders of Gut-Brain Interaction Other Than Medication. 非药物治疗的肠脑相互作用障碍的治疗方法。
Gastroenterology and Hepatology Pub Date : 2026-07-01
Gary R Lichtenstein
{"title":"Therapeutic Approaches for Disorders of Gut-Brain Interaction Other Than Medication.","authors":"Gary R Lichtenstein","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":52498,"journal":{"name":"Gastroenterology and Hepatology","volume":"22 4","pages":"140"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13322325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How AI Will Transform the Care of Patients With DGBIs. 人工智能将如何改变dgbi患者的护理。
Gastroenterology and Hepatology Pub Date : 2026-07-01
Brennan Spiegel
{"title":"How AI Will Transform the Care of Patients With DGBIs.","authors":"Brennan Spiegel","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":52498,"journal":{"name":"Gastroenterology and Hepatology","volume":"22 5","pages":"269-272"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13322320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Managing the Diagnostic and Therapeutic Challenges of Irritable Bowel Syndrome. 管理肠易激综合征的诊断和治疗挑战。
Gastroenterology and Hepatology Pub Date : 2026-07-01
Jessica C Petrov, Brian E Lacy, David J Cangemi
{"title":"Managing the Diagnostic and Therapeutic Challenges of Irritable Bowel Syndrome.","authors":"Jessica C Petrov, Brian E Lacy, David J Cangemi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The management of patients with irritable bowel syndrome (IBS) remains a common clinical challenge for health care providers. IBS is a prevalent disorder that encompasses a constellation of symptoms that may be caused by a variety of underlying conditions; as a result, there is no one-size-fits-all approach, and clinicians must tailor their approach to the individual. This article outlines the challenges associated with the management of IBS and offers practical solutions to help providers care for patients with IBS.</p>","PeriodicalId":52498,"journal":{"name":"Gastroenterology and Hepatology","volume":"22 6","pages":"296-302"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13322402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review of Therapies for Primary Biliary Cholangitis. 原发性胆道胆管炎的治疗综述。
Gastroenterology and Hepatology Pub Date : 2026-07-01
Mariam Alamgir, Sheena Bhushan, Aalam Sohal, Kris V Kowdley
{"title":"A Review of Therapies for Primary Biliary Cholangitis.","authors":"Mariam Alamgir, Sheena Bhushan, Aalam Sohal, Kris V Kowdley","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Primary biliary cholangitis (PBC) is a rare, chronic, progressive autoimmune cholestatic liver disease that can lead to cirrhosis if left untreated. Ursodeoxycholic acid remains the standard first-line therapy; however, approximately 40% of patients exhibit an inadequate or partial biochemical response, and approximately 5% to 10% of patients are intolerant to the drug. Consequently, there remains a substantial need for effective second-line agents. Until recently, obeticholic acid (OCA) and fibrates were the only available second-line therapies. However, the therapeutic landscape for PBC has evolved significantly with the US Food and Drug Administration conditional approval of elafibranor and seladelpar as second-line therapies for patients without cirrhosis. Notably, OCA has been withdrawn as an available treatment option, further shifting the current treatment paradigm. This article aims to examine the current pharmacologic landscape of first-line and second-line PBC treatments, with an emphasis on clinical considerations and strategies for individualized treatment selection to optimize patient outcomes.</p>","PeriodicalId":52498,"journal":{"name":"Gastroenterology and Hepatology","volume":"22 5","pages":"227-234"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13322329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Point-of-Care Esophageal Mucosal Impedance Testing for Diagnosing GERD and EoE. 即时食管黏膜阻抗测试诊断胃食管反流和EoE。
Gastroenterology and Hepatology Pub Date : 2026-07-01
Michael F Vaezi
{"title":"Point-of-Care Esophageal Mucosal Impedance Testing for Diagnosing GERD and EoE.","authors":"Michael F Vaezi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":52498,"journal":{"name":"Gastroenterology and Hepatology","volume":"22 6","pages":"330-332"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13322319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
JAK Inhibitor-Associated Acne in IBD: Recognition and Management. IBD中JAK抑制剂相关痤疮：识别和管理。
Gastroenterology and Hepatology Pub Date : 2026-07-01
Britt Christensen
{"title":"JAK Inhibitor-Associated Acne in IBD: Recognition and Management.","authors":"Britt Christensen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":52498,"journal":{"name":"Gastroenterology and Hepatology","volume":"22 5","pages":"259-261"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13322332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Connecting the Dots Between Theory and Practice: Speaking With Your Patients About IBS-C Management. 连接理论与实践之间的点：与你的病人谈论肠易激综合征的管理。
Gastroenterology and Hepatology Pub Date : 2026-07-01
Brian E Lacy
{"title":"Connecting the Dots Between Theory and Practice: Speaking With Your Patients About IBS-C Management.","authors":"Brian E Lacy","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":52498,"journal":{"name":"Gastroenterology and Hepatology","volume":"22 5","pages":"235-243"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13322330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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