European Journal of Translational and Clinical Medicine最新文献_第6页

Persistence of long-term insulin independence after islet transplantation and two subsequent pregnancies. 胰岛移植和随后的两次妊娠后长期胰岛素独立的持续。

European Journal of Translational and Clinical Medicine Pub Date : 2023-01-01 DOI: 10.31373/ejtcm/166178

Sarah Gondek, Mateusz Ogledzinski, William Lin, Kamila Milejczyk, Braden Juengel, Lisa Potter, Piotr J Bachul, Lindsay Basto, Laurencia Perea, Ling-Jia Wang, Martin Tibudan, Zuzanna Witkowska, Rolf Barth, John Fung, Piotr Witkowski

引用次数: 0

Distribution and Clinicopathological Characteristics of Breast Cancer Molecular Subtypes in Turkish Women 土耳其妇女乳腺癌分子亚型的分布和临床病理特征

European Journal of Translational and Clinical Medicine Pub Date : 2022-12-23 DOI: 10.24018/clinicmed.2022.3.6.220

Ş. Dokcu, M. Çaparlar, S. Basceken, A. Eroğlu

{"title":"Distribution and Clinicopathological Characteristics of Breast Cancer Molecular Subtypes in Turkish Women","authors":"Ş. Dokcu, M. Çaparlar, S. Basceken, A. Eroğlu","doi":"10.24018/clinicmed.2022.3.6.220","DOIUrl":"https://doi.org/10.24018/clinicmed.2022.3.6.220","url":null,"abstract":"\u0000Purpose: Today, racial/ethnic differences in the incidence and prognosis of breast cancer (BC) are a well-known fact. This study aimed to examine the distribution of BC molecular subtypes in Turkish women and their relationship with other prognostic clinicopathological variables.\u0000\u0000\u0000Methods: In our surgical oncology clinic, the database of 480 BC cases was retrospectively scanned between January 2008 and December 2020, and the demographic and histopathological results of the patients were recorded. Patients were classified into five main molecular subtypes. Survival curves were estimated using the Kaplan – Meier method. The relationship between categorical variables was analyzed using the chisquare test.\u0000\u0000\u0000Results: The mean age of the patients at the time of diagnosis was 54.5 years, 46.3% were premenopausal, the mean tumor size was 28.7 mm, most of them were T1 (54%), ER, PR, HER-2 positivity rates were 79.6%, 73.1%, 38.3%, respectively and Ki-67 index average was 31.6. The most common molecular subtype was Luminal B Her2B-(33.5%). During a mean follow-up period of 56.9 months, 5 and 10-year overall survival (OS) rates were 89.5%, 79.6%, respectively, and disease-free survival (DFS) rates were 86.9%, 70.5%, respectively. The recurrence rate was 12.3%, distribution by molecular subtypes was significant (p=0.02). Luminal A and Luminal B/Her2- were in relation with Lobular Carcinoma (p=0.005), low histological grade (p=0.00), small tumor size (p=0.00), absence of lymphovascular invasion (LVI) (p=0.00), breast conserving surgery (p=0.022), presence of menopause (p =0.005) and local disease (p =0.013).\u0000\u0000\u0000Conclusions: This study showed that there are differences in molecular subtyping for symptomatic BC in Turkish women.\u0000","PeriodicalId":52409,"journal":{"name":"European Journal of Translational and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77086061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Advantages, limitations and new perspectives on the implantation of subcutaneous cardioverter-defibrillator 皮下心脏转复除颤器植入的优点、局限性及新展望

European Journal of Translational and Clinical Medicine Pub Date : 2022-12-07 DOI: 10.31373/ejtcm/156835

B. Opielowska-Nowak, G. Raczak, Martyna Badyoczek

引用次数: 0

In the midst of imbalance: medical and healthcare students versus SARS-CoV-2 处于失衡之中：医学和医疗保健专业学生与严重急性呼吸系统综合征冠状病毒2型

European Journal of Translational and Clinical Medicine Pub Date : 2022-12-07 DOI: 10.31373/ejtcm/143211

Alexandra Kamieniecki, Dawid Marek, N. Dułak, Paulina Skrzypkowska, Hanna Karin Louise Olofsson, T. Szmuda, P. Słoniewski, Shan Ali

{"title":"In the midst of imbalance: medical and healthcare students versus SARS-CoV-2","authors":"Alexandra Kamieniecki, Dawid Marek, N. Dułak, Paulina Skrzypkowska, Hanna Karin Louise Olofsson, T. Szmuda, P. Słoniewski, Shan Ali","doi":"10.31373/ejtcm/143211","DOIUrl":"https://doi.org/10.31373/ejtcm/143211","url":null,"abstract":"Background: During the COVID-19 era, it is crucial to determine the level of relevant infectious disease knowledge amongst medical students as they may influence public opinion by acting as informal medical advisors to their friends and family. We sought to assess the knowledge of students regarding COVID-19 at a single Polish medical university, to understand the level of knowledge and determine if dedicated COVID-19 education is necessary. Material and methods: The survey was conducted in Google Forms and access was obtained through the university's secure email. After exclusion, 1 001 students were enrolled. Results: The most common mask used amongst students is a surgical mask. Regarding SARS-CoV-2 transmission, 79.1% chose droplet and 19.3% chose airborne transmission. Only 35% agreed that surgical masks protect them from coronavirus and 70% strongly agreed or agreed that all healthcare workers should wear an N95/FFP3 mask. Students with a healthcare worker in the family more likely agreed that all healthcare workers should wear N95/FFP3 (p = 0.001). The source of information used affected the route of transmission chosen (p = 0.006). Conclusions: We recommend combating contradictory information by implementing dedicated education into the healthcare student curriculum on SARS-CoV-2, PPE, filtering efficiency of masks, modes of transmission of viruses, and how to use evidence-based medicine. Copyright © Medical University of Gdańsk.","PeriodicalId":52409,"journal":{"name":"European Journal of Translational and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42647049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of biomarkers in early prediction and molecular mechanisms of preeclampsia 生物标志物在先兆子痫早期预测中的作用及其分子机制

European Journal of Translational and Clinical Medicine Pub Date : 2022-12-07 DOI: 10.31373/ejtcm/156837

Iyshwarya Bhaskar Kalarani, Ramakrishnan Veerabathiran, Vajagathali Mohammed

{"title":"The role of biomarkers in early prediction and molecular mechanisms of preeclampsia","authors":"Iyshwarya Bhaskar Kalarani, Ramakrishnan Veerabathiran, Vajagathali Mohammed","doi":"10.31373/ejtcm/156837","DOIUrl":"https://doi.org/10.31373/ejtcm/156837","url":null,"abstract":"Preeclampsia (PE) is defined as new onset hypertension after 20 weeks of gestation with evidence of maternal organ or uteroplacental dysfunction or proteinuria. PE is a leading cause of maternal death, with about 55000 deaths worldwide each year. Toxic substances that damage the maternal vascular endothelium induce PE, resul - ting in liver and kidney malfunction. It is crucial for obstetricians to identify as early as possible the patients who are at risk for PE. Polycystic ovarian disease, sleeping disorders, urinary infections, periodontal disease, smoking, lifestyle and familial history of PE are the major risk factors involved in this disease. VEGF, sFlt1, sENG, PAPP-A, inhibin A and activin A proteins, fetal hemoglobin, heat shock protein and placental protein have been helpful in predicting or diagnosing PE and in understanding its pathogenesis. In addition, a better understanding of PE pathogenesis would aid in identifying the most effective treatments that do not impair the fetus’ prognosis. The aim of our study is a review of the pathophysiology and biomarkers, such as pro- and anti-angiogenic substan - ces, that may be useful in the detection of PE in the future","PeriodicalId":52409,"journal":{"name":"European Journal of Translational and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44714707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comorbidities and clinical outcomes of a lung cancer screening trial participants with chronic obstructive pulmonary disease in three-year follow-up 慢性阻塞性肺疾病肺癌筛查试验参与者三年随访的合并症和临床结果

European Journal of Translational and Clinical Medicine Pub Date : 2022-12-07 DOI: 10.31373/ejtcm/153487

A. Undrunas, A. Bąk, P. Kasprzyk, R. Dziedzic, D. Dziurda, W. Rzyman, M. Gierlotka, K. Kuziemski

{"title":"Comorbidities and clinical outcomes of a lung cancer screening trial participants with chronic obstructive pulmonary disease in three-year follow-up","authors":"A. Undrunas, A. Bąk, P. Kasprzyk, R. Dziedzic, D. Dziurda, W. Rzyman, M. Gierlotka, K. Kuziemski","doi":"10.31373/ejtcm/153487","DOIUrl":"https://doi.org/10.31373/ejtcm/153487","url":null,"abstract":"Background: To improve the effectiveness of lung cancer screening using low-dose computed tomography (LDCT), the presence of smoking-related comorbidities that may significantly affect mortality in this group should be taken into account. Material and methods: A questionnaire survey and spirometry tests were conducted in a group of 730 respondents as part of a lung cancer screening study between 2016 and 2018. People diagnosed with COPD underwent a three-year follow-up to assess the incidence of medical events. Results: Our study confirmed that cardiovascular diseases (CVDs) were the most common comorbidities in patients who were dia - gnosed with COPD and participated in LDCT lung cancer screening. Among the CVDs, the most common were arterial hypertension (45.8%) and coronary artery disease (12.5%). Tobacco-related diseases (e.g. CVD, lung can - cer, and exacerbations of COPD) were the leading causes of emergency department visits and hospitalizations. The number of visits due to COPD in specialized clinics more than doubled in the observed period. Conclusions: Properly planned screening tests allow not only for the detection of the disease for which they were designed but also for the assessment of comorbidities. In patients undergoing lung cancer screening, it is justified to extend the diagnostics to include spirometry.","PeriodicalId":52409,"journal":{"name":"European Journal of Translational and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43565960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early extubation protocol post-coronary artery bypass graft & open heart surgery 冠状动脉旁路移植术和心内直视手术后的早期拔管方案

European Journal of Translational and Clinical Medicine Pub Date : 2022-12-07 DOI: 10.31373/ejtcm/153486

Mansour Jannati

{"title":"Early extubation protocol post-coronary artery bypass graft & open heart surgery","authors":"Mansour Jannati","doi":"10.31373/ejtcm/153486","DOIUrl":"https://doi.org/10.31373/ejtcm/153486","url":null,"abstract":"Fast-tracking in cardiac care refers to the complex intervention including early extubation, care during anesthesia, mobilization and hospital discharge to reduce perioperative morbidity, costs, and length of stay in the intensive care unit and the hospital. This review was designed to evaluate early extubation protocols, the differences in early and late extubation, the safety and efﬁcacy of early extubation among the patients in surgical intensive care after coronary artery bypass graft (CABG) surgery. The analyzed studies showed many signiﬁcant differences in the mortality and postoperative complications of time-directed extubation practices and low dose-based general anesthesia in patients with low to moderate risk undergoing early extubation (fast-track) and the conventional care methods. Different fast-track interventions could diminish extubation time, costs, and the length of hospital stay. However, several factors including patient’s stay in the intensive therapy ward vs general ward, patient selection, skills and experience of the staff, and fast-track anesthesia methods could be considered to perform safe fast-tracking in patients undergoing cardiac surgery. On the other hand, to achieve this safety for high-risk cardiosurgery patients multidisciplinary coordination is needed.","PeriodicalId":52409,"journal":{"name":"European Journal of Translational and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43684109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Periprocedural decrease in tumor necrosis factor alpha is a risk factor for atrial fibrillation recurrence after ablation 术中肿瘤坏死因子α降低是消融后房颤复发的危险因素

European Journal of Translational and Clinical Medicine Pub Date : 2022-12-07 DOI: 10.31373/ejtcm/156997

E. Szczerba, E. Koźluk, Łukasz Januszkiewicz, Monika Lisicka, J. Nowak, A. Kondracka, Joanna Majstrak, Dariusz Rodkiewicz, A. Piątkowska, M. Kiliszek, G. Opolski

{"title":"Periprocedural decrease in tumor necrosis factor alpha is a risk factor for atrial fibrillation recurrence after ablation","authors":"E. Szczerba, E. Koźluk, Łukasz Januszkiewicz, Monika Lisicka, J. Nowak, A. Kondracka, Joanna Majstrak, Dariusz Rodkiewicz, A. Piątkowska, M. Kiliszek, G. Opolski","doi":"10.31373/ejtcm/156997","DOIUrl":"https://doi.org/10.31373/ejtcm/156997","url":null,"abstract":"Background: Concentration of tumor necrosis factor alpha (TNF-alpha) might be useful in selecting patients with paroxysmal atrial fibrillation (PAF) who will benefit the most from pulmonary vein isolation. Material and methods: This is a prospective cohort study among patients with PAF who had sinus rhythm prior to undergoing either radiofrequency ablation or cryoablation procedure. Blood samples were collected at the start of the procedure and 16-24 h after. TNF-alpha concentrations were measured. Follow-up data was obtained during a structured telephone interview and 24-hour ECG Holter monitoring 12 months after the ablation procedure. Results: Thirty seven patients were enrolled. After 12-month follow-up 27 patients maintained sinus rhythm, 8 had recurrence of AF and 2 were lost to follow-up. There was no significant correlation between TNF-alpha concentrations in any of the samples and the recurrence of arrhythmia (for pre-procedural samples: 1.75 pg/ ml vs. 1.74 pg/ml; p = 0.72; for post-procedural samples: 1.49 pg/ml vs. 1.79 pg/ml; p = 0.16). In patients who had a recurrence of AF, we observed a decrease in the periprocedural TNF-alpha concentration (-0.12 pg/ml vs 0.05 pg/ml; p = 0.05). Conclusions: Neither pre- nor post-procedural TNF-alpha concentrations are predictive of ablation outcome in patients with PAF. We observed a decrease in the periprocedural TNF-alpha concentration in patients who had AF recurrence.","PeriodicalId":52409,"journal":{"name":"European Journal of Translational and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42155790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Positive affect, well-being and the human conserved transcriptional response to adversity: a descriptive review 积极情感、幸福感和人类对逆境的保守转录反应：描述性综述

European Journal of Translational and Clinical Medicine Pub Date : 2022-12-07 DOI: 10.31373/ejtcm/152870

Michalina Frankowska, Magdalena Błażek

引用次数: 0

Access to healthcare as an important moderating variable for understanding geography of COVID-19 outcomes – preliminary insights from Poland 获得医疗保健是了解COVID-19结果地理分布的重要调节变量——来自波兰的初步见解

European Journal of Translational and Clinical Medicine Pub Date : 2022-12-07 DOI: 10.31373/ejtcm/147842

A. Jarynowski, V. Belik

{"title":"Access to healthcare as an important moderating variable for understanding geography of COVID-19 outcomes – preliminary insights from Poland","authors":"A. Jarynowski, V. Belik","doi":"10.31373/ejtcm/147842","DOIUrl":"https://doi.org/10.31373/ejtcm/147842","url":null,"abstract":"Introduction: Biases in the measurement of COVID-19 burden and the uncertainty in estimation of the corresponding epidemiologic indexes are known and common phenomena in infectious diseases. We investigated to what extent healthcare access (HCA)-related supply/demand interfered with the registered data on COVID-19 in Poland. Material and Methods: We ran a multiple linear regression model with interactions to explain the geographic variation in seroprevalence, hospitalizations (on the voivodeship - NUTS-2 level) and current (beginning of the 4th wave of COVID cases - 15.09-21.11.2021) case notifications/crude mortality (on poviat - old NUTS-4 level). We took vaccination coverage and cumulative case notifications up to the so called 3rd wave as predictor variables and supply/demand (HCA) as moderating variables. Results: HCA with interacting terms (mainly demand) explained to the great extent the variance of current incidence and most of the variance in the current mortality rates. HCA (mainly supply) was significantly moderating cumulative case notifications until the 3rd wave of cases, thus explaining the variance in seroprevalence and hospitalization. Conclusion: Seeking causal relations between the vaccination- or infection-gained immunity level and the current infection dynamics could be misleading without understanding the socio-epidemiologic context such as the moderating role of HCA (sensu lato). After quantification, HCA could be incorporated into epidemiologic models for improved prediction of the actual disease burden. Copyright © Medical University of Gdańsk.","PeriodicalId":52409,"journal":{"name":"European Journal of Translational and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41271813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0