{"title":"Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH): A Case of Indolent Pulmonary Nodules Diagnosed with Robotic-Assisted Navigational Bronchoscopy.","authors":"Adam Purdy, Firas Ido, Deborah Stahlnecker","doi":"10.1155/2021/6312296","DOIUrl":"https://doi.org/10.1155/2021/6312296","url":null,"abstract":"<p><p>Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is an atypical pulmonary disorder with limited understanding. Given the rare nature of this disease, it is essential to obtain adequate tissue pathology to confirm the diagnosis. This disease is mainly diagnosed in middle-aged, nonsmoking females, and it is now accepted as a precursor lesion to pulmonary carcinoid tumors. DIPNECH presents with characteristic radiographic and histologic findings, but its diagnosis, management, and prognosis are often underrecognized and poorly understood. Those with symptoms may present with shortness of breath, wheezing, and persistent cough and are often misdiagnosed with reactive airway disease. Pulmonary function testing may reveal airflow obstruction and air trapping. Imaging is characterized by multiple lung nodules, typically less than 5 mm in size, with a background mosaic attenuation on computed tomography imaging. Histologically, DIPNECH can be suspected based on the presence of hyperplastic neuroendocrine cells. DIPNECH is considered a precursor to invasive neuroendocrine tumor, and up to 50% of patients may have a well-differentiated neuroendocrine tumor at the time of presentation. Here, we present the case of a 46-year-old female with a history of ulcerative colitis on mesalamine who presented with a 6-month history of ongoing shortness of breath, chest tightness, wheezing, and cough. She was initially diagnosed with asthma before imaging later revealed as multiple pulmonary nodules with a diffuse mosaic pattern. Using robotic-assisted navigational bronchoscopy, she underwent sampling of a dominant 1.8 cm right middle lobe pulmonary nodule and pathology was consistent with low-grade neuroendocrine tumor.</p>","PeriodicalId":52364,"journal":{"name":"Case Reports in Pulmonology","volume":"2021 ","pages":"6312296"},"PeriodicalIF":0.0,"publicationDate":"2021-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39827979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Richard Jesse Durrance, Alice Kyungsun Min, Marilyn Fabbri, Terrence McGarry
{"title":"Cavitary Legionella Pneumonia in AIDS: When Intracellular Immunity Failure Leads to Rapid Intrapulmonary Cavitation.","authors":"Richard Jesse Durrance, Alice Kyungsun Min, Marilyn Fabbri, Terrence McGarry","doi":"10.1155/2021/6754094","DOIUrl":"https://doi.org/10.1155/2021/6754094","url":null,"abstract":"<p><p><i>Introduction</i>. Legionella is a frequent cause of bacterial pneumonia in patients with AIDS. While multiple organisms have been associated with cavitary pneumonia in this population, Legionella has not. <i>Clinical Case</i>. A middle-aged woman with HIV-AIDS and severely depressed CD-4 count presented with one month of progressively worsening productive cough and dyspnea. Serial imaging showed focal consolidations which multiplied and cavitated over the subsequent days. Legionella urine antigen was positive, and appropriate treatment was continued for 3 weeks total. The patient recovered quickly, and follow-up imaging 8 weeks later showed near-resolution of all lesions. <i>Discussion</i>. Cavitary pneumonia secondary to Legionella has been seldom described, traditionally in the context of immunosuppressive therapy. Patients with AIDS and severely depressed CD4 counts have significantly compromised cell-mediated immunity. This case highlights the importance of consideration for legionellosis in rapidly progressing cavitary pneumonia, especially in patients with severely compromised cell-mediated immunity, including those with HIV-AIDS.</p>","PeriodicalId":52364,"journal":{"name":"Case Reports in Pulmonology","volume":"2021 ","pages":"6754094"},"PeriodicalIF":0.0,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39710744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mehmet M Tatari, David Abia-Trujillo, Mathew Thomas, Neal M Patel, Sebastian Fernandez-Bussy, Britney N Hazelett, Margaret M Johnson
{"title":"Tracheobronchoplasty and Diaphragmatic Plication under VV ECMO for Combined ECAC and Diaphragmatic Paralysis.","authors":"Mehmet M Tatari, David Abia-Trujillo, Mathew Thomas, Neal M Patel, Sebastian Fernandez-Bussy, Britney N Hazelett, Margaret M Johnson","doi":"10.1155/2021/5565754","DOIUrl":"https://doi.org/10.1155/2021/5565754","url":null,"abstract":"<p><p>The coexistence of expiratory central airway collapse and diaphragmatic paralysis presents a diagnostic and treatment challenge. Both entities are underrecognized causes of dyspnea, cough, sputum production, and orthopnea. Optimal treatment must be individualized and is best achieved by a multidisciplinary team. We present a case of a patient with profound functional impairment from dyspnea and hypoxemia due to expiratory central airway collapse, complicated by bronchiectasis from recurrent respiratory infections, and diaphragmatic paralysis.</p>","PeriodicalId":52364,"journal":{"name":"Case Reports in Pulmonology","volume":"2021 ","pages":"5565754"},"PeriodicalIF":0.0,"publicationDate":"2021-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39763169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Conservative Approach to a Large Mycotic Pulmonary Pseudoaneurysm.","authors":"Erin Torpey, Jenna Spears, Yousif Al-Saiegh, Mindi Roeser","doi":"10.1155/2021/6456216","DOIUrl":"https://doi.org/10.1155/2021/6456216","url":null,"abstract":"<p><p>Pulmonary mycotic pseudoaneurysm is a rare complication of bacteremia with high associated mortality. We present a case of a large proximal pulmonary artery pseudoaneurysm as a result of methicillin-sensitive Staphylococcus aureus bacteremia, originating from a tunneled dialysis catheter infection. This case was ultimately managed conservatively with surveillance imaging and a prolonged intravenous antibiotic course, rather than with surgical or interventional management. To our knowledge, this is the first reported case of a mycotic pulmonary pseudoaneurysm due to septic embolization of an infected superior vena cava thrombus.</p>","PeriodicalId":52364,"journal":{"name":"Case Reports in Pulmonology","volume":"2021 ","pages":"6456216"},"PeriodicalIF":0.0,"publicationDate":"2021-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39763170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christian Akem Dimala, Urvi Patel, Benjamin Lloyd, Anthony Donato, William B Kimmel, Robert Hallowell, Caitlyn Moss
{"title":"A Case Report of Steroid-Resistant Cryptogenic Organizing Pneumonia Managed with Intravenous Immunoglobulins.","authors":"Christian Akem Dimala, Urvi Patel, Benjamin Lloyd, Anthony Donato, William B Kimmel, Robert Hallowell, Caitlyn Moss","doi":"10.1155/2021/9343491","DOIUrl":"https://doi.org/10.1155/2021/9343491","url":null,"abstract":"<p><p>Fewer than ten reported cases of cryptogenic organizing pneumonia (COP) have been managed with intravenous immunoglobulins (IVIg). We report a case of a 72-year-old man who presented with a worsening cough and diffuse opacities on chest radiograph. Following no improvement with antibiotics and negative complementary investigations for infectious, malignant, and autoimmune etiologies, COP was confirmed on lung biopsy. Due to continued clinical deterioration despite high-dose steroids and new severe steroid-induced hallucinations, the patient was placed on intravenous immunoglobulins (IVIg) and mycophenolate mofetil and made a satisfactory recovery. IVIg should be considered as an important steroid-sparing alternative in patients with COP.</p>","PeriodicalId":52364,"journal":{"name":"Case Reports in Pulmonology","volume":"2021 ","pages":"9343491"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39909450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pleuropulmonary Blastoma (PPB) in Child with <i>DICER1</i> Mutation: The First Case Report in the State of Qatar.","authors":"Sara G Hamad, Amal Al-Naimi, Mutasim Abu-Hasan","doi":"10.1155/2021/1983864","DOIUrl":"https://doi.org/10.1155/2021/1983864","url":null,"abstract":"<p><p>Pleuropulmonary blastoma (PPB) is a rare intrathoracic malignancy, which arises from the lung parenchyma and/or pleura. PPB has strong genetic association with mutations in <i>DICER1</i> gene. Despite being rare, PPB is the most common lung tumor in children below 6 years of age. International registry of the disease has a total of 350 cases worldwide. We report the first case of PPB in the state of Qatar, which presented as a large cystic lung lesion. The patient was first thought to have benign congenital pulmonary airway malformation (CPAM) based on chest X-ray findings. The diagnosis of PPB was suspected based on chest CT scan findings and was confirmed after surgical resection of the cystic mass. The case highlights the need to consider PPB in the differential diagnosis of cystic lung lesions in children and the need for further radiological imaging (i.e., CT scan), genetic testing, and/or excisional biopsy to confirm the diagnosis.</p>","PeriodicalId":52364,"journal":{"name":"Case Reports in Pulmonology","volume":"2021 ","pages":"1983864"},"PeriodicalIF":0.0,"publicationDate":"2021-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39598315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intrapleural Tenecteplase for Complicated Parapneumonic Pleural Effusion.","authors":"Husain Kadhem, Kannan Sridharan, Naser Naser","doi":"10.1155/2021/2206692","DOIUrl":"https://doi.org/10.1155/2021/2206692","url":null,"abstract":"<p><p>Intrapleural thrombolytics have shown promising results in complicated parapneumonic pleural effusions reducing the need for surgical interventions. Until now, studies have evaluated primarily streptokinase, urokinase, and recently, alteplase. In this case series, we share our experience with tenecteplase-a tissue-specific plasminogen activator in 15 patients. We observed that tenecteplase is effective in 14/15 (93.3%) of our patients, and none of them had any bleeding episodes.</p>","PeriodicalId":52364,"journal":{"name":"Case Reports in Pulmonology","volume":"2021 ","pages":"2206692"},"PeriodicalIF":0.0,"publicationDate":"2021-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39529129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Management of Submassive Bilateral Pulmonary Embolism in an Adolescent Female.","authors":"Adeline Yi Ling Lim, John Roy, Ajay Kevat","doi":"10.1155/2021/1678528","DOIUrl":"https://doi.org/10.1155/2021/1678528","url":null,"abstract":"Pulmonary embolism (PE) is a rare presentation in the pediatric population. We report a case of submassive PE in an adolescent female following commencement of a combined oral contraceptive pill (COCP). In the setting of cardiac dysfunction, she received systemic thrombolysis with significant reduction of clot burden and clinical improvement objectively demonstrated shortly thereafter. This case highlights challenges in clinical decision-making regarding surgical or catheter-based interventions versus medical management approaches when addressing life-threatening PE in children. Our case demonstrates that submassive PE in pediatrics can be managed successfully with systemic thrombolysis and therapeutic anticoagulation.","PeriodicalId":52364,"journal":{"name":"Case Reports in Pulmonology","volume":"2021 ","pages":"1678528"},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39503360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A Burkett, S McElwee, C Margaroli, P Bajpai, A Elkholy, U Manne, K Wille, P Benson
{"title":"Positive Retrospective SARS-CoV-2 Testing in a Case of Acute Respiratory Distress Syndrome of Unknown Etiology.","authors":"A Burkett, S McElwee, C Margaroli, P Bajpai, A Elkholy, U Manne, K Wille, P Benson","doi":"10.1155/2021/5484239","DOIUrl":"https://doi.org/10.1155/2021/5484239","url":null,"abstract":"<p><p>In order to elucidate the cause of acute respiratory distress syndrome of unknown etiology in a pre-pandemic patient, molecular techniques were used for detection of SARS-CoV-2. We used a SARS-CoV-2 nucleocapsid protein immunofluorescence stain to retrospectively identify an individual with diffuse alveolar damage on autopsy histology who had negative respiratory virus panel results in February, 2020, in Birmingham, Alabama. In situ hybridization for SARS-CoV-2 RNA revealed evidence of widespread multiorgan SARS-CoV-2 infection. This death antecedes the first reported death of a State of Alabama resident diagnosed with SARS-CoV-2 by 26 days.</p>","PeriodicalId":52364,"journal":{"name":"Case Reports in Pulmonology","volume":"2021 ","pages":"5484239"},"PeriodicalIF":0.0,"publicationDate":"2021-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39411601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anton Dzian, Marek Malík, Ľuboš Hamada, Jozef Mičák, Ivana Gregorová, Gabriela Košturiaková
{"title":"A Rare Case Diagnosed by Videothoracoscopic Lung Biopsy: Diffuse Pulmonary Meningotheliomatosis.","authors":"Anton Dzian, Marek Malík, Ľuboš Hamada, Jozef Mičák, Ivana Gregorová, Gabriela Košturiaková","doi":"10.1155/2021/1990433","DOIUrl":"https://doi.org/10.1155/2021/1990433","url":null,"abstract":"<p><p>Diffuse pulmonary meningotheliomatosis (DPM) is reported as a diffuse parenchymal lung disease characterized by disseminating small asymptomatic nodules. These lesions are often detected incidentally as microscopic findings in lung specimens or autopsies examined by a pathologist. We report a case of a 60-year-old male asymptomatic patient presenting with multiple bilateral pulmonary nodules on high-resolution computed tomography and diagnosed by videothoracoscopic surgery. Differential diagnosis of patients presenting with diffuse indeterminate nodules is very important. Definitive diagnosis of DPM requires histopathology and most often videothoracoscopic lung biopsy.</p>","PeriodicalId":52364,"journal":{"name":"Case Reports in Pulmonology","volume":"2021 ","pages":"1990433"},"PeriodicalIF":0.0,"publicationDate":"2021-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39397538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}