Case Reports in Pulmonology最新文献_第4页

Treating Acute Severe Eosinophilic Asthma with IL-5 Inhibitors in ICU. IL-5抑制剂治疗重症急性嗜酸性粒细胞哮喘。

Case Reports in Pulmonology Pub Date : 2022-08-21 eCollection Date: 2022-01-01 DOI: 10.1155/2022/2180795

Nicolas Barbarot, Emmanuelle Nourry, Nicolas Massart, François Legay, Matthieu Debarre, Pierre Fillatre, Eric Magalhaes, Arnaud Mari, Julien Wallois, Eric Briens, Stéphane Jouneau

{"title":"Treating Acute Severe Eosinophilic Asthma with IL-5 Inhibitors in ICU.","authors":"Nicolas Barbarot, Emmanuelle Nourry, Nicolas Massart, François Legay, Matthieu Debarre, Pierre Fillatre, Eric Magalhaes, Arnaud Mari, Julien Wallois, Eric Briens, Stéphane Jouneau","doi":"10.1155/2022/2180795","DOIUrl":"https://doi.org/10.1155/2022/2180795","url":null,"abstract":"Introduction: About 10% of the 300 million people worldwide who suffer from asthma have a severe disease that is uncontrolled despite treatment with inhaled corticosteroids and long-acting beta agonists. The eosinophilic inflammation pathway in the respiratory tract and blood is involved and interleukin-5 (IL-5) has recently been identified as a major promotor of this pathway. The anti-IL-5 antibodies reduce the incidence of exacerbation and allowed steroid sparing in severe asthma patients but only two case reports have been published on their use in critical care. Case Presentation. This report describes the extraordinary clinical improvement of a young patient with steroid-refractory eosinophilic acute severe asthma who required mechanical ventilation, VV-ECMO followed by treatment with mepolizumab. The salient point in this case is the use of an anti-IL-5 monoclonal antibody for a critically ill patient whose condition was deteriorating despite mechanical ventilation and VV-ECMO. The usual steroid treatment failed to control the increase in blood eosinophils or his bronchial inflammation and constriction.Conclusion: Anti-IL-5 antibodies are now a standard treatment for severe eosinophilic asthma that can also be useful in an emergency to treat steroid-refractory eosinophilic acute severe asthma.","PeriodicalId":52364,"journal":{"name":"Case Reports in Pulmonology","volume":" ","pages":"2180795"},"PeriodicalIF":0.0,"publicationDate":"2022-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40335939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Noninvasive Management of Fractured Indwelling Tunneled Pleural Catheter Valve. 胸膜导管瓣膜断裂的无创处理。

Case Reports in Pulmonology Pub Date : 2022-08-13 eCollection Date: 2022-01-01 DOI: 10.1155/2022/2541285

Azib Shahid, Harpreet Singh, Toni-Denise Espina, Mohammad Abdalla, Uzair Ghori, Bryan S Benn

引用次数: 0

Double Lung Transplantation for Idiopathic Pulmonary Fibrosis in a Patient with a History of Liver Transplantation and Prolonged Journey for Disease-Specific Antifibrotic Therapy. 双肺移植治疗特发性肺纤维化患者的肝移植史和长期疾病特异性抗纤维化治疗。

Case Reports in Pulmonology Pub Date : 2022-08-13 eCollection Date: 2022-01-01 DOI: 10.1155/2022/4054339

Sebastian Majewski, Maria Królikowska, Ulrich Costabel, Wojciech J Piotrowski, Marek Ochman

{"title":"Double Lung Transplantation for Idiopathic Pulmonary Fibrosis in a Patient with a History of Liver Transplantation and Prolonged Journey for Disease-Specific Antifibrotic Therapy.","authors":"Sebastian Majewski, Maria Królikowska, Ulrich Costabel, Wojciech J Piotrowski, Marek Ochman","doi":"10.1155/2022/4054339","DOIUrl":"https://doi.org/10.1155/2022/4054339","url":null,"abstract":"Idiopathic pulmonary fibrosis (IPF) is characterized by uncontrolled progressive lung fibrosis with a median survival of 3 to 5 years. Although currently available pharmacotherapy cannot cure the disease, antifibrotics including pirfenidone and nintedanib were shown to slow disease progression and improve survival in IPF. Nevertheless, there is a knowledge gap on the safety of antifibrotics in patients after liver transplantation receiving concomitant immunosuppressive therapy. This case report of a 68-year-old male patient with IPF illustrates how a complex medical history has led to diagnostic and therapeutic challenges considerably affecting clinical decisions and impacting the patient's journey. The increasing severity of lung function impairment due to the progressive natural history of IPF ultimately led to severe respiratory failure. Double lung transplantation (LTx) was performed as the only therapeutic option in end-stage disease with the potential to improve quality of life and survival. To the best of our knowledge, this is the first case report describing the feasibility and safety of antifibrotic therapy with pirfenidone for IPF in a 68-year-old patient with a history of liver transplantation receiving concomitant immunosuppressive therapy with tacrolimus who underwent successful double lung transplantation when alternative medical interventions had been exhausted.","PeriodicalId":52364,"journal":{"name":"Case Reports in Pulmonology","volume":" ","pages":"4054339"},"PeriodicalIF":0.0,"publicationDate":"2022-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40648628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Severe Nonspecific Interstitial Pneumonia (NSIP) in an Adolescent. 青少年严重非特异性间质性肺炎(NSIP)。

Case Reports in Pulmonology Pub Date : 2022-08-09 eCollection Date: 2022-01-01 DOI: 10.1155/2022/7757776

Giuliana Cerro Chiang, Christopher Lee, Alberto Marchevsky, Michael I Lewis

引用次数: 0

Necrotizing Granulomatous Pneumocystis Infection Presenting as a Solitary Pulmonary Nodule: A Case Report and Review of the Literature. 坏死性肉芽肿性肺囊虫感染表现为孤立性肺结节:1例报告及文献复习。

Case Reports in Pulmonology Pub Date : 2022-07-28 eCollection Date: 2022-01-01 DOI: 10.1155/2022/7481636

Mansur Assaad, Mohamed Swalih, Apurwa Karki

{"title":"Necrotizing Granulomatous Pneumocystis Infection Presenting as a Solitary Pulmonary Nodule: A Case Report and Review of the Literature.","authors":"Mansur Assaad, Mohamed Swalih, Apurwa Karki","doi":"10.1155/2022/7481636","DOIUrl":"https://doi.org/10.1155/2022/7481636","url":null,"abstract":"Pneumocystis jirovecii is an opportunistic fungus that is classically associated with pneumonia in immunocompromised patients, particularly those with human immunodeficiency virus and acquired immunodeficiency syndrome (HIV/AIDS). However, this infection is now more commonly seen in those with malignancy, particularly lymphoproliferative disorders. Classic image findings with Pneumocystis jirovecii pneumonia (PJP) include bilateral ground-glass opacities with or without cyst formation. Up to 5% of patients with PJP may present with atypical image findings, specifically nodular opacities or masses thought to represent granulomatous inflammation. The differential diagnosis for a new solitary pulmonary nodule in an immunocompromised patient is broad. One must first rule out a recurrence of malignancy or new primary malignancy. In our patient's case, two nondiagnostic bronchoscopies with EBUS-TBNA eventually led to a surgical resection, which revealed a diagnosis of nodular necrotizing granulomatous Pneumocystis jirovecii. The diagnostic yield from EBUS is not well established, and most cases require surgical biopsy for definitive diagnosis. Further data regarding the use of EBUS-TBNA in diagnosing granulomatous PJP is needed.","PeriodicalId":52364,"journal":{"name":"Case Reports in Pulmonology","volume":" ","pages":"7481636"},"PeriodicalIF":0.0,"publicationDate":"2022-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40677635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Spontaneous Pneumomediastinum, Pneumoperitoneum, and Subcutaneous Emphysema beyond the Inguinal Ligament Secondary to Inversion Maneuvers. 腹股沟韧带继发的自发性纵隔气肿、气腹和皮下肺气肿。

Case Reports in Pulmonology Pub Date : 2022-06-25 eCollection Date: 2022-01-01 DOI: 10.1155/2022/7054146

Keegan Plowman, David Lindner, Jose Ruben Valle-Giler

{"title":"Spontaneous Pneumomediastinum, Pneumoperitoneum, and Subcutaneous Emphysema beyond the Inguinal Ligament Secondary to Inversion Maneuvers.","authors":"Keegan Plowman, David Lindner, Jose Ruben Valle-Giler","doi":"10.1155/2022/7054146","DOIUrl":"https://doi.org/10.1155/2022/7054146","url":null,"abstract":"Pneumomediastinum is free air within the mediastinal cavity which can spread along tissue planes leading to the accumulation of large amounts of subcutaneous emphysema. Patient is a 21-year-old male with a history of autism spectrum disorder and rhabdomyolysis who presented with diffuse \"popping under the skin\" and was found to have crepitus extending from his neck to his bilateral ankles. He exercises frequently and performs chin-up pullovers and will often hold his breath during this movements. He uses an inversion table but denies any valsalva maneuvers or straining while inverted. Radiological imaging demonstrated pneumomediastinum, pneumoperitoneum, and diffuse subcutaneous emphysema extending into the pelvis. Diagnosis requires a combination of history, physical exam findings, and imaging findings. Patients with spontaneous pneumomediastinum typically experience self-limited disease, and efforts should be made to minimize low yield invasive testing. Most patients can be treated on an outpatient basis after monitoring and education about potential complications.","PeriodicalId":52364,"journal":{"name":"Case Reports in Pulmonology","volume":" ","pages":"7054146"},"PeriodicalIF":0.0,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40488296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Metastatic Glioblastoma Diagnosed by Endobronchial Ultrasound-Transbronchial Needle Aspiration. 支气管超声经支气管针吸诊断转移性胶质母细胞瘤1例。

Case Reports in Pulmonology Pub Date : 2022-06-18 eCollection Date: 2022-01-01 DOI: 10.1155/2022/5453420

Mais Al-Sardi, Ali Alfayez, Yazeed Alwelaie, Abdullah Al-Twairqi, Faris Hamadi, Khalid AlOkla

{"title":"A Rare Case of Metastatic Glioblastoma Diagnosed by Endobronchial Ultrasound-Transbronchial Needle Aspiration.","authors":"Mais Al-Sardi, Ali Alfayez, Yazeed Alwelaie, Abdullah Al-Twairqi, Faris Hamadi, Khalid AlOkla","doi":"10.1155/2022/5453420","DOIUrl":"https://doi.org/10.1155/2022/5453420","url":null,"abstract":"Glioblastoma is a common primary brain tumor that has a high mortality rate. Reports of intrathoracic metastases are uncommon, with the most commonly reported site for metastases are the lung and pleura. However, involvement of the mediastinum is not well documented, and few reports of confirmed mediastinal metastases diagnosed by endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA) exist. Herein, we report a rare case of metastatic glioblastoma to the thorax. A lady in her 40s has been previously diagnosed with intracranial glioblastoma with multiple incidences of disease recurrence despite treatment with chemoradiotherapy, adjuvant chemotherapy, and repeated surgical resections. She presented with dyspnea and pleural effusion, for which radiological imaging revealed lung, pleural, and mediastinal lesions. Further diagnostic workup with EBUS and pleural fluid sampling confirmed metastatic disease to both sites. The pleural fluid showed highly atypical cells positive for GFAP, and EBUS-TBNA immunostains were GFAP, S100, and synaptophysin positive, giving an overall picture consistent with metastatic glioblastoma. The patient was referred for palliative care, and unfortunately, she passed away after several months.","PeriodicalId":52364,"journal":{"name":"Case Reports in Pulmonology","volume":" ","pages":"5453420"},"PeriodicalIF":0.0,"publicationDate":"2022-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40406675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Allergic Bronchopulmonary Aspergillosis with an Atypical Mass-Like Presentation. 过敏性支气管肺曲霉病伴非典型肿块样表现。

Case Reports in Pulmonology Pub Date : 2022-06-13 eCollection Date: 2022-01-01 DOI: 10.1155/2022/3627202

Mahmoud Ibrahim Mahmoud, Alaeldin Elfaki, Ziad A Alhaj, Abir Hamad Said

引用次数: 0

Remarkable Differences in Calcification between the Primary Tumor and Metastatic Lymph Nodes in a Patient with ALK-Positive Non-Small-Cell Lung Cancer alk阳性非小细胞肺癌原发肿瘤与转移淋巴结钙化的显著差异

Case Reports in Pulmonology Pub Date : 2022-02-26 DOI: 10.1155/2022/1160000

K. Sunata, Tetsuo Tani, Takahiko Ui, Hidehiro Irie, Y. Funatsu, Hidefumi Koh

引用次数: 0

Successful Treatment for a Large Chronic Expanding Hematoma Treated by Pneumonectomy after Arterial Embolization 动脉栓塞后肺切除术治疗大型慢性扩张血肿的成功治疗

Case Reports in Pulmonology Pub Date : 2022-02-18 DOI: 10.1155/2022/1932420

Aki Fujiwara-Kuroda, Nozomu Iwashiro, M. Ohara, Kichizo Kaga

引用次数: 2