Problemy Osobo Opasnykh Infektsii最新文献

{"title":"Methodological Approaches to Assessing the Economic Damage Associated with the Incidence of Hemorrhagic Fever with Renal Syndrome in the Russian Federation","authors":"A. V. Ivanova, V. A. Safronov, A. Zubova, N. V. Popov, O. I. Kozhanova, N. Matveeva, I. Vyatkin, S. A. Shcherbakova, V. Kutyrev","doi":"10.21055/0370-1069-2023-1-96-104","DOIUrl":"https://doi.org/10.21055/0370-1069-2023-1-96-104","url":null,"abstract":"The aim of the study was to develop methodological approaches to assessing the economic damage associated with the incidence of hemorrhagic fever with renal syndrome (HFRS) and to calculate the economic damage by the example of an outbreak of HFRS in the Saratov region in 2019. Materials and methods. The paper analyzes the economic indicators of the Federal State Statistics Service; data on the incidence of HFRS in the Russian Federation for the period of 2019–2022. To calculate the cost of outpatient and inpatient medical care, as well as the costs associated with the medical follow-up of convalescents, the indicators of the Program of state guarantees of free provision of medical care to citizens for 2022 and for the scheduled period of 2023 and 2024 were used. The calculation of economic losses associated with the payment of temporary disability benefits was carried out according to the equation provided in the Federal Law No. 255-FZ dated December 29, 2006 (as amended on October 07, 2022). Economic losses associated with premature death at an economically active age were calculated based on the value of unproduced GDP due to lost years of life in the corresponding age group. Results and discussion. The costs of treatment, rehabilitation and payment of temporary disability benefits for 1 case of HFRS at the age of 0 to 56.5 years for the female population and from 0 to 61.5 years for the male population amount to 140 495 rubles; over the age of 56.5 years for the female population and 61.5 years for the male population – 95 412 rubles, respectively. Each fatal case of HFRS aged 0 to 16 years among the male population costs the state 38 976 231 rubles; among the female population – 34 708 331 rubles; in active working age – the value of economic damage varies depending on the age of the person who died of HFRS. The economic damage of the outbreak of HFRS in the Saratov Region (2019), taking into account the direct expenditures of the healthcare system and indirect losses of the country’s economy amounted to 441 453 432 rubles. It is of note that the structure of the main damage is dominated by indirect losses in the economy caused by the premature death of people in economically active age.","PeriodicalId":52264,"journal":{"name":"Problemy Osobo Opasnykh Infektsii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49256034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"West Nile Fever in the Russian Federation in 2022, the Incidence Forecast for 2023","authors":"E. Putintseva, S. K. Udovichenko, D. Nikitin, N. Boroday, A. Baturin, A. Y. Machneva, A. Antonov, N. A. Zarubin, A. Toporkov","doi":"10.21055/0370-1069-2023-1-75-84","DOIUrl":"https://doi.org/10.21055/0370-1069-2023-1-75-84","url":null,"abstract":"The review presents an analysis of West Nile fever (WNF) epidemiological situation in the Russian Federation in 2022 and the summarized results of monitoring over the pathogen. The following features of the WNF epidemic process in Russia are outlined: the decrease (by 4 times) in the incidence rates compared to the long-term average values against an extremely extensive nature of manifestations (16 constituent entities in 6 federal districts), including the detection of local cases in 5 new territories (Tver, Tambov, Vladimir Regions, Khanty-Mansi Autonomous District, and Karachay-Cherkess Republic), predominant registration of incidence in the Central Federal District (51 %), early start and termination of the epidemic season. There is a decrease in the proportion of neuroinvasive forms in the structure of incidence, prevalence of females and the age group of “60 years and over”, as well as record rate values of people infected at the place of residence in cities, which is associated with the peculiarities of case detection, namely, screening examinations of febrile patients in hospitals by efforts of the Reference Center, according to the results of which 60 % of all registered patients with WNF in Russia were diagnosed. Monitoring studies of the Reference Center in the territory of the Central, Southern and North-Caucasian Federal Districts confirmed the intensive circulation of the pathogen. The low level of officially registered incidence is caused by insufficiently effective identification of patients. Molecular genetic studies have shown that West Nile virus lineage 2 circulated in the European part of Russia, both in epizootic and epidemic cycles. Phylogenetic analysis has revealed that 4 West Nile virus isolates found in Astrakhan, Volgograd Regions, the Republic of Kalmykia and Stavropol Territory in 2022 belong to a new genovariant of the genotype 2, first identified in Russia in 2021. Possible complication of the epidemiological situation in all federal districts of the center and south of the European part of Russia is predicted.","PeriodicalId":52264,"journal":{"name":"Problemy Osobo Opasnykh Infektsii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46997831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement of Epidemiological Surveillance of Natural Plague Foci of the Russian Federation and the Forecast of Their Epizootic Activity for 2023","authors":"N. V. Popov, I. G. Karnaukhov, A. A. Kuznetsov, A. Matrosov, A. V. Ivanova, K. S. Martsokha, V. Korzun, D. Verzhutsky, E. V. Chipanin, A. V. Kholin, A. A. Lopatin, V. Dubyansky, U. Ashibokov, A. Y. Gazieva, S. Balakhonov, A. Kulichenko, V. Kutyrev","doi":"10.21055/0370-1069-2023-1-67-74","DOIUrl":"https://doi.org/10.21055/0370-1069-2023-1-67-74","url":null,"abstract":"The aim of the work was to assess the epidemic situation on plague in the world and epizootic activity of natural plague foci of the Russian Federation in 2022. Following the implementation of comprehensive preventive interventions plans, there was a decrease in the epizootic activity of the Gorno-Altai high-mountain and Tuva mountain natural foci, the cessation of plague epizootics in the Central Caucasian high-mountain focus. The total area of epizootics in the Russian Federation in 2022 reached 248.3 km2, which is 7 times less than in 2021. Infected animals were not found in the Tersko-Sunzhensky low-mountain, Dagestan plain-piedmont, Caspian North-Western steppe, Volga-Ural steppe, Trans-Baikal steppe, Volga-Ural sandy, Caspian sandy, East Caucasian high-mountain natural foci. Persistence of tense epizootiological situation in 2023 is predicted for the territory of the Altai Republic and the Republic of Tuva. The prospects of using the GIS portal of the Russian Anti-Plague Institute “Microbe” of the Rospotrebnadzor for an operational assessment of the actual epidemiological situation in natural plague foci are substantiated.","PeriodicalId":52264,"journal":{"name":"Problemy Osobo Opasnykh Infektsii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48904883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Epidemiological Situation of Hemorrhagic Fever with Renal Syndrome in the Russian Federation in 2022 and Forecast of its Development for 2023","authors":"T. Savitskaya, A. V. Ivanova, G. Isaeva, I. Reshetnikova, V. Trifonov, V. B. Ziatdinov, S. V. Magerramov, R. Khusainova, D. V. Trankvilevsky","doi":"10.21055/0370-1069-2023-1-85-95","DOIUrl":"https://doi.org/10.21055/0370-1069-2023-1-85-95","url":null,"abstract":"The paper provides the analysis of epidemiological process of hemorrhagic fever with renal syndrome (HFRS) in the Russian Federation in the context of federal districts in 2022 and a forecast of the HFRS incidence for 2023. According to the results of the analysis, there was a three-fold increase in the morbidity rates of HFRS in Russia in 2022 as compared to the indicators of 2021. The evidence of epizootiological survey and laboratory studies in certain federal districts of the Russian Federation indicate the continuing tense epidemiological situation on HFRS. In a number of regions of the country, high risk of infection with HFRS is predicted due to the favorable natural and climatic conditions of the winter period 2022/2023 for reservoir hosts of pathogenic for humans Hantaviruses. The findings of infected rodents attest to a high probability of complication of the epidemiological situation in the territories of increased epidemic hazard as regards HFRS.","PeriodicalId":52264,"journal":{"name":"Problemy Osobo Opasnykh Infektsii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46639812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial Ghosts of the Causative Agents of Particularly Dangerous Infections","authors":"A. S. Vagaiskaya, S. V. Dentovskaya, A. P. Anisimov","doi":"10.21055/0370-1069-2023-1-17-26","DOIUrl":"https://doi.org/10.21055/0370-1069-2023-1-17-26","url":null,"abstract":"Bacterial ghosts are intact walls of bacterial cells that are relieved of their contents through pores formed by mild biological or chemical methods. Methodology for generating bacterial ghosts increases the safety of killed vaccines while maintaining their antigenicity through milder preparation procedures. Moreover, bacterial ghosts can simultaneously carry several antigens or plasmid DNAs encoding protein epitopes. In recent years, there has been a growing interest in the development of prototype vaccines and systems for delivery of biologically active substances based on bacterial ghosts. This review discusses the progress in the development of this type of medications over the last years. Various methods of obtaining bacterial ghosts, their advantages and limitations are considered. The phage-mediated lysis of bacteria, molecular manipulations with lysis genes, difficulties encountered in scaling the biotechnological production of bacterial ghosts, and ways to overcome them are described in detail. The use of bacterial ghosts as alternative killed vaccines, adjuvants, recombinant antigenic platform, carrier of plasmid DNA by the models of pathogens of particularly dangerous infections of bacterial etiology is investigated.","PeriodicalId":52264,"journal":{"name":"Problemy Osobo Opasnykh Infektsii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47996022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidrug Resistance of F. tularensis subsp. holarctica, Epizootiological and Epidemiological Analysis of the Situation on Tularemia in the Russian Federation in 2022 and Forecast for 2023","authors":"T. Kudryavtseva, V. Popov, A. Mokrievich, E. S. Kulikalova, A. V. Kholin, A. Mazepa, M. A. Borzenko, N. Pichurina, N. Pavlovich, A. Noskov, D. V. Trankvilevsky, M. V. Khramov, I. Dyatlov","doi":"10.21055/0370-1069-2023-1-37-47","DOIUrl":"https://doi.org/10.21055/0370-1069-2023-1-37-47","url":null,"abstract":"The review provides concise information on the innate ability of cells of the tularemia pathogen, Francisella tularensis subsp. Holarctica, to resist antimicrobials through a variety of mechanisms, leading to its multi-resistance. In total, taking into account new territories, 120 cases of human infection were registered in the Russian Federation in 2022. Epizootic manifestations of the infection of varying degrees of intensity were detected in 58 constituent entities. Against this background, sporadic cases of tularemia in humans were reported in 18 regions of the country. An outbreak of tularemia occurred in the Stavropol Territory; the disease of mild and moderate severity was found in 76 people. The increased incidence of tularemia persists in the Republic of Karelia with severe cases of the disease in the absence of immunoprophylaxis of this infection in the region. A total of 61 cultures of the tularemia pathogen F. tularensis subsp. holarctica, out of which 20 erythromycin-resistant strains were isolated in the Stavropol Territory. In addition, 8 cultures of F. tularensis subsp. mediasiatica from a silt sample and mites Dermacentor silvarum and Haemaphysalis concinna caught in the Republic of Altai were isolated. On the territory of the Russian Federation in 2022, 930 999 people were vaccinated and revaccinated against tularemia. Based on the analysis of the data obtained in 2022, epidemic complications in 2023 in the form of sporadic cases of the disease among the unvaccinated population are most likely to occur in the territories of the Central Federal District – in the Vladimir, Ryazan and Smolensk Regions; Northwestern Federal District – in the Arkhangelsk Region and the Republic of Karelia; Southern Federal District – in the Volgograd and Rostov Regions. The situation in the North Caucasian Federal District will remain tense in the Stavropol Territory; in the Volga Federal District – in the territories of the Saratov Region, as well as in the Kirov Region and the Republic of Mordovia; Ural Federal District – in Khanty-Mansi and Yamalo-Nenets Autonomous Districts; Siberian Federal District – in certain territories of Omsk, Kemerovo, Tomsk, Novosibirsk, Irkutsk Regions, Altai, Krasnoyarsk Territories; in the Far Eastern Federal District, the most intense epizootic activity of natural tularemia foci is in Primorsky Krai.","PeriodicalId":52264,"journal":{"name":"Problemy Osobo Opasnykh Infektsii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41983510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholera: Analysis and Assessment of Epidemiological Situation around the World and in Russia (2013–2022). Forecast for 2023","authors":"A. Noskov, V. D. Kruglikov, E. Moskvitina, L. V. Mironova, E. Monakhova, E. G. Soboleva, O. Chemisova, A. Vodop’yanov, A. A. Lopatin, S. Ivanova, E. A. Men’shikova, O. A. Podoynitsyna, M. Ezhova, A. Evteev","doi":"10.21055/0370-1069-2023-1-56-66","DOIUrl":"https://doi.org/10.21055/0370-1069-2023-1-56-66","url":null,"abstract":"The aim of the review was to analyze and assess the epidemiological situation on cholera in the world and Russia in 2013–2022 and to make a forecast for 2023. Over the period of 2013–2022, 500 administrative territories affected by cholera were identified in various regions of 71 countries of Asia, Africa and America (the Caribbean region) with formation of 69 endemic foci in 16, 41 and 12 countries, respectively. In 2022, 1 209 301 cases of cholera were registered in 36 countries of the world. The intensity of epidemic process in Asian countries (Syria, Lebanon) increased. Unfavorable epidemiological situation on the African continent persisted. Epidemics and large outbreaks, which began in 2021–2022 due to emergency situations (ES) of social and natural character, continued. The prediction of the stability of the epidemiological situation on cholera in the territories of constituent entities of the Russian Federation (RF), given for 2022, has been confirmed. In 2022, 43 non-toxigenic strains of Vibrio cholerae О1 were isolated from surface water bodies, 8 V. cholerae nonO1/nonO139 strains – from humans. Similarity of those strains with genetically closely related ones isolated in the course of monitoring in previous years in Russia, Donetsk People’s Republic (DPR) and Zaporozhye Region was demonstrated. In 2023, the risks of importation of the infection into RF are retained. It is associated with the intensification of epidemic processes in Asian, African and Caribbean region countries. The extended border with Ukraine, to where importation of cholera from endemic countries is possible, contributes to increased degree of threat. Bioterrorism is also not excluded. The consequences of a possible cholera epidemic complication in DPR, Lugansk People’s Republic, Zaporozhye and Kherson Regions are exacerbated by social emergencies resulting in disruption of infrastructure, interruptions in water supply, etc. In the absence of implementation of the risks of importation of this infection on the territory of RF, a stable epidemiological situation on cholera will be retained. Detection of non-toxigenic V. cholerae O1 strains (including probability of clonal complexes formation), as well as strains of non-O1/non-O139 serogroups, which can be etiological factors of sporadic cases or outbreaks of diarrheal diseases, in surface water bodies is predicted.","PeriodicalId":52264,"journal":{"name":"Problemy Osobo Opasnykh Infektsii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48196872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Data on the Dissemination of the Nipah Virus (Henipavirus. Paramyxoviridae) and Methods of its Indication and Identification","authors":"E. I. Krivosheina, M. Y. Kartashov, Tran Thi Nhai, E. Naidenova","doi":"10.21055/0370-1069-2023-1-27-36","DOIUrl":"https://doi.org/10.21055/0370-1069-2023-1-27-36","url":null,"abstract":"Nipah virus (Nipah virus, NiV) is a representative of the genus Henipavirus of the Paramyxoviridae family, the causative agent of a dangerous infectious disease with a wide range of clinical manifestations – from an asymptomatic (subclinical) form to severe encephalitis with fatal outcome. Despite the fact that the disease caused by this virus is registered only in the countries of Southeast Asia, the possibility of importing the pathogen to non-endemic territories is not excluded. Also, this pathogen is able to infect not only a large number of people, but also animals, causing serious diseases and significant economic damage, posing both, a medical and veterinary problem. This review presents the data available in the modern press on the structure and classification of the Nipah virus, possible cycles of its transmission, spread, methods of indication and identification in clinical and biological material, as well as the effectiveness of their use depending on the timing of the onset of the disease and available commercial diagnostic and preventive drugs.","PeriodicalId":52264,"journal":{"name":"Problemy Osobo Opasnykh Infektsii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42133616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review on the Epizootiological Situation on Highly Pathogenic Avian Influenza around the World and in Russia in 2022","authors":"V. Marchenko, S. Svyatchenko, G. Onkhonova, N. I. Goncharova, A. B. Ryzhikov, R. Maksyutov, E. Gavrilova","doi":"10.21055/0370-1069-2023-1-48-55","DOIUrl":"https://doi.org/10.21055/0370-1069-2023-1-48-55","url":null,"abstract":"This paper describes the current situation on highly pathogenic avian influenza virus in 2022 and provides forecast of the possible further spread of avian influenza in Russia. In 2022, the circulation of a wide variety of highly pathogenic avian influenza virus subtypes, which have epizootiological and epidemiological significance, was recorded in the world. Outbreaks caused by highly pathogenic avian influenza virus were reported in over 60 countries. In addition, human infections with influenza viruses of the A(H5Nx) and A(H9N2) subtypes were registered. There was a large-scale epizootic which affected more than 10 regions of the European part of Russia and the Russian Far East in 2022. Outbreaks among wild birds and poultry were caused by the highly pathogenic influenza virus A(H5N1) of the clade 2.3.4.4b, at the same time genetic and antigenic diversity was observed among viruses circulating in Russia. Thus, an essential geographical role of the territory of Russia in the global spread of avian influenza virus has been shown once again, which highlights the importance of continuous avian influenza virus surveillance in the country.","PeriodicalId":52264,"journal":{"name":"Problemy Osobo Opasnykh Infektsii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49113448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological Situation on Tick-Borne Viral Encephalitis in the Russian Federation in 2022 and Forecast of its Development for 2023","authors":"E. I. Andaev, A. Nikitin, M. I. Tolmacheva, I. D. Zarva, E. V. Yatsmenko, V. Matveeva, E. A. Sidorova, V. Kolesnikova, S. Balakhonov","doi":"10.21055/0370-1069-2023-1-6-16","DOIUrl":"https://doi.org/10.21055/0370-1069-2023-1-6-16","url":null,"abstract":"The aim of this review is to predict the incidence of tick-borne viral encephalitis (TBVE) in the Russian Federation for 2023 based on analysis of the epidemiological situation on TBVE during 2012–2022. Over the decade, the highest incidence of TBVE was registered in the Siberian, Volga and Ural Federal Districts. In 2022, the Ural Federal District took the second place, the share of the North-Western one decreased by almost two times. Ranking of territories according to the rate of TBVE incidence at the level of constituent entities has made it possible to attribute 16 of them to the group of regions with a high epidemic risk, 14 – to medium epidemic risk, and 18 – to a low epidemic risk. In 2022, the incidence of TBVE in Russia increased by 1.9 times compared to 2021, and amounted to 1.34 0/0000. Despite the increase in the incidence of TBVE in 2022, a significant downward trend has been retained. The rate of infection of ticks removed from humans in 2022 was below the long-term average values. PCR and ELISA were applied for tests. Infection rate of ticks from environmental objects when studied by PCR was higher than the multi-year average values, and lower when studied by ELISA. In 2022, 3.5 million people were immunized against TBVE (vaccinated and revaccinated). Emergency immunoprophylaxis with immunoglobulin covered 24.5 % of the people affected by tick bites (children accounted for 34.3 %). The forecast for TBVE incidence in Russia in 2023 remains favorable. It is expected to be reduced to (0.83±0.298) 0/0000. However, there was not only an increase in the number of TBVE cases, but also the proportion of clinical manifestations of the disease, as well as lethal outcomes among those who suffered from tick bites in 2022. If this pattern holds, the incidence of TBVE in 2023 will be higher than predicted, especially in the constituent entities where the share of individuals with manifest forms among those who suffered from tick bites has increased greatly.","PeriodicalId":52264,"journal":{"name":"Problemy Osobo Opasnykh Infektsii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45587596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}