Pain Reports最新文献

{"title":"Rethinking coping in chronic pain: a systematic review and dynamic interaction model of coping.","authors":"Merethe Blandhol, Seoyoung Lee, Dan-Mikael Ellingsen","doi":"10.1097/PR9.0000000000001421","DOIUrl":"10.1097/PR9.0000000000001421","url":null,"abstract":"<p><p>Living with chronic pain presents significant challenges and disruptions, thus motivating the use of coping strategies to manage pain and its impact in everyday life. Yet how individuals cope with chronic pain and why some people show better functional outcomes is not clearly understood. Previous literature on coping has often focused on describing different coping strategies and their comparative effectiveness, often with the assumption that some are overall more adaptive. Existing theoretical models of coping often lack descriptions of how factors unfold over time and assume relationships between factors remain stable. However, pain coping is not only influenced by continuously changing internal and external contextual factors, but by changing interactions as the process reiterates over time. Moreover, the short- and long-term efficacy of different coping approaches depends on individual appraisal and changing contextual demands. In this review, we first synthesise selected theoretical models of coping in health-related stress or pain that were identified through a systematic search. Next, we present the \"Dynamic Interaction Model of Coping in Chronic Pain\" which builds on concepts from the stress and coping literature to address gaps in the selected models. Specifically, we outline how 5 central factors: (1) controllability, (2) predictability, (3) salience, (4) resources, and (5) motivation, interact in a dynamic coping process guided by updating predictions, feedback, and expectations. The model outlines putative pathways of moment-to-moment and long-term adaptations to chronic pain, and potential targets for intervention.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 2","pages":"e1421"},"PeriodicalIF":4.3,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12999111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trajectories of school absenteeism in adolescents with recurrent pain: predictors and distal outcomes.","authors":"Christiana Owiredua, Ida Flink, Brittany Evans, Katja Boersma","doi":"10.1097/PR9.0000000000001416","DOIUrl":"10.1097/PR9.0000000000001416","url":null,"abstract":"<p><strong>Introduction: </strong>A sizeable number of adolescents with recurrent pain frequently miss school, yet the trajectories of absenteeism and their correlates remain unclear. We aimed to explore trajectories of school absenteeism due to pain among adolescents with recurrent pain, and predictors and correlates of the trajectories.</p><p><strong>Methods: </strong>A prospective cohort design with 3 yearly measurement points between 2016 and 2018 was used. The sample included 873 Swedish upper secondary school adolescents (mean age = 16.5 years; 60.8% girls; 11.7% immigrants) with recurrent pain (headache, abdominal and/or musculoskeletal pain ≥1/wk for 6 months). Predictors were sociodemographic variables, pain characteristics, depressive symptoms, and stressors in the school context. Distal outcomes were perceived future work ability and overall future expectancy.</p><p><strong>Results: </strong>We identified 3 trajectories of absenteeism through latent class growth analysis: persistently high absenteeism (18.1%), persistently low absenteeism (49.4%), and persistently no absenteeism (32.5%). Pain intensity and school-related stressors independently predicted absenteeism trajectories. Compared with the other trajectories, the persistently high absenteeism subgroup had more negative perceived future work ability and overall future expectancy.</p><p><strong>Conclusion: </strong>A substantial subgroup of adolescents showed a stable pattern of high absenteeism across their upper secondary education, which was associated with overall negative expectancies for the future and specifically future work ability. Therefore, there is a need to identify this subgroup and intervene early in the life course to prevent long-term disadvantages in education, employment, and overall well-being.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 2","pages":"e1416"},"PeriodicalIF":4.3,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analgesic strategies for ischaemic pain in chronic limb-threatening ischaemia: a systematic review and meta-analysis.","authors":"Henry Davies, Ahmed Boalot, Annabel Howitt, Marie-José Vleugels, Sharon Ka Po Tam, Jing Yi Kwan, Sheila Black, Ingrid Francis, Christopher Bull, Barend M E Mees, Sarah Mitchell, David Russell","doi":"10.1097/PR9.0000000000001426","DOIUrl":"10.1097/PR9.0000000000001426","url":null,"abstract":"<p><p>To evaluate the effectiveness of pharmacological (eg, ketamine, lidocaine) and nonpharmacological (eg, spinal cord stimulation, mononuclear cell therapy) analgesic strategies-outside the WHO pain ladder-for patients with chronic limb-threatening ischaemia (CLTI). A systematic review and meta-analysis was conducted in accordance with PRISMA guidelines, searching 5 electronic databases for studies evaluating analgesia in CLTI. Both randomised and nonrandomised studies were included. Standardised mean differences (SMDs) in post-treatment pain scores were extracted or calculated, and random-effects meta-analyses performed for comparable studies. Twenty-one studies met inclusion criteria. Most investigated mononuclear cell therapy, hepatocyte growth factor, or prostaglandin infusions. Meta-analyses of mononuclear cell therapy vs standard treatment at 3 months showed significant benefit (3 studies; SMD = -2.12, 95% confidence interval [CI] -3.19 to -1.05, <i>P</i> = 0.001, I² = 86.95%). At 6 months, benefit persisted (3 studies; SMD = -2.54, 95% CI -3.95 to -1.14, <i>P</i> = 0.0004, I² = 92.0%). Across studies, mononuclear cell therapy showed the largest effect sizes but was associated with high heterogeneity and, due to restrictive exclusion criteria, had limited generalisability and poor practicality. Hepatocyte growth factor therapy showed a nonsignificant trend towards pain reduction, and prostaglandin infusion demonstrated no meaningful effect; both excluded large proportions of the CLTI cohort. Of the single-study interventions, subcutaneous lidocaine and ketamine provided short-term analgesic benefit with acceptable safety, whereas others did not produce statistically significant improvements. Pharmacological management of pain in CLTI remains challenging. No recommendations can be made for agents outside standard care. Several novel approaches, including ketamine and subcutaneous lidocaine, warrant further investigation. Further research into novel analgesics for CLTI is urgently needed.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 2","pages":"e1426"},"PeriodicalIF":4.3,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravenous galanin (1-16) and a GalR1 agonist attenuate allodynia in rats with spared nerve injury.","authors":"Bernardo Miguel, Marcelo J Villar, Tobías Giovannetti, Valentino Desanto, Sofía Villalba, Verónica Bisagno, Mailín Casadei, Tambet Teesalu, Tomas Hökfelt, Pablo R Brumovsky","doi":"10.1097/PR9.0000000000001422","DOIUrl":"10.1097/PR9.0000000000001422","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic pain is a major unmet medical need, with current treatments often providing limited relief. The neuropeptide galanin, acting through GalR1-3 receptors, has been implicated in pain modulation. Although galanin analogues are typically administered intrathecally, emerging evidence suggests that peptides can cross the blood-brain barrier. We hypothesized that systemic administration of the biologically active fragment galanin (1-16) could attenuate neuropathic pain.</p><p><strong>Objectives: </strong>To evaluate whether intravenous galanin (1-16) reduces pain-like behaviors in a rat model of neuropathic pain and to compare its effects when using a selective GalR1 agonist.</p><p><strong>Methods: </strong>Male Sprague-Dawley rats underwent spared nerve injury. Animals received intravenous galanin (1-16), M617 (selective GalR1), or vehicle. Mechanical and cold allodynia were assessed using von Frey filaments and acetone testing, respectively. Open-field tests evaluated locomotor activity to exclude more general behavioral effects. Data were analyzed using blinded protocols and appropriate statistical tests.</p><p><strong>Results: </strong>Galanin (1-16) and M617 significantly reversed mechanical allodynia compared with vehicle, with effects evident at 0.5 hours, peaking at 2 hours, still present after 4 hours, and absent by 6 hours (<i>P</i> < 0.0001). No significant differences were observed between galanin (1-16) and M617. By contrast, neither compound significantly affected cold allodynia. Locomotor activity, total distance travelled, or center time were not affected by galanin (1-16).</p><p><strong>Conclusion: </strong>Intravenous administration of galanin (1-16) produces robust but transient antiallodynic effects in neuropathic rats, likely mediated through GalR1 activation, without impairing locomotion. These findings highlight the therapeutic potential of systemically administered galanin or galanin analogues targeting GalR1 for neuropathic pain management.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 2","pages":"e1422"},"PeriodicalIF":4.3,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterogeneity of treatment effects in transcranial direct current stimulation for knee osteoarthritis pain and symptoms.","authors":"Chiyoung Lee, Xiaoxiao Sun, Juyoung Park, Chen X Chen, Christine Pellegrini, Nan-Kuei Chen, David O Garcia, Heewon Kim, C Kent Kwoh, Hyochol Ahn","doi":"10.1097/PR9.0000000000001411","DOIUrl":"10.1097/PR9.0000000000001411","url":null,"abstract":"<p><strong>Introduction: </strong>Although heterogeneity of treatment effects (HTEs) is commonly observed in clinical trials, it has received little attention in studies on transcranial direct current stimulation (tDCS).</p><p><strong>Objectives: </strong>This study identified the presence of HTE in tDCS treatment among participants with symptomatic knee osteoarthritis (KOA) and explored participant characteristics associated with this heterogeneity.</p><p><strong>Methods: </strong>This secondary analysis of a randomized clinical trial included 120 participants with symptomatic KOA who received 15 daily sessions of home-based 2-mA active or sham tDCS over 3 weeks. We used a multitrajectory analysis to identify distinct subgroups based on the longitudinal trajectories of KOA pain and symptoms from baseline to 3 months postintervention, capturing differential responses to tDCS. We then performed bivariate analyses to examine associations between trajectory groups and baseline demographic, clinical, and quantitative sensory testing characteristics.</p><p><strong>Results: </strong>In the active tDCS group, 2 distinct trajectories emerged: \"low initial symptoms with significant improvement\" (high responders; n = 28) and \"high initial symptoms with minimal improvement\" (low responders; n = 32). Compared to high responders, low responders had a higher body mass index, lower educational attainment, and greater pain catastrophizing (all <i>P</i> < 0.05). Low responders also exhibited lower pressure pain thresholds at both the medial knee and trapezius, higher punctate mechanical pain at both the patella and hand, lower conditioned pain modulation, and higher cold pain intensity at baseline (all <i>P</i> < 0.05). No notable HTE was observed in the sham tDCS group.</p><p><strong>Conclusion: </strong>Participants exhibited varying responses to active tDCS. The characteristics associated with HTE may inform the development of personalized stimulation protocols.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 2","pages":"e1411"},"PeriodicalIF":4.3,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating controlled direct treatment effects on pain intensity using structural mean models.","authors":"Rui Wang, Patrick J Heagerty, Kwun Chuen Gary Chan, Pradeep Suri","doi":"10.1097/PR9.0000000000001409","DOIUrl":"10.1097/PR9.0000000000001409","url":null,"abstract":"<p><strong>Introduction: </strong>Without valid inclusion of concurrent analgesic use, the primary analyses of pain intensity in pain randomized controlled trials (RCTs) may produce diminished estimated treatment effects.</p><p><strong>Methods: </strong>We used contemporary causal inference methods to reanalyze RCT data examining the effect of epidural steroid injection (ESI) as an example of a pain treatment. Specifically, we define an \"attributable to ESI estimand,\" which is the controlled direct effect of ESI. We used a simple composite pain intensity outcome, the QPAC_1.5, and structural mean models (SMM) to estimate the target estimand. Compared with traditional methods such as strict intention to treat analysis (strict ITT), SMMs can account for analgesic use without assuming no unmeasured confounding between the analgesic use and the outcome. We estimated treatment effects of ESI on leg pain intensity using the numeric rating scale with strict ITT, 3 SMM estimating methods (estimating equations, g-estimation, and generalized method of moments), and the QPAC_1.5.</p><p><strong>Results: </strong>The treatment effect of ESI on leg pain intensity using strict ITT was -0.751 numeric rating scale points (95% confidence interval [CI]: -1.287 to -0.214). Estimates for the attributable to ESI estimand were -0.864 (95% CI: -3.207 to 1.478) for estimating equations, -0.935 (95% CI: -1.779 to 0.090) for g-estimation, -0.653 (95% CI: -1.218 to -0.089) for generalized method of moments, and -0.930 (95% CI: -1.508 to -0.352) for the QPAC1.5.</p><p><strong>Discussion: </strong>We illustrate how contemporary causal inference methods and alternative estimands can be used to account for concurrent analgesic use in pain RCTs in a manner that may result in larger treatment effects.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 2","pages":"e1409"},"PeriodicalIF":4.3,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-impact chronic pain after total joint arthroplasty: a longitudinal cohort study.","authors":"Maggie E Horn, Michelle M Ramirez, Cynthia L Green, Michael P Bolognesi, Steven Z George","doi":"10.1097/PR9.0000000000001413","DOIUrl":"10.1097/PR9.0000000000001413","url":null,"abstract":"<p><strong>Introduction: </strong>High-impact chronic pain (HICP) is associated with impaired function, diminished quality of life, and greater healthcare utilization. Although total joint arthroplasty (TJA) is effective for osteoarthritis, up to 20% of patients report persistent pain and limitations.</p><p><strong>Objective: </strong>To examine transitions in HICP status and identify predictors of postoperative HICP following TJA.</p><p><strong>Methods: </strong>This was a retrospective longitudinal cohort study of 6631 patients who underwent total knee (46.6%), hip (31.2%), or shoulder (22.2%) arthroplasty at a large US academic medical center between January 2018 and August 2024. Transitions in HICP status were described, and multivariable logistic regression was used to evaluate predictors of postoperative HICP. Results were reported as odds ratios (OR) with 95% confidence intervals (CI). Model performance was assessed using classification accuracy, receiver operating characteristic analysis, and the area under the curve.</p><p><strong>Results: </strong>Preoperatively, 45.3% of patients reported HICP, which declined to 15.2% after surgery. However, 4.8% developed new-onset HICP, yielding an overall postoperative prevalence of 20.0%. Preoperative HICP (OR = 2.50, 95% CI: 2.10-2.94), lower physical function (OR = 0.95, 95% CI: 0.93-0.96), higher pain intensity (OR = 1.07, 95% CI: 1.04-1.10), and postoperative opioid exposure (OR = 1.83, 95% CI: 1.59-2.11) were the strongest predictors. Additional factors included younger age, sex, alcohol use, revision surgery, and comorbidity burden.</p><p><strong>Conclusion: </strong>Although TJA substantially reduces HICP prevalence, 1 in 5 patients continues to experience significant postoperative pain. Early identification of at-risk individuals and the integration of targeted perioperative interventions are critical to optimize recovery and long-term outcomes.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 2","pages":"e1413"},"PeriodicalIF":4.3,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12959783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific effects of naturally shorter sleep on experimental pain perception.","authors":"Shima Rouhi, Amy S Jordan, Natalia Egorova-Brumley","doi":"10.1097/PR9.0000000000001418","DOIUrl":"10.1097/PR9.0000000000001418","url":null,"abstract":"<p><strong>Introduction: </strong>Experimental sleep loss has been linked to sex-specific alterations in pain perception, with women exhibiting greater impairment in pain inhibition.</p><p><strong>Objectives: </strong>This study investigated whether habitual short sleep (<6 hours) affects pain processing in a sex-dependent manner.</p><p><strong>Methods: </strong>A total of 81 participants (44 self-reported shorter sleepers, 37 longer sleepers) completed a night of home-based EEG sleep monitoring, followed by next-day quantitative sensory testing. A General Linear Model assessed the effects of sleep duration (<i>shorter vs. longer sleepers</i>)<i>,</i> sex (<i>male vs. female</i>), and their interaction on pain perception.</p><p><strong>Results: </strong>A significant sleep × sex interaction (<i>F</i> [1, 76] = 9.06, <i>P</i> = 0.004) emerged for conditioned pain modulation; shorter-sleeping women showed reduced pain inhibition, while men showing enhanced pain inhibition. This effect was moderated by non-rapid eye movement sleep (<i>B</i> = 0.065, <i>P</i> = 0.017). While no other pain measures showed a sleep duration × sex interaction, a significant main effect of sleep was found for cold pain threshold, with shorter sleepers of both sexes showing decreased cold threshold (lower pain response). A significant main effect of sex was observed in heat, and pressure thresholds, with women showing increased pain responses.</p><p><strong>Conclusion: </strong>Habitually short sleep is associated with impaired conditioned pain modulation in women but not in men, suggesting a sex-specific vulnerability to the effects of chronic sleep deficiency on pain regulation. These findings highlight the importance of maintaining adequate sleep duration, particularly in women, to mitigate the negative effect on pain.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 2","pages":"e1418"},"PeriodicalIF":4.3,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12959763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic pain is associated with disability: results from a large, population-based survey in South Africa.","authors":"Murray McDonald, Peter R Kamerman, Romy Parker","doi":"10.1097/PR9.0000000000001417","DOIUrl":"10.1097/PR9.0000000000001417","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic pain significantly contributes to global disability, but data from South Africa and other low- and middle-income countries are limited.</p><p><strong>Objectives: </strong>We assessed the association between chronic pain (pain/discomfort ≥3 months) and disability using data from a large, population-based household survey. As an exploratory analysis, we also assessed for differences between individuals with high-impact chronic pain (HICP) (chronic pain with significant disability) to those with low-impact chronic pain (chronic pain with no disabilities) in demographics and health status variables.</p><p><strong>Methods: </strong>This cross-sectional, descriptive, secondary analysis used data collected in the 2016 South African Demographic and Health Survey, including 10336 adults. Disability was assessed using the Washington Group on Disability items. Statistical analyses were conducted using R v4.2.0 with the <i>survey</i> package.</p><p><strong>Results: </strong>Chronic pain prevalence was 18.3% (95% confidence interval [CI]: 16.9-19.7), with 27.8% (95% CI: 25.2-30.5) of individuals with chronic pain experiencing some form of disability. Chronic pain was associated with difficulties in cognition (adjusted odds ratio = 1.74 [95% CI: 1.41-2.14]) and mobility (AOR = 2.07 [95% CI: 1.70-2.52]), but not self-care (AOR = 1.07 [95% CI: 0.71-1.62]). The HICP group represented 1.7% (95% CI: 1.4-2.0) of the population and 9.2% (95%: 7.7-10.7) of those with chronic pain. Compared to the low-impact chronic pain group, the HICP group tended to be older and were more likely to be female, to receive a government grant, and to perceive their health as poor.</p><p><strong>Conclusion: </strong>Weak and moderately strong positive associations were found between chronic pain and greater cognitive and mobility disability, respectively.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 2","pages":"e1417"},"PeriodicalIF":4.3,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12959808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring real-world acute associations between physical activity and bodily pain in middle-aged and older adults.","authors":"Monica Teegardin, Anthony Kaleth, Priscilla Stone, Taylor Kelly, Easton Hewitt, Kelly Naugle","doi":"10.1097/PR9.0000000000001407","DOIUrl":"10.1097/PR9.0000000000001407","url":null,"abstract":"<p><strong>Introduction: </strong>Acute real-world associations between moderate-to-vigorous physical activity (MVPA), sedentary behavior, and daily fluctuations in pain levels of older adults are not well-understood. <b>Objectives:</b> Using a real-world approach in middle-aged and older adults with musculoskeletal pain, the purpose of this observational study was to determine (1) within-person relationships between bodily pain intensity and PA levels in the hour prior and (2) whether the within-person relationships were moderated by typical pain levels and kinesiophobia.</p><p><strong>Methods: </strong>Participants (n = 46, age 55-85 years) completed questionnaires including the Graded Chronic Pain Scale (typical pain levels) and Tampa Scale of Kinesiophobia. Participants wore an accelerometer for 7 consecutive days to measure MVPA and sedentary time. During the same 7-day period, participants completed daily ecological momentary assessments (EMAs) of their bodily pain on a 0 to 10 scale using a smartphone app. Linear mixed models examined within-person associations between EMA pain intensity rating and the prior hour's PA levels and cross-level interactions.</p><p><strong>Results: </strong>Greater sedentary minutes in the hour before the EMAs predicted greater bodily pain, with characteristic pain moderating this relationship. A positive relationship was shown between sedentary minutes and pain intensity at higher characteristic pain levels. Kinesiophobia moderated the effect of hourly MVPA minutes on bodily pain. For those with relatively lower kinesiophobia, greater minutes in MVPA predicted lower pain; however, no relationship existed between MVPA and pain for those with higher kinesiophobia.</p><p><strong>Conclusion: </strong>Hourly MVPA acutely influenced subsequent bodily pain in the natural environment of middle-to-older aged adults with musculoskeletal pain.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 2","pages":"e1407"},"PeriodicalIF":4.3,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12959780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}