Pain Reports最新文献

{"title":"Understanding the pain experience of lionfish envenomation.","authors":"Stephanie Mouchbahani-Constance, Manon Choinière, Reza Sharif-Naeini","doi":"10.1097/PR9.0000000000001090","DOIUrl":"10.1097/PR9.0000000000001090","url":null,"abstract":"<p><strong>Introduction: </strong>Stings from the lionfish (Pterois volitans) constitute one of the most painful wounds in the ocean. This species has invaded the Atlantic coast of the United States, Gulf of Mexico, Caribbean, and Mediterranean Sea. In addition to its ecological impact on local fish populations, stings from the lionfish pose a medical problem because of the debilitating nature of the pain they produce. However, there are no studies examining the human pain experience of lionfish stings.</p><p><strong>Objective: </strong>To characterize the various aspects of the pain experience following a lionfish sting.</p><p><strong>Methods: </strong>We developed a pain questionnaire that includes validated scales used with patients having acute or chronic pain to understand the pain variability, as well as the use of health care resources and treatments.</p><p><strong>Results: </strong>We provide the first study of the pain experience from lionfish stings. Here, we show that the pain is intense from the start and peaks approximately 1 hour later, resolving itself in 7 days for most victims. Furthermore, pain intensity can be influenced by several factors, including (1) age of the victim, where older victims experience significantly higher pain intensities, (2) the number of spines involved, (3) and whether infection occurred at the injury site. However, pain intensity was not different between male and female participants.</p><p><strong>Conclusion: </strong>These findings will inform the medical community on the pain experience and can be used by local authorities to better appreciate the impact of lionfish envenomations to develop programs aimed at curtailing the expansion of the lionfish.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10789455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41570734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased expression of hyaluronan synthase and loss of hyaluronan-rich cells in the anterior tibial fascia of the rat model of chemotherapy-induced peripheral neuropathy.","authors":"Ruilin Wang,&nbsp;Yoshikazu Matsuoka,&nbsp;Nobutaka Sue,&nbsp;Kosuke Nakatsuka,&nbsp;Chika Tsuboi,&nbsp;Hiroshi Morimatsu","doi":"10.1097/PR9.0000000000001088","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001088","url":null,"abstract":"<p><strong>Introduction: </strong>Previous studies on chemotherapy-induced peripheral neuropathy (CIPN) have focused on neuronal damage. Although some studies have revealed that the fascia is an important sensory organ, currently, we do not know about chemotherapy drug-induced fascial dysfunction.</p><p><strong>Objectives: </strong>This study aimed to explore the fascia as a nonneural cause of mechanical hypersensitivity in CIPN by investigating the expression of hyaluronic acid synthase (HAS) and histology of the fascia in an animal model of CIPN.</p><p><strong>Methods: </strong>Rats were intraperitoneally administered with vincristine (VCR). Mechanical hypersensitivities of the hind paw and the anterior tibial muscle were assessed. The expression of HAS mRNA in the fascia of the anterior tibial muscles was quantitated using reverse transcription polymerase chain reaction. Immunohistochemistry was also performed for HAS2, hyaluronic acid-binding protein, and S100A4 in the fascia.</p><p><strong>Results: </strong>Vincristine administration significantly decreased mechanical withdrawal thresholds in the hind paw and the anterior tibial muscle after day 3. Quantitative polymerase chain reaction showed significant downregulation of HAS mRNAs in the fascia of VCR-treated rats. Immunohistochemical analysis showed that the number of cells with strong HAS2 immunoreactivity, classified as fasciacytes by morphology and colocalized marker S100A4, decreased significantly in the VCR group.</p><p><strong>Conclusion: </strong>Hyaluronic acid plays a critical role in somatic pain sensation. Damaged fascia could be a possible cause of musculoskeletal pain in patients with CIPN. This study suggests that fascia is a nonneural cause and novel therapeutic target for chemotherapy-induced \"peripheral neuropathy.\"</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9729613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Online information on chronic pain in 3 countries: an assessment of readability, credibility, and accuracy.","authors":"Ritu Basnet,&nbsp;David Ruiz Mendez,&nbsp;Isaías Lugo-González,&nbsp;Edel O'Hagan,&nbsp;Mary O'Keeffe,&nbsp;Saurab Sharma,&nbsp;Joshua W Pate,&nbsp;David S Kennedy","doi":"10.1097/PR9.0000000000001078","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001078","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the readability, credibility, and accuracy of online information on chronic pain in Australia, Mexico, and Nepal.</p><p><strong>Methods: </strong>We assessed Google-based websites and government health websites about chronic pain for readability (using the Flesch Kincaid Readability Ease tool), credibility (using the Journal of American Medical Association [JAMA] benchmark criteria and Health on the Net Code [HONcode]), and accuracy (using 3 core concepts of pain science education: (1) pain does not mean my body is damaged; (2) thoughts, emotions, and experiences affect pain; and (3) I can retrain my overactive pain system)<i>.</i></p><p><strong>Results: </strong>We assessed 71 Google-based websites and 15 government websites. There were no significant between-country differences in chronic pain information retrieved through Google for readability, credibility, or accuracy. Based on readability scores, the websites were \"fairly difficult to read,\" suitable for ages 15 to 17 years or grades 10 to 12 years. For credibility, less than 30% of all websites met the full JAMA criteria, and more than 60% were not HONcode certified. For accuracy, all 3 core concepts were present in less than 30% of websites. Moreover, we found that the Australian government websites have low readability but are credible, and the majority provided all 3 core concepts in pain science education. A single Mexican government website had low readability without any core concepts but was credible.</p><p><strong>Conclusion: </strong>The readability, credibility, and accuracy of online information on chronic pain should be improved internationally to support facilitating better management of chronic pain.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/23/4e/painreports-8-e1078.PMC10278708.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9709219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tampa Scale of Kinesiophobia may underestimate task-specific fear of movement in people with and without low back pain.","authors":"Liam-Pierre Mathieu Tissot,&nbsp;David William Evans,&nbsp;Edward Kirby,&nbsp;Bernard Xian Wei Liew","doi":"10.1097/PR9.0000000000001081","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001081","url":null,"abstract":"<p><strong>Introduction: </strong>The Tampa Scale of Kinesiophobia (TSK) is commonly used to assess fear of movement (FoM) in people with low back pain (LBP). However, the TSK does not provide a task-specific measure of FoM, whereas image-based or video-based methods may do so.</p><p><strong>Objectives: </strong>To compare the magnitude of FoM when assessed using 3 methods (TSK-11, image of lifting, video of lifting) in 3 groups of people: current LBP (LBP), recovered LBP (rLBP), and asymptomatic controls (control).</p><p><strong>Methods: </strong>Fifty-one participants completed the TSK-11 and rated their FoM when viewing images and videos depicting people lifting objects. Low back pain and rLBP participants also completed the Oswestry Disability Index (ODI). Linear mixed models were used to estimate the effects of methods (TSK-11, image, video) and group (control, LBP, rLBP). Linear regression models were used to assess associations between the methods on ODI after adjusting for group. Finally, a linear mixed model was used to understand the effects of method (image, video) and load (light, heavy) on fear.</p><p><strong>Results: </strong>In all groups, viewing images (<i>P</i> = 0.009) and videos (<i>P</i> = 0.038) elicited greater FoM than that captured by the TSK-11. Only the TSK-11 was significantly associated with the ODI (<i>P</i> < 0.001). Finally, there was a significant main effect of load on fear (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>Fear of specific movements (eg, lifting) may be better measured using task-specific measures, such as images and videos, than by task-generic questionnaires, such as the TSK-11. Being more strongly associated with the ODI, the TSK-11 still plays an important role in understanding the impact of FoM on disability.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10247215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9663317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between chronotype and pain threshold in a sample of young healthy adults.","authors":"Giulia Zerbini,&nbsp;Peter Justus Göller,&nbsp;Katharina Lembke,&nbsp;Miriam Kunz,&nbsp;Philipp Reicherts","doi":"10.1097/PR9.0000000000001085","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001085","url":null,"abstract":"<p><strong>Introduction: </strong>Chronotype indicates the biological preference for timing of activity and sleep. Being a late chronotype (ie, having a tendency for late sleep times) is associated with several mental and physical health problems. Previous studies found that late chronotypes are also more susceptible to chronic pain, but the relationship between chronotype and pain sensitivity remains unclear.</p><p><strong>Objectives: </strong>The aim of this study was to investigate the relationship between chronotype and heat pain threshold (as an indicator of pain sensitivity) in a sample of young healthy adults.</p><p><strong>Methods: </strong>We analyzed data from 316 young healthy adults participating in 4 different studies run at the Medical Faculty of the University of Augsburg. In all studies, chronotype and other sleep variables (eg, sleep duration) were assessed using the micro Munich ChronoType Questionnaire. Heat pain threshold was assessed with the method of adjustment.</p><p><strong>Results: </strong>Chronotype was not significantly associated with the heat pain threshold. Entering the other sleep variables in separate regression models did also not significantly explain variance in heat pain threshold.</p><p><strong>Conclusion: </strong>Our null findings are in contrast with previous notions that late chronotypes might be more sensitive to pain and more susceptible to chronic pain. Given the scarcity of the literature on this topic, more studies are needed to clarify the relationship between chronotype and pain sensitivity in different age populations, while also considering distinct pain modalities or other types of pain tests.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/29/e5/painreports-8-e1085.PMC10287117.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9713373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trauma in childhood is associated with greater pain catastrophizing but not anxiety sensitivity: a cross-sectional study.","authors":"Ariane Delgado-Sanchez,&nbsp;Christopher Brown,&nbsp;Christiana Charalambous,&nbsp;Manoj Sivan,&nbsp;Anthony Jones","doi":"10.1097/PR9.0000000000001083","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001083","url":null,"abstract":"<p><strong>Introduction: </strong>Adverse life experiences have been identified as a possible vulnerability factor for chronic pain. This association could result from the effect of trauma on the psychological state of individuals. Previous studies found childhood trauma to be associated with pain catastrophizing and anxiety sensitivity, both of which have been associated with an increased risk of chronic pain. However, it is unknown whether trauma in adulthood affects these variables and whether the effect on pain catastrophizing is independent of confounds such as depression and anxiety.</p><p><strong>Objectives: </strong>To test the effect of childhood and adulthood trauma on pain catastrophizing and anxiety sensitivity whilst controlling for depression and anxiety.</p><p><strong>Methods: </strong>In the current study, we conducted an online survey in the United Kingdom in a chronic pain sample (N = 138; 123 women; age range 19-78). We analysed whether there is an association between different types of trauma (both in childhood and through the lifespan), pain catastrophizing, and anxiety sensitivity while controlling for anxiety and depression.</p><p><strong>Results: </strong>We found that childhood trauma (particularly emotional abuse) significantly predicts pain catastrophizing, even when controlling for depression and anxiety, whereas it did not have a significant effect on anxiety sensitivity. Trauma through the lifespan (not childhood) did not have a significant effect on anxiety sensitivity nor did it have a significant effect on pain catastrophizing.</p><p><strong>Conclusions: </strong>Our results show that the life stage in which trauma occurs is key in its psychological effects on patients with chronic pain. Furthermore, it shows that trauma affects some psychological variables but not others.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9737529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory pain affects alcohol intake in a dose-dependent manner in male rats in the intermittent access model.","authors":"Yolanda Campos-Jurado, Jose A Morón","doi":"10.1097/PR9.0000000000001082","DOIUrl":"10.1097/PR9.0000000000001082","url":null,"abstract":"<p><strong>Introduction: </strong>Epidemiological studies have shown that there is a relation between pain and alcohol use disorder (AUD). Persistent pain is directly correlated with an increment in alcohol consumption and an increased risk of developing an AUD. Greater levels of pain intensity and unpleasantness are associated with higher levels of relapse, an increase in alcohol consumption, rates of hazardous drinking, and delay to seek for treatment. However, this interaction has not been deeply studied in the preclinical setting.</p><p><strong>Methods: </strong>Here, we aim to evaluate how inflammatory pain affects levels of alcohol drinking in male and female rats with a history of alcohol. For that, we used an intermittent access 2-bottle choice paradigm combined with the complete Freund Adjuvant (CFA) model of inflammatory pain.</p><p><strong>Results: </strong>Our results show that CFA-induced inflammatory pain does not alter total intake of 20% alcohol in male or female rats. Interestingly, in males, the presence of CFA-induced inflammatory pain blunts the decrease of alcohol intake when higher concentrations of alcohol are available, whereas it does not have an effect on intake at any concentration in female rats.</p><p><strong>Conclusion: </strong>Altogether, this study provides relevant data and constitutes an important contribution to the study of pain and AUD and it highlights the necessity to design better behavioral paradigms in animal models that are more translational and reflect current epidemiological findings.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/98/82/painreports-8-e1082.PMC10306431.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10114987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-dose naltrexone for treatment of pain in patients with fibromyalgia: a randomized, double-blind, placebo-controlled, crossover study.","authors":"Kirsten Bested, Lotte M Jensen, Trine Andresen, Grete Tarp, Louise Skovbjerg, Torben S D Johansen, Anne V Schmedes, Ida K Storgaard, Jonna S Madsen, Mads U Werner, Anette Bendiksen","doi":"10.1097/PR9.0000000000001080","DOIUrl":"10.1097/PR9.0000000000001080","url":null,"abstract":"<p><strong>Introduction: </strong>Fibromyalgia (FM) is a chronic fluctuating, nociplastic pain condition. Naltrexone is a µ-opioid-receptor antagonist; preliminary studies have indicated a pain-relieving effect of low-dose naltrexone (LDN) in patients with FM. The impetus for studying LDN is the assumption of analgesic efficacy and thus reduction of adverse effects seen from conventional pharmacotherapy.</p><p><strong>Objectives: </strong><i>First</i>, to examine if LDN is associated with analgesic efficacy compared with control in the treatment of patients with FM. <i>Second</i>, to ascertain the analgesic efficacy of LDN in an experimental pain model in patients with FM evaluating the competence of the descending inhibitory pathways compared with controls. <i>Third,</i> to examine the pharmacokinetics of LDN.</p><p><strong>Methods: </strong>The study used a randomized, double-blind, placebo-controlled, crossover design and had a 3-phase setup. The first phase included baseline assessment and a treatment period (days -3 to 21), the second phase a washout period (days 22-32), and the third phase a baseline assessment followed by a treatment period (days 33-56). Treatment was with either LDN 4.5 mg or an inactive placebo given orally once daily. The primary outcomes were Fibromyalgia Impact Questionnaire revised (FIQR) scores and summed pain intensity ratings (SPIR).</p><p><strong>Results: </strong>Fifty-eight patients with FM were randomized. The median difference (IQR) for FIQR scores between LDN and placebo treatment was -1.65 (18.55; effect size = 0.15; <i>P</i> = 0.3). The median difference for SPIR scores was -0.33 (6.33; effect size = 0.13; <i>P</i> = 0.4).</p><p><strong>Conclusion: </strong>Outcome data did not indicate any clinically relevant analgesic efficacy of the LDN treatment in patients with FM.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10789452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45903023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative sensory testing as an assessment tool to predict the response to standard pain treatment in knee osteoarthritis: a systematic review and meta-analysis.","authors":"Kristian Kjær-Staal Petersen, Kübra Kilic, Emma Hertel, Trine Hyttel Sejersgaard-Jacobsen, Marlene Kanstrup Jørgensen, Anders Troelsen, Lars Arendt-Nielsen, Dennis Boye Larsen","doi":"10.1097/PR9.0000000000001079","DOIUrl":"10.1097/PR9.0000000000001079","url":null,"abstract":"<p><p>Emerging evidence suggest that quantitative sensory testing (QST) may predict the treatment response to pain-relieving therapies. This systematic review and meta-analysis focus on the predictive value of QST for pain management of knee osteoarthritis (OA). MEDLINE and EMBASE were systematically searched for all studies from year 2000 to 2023 on pretreatment QST and treatment of OA including surgical, pharmaceutical, and nonsurgical and nonpharmaceutical therapies. Preclinical studies and reviews were excluded. The systematic review followed the PRISMA guidelines and was pre-registered on the Open Science Framework website (link: https://osf.io/4FETK/, Identifier: DOI 10.17605/OSF.IO/4FETK). Meta-analysis were conducted to demonstrate the strength of the pre-treatment QST predictions on pain outcomes after OA treatments. Sixteen surgical (all on total knee arthroplasty [TKA], N = 1967), 5 pharmaceutical (4 on non-steroidal anti-inflammatory drugs [NSAIDs], N = 271), and 4 exercise-based therapy studies (N = 232) were identified. Pretreatment QST parameters predicted pain-relieving treatment outcomes in 81% of surgical, 100% of pharmaceutical, and 50% of exercise-based therapy studies. Meta-analyses found pretreatment QST profiles to predicted pain outcomes after TKA (random effects: 0.309, 95% confidence interval [CI]: 0.206-0.405, <i>P</i> < 0.001), NSAIDs (random effects: 0.323, 95% CI: 0.194-0.441, <i>P</i> < 0.001), and exercise-based therapies (random effects: 0.417, 95% CI: 0.138-0.635, <i>P</i> = 0.004). The overall risk of bias for the included studies was low to moderate. This systematic review and meta-analysis demonstrate weak-to-moderate associations between pretreatment QST and pain outcomes after standard OA pain treatments. Based on this work, it is hypothesized that a subset of specific pain sensitive patients with OA exist and that these patients do not respond adequately to standard OA pain treatments.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11065125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44372862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct trajectories of caregiver-toddler physiological attunement during routine vaccinations.","authors":"Miranda G Di Lorenzo-Klas,&nbsp;Jordana A Waxman,&nbsp;David B Flora,&nbsp;Louis A Schmidt,&nbsp;Hartley Garfield,&nbsp;Dan Flanders,&nbsp;Eitan Weinberg,&nbsp;Deena Savlov,&nbsp;Rebecca R Pillai Riddell","doi":"10.1097/PR9.0000000000001077","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001077","url":null,"abstract":"<p><strong>Introduction: </strong>Toddlers rely on their caregivers for regulatory support when faced with pain-related distress. The caregiver's ability to support their toddler relies on their capacity to regulate their own distress and respond effectively to the child's need for support. The aim of the current study was to describe patterns of caregiver-toddler physiological co-regulatory patterns, also known as attunement, during routine vaccinations across the second year of life.</p><p><strong>Methods: </strong>Caregiver-toddler dyads (N = 189) were part of a longitudinal cohort observed at either 12-, 18-, or 24-month well-baby vaccinations. Parallel-process growth-mixture modeling was used to examine patterns of dyadic physiological co-regulatory responses, indexed by high-frequency heart rate variability (HF-HRV).</p><p><strong>Results: </strong>Three groups of dyads were discerned. The largest group (approximately 80%) demonstrated physiological attunement, with a stable and parallel regulatory pattern of HF-HRV from baseline to postneedle. The second group (7.9%) had parallel regulatory trajectories but with notably lower (ie, less regulated) HF-HRV values, which indicates independent regulatory responses (ie, a lack of attunement among dyad members). The third group (11.1%) showed diverging regulatory trajectories: Caregivers showed a stable regulatory trajectory, but toddlers demonstrated a steep decrease followed by an increase in HF-HRV values that surpassed their baseline levels by the third minute postneedle. Post hoc analyses with the HF-HRV groupings explored heart rate patterns and potential predictors.</p><p><strong>Conclusions: </strong>These findings elucidate potential adaptive and maladaptive co-regulatory parasympathetic patterns in an acute pain context.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/97/9f/painreports-8-e1077.PMC10508426.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41156359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}