Cardiovascular diabetology. Endocrinology reports最新文献

{"title":"Diabetes-induced right ventricular remodeling precedes left ventricular remodeling and occurs via a distinct fatty acid uptake pathway.","authors":"Sushumna B Satyanarayana, Jaden S Campbell, Marjie P Schmitt, Jose E Campos, Rammohan Shukla, Donald F Smith, Sreejayan Nair, Danielle R Bruns","doi":"10.1186/s40842-026-00287-3","DOIUrl":"https://doi.org/10.1186/s40842-026-00287-3","url":null,"abstract":"","PeriodicalId":521069,"journal":{"name":"Cardiovascular diabetology. Endocrinology reports","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13141328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147848202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The long-term cardiovascular safety and efficacy of glucagon-like peptide-1 (GLP-1) receptor agonists in high-risk cardiovascular populations: a systematic review and meta-analysis.","authors":"Kezia Peter, Ocin Roka, Emma Sepp, Maya Warburton, Jufen Zhang, Simon C Cork","doi":"10.1186/s40842-026-00295-3","DOIUrl":"https://doi.org/10.1186/s40842-026-00295-3","url":null,"abstract":"<p><strong>Background: </strong>Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used for the management of type 2 diabetes and obesity, yet their long-term cardiovascular effects in high-risk populations continue to be actively evaluated. Given emerging evidence of both metabolic and direct cardiovascular actions, a comprehensive synthesis of cardiovascular outcome trial data is required to clarify the efficacy and safety of this drug class.</p><p><strong>Methods: </strong>We conducted a systematic review and meta-analysis of randomised, placebo-controlled cardiovascular outcome trials evaluating GLP-1RAs in adults at high cardiovascular risk. Searches of PubMed, Embase (via OVID), and the Cochrane Library were performed for studies published between January 2015 and May 2025, in accordance with PRISMA 2020 guidelines. Eligible trials included ≥ 3,000 participants with a minimum follow-up of 12 months. The primary outcome was major adverse cardiovascular events (MACE). Secondary outcomes included cardiovascular mortality, all-cause mortality, non-fatal myocardial infarction, non-fatal stroke, hospitalisation for heart failure, and adverse events. Hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled using random-effects meta-analysis. Risk of bias was assessed using the Cochrane RoB 2 tool, and certainty of evidence was evaluated using GRADE.</p><p><strong>Results: </strong>Eleven cardiovascular outcome trials comprising 91,490 participants were included, with a mean follow-up of 2.7 years. GLP-1RA treatment was associated with a significant reduction in MACE compared with placebo (HR 0.86, 95% CI 0.81-0.92). Meta-analysis also demonstrated significant reductions in cardiovascular mortality, all-cause mortality, non-fatal myocardial infarction, non-fatal stroke, and hospitalisation for heart failure. GLP-1RAs did not materially increase the risk of severe hypoglycaemia or acute pancreatitis, while gastrointestinal adverse effects were consistently more frequent.</p><p><strong>Conclusions: </strong>GLP-1 receptor agonists significantly reduce major cardiovascular events and mortality in high-risk populations, with a favourable long-term safety profile. These findings support the broader integration of GLP-1RAs into cardiovascular risk reduction strategies beyond glycaemic control.</p>","PeriodicalId":521069,"journal":{"name":"Cardiovascular diabetology. Endocrinology reports","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise volume modulates cardiac protection in a type 2 diabetic rat model: differential effects of high- and low-volume moderate-intensity endurance exercise training on diabetic cardiomyopathy.","authors":"Rob Simons, Ileana Bonilauri, Lotte Vastmans, Lisa Steegen, Ellen Heeren, Vincent Vandenboer, Eline Verghote, Sarah D'Haese, Guido Claessen, Ivo Lambrichts, Beatriz Martín-Fernández, Pieter-Jan Volders, Dominique Hansen, Dorien Deluyker, Virginie Bito","doi":"10.1186/s40842-026-00288-2","DOIUrl":"https://doi.org/10.1186/s40842-026-00288-2","url":null,"abstract":"","PeriodicalId":521069,"journal":{"name":"Cardiovascular diabetology. Endocrinology reports","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid hormone resistance beta and autoimmune thyroid disease - a family case study highlighting diagnostic and therapeutic challenges.","authors":"Mirjana Đukić, Zlata Kovačević, Karin Zibar Tomšić, Emir Muzurović","doi":"10.1186/s40842-026-00291-7","DOIUrl":"https://doi.org/10.1186/s40842-026-00291-7","url":null,"abstract":"","PeriodicalId":521069,"journal":{"name":"Cardiovascular diabetology. Endocrinology reports","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13122975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147795969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of cumulative exposure and dynamic change patterns of metabolic syndrome score with cardiometabolic multimorbidity progression among middle-aged and older Chinese adults: a longitudinal analysis based on CHARLS.","authors":"Jingjing Zhang, Xiaoyu Ding, Qiuyi Xia, Jialin Cong, Hairong Zhang, Zhicheng Song, Li Wang, Anye Du, Yuan Yuan","doi":"10.1186/s40842-026-00289-1","DOIUrl":"https://doi.org/10.1186/s40842-026-00289-1","url":null,"abstract":"","PeriodicalId":521069,"journal":{"name":"Cardiovascular diabetology. Endocrinology reports","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147795942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of semaglutide injection in Indian patients with type 2 diabetes mellitus inadequately controlled on metformin: a phase 3, randomized, active-controlled trial (SIZE-DM study).","authors":"Nitin Kapoor, Shehla Shaikh, Saptarshi Bhattacharya, Sanjay Kalra, Sambit Das, Sunil Kota, Vipul Khandelwal, Arindam Naskar, Amol Dange, Sanket Sorate, Mayura Choudhari, Narayan Deogaonkar, Jayashree Shembalkar, Deepak Varade, Shejole Vivek Samadhan, Shrikant Somani, Richa Giri, Jasminder Singh, Rajesh Kumar Palaparthi, Narendra Prasad, Paramesh Shamanna, Santosh Saklecha, Kushal Bangar, Aruna Mangipudi, Mayur Mayabhate, Nitin Kapure, Akhilesh Sharma, Radhakrishna Vaddem, Mukesh Jaiswal","doi":"10.1186/s40842-026-00290-8","DOIUrl":"https://doi.org/10.1186/s40842-026-00290-8","url":null,"abstract":"<p><strong>Background: </strong>This study evaluated the efficacy and safety of generic semaglutide compared with innovator Semaglutide in Indian adults with type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>This Phase 3, multicenter, randomized, active-controlled, non-inferiority trial enrolled 320 adults with T2DM inadequately controlled on metformin. Participants were randomized 1:1 to receive either generic semaglutide (Alkem laboratories Ltd.) or innovator Inj. semaglutide (Novo Nordisk) for 24 weeks in step-wise dose escalation from 0.25 mg/week to 2 mg/week. The primary endpoint was change in HbA1c from baseline to Week 24. Secondary endpoints included changes in fasting and post-prandial glucose, body weight, and proportion of patients achieving HbA1c < 7.0%. Safety assessments included adverse events, hypoglycemia, various laboratory parameters.</p><p><strong>Results: </strong>Of 320 participants randomized, 313 completed the study. Baseline demographic and clinical characteristics were comparable between groups. At Week 24, both treatments achieved significant HbA1c reductions (mean - 2.20%), with generic semaglutide demonstrating non-inferiority to the reference. Reductions in body weight, fasting and post-prandial glucose were similar between arms. A total of 86.62% of participants achieved HbA1c < 7.0%. Safety profiles were comparable, with predominantly mild-to-moderate adverse events and no treatment-related serious adverse events.</p><p><strong>Conclusion: </strong>Generic semaglutide demonstrated non-inferior efficacy and comparable safety to innovator Semaglutide in Indian adults with T2DM inadequately controlled on metformin, offering an effective and accessible therapeutic option in resource-limited settings.</p>","PeriodicalId":521069,"journal":{"name":"Cardiovascular diabetology. Endocrinology reports","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13107781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147795908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Epidemiology of cardiovascular disease and diabetes in 2026: expanding prevalence, escalating costs, and the limits of contemporary prevention.","authors":"Gaetano Santulli","doi":"10.1186/s40842-026-00297-1","DOIUrl":"https://doi.org/10.1186/s40842-026-00297-1","url":null,"abstract":"","PeriodicalId":521069,"journal":{"name":"Cardiovascular diabetology. Endocrinology reports","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147795944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The combined predictive value of the triglyceride-glucose index and A Body Shape Index on all-cause mortality: a 26-year prospective cohort analysis from the Rancho Bernardo Study.","authors":"Ziad Gerges, Agalya Ramkumar, Md Imran Hossain, Sui Seng Tee","doi":"10.1186/s40842-026-00284-6","DOIUrl":"10.1186/s40842-026-00284-6","url":null,"abstract":"","PeriodicalId":521069,"journal":{"name":"Cardiovascular diabetology. Endocrinology reports","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13093925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular disease risk factors in young people with diabetes mellitus.","authors":"Mumtaz Murat Yardimci","doi":"10.1186/s40842-026-00277-5","DOIUrl":"10.1186/s40842-026-00277-5","url":null,"abstract":"<p><strong>Background: </strong>The increasing prevalence of diabetes in young adults raises concerns regarding its early cardiometabolic consequences. This study aimed to evaluate cardiac function, renal markers, lipid profile, insulin resistance, and vascular risk indicators in young adults with diabetes compared with non-diabetic controls.</p><p><strong>Methods: </strong>This retrospective study included patients aged 18-45 years whose medical records were reviewed between 01/01/2012 and 31/12/2023. Clinical, metabolic, and cardiovascular parameters were analyzed to identify early cardiometabolic alterations associated with diabetes.</p><p><strong>Results: </strong>Young adults with diabetes demonstrated early signs of adverse cardiometabolic remodeling, characterized by mild reductions in ejection fraction, elevated myocardial stress biomarkers, atherogenic dyslipidemia, increased insulin resistance, and subtle renal alterations. Stent use was also more common among diabetic patients, reflecting greater cardiovascular burden. These differences remained consistent across multiple metabolic domains.</p><p><strong>Conclusion: </strong>Diabetes in young adults is associated with an early and unfavorable cardiometabolic phenotype, highlighting the need for proactive cardiovascular risk assessment and targeted preventive strategies. Future longitudinal studies incorporating metabolic, inflammatory, and imaging markers are warranted to clarify progression patterns and guide precision-based interventions.</p>","PeriodicalId":521069,"journal":{"name":"Cardiovascular diabetology. Endocrinology reports","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13051494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of empagliflozin on cardiac function and cardiorespiratory fitness in people with type 2 diabetes: a randomised controlled trial.","authors":"Natalie Nanayakkara, Michael L H Huang, Andre La Gerche, David M Kaye, Mark E Cooper, Murray D Esler, Anne T Reutens, Jonathan E Shaw, Alicia Jenkins, Neale D Cohen","doi":"10.1186/s40842-026-00281-9","DOIUrl":"10.1186/s40842-026-00281-9","url":null,"abstract":"","PeriodicalId":521069,"journal":{"name":"Cardiovascular diabetology. Endocrinology reports","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13041438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}