Cardiovascular diabetology. Endocrinology reports最新文献

{"title":"A cross-sectional study to determinate the relationship between body composition & neuropathy in patients with type 2 diabetes mellitus.","authors":"María Fernanda Garcés Pérez, Juan Enrique Santos Macías, Arnulfo González Cantú, Arnulfo Garza-Silva, Miguel Ángel Sanz Sánchez, María Elena Romero-Ibarguengoitia","doi":"10.1186/s40842-025-00216-w","DOIUrl":"10.1186/s40842-025-00216-w","url":null,"abstract":"<p><strong>Background: </strong>More information is required where the relation of diabetic neuropathy and body composition through bioimpedance is addressed. Therefore the aim of this study was to investigate the association between peripheral (PN) and autonomic neuropathy (AN) with bioimpedance in patients with type 2 diabetes mellitus (T2DM) aged 18 to 64 years.</p><p><strong>Methods: </strong>A cross-sectional study was conducted at a private hospital in Northeastern Mexico between November 2023 and March 2024. Patients with T2DM were evaluated using the Michigan Neuropathy Screening Instrument (MNSI) for PN, Sudoscan for AN, and bioimpedance analysis (InBody) for body composition. Other variables considered included diabetes duration, hemoglobin A1C (HbA1C), and lipid profile. Chi-square, T-test, and Wilcoxon tests were used for independent variables, Cohen's kappa for concordance, and logistic regression models for association analyses.</p><p><strong>Results: </strong>A total of 160 patients were analyzed, with a median (IQR) age of 51 (12) years, and a majority being male (n = 81, 51%). The prevalence of PN was 30% (n = 48) and AN was 35.6% (n = 57), with a Cohen's kappa concordance of 0.282. Patients with PN had higher median (IQR) visceral fat mass [20 (8.3) vs. 17 (10.3) kg, p = 0.010], arm fat mass [3.65 (3.35) vs. 2.70 (2.30) kg, p = 0.004], torso fat percentage [485 (166) vs. 369 (173), p < 0.001], arm circumference [40.1 (7.4) vs. 36.4 (5.7) cm, p < 0.001], arm muscle circumference [32.1 (3.8) vs. 30.7 (4.7) cm, p = 0.008], and skeletal muscle index (SMI) [8.35 (1.25) vs. 7.95 (1.55), p = 0.009]. For AN, a higher torso muscle percentage was observed [105.2 (6.2) vs. 103.3 (7), p = 0.02]. No significant differences were found in HbA1C or lipid profile. Logistic regression for PN showed associations with T2DM duration (OR = 1.111, p = 0.006), age (OR = 1.080, p = 0.004), leg fat mass (OR = 187.197, p = 0.003), and SMI (OR = 0.612, p = 0.021), with a Nagelkerke R² of 0.328. No significant predictors were found for AN.</p><p><strong>Conclusion: </strong>A high prevalence of neuropathy was observed, with a significant association between body composition and PN, highlighting greater adiposity in limbs, torso, and visceral fat, as well as age, T2DM duration, and SMI.</p>","PeriodicalId":521069,"journal":{"name":"Cardiovascular diabetology. Endocrinology reports","volume":"11 1","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11964148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Long-term TNF-alpha therapy for preserving beta cell function in new onset type 1 diabetes: a case report.","authors":"Adya Rao, Lauren M Quinn, Parth Narendran","doi":"10.1186/s40842-025-00217-9","DOIUrl":"10.1186/s40842-025-00217-9","url":null,"abstract":"","PeriodicalId":521069,"journal":{"name":"Cardiovascular diabetology. Endocrinology reports","volume":"11 1","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11964146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between type II diabetes mellitus and oral health status among middle-aged iranians patients.","authors":"Forough Ahrari, Hamidreza Zivarifar, Tahereh Ahrari Roodi, Leili Alizadeh","doi":"10.1186/s40842-024-00205-5","DOIUrl":"10.1186/s40842-024-00205-5","url":null,"abstract":"<p><strong>Background and aim: </strong>Type 2 diabetes is among the most prevalent endocrine disruptors. One of the most significant symptoms reported by diabetic patients is dry mouth, which results in reduced saliva buffering capacity and an increased risk of dental caries. So, the purpose of this study was to compare the oral health indicators of type 2 diabetic patients with non-diabetic controls.</p><p><strong>Materials and methods: </strong>In this case-control study, A total of 306 individuals included in the study (103 T2DM cases and 203 non-diabetic controls) in the age range of 40 to 60 years old. Participants were interviewed using a structured questionnaire including socio-demographics and oral health related to dry mouth factors. The clinical examination included full-mouth probing depths and an assessment of oral mucosal conditions and to identify any mucosal lesions. Data analysis was performed using SPSS software with a significance level set at 5%.</p><p><strong>Results: </strong>The patients had more probing depths > 4 mm, tooth mobility, furcation involvement and missing teeth. The mean score of dry mouth and DMFT indexes were 3.38 ± 2.64, 2.17 ± 1.09 and 19.33 ± 9.54, 15.48 ± 6.93 in the case and control groups respectively. The adjusted odds ratios (AOR) and their 95% confidence Intervals (CI) reported a significant association as 2.96 (1.36-6.45), 5.90 (2.26-15.39), 0.23 (0.08-0.63) and 4.07 (1.74-9.49) for the above variables respectively.</p><p><strong>Conclusion: </strong>Overall, the results of this study highlight that chronic periodontitis, tooth mobility, furcation and involvement were more prevalent among T2DM patients compared to non-diabetic controls. By recognizing these relationships and implementing targeted interventions, healthcare providers can improve oral health outcomes.</p>","PeriodicalId":521069,"journal":{"name":"Cardiovascular diabetology. Endocrinology reports","volume":"11 1","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11964097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of gestational diabetes mellitus and diabetes mellitus on lipid profile, antioxidants, hormones and electrolytes status in a population of Nigerian women.","authors":"Moses Orimoloye Akinjiyan, Adeniran Samuel Atiba, Modupe Fisayo Asaolu","doi":"10.1186/s40842-024-00206-4","DOIUrl":"10.1186/s40842-024-00206-4","url":null,"abstract":"<p><strong>Aim: </strong>Gestational diabetes mellitus (GDM) cases are rising globally. This research examined the effects of GDM and diabetes mellitus whose hallmark is hyperglycemia on hormones, lipid profiles, electrolytes and antioxidants in freshly diagnosed women attending teaching hospitals in Ekiti State, Nigeria.</p><p><strong>Methods: </strong>The cross-sectional design followed convenience sampling in four groups (n = 50): gestational diabetes women (GDM), normal pregnant women (NP), diabetes nonpregnant women (DM) and nondiabetes nonpregnant women (ND-NP). Blood samples were collected from fasting subjects through antecubital fossa. BMI, FPG, TC, TG, LDL-C, HDL-C, sodium, potassium and bicarbonate ions, MDA and antioxidants were investigated using standard procedures and spectrophotometer. Results were analysed using one-way ANOVA and p < 0.05 was used as significant difference.</p><p><strong>Results: </strong>There was significant (p < 0.05) increase in FPG of GDM and DM (> 5.56 mmol/l) subjects compared to NP and ND-NP subjects. TC, TG, HDL-C and LDL-C were elevated in GDM and DM groups compared to NP and ND-NP groups. Sodium ion concentration was significantly (p˂0.05) elevated in ND-NP group relative to GDM and DM groups. There was significant (p < 0.05) increase in MDA levels in DM and NP groups compared to ND-NP. Superoxide dismutase activity was significantly (p < 0.05) greater in ND-NP than in DM and NP. Progesterone level was greater in GDM group than in other groups. The FSH concentration was lower in the GDM and NP groups than in the DM and ND-NP groups, and prolactin concentration was greater in the GDM group than in the NP.</p><p><strong>Conclusion: </strong>This study suggested that GDM and DM could result in hormonal and electrolyte imbalances, elevated lipid profiles, and reduced antioxidant levels.</p>","PeriodicalId":521069,"journal":{"name":"Cardiovascular diabetology. Endocrinology reports","volume":"11 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11964098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}