Cardiovascular diabetology. Endocrinology reports最新文献

{"title":"Epidemiology of cardiovascular disease and diabetes in 2026: expanding prevalence, escalating costs, and the limits of contemporary prevention.","authors":"Gaetano Santulli","doi":"10.1186/s40842-026-00283-7","DOIUrl":"10.1186/s40842-026-00283-7","url":null,"abstract":"","PeriodicalId":521069,"journal":{"name":"Cardiovascular diabetology. Endocrinology reports","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13041046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A one-week reduced-carbohydrate diet lowers insulin requirements and shifts the IGF axis with no detectable short-term change in endothelial function in a randomized, crossover trial of adults with type 1 diabetes.","authors":"M Naweed Akbar, T Jordan Smith, Sivaprakasam Chinnarasu, Wendi Welch, Wang Zuofei, Bridget Litts, Lauren M LeStourgeon, Mohammad Saleem, Mohd Mabood Khan, Annet Kirabo, Justin M Gregory","doi":"10.1186/s40842-026-00276-6","DOIUrl":"10.1186/s40842-026-00276-6","url":null,"abstract":"<p><strong>Background: </strong>Individuals with type 1 diabetes mellitus (T1DM) must deliver insulin into the peripheral circulation rather than more physiologically into the hepatic portal circulation, leading to a chronic state of underinsulinization in the liver. Previous research suggests that decreased hepatic insulin perturbs the growth hormone-IGF-1 system in these patients. We tested whether short-term carbohydrate restriction, by lowering exogenous insulin requirements and exacerbating hepatic underinsulinization, modifies IGF axis hormones, binding proteins, and vascular function.</p><p><strong>Methods: </strong>We performed a secondary analysis of plasma samples collected during a single-blind crossover study of twelve adults with T1DM using automated insulin delivery. In random order, the participants consumed a one-week reduced carbohydrate diet (RCD) and an isocaloric standard carbohydrate diet (SCD), each followed by a study visit. We measured total and free IGF-1 and IGF-binding proteins (IGFBP-1, IGFBP-2, and IGFBP-3) after overnight fasting and during the final 30 min of a hyperinsulinemic-euglycemic clamp. We also measured endothelial function using brachial artery flow-mediated dilation (FMD).</p><p><strong>Results: </strong>The RCD lowered the total daily insulin dose versus SCD (16% during the week and 24% in the 24 h before testing), with similar glucose levels across diets. Compared with SCD, RCD reduced total IGF-1 and IGFBP-3 and increased IGFBP-1 and IGFBP-2 at baseline. These patterns also persisted during insulin-stimulated conditions. Free IGF-1 was more variable and did not differ significantly between diets. Despite clear shifts in the IGF axis, FMD did not differ between diets and did not correlate with IGF axis markers after either intervention.</p><p><strong>Conclusions: </strong>In adults with T1DM studied under nearly matched glycemia, one week of carbohydrate reduction lowered insulin requirements and shifted the IGF axis in a pattern akin to reduced portal insulin exposure, without detectable changes in conduit artery endothelial function. These findings identify the IGF axis as a sensitive physiologic readout of insulin exposure. Longer-term studies are needed to determine whether sustained changes in the IGF axis impact vascular biology or cardiometabolic risk.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov NCT04118374.</p>","PeriodicalId":521069,"journal":{"name":"Cardiovascular diabetology. Endocrinology reports","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13020340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147518329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fuel toxicity-associated spectrum (FTAS): a unifying nomenclature for metabolic disorders.","authors":"Pichakacheri Sureshkumar","doi":"10.1186/s40842-026-00282-8","DOIUrl":"10.1186/s40842-026-00282-8","url":null,"abstract":"","PeriodicalId":521069,"journal":{"name":"Cardiovascular diabetology. Endocrinology reports","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12998352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147477910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in the use of sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists among ischemic stroke patients.","authors":"Qinglan Ding, Jason J Sico, Anthony J Perkins, Laura J Myers, Joanne K Daggy, Ali Sexson, Stanley E Taylor, Laura Burrone, Kimberly Waddell, Dawn M Bravata","doi":"10.1186/s40842-026-00280-w","DOIUrl":"10.1186/s40842-026-00280-w","url":null,"abstract":"","PeriodicalId":521069,"journal":{"name":"Cardiovascular diabetology. Endocrinology reports","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12973876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147392239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A bibliometric analysis of systematic reviews and meta-analyses on diabetes mellitus: global research trends from scopus database (1988-2024).","authors":"Alaleh Dalvand, Hossein Aazami, Hassan Akbarniakhaky, Sajad Parvar, Reza Habibi, Ghazal Mohammadi, Ali Faryabi, Hojat Dehghanbanadaki","doi":"10.1186/s40842-026-00272-w","DOIUrl":"10.1186/s40842-026-00272-w","url":null,"abstract":"","PeriodicalId":521069,"journal":{"name":"Cardiovascular diabetology. Endocrinology reports","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12964769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147367822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metformin and beyond: glucose-lowering therapy as a potential modulator of abdominal aortic aneurysm growth and stability- systematic review with narrative synthesis.","authors":"Margaret Plamenova Dimova, Bistra Petrova Boneva, Boris Nikolaev Ilchev, Yanislava Ivo Karusheva","doi":"10.1186/s40842-026-00275-7","DOIUrl":"10.1186/s40842-026-00275-7","url":null,"abstract":"","PeriodicalId":521069,"journal":{"name":"Cardiovascular diabetology. Endocrinology reports","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12950239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147322776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the heterogeneity of T2DM: a narrative review of clustering algorithms in stratifying comorbidity and complication risk.","authors":"Namra Aziz, Neha Kamran, Aysha Almas, Gerald S Bloomfield, Asma Ahmed, Zainab Samad, Tariq Mahmood","doi":"10.1186/s40842-026-00273-9","DOIUrl":"10.1186/s40842-026-00273-9","url":null,"abstract":"","PeriodicalId":521069,"journal":{"name":"Cardiovascular diabetology. Endocrinology reports","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12949498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147319070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of orforglipron, an oral small-molecule GLP-1 receptor agonist, on cardiometabolic outcomes: a meta-analysis and systematic review.","authors":"Adir Alper, Gal Peleg, Adina Fagin, Priyansh Shah, Ishmum Chowdhury, Antony Gonzales, Robert Faillace","doi":"10.1186/s40842-025-00270-4","DOIUrl":"10.1186/s40842-025-00270-4","url":null,"abstract":"","PeriodicalId":521069,"journal":{"name":"Cardiovascular diabetology. Endocrinology reports","volume":"12 1","pages":"9"},"PeriodicalIF":0.0,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12922244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antihypertensive therapy in diabetes mellitus: efficacy, safety, and metabolic impacts in type 1 and type 2 diabetes.","authors":"Pooja Joshi, Griffin Rick, Srihitha Mesineni, Sujan Bohara, Sehrish Atif, Nandakumar Poonthottam, Aiesha Azam, Yasir Mehmood, Ramsha Ali, Naama Raquib, Abhijith Sasikumar, Areeba Khalid, Onyekachi Emmanuel Anyagwa","doi":"10.1186/s40842-025-00268-y","DOIUrl":"10.1186/s40842-025-00268-y","url":null,"abstract":"","PeriodicalId":521069,"journal":{"name":"Cardiovascular diabetology. Endocrinology reports","volume":"12 1","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12914936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146215509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid-based atherogenic indices and their relationship with cardiovascular disease risk in an African population of type 2 diabetes mellitus patients.","authors":"Izuchukwu Nnachi Mba, Bruno Basil, Jamila Aminu Mohammed, Chizoba Joseph Akujieze, Blessing Kenechi Myke-Mbata","doi":"10.1186/s40842-025-00269-x","DOIUrl":"10.1186/s40842-025-00269-x","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM), driven largely by atherogenic dyslipidaemia. Conventional lipid parameters such as total and low-density lipoprotein cholesterol (LDL-C) do not adequately reflect the complex lipid disturbances that characterize T2DM. Composite lipid-based indices offer inexpensive and integrative measures of cardiovascular risk, but their predictive utility in African populations remains poorly characterized. This study investigated the association between multiple atherogenic indices and 10-year estimated CVD risk in Nigerian adults with T2DM.</p><p><strong>Methods: </strong>In this analytical cross-sectional study, 197 adults with T2DM aged 40-74 years without established CVD were included in the final analysis from an endocrinology clinic in Makurdi, Nigeria. Sociodemographic, clinical, and fasting lipid data were collected. Ten-year CVD risk was estimated using the World Health Organization (WHO) risk prediction laboratory-based chart for Western sub-Saharan Africa. Several atherogenic indices were derived, and a series of hierarchical multiple regression analyses was used to determine their comparative incremental predictive value beyond traditional risk factors like age, systolic blood pressure, diabetes duration, anti-lipid therapy, and anti-hypertensive therapy. Receiver operating characteristic (ROC) analysis assessed their discriminatory performance for elevated CVD risk (≥ 10%).</p><p><strong>Results: </strong>Traditional risk factors accounted for 72.4% of the variance in estimated 10-year CVD risk. Non-high-density lipoprotein cholesterol (non-HDL-C) demonstrated the strongest incremental predictive value, explaining an additional 6.2% of the variance (ΔR² = 0.062, p < 0.001). Other cholesterol-based ratios (CRI-II, CRI-I) added minor, significant value, but triglyceride-centric indices like the Atherogenic Index of Plasma (AIP) did not. However, none of the indices alone demonstrated significant discriminative power in ROC analysis.</p><p><strong>Conclusions: </strong>In this study population, non-HDL-C significantly enhances the prediction of 10-year CVD risk beyond conventional factors, outperforming other cholesterol-based ratios. Triglyceride-centric indices, including AIP, offered no significant incremental value. Therefore, incorporating this low-cost index into existing risk assessment frameworks could strengthen early identification of high-risk individuals in resource-limited settings.</p><p><strong>Clinical trial number: </strong>Not Applicable.</p>","PeriodicalId":521069,"journal":{"name":"Cardiovascular diabetology. Endocrinology reports","volume":"12 1","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12888452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146152155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}