Post reproductive health最新文献_第6页

Post reproductive health Pub Date : 2025-09-01 Epub Date: 2025-09-14 DOI: 10.1177/20533691251368695

Ann Jones, Edward Morris

引用次数: 0

Rethinking sarcopenia and frailty of the elderly. 老年人肌肉减少症与虚弱的再思考。

Post reproductive health Pub Date : 2025-09-01 Epub Date: 2025-04-22 DOI: 10.1177/20533691251337173

Janice Blumer, Bachtuyet Le

{"title":"Rethinking sarcopenia and frailty of the elderly.","authors":"Janice Blumer, Bachtuyet Le","doi":"10.1177/20533691251337173","DOIUrl":"10.1177/20533691251337173","url":null,"abstract":"Sarcopenia, or 'frailty of the elderly', is a condition of low muscle mass which is prevalent in older adults and post-menopausal women, leading to falls or worsening after falls. Age-related muscle thinning contributes to falls and fractures. Fractures lead to downward spiral toward the loss of independence in the elderly and ultimately, increased health care expenditures of approximately 4 billion pounds a year. The diagnosis of sarcopenia is based on muscle mass, muscle strength, and physical performance. Sarcopenia is caused by imbalance between the anabolic and catabolic processes on the protein production pathway, as well as a decrease in satellite cells. Denervation, inflammation, hormonal changes, and mitochondrial decline further complicate the issue. Is it time that physicians begin to rethink the diagnosis of sarcopenia or frailty as a process that begins in mid-life? In women, it begins in menopause and ends with falls, fractures, or immobility due to weakness. Physicians often question which came first; frailty causing the fall or the fall worsening frailty, which leads to challenges in treatment. Sarcopenia treatment involves resistance training, appropriate diet and being proactive about the diagnosis. These low-risk lifestyle interventions should be recommended during mid-life well woman visits. Physicians can influence the outcomes of sarcopenia simply by providing an exercise prescription, supplement, and diet recommendation in early menopause. This article aims to change the thinking around sarcopenia from an 'end stage' diagnosis to a mid-life discussion around disease prevention and maintenance of health and muscle.","PeriodicalId":52104,"journal":{"name":"Post reproductive health","volume":" ","pages":"184-187"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular outcomes of menopause hormone therapy initiated in women aged ≥60 years or ≥10 years post-menopause: A systematic review of the literature. ≥60岁或≥10年绝经后妇女开始绝经激素治疗的心血管结局：文献系统综述

Post reproductive health Pub Date : 2025-09-01 Epub Date: 2025-05-09 DOI: 10.1177/20533691251341713

Nancy Yaneth Contreras Garza, José Antonio Dávila Rivas, Carlos Félix Arce, María Elizabeth Fraustro Avila, Celina Salas Castro, Sergio Alejandro Villarreal González, Grecia Villa Cruz, Belinda Maricela Contreras Garza, José Luis Neyro Bilbao

{"title":"Cardiovascular outcomes of menopause hormone therapy initiated in women aged ≥60 years or ≥10 years post-menopause: A systematic review of the literature.","authors":"Nancy Yaneth Contreras Garza, José Antonio Dávila Rivas, Carlos Félix Arce, María Elizabeth Fraustro Avila, Celina Salas Castro, Sergio Alejandro Villarreal González, Grecia Villa Cruz, Belinda Maricela Contreras Garza, José Luis Neyro Bilbao","doi":"10.1177/20533691251341713","DOIUrl":"10.1177/20533691251341713","url":null,"abstract":"IntroductionMenopause hormone therapy (MHT) is the most effective treatment for climacteric syndrome. However, its cardiovascular effects remain complex. The 'timing hypothesis' suggests these effects depend on the timing of initiation, but this has been increasingly questioned. This study evaluates evidence on cardiovascular risks associated with late MHT initiation in healthy women aged ≥60 years or ≥10 years post-menopause.MethodsA comprehensive literature search was conducted from the inception of each database until November 2023. The databases searched included PubMed, SciELO, Embase, and Cochrane. RCTs of human studies examining the cardiovascular effects of MHT in healthy women aged ≥60 years or those ≥10 years post-menopause were included. Eligibility screening, data extraction, risk of bias assessment were performed independently and in duplicate.ResultsNine RCTs comprising 36,051 participants were included. We focus on results from participants aged ≥60 years. The mean follow-up was 7.2 years. Six studies were sub-analyses of the Women's Health Initiative (WHI) trial, while three studies originated from other trials. Results from the WHI indicated no significant increase in cardiovascular risks with either CEE + MPA or Estrogen-only therapy. Non-WHI studies showed an elevated stroke risk with tibolone and higher doses of combined MHT, but no cardiovascular complications were observed with low doses.ConclusionThe increased risk of cardiovascular events in our target population is not statistically significant. There is a lack of high-quality evidence to suggest an increased risk of adverse cardiovascular outcomes in healthy women who initiate MHT at age ≥60 years or ≥10 years post-menopause.","PeriodicalId":52104,"journal":{"name":"Post reproductive health","volume":" ","pages":"173-183"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Results of a patient survey exploring skin symptoms in a menopause clinic. 绝经期门诊患者皮肤症状调查结果。

Post reproductive health Pub Date : 2025-09-01 Epub Date: 2025-04-02 DOI: 10.1177/20533691251332403

Hamisha Salih, Zoe Schaedel, Olivia Hum, Claudia DeGiovanni

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Uniting minds and advancing menopause care: Reflections from the 2025 British Menopause Society Conference. 团结思想，推进更年期护理：从2025年英国更年期学会会议的反思。

Post reproductive health Pub Date : 2025-09-01 Epub Date: 2025-08-22 DOI: 10.1177/20533691251366801

Katie Barber, Nick Panay

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News and views. 新闻和观点。

Post reproductive health Pub Date : 2025-09-01 Epub Date: 2025-08-12 DOI: 10.1177/20533691251368694

Simon Brown

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The gut microbiota in menopause: Is there a role for prebiotic and probiotic solutions? 绝经期的肠道微生物群：益生元和益生菌解决方案是否有作用？

Post reproductive health Pub Date : 2025-06-01 Epub Date: 2025-05-07 DOI: 10.1177/20533691251340491

Marrium Liaquat, Anne Marie Minihane, David Vauzour, Matthew G Pontifex

{"title":"The gut microbiota in menopause: Is there a role for prebiotic and probiotic solutions?","authors":"Marrium Liaquat, Anne Marie Minihane, David Vauzour, Matthew G Pontifex","doi":"10.1177/20533691251340491","DOIUrl":"10.1177/20533691251340491","url":null,"abstract":"The gut microbiota, comprising a diverse array of microorganisms in the gastrointestinal tract, has emerged as a key player in human health. Emerging research indicates that this gut microbial composition is influenced by sex. These sex differences are not necessarily static and likely alter across the life course in response to several factors including changing hormone profile. As such, the menopause transition-a pivotal phase in female ageing in which the hormone profile changes dramatically is receiving increasing attention. Declining estrogen which occurs during menopause appears to influence the microbiota, which may in turn contribute to menopause-related conditions such as weight gain, bone health, cancer risk and cognitive health. The modulation of estrogen through the gut's 'estrobolome', a collection of bacterial genes involved in estrogen metabolism, may offer explanation for some of the interindividual differences observed during menopause (e.g. length, symptoms and disease risk). Therapeutic modulation of the gut microbiota therefore represents a potential approach towards managing menopausal symptoms. Indeed, prebiotics and probiotics such as Lactobacillus have been shown to increase bacterial diversity and improve metabolic and overall health in menopausal women. However, evidence remains limited regarding the specific underlying mechanisms, highlighting an urgent need for a research focus in the area. This review summarizes the current understanding of the gut microbiota's role in menopausal health and the potential of prebiotics and probiotics as therapeutic interventions. Further research into gut microbiota modulation may enable more effective, personalised treatments for menopause-associated health challenges, and supporting women's health into older ages.","PeriodicalId":52104,"journal":{"name":"Post reproductive health","volume":" ","pages":"105-114"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary patterns and their associations with body composition, cardiometabolic and bone health in postmenopausal women. 绝经后妇女的饮食模式及其与身体组成、心脏代谢和骨骼健康的关系

Post reproductive health Pub Date : 2025-06-01 Epub Date: 2025-05-02 DOI: 10.1177/20533691251339566

Nicola Best

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Nutrition and menopausal well-being. 营养和更年期健康。

Post reproductive health Pub Date : 2025-06-01 Epub Date: 2025-07-02 DOI: 10.1177/20533691251345940

Anne Marie Minihane

引用次数: 0

Dietary interventions to support and improve sleep disturbances and insomnia disorder in menopause: From bench to bedside. 饮食干预支持和改善更年期睡眠障碍和失眠症：从实验室到床边。

Post reproductive health Pub Date : 2025-06-01 Epub Date: 2025-07-02 DOI: 10.1177/20533691251350518

Rosie H Musgrave, Sara Nowakowski, Tamlyn J Watermeyer, Emily J Arentson-Lantz, Greg J Elder

{"title":"Dietary interventions to support and improve sleep disturbances and insomnia disorder in menopause: From bench to bedside.","authors":"Rosie H Musgrave, Sara Nowakowski, Tamlyn J Watermeyer, Emily J Arentson-Lantz, Greg J Elder","doi":"10.1177/20533691251350518","DOIUrl":"10.1177/20533691251350518","url":null,"abstract":"Sleep is essential for maintaining physical and psychological health, and also cognitive health (referred to as 'brain health'). However, the transition to menopause has a direct impact upon sleep. Sleep disturbances are reported by approximately 40%-60% of menopausal women, and insomnia disorder is also prevalent. Diet-based interventions could potentially be used to improve subjective sleep quality in this population, and although there are several promising interventions which have been used in other groups that could be trialled, the evidence base is currently lacking. One particularly promising area for future research is that these interventions might be used alongside, or instead of, established treatments for insomnia disorder. This may also help to prevent the development of longer-term insomnia disorder. Future studies should use well-controlled, adequately powered, clinical trial designs to assess the effectiveness of dietary interventions in improving subjective sleep quality, treating insomnia disorder, and preventing acute sleep disturbances from progressing to chronic insomnia. Given the strong association between sleep and neurodegeneration, optimizing sleep in menopausal women, using targeted diet-based strategies, may have significant implications for brain health.","PeriodicalId":52104,"journal":{"name":"Post reproductive health","volume":"31 2","pages":"122-126"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0