Post reproductive health最新文献

{"title":"Autism, ADHD and the menopause.","authors":"Rachel L Moseley, Julie M Gamble-Turner, Eunhee Kim, Clare Spencer","doi":"10.1080/20533691.2026.2631222","DOIUrl":"10.1080/20533691.2026.2631222","url":null,"abstract":"<p><p>There is increasing awareness that neurodivergent people, particularly those who are autistic or have ADHD (ADHDers), may have a particularly difficult time during menopause. The menopausal transition can amplify aspects of neurodivergence which make everyday life challenging, and can exacerbate co-occurring mental and physical health conditions which are highly likely in these populations. In this article, we provide practical guidance for healthcare professionals towards understanding: the key features of autism and ADHD, and their relevance to a menopause context; what difficulties autistic people and ADHDers might experience during menopause; optimal management of symptoms in these neurodivergent patients, and how best to support them; and how to recognise undiagnosed individuals, and what to do next.</p>","PeriodicalId":52104,"journal":{"name":"Post reproductive health","volume":" ","pages":"145-155"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148551410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopausal 'brain fog' or dementia?-a practical guide for clinicians.","authors":"Kathy Abernethy, Caroline Gurvich, Aimee Spector","doi":"10.1080/20533691.2026.2705046","DOIUrl":"10.1080/20533691.2026.2705046","url":null,"abstract":"<p><p>Cognitive symptoms commonly described by patients as menopausal 'brain fog' are increasingly recognised during the menopause transition and can cause significant distress, anxiety and concern about early dementia. This BMS Tool for Clinicians provides a practical clinical overview of how to distinguish menopause-related cognitive symptoms from mild cognitive impairment and dementia. Brain fog around the time of menopause is typically subjective, fluctuating and associated with perimenopausal symptoms such as sleep disturbance, vasomotor symptoms and mood change, while dementia is more likely to be progressive, objectively impairing and associated with functional decline. The Tool summarises key features for history-taking, assessment and escalation, including consideration of medical, psychological and lifestyle contributors. It highlights the importance of reassurance, education, management of modifiable factors, workplace support and appropriate use of hormone therapy where indicated. A structured approach can help clinicians validate patient concerns while identifying red flags that require further cognitive assessment or specialist referral.</p>","PeriodicalId":52104,"journal":{"name":"Post reproductive health","volume":" ","pages":"217-221"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review- hormone replacement therapy in postmenopausal women with medical co-morbidities.","authors":"Garima Sachdeva, Geeta Kumar, Bidyut Kumar","doi":"10.1080/20533691.2026.2690376","DOIUrl":"10.1080/20533691.2026.2690376","url":null,"abstract":"<p><strong>Background: </strong>Safety and efficacy of HRT in women with chronic medical conditions remain incompletely understood. As life expectancy rises and the use of HRT becomes more common, condition-specific recommendations are crucial to support clinical decisions.</p><p><strong>Objectives: </strong>Systematic review on disease-specific effects of HRT in peri- and postmenopausal women with chronic medical disorders.</p><p><strong>Data sources: </strong>Comprehensive search of PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Science was conducted from inception to 31 August 2025. Cross reference was undertaken.</p><p><strong>Eligibility criteria: </strong>Systematic reviews, meta-analysis, Randomised controlled trials, cohort, and case-control studies examining oral, transdermal, or other HRT formulations in peri- or postmenopausal women with chronic diseases were included. Case reports, editorials, conference abstracts, and non-English publications were excluded.</p><p><strong>Methodology: </strong>Titles, abstracts, and full-text articles were independently evaluated by three reviewers. Data extraction included study design, participant characteristics, HRT regimen, and outcomes.</p><p><strong>Results: </strong>Fifty-four studies met inclusion criteria, covering neurological (epilepsy, migraine, Alzheimer's, Parkinson's, multiple sclerosis, meningioma), metabolic, cardiovascular, autoimmune, renal, hepatic, and endocrine conditions. Oral estrogen formulations may increase risk whereas transdermal preparations may confer lower thrombotic and hepatic risk (limited evidence). Neurological benefits were observed in Parkinson's disease and multiple sclerosis, but evidence was limited for Alzheimer's disease and migraine. HRT was generally safe in stable autoimmune conditions. Cardiovascular safety is supported in women without pre-existing disease.</p><p><strong>Conclusions: </strong>HRT should be individualised according to comorbidities, formulation, and route, with preference for transdermal or low-dose regimens in high-risk populations.</p><p><p>Registration: PROSPERO ID CRD420251233527.</p>","PeriodicalId":52104,"journal":{"name":"Post reproductive health","volume":" ","pages":"157-168"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148431463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of menopause on dry eye disease: a cross-sectional comparative study.","authors":"Harshita Pandey, Raj Kumar","doi":"10.1080/20533691.2026.2659566","DOIUrl":"10.1080/20533691.2026.2659566","url":null,"abstract":"<p><strong>Background: </strong>Post-menopausal women frequently experience ocular dryness, with a notably greater severity of clinical symptoms and signs. Despite the high burden of dry eye disease in this population, limited evidence exists regarding the underlying nature and characteristics of this condition.</p><p><strong>Methods: </strong>In this cross-sectional comparative study, 319 participants were enrolled: 102 post-menopausal women, 105 age-matched men, and 112 younger healthy females. Assessments included the Ocular Surface Disease Index (OSDI), tear breakup time, corneal and conjunctival staining, Schirmer's test, and meibomian gland evaluations. Severity was classified using established clinical criteria. Multivariable logistic regression was performed to identify predictors of severe DED.</p><p><strong>Results: </strong>Post-menopausal women exhibited significantly higher mean OSDI scores (24.1 ± 16.5) compared to age-matched men (20.2 ± 16.7) and younger females (19.8 ± 15.3; <i>p</i> = 0.043). They also had notably shorter TBUT, greater ocular surface staining, and more pronounced meibomian gland dysfunction. Burning (20.6%) and itching were more frequent in this group (<i>p</i> < 0.05). Severe DED prevalence was highest among post-menopausal women (24.5%), versus age-matched men (16.2%) and younger females (18.8%; <i>p</i> = 0.047). Multivariable regression analysis identified burning symptoms as a significant predictor of severe DED (OR ∼ 2.40), while post-menopausal status (OR ∼ 1.19) and lid-margin changes (OR ∼ 1.42) showed weaker associations.</p><p><strong>Conclusion: </strong>DED in post-menopausal women is more severe and predominantly exhibits an evaporative profile, characterised by tear film instability and meibomian gland dysfunction.</p>","PeriodicalId":52104,"journal":{"name":"Post reproductive health","volume":" ","pages":"169-175"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148551450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of sexual function according to age in women referred to urogynaecology clinics.","authors":"Victoria Kershaw, Ruth Athey, Olivia Baggaley, Thomas Gray, Stephen Radley","doi":"10.1080/20533691.2026.2706024","DOIUrl":"https://doi.org/10.1080/20533691.2026.2706024","url":null,"abstract":"<p><strong>Objective: </strong>Sex can be an important aspect of life with no upper age limit; however, research into sexual function in older women is limited. This multi-centre study aims to assess the relationship between age and sexual activity/function, in women attending urogynaecology clinics.</p><p><strong>Study design: </strong>Data collected using the validated electronic Personal Assessment Questionnaire - Pelvic Floor patient reported outcome measure were collated from seven public UK Hospitals between April 2018 and January 2022.</p><p><strong>Main outcome measures: </strong>The primary outcome was the proportion of sexually active women in each age group category. Secondary outcomes were symptom scores and impact factor scores for domains of sexual function, and their correlation with age.</p><p><strong>Results: </strong>There were 1,2877 responses obtained, of which 8372 were valid for inclusion. Sexual activity decreased with increasing age (<i>p</i> < .001). In the majority of sexual function domains, peak symptom and impact scores were found in women aged 40-59. 'Body Image' peak scores were observed in women aged 30-39. Mean scores for both symptom frequency and impact in all domains decreased with increasing age ≥60 years.</p><p><strong>Conclusions: </strong>Sexual activity declines with increasing age but this is not associated with increased sexual dysfunction scores in those who remain sexually active. Impaired sexual function is more commonly reported in women aged 40-60, likely reflecting the impact of the menopause. Further research is required to better understand reasons for cessation of sexual activity and identify patients who have treatable causes of sexual dysfunction.</p>","PeriodicalId":52104,"journal":{"name":"Post reproductive health","volume":" ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between body composition and perimenopausal symptom severity in Irish women.","authors":"Miriam Bernadette Murphy, Geraldine Cuskelly, Patricia Heavey","doi":"10.1080/20533691.2026.2704833","DOIUrl":"10.1080/20533691.2026.2704833","url":null,"abstract":"<p><strong>Background: </strong>Perimenopause is associated with somatic, psychological, and urogenital symptoms that may negatively impact quality of life. Changes in body composition, including increased body fat and central adiposity, are common during midlife. While elevated body mass index (BMI) has been linked to menopausal symptom severity in postmenopausal women, limited research has focused on perimenopause. This study examined the association between body composition and symptom severity in Irish perimenopausal women.</p><p><strong>Methods: </strong>This cross-sectional study included 112 perimenopausal women aged over 40 years in Ireland. Symptom severity was assessed using the 11-item Menopause Rating Scale (MRS). Anthropometric measures included BMI, waist circumference (WC), and body fat percentage (%BF). Spearman's correlations and hierarchical multiple regression models examined associations, adjusting for age, marital status, and physical activity.</p><p><strong>Results: </strong>Median age was 48.4 years (IQR 5.2), median BMI 28.3 kg/m² (IQR 7.1), and mean %BF was 34.9 ± 7.3%. Median MRS score was 15.0 (IQR 10.0). Overall symptom score correlated with BMI, WC, and %BF (all <i>p</i> ≤ 0.002). Somatic sub-scores were associated with BMI, WC, and %BF. In adjusted models, BMI, WC, and %BF predicted somatic symptoms only.</p><p><strong>Conclusions: </strong>Higher BMI, WC, and %BF were associated with greater somatic symptom severity during perimenopause.</p>","PeriodicalId":52104,"journal":{"name":"Post reproductive health","volume":" ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148725144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tendinopathies in physically active post-menopausal women: a concise review.","authors":"Jana Bourhill, Helen Carslaw, Trevor Alexanderson, Angelina Cross","doi":"10.1080/20533691.2026.2706025","DOIUrl":"https://doi.org/10.1080/20533691.2026.2706025","url":null,"abstract":"<p><p>Menopause is characterised by declining estrogen levels and cessation in menstruation. It has a global impact on the structure and function of tissues. Within the musculoskeletal system, the drop in circulating estrogen is associated with decreases in bone density and cartilage production. The tensile strength of tendons also diminishes, thus increasing the risk of tendinopathies in peri- and post-menopausal women. Tendinopathy represents a significant barrier to physical activity as it is painful and/or attenuates tendon function. Hormone replacement therapy (HRT) may improve tendon composition and structure in post-menopausal women. Some studies suggest that physically active women demonstrate greater improvement in tendinopathy symptoms with HRT compared to their inactive counterparts. This concise review aims to summarise the pathophysiology of tendinopathy in the context of physically active peri- and post-menopausal women, appraise the available evidence for the use of the HRT in the prevention or management of tendinopathies and make recommendations regarding areas for future research.</p>","PeriodicalId":52104,"journal":{"name":"Post reproductive health","volume":" ","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148674631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"News and views.","authors":"Simon Brown","doi":"10.1080/20533691.2026.2701607","DOIUrl":"https://doi.org/10.1080/20533691.2026.2701607","url":null,"abstract":"","PeriodicalId":52104,"journal":{"name":"Post reproductive health","volume":" ","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148622544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A bus crossing on Mull: consent, communication, and the missing hormonal continuum.","authors":"Vicky Jo Varner","doi":"10.1080/20533691.2026.2701000","DOIUrl":"https://doi.org/10.1080/20533691.2026.2701000","url":null,"abstract":"","PeriodicalId":52104,"journal":{"name":"Post reproductive health","volume":" ","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148551426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopausal transition and early psychosis: need for individualised care.","authors":"Marlene Kelbrick, Chinenye Okoro, Ogechi Ernest-Amaziro, Anitha Chadalavada, Mary Sam, Gabriela Paduret, Sue Jugon","doi":"10.1080/20533691.2026.2629209","DOIUrl":"https://doi.org/10.1080/20533691.2026.2629209","url":null,"abstract":"<p><p>Menopausal transition represents a vulnerable period for both first and repeated episode psychosis, with important implications for treatment and outcomes. From a retrospective case note service evaluation of patients within a UK NHS Early Intervention for Psychosis (EIP) service, this patient group represents a notable cohort. There is a need for individualised care that include clinician awareness of pharmacokinetic and pharmacodynamic factors when prescribing antipsychotic medication, risk benefit analysis when considering the use of HRT within this group, improved education and good communication and integrated care between GPs and early intervention for psychosis services to improve overall quality of care.</p>","PeriodicalId":52104,"journal":{"name":"Post reproductive health","volume":"32 2","pages":"105-109"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148551353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}