Post reproductive health最新文献_第2页

Weight loss and prevention of weight gain in menopause. 绝经期减肥和预防体重增加。

Post reproductive health Pub Date : 2025-06-01 Epub Date: 2025-05-19 DOI: 10.1177/20533691251342325

Nigel Denby

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Erratum to "Weight loss and prevention of weight gain in menopause". “更年期减肥和预防体重增加”的勘误。

Post reproductive health Pub Date : 2025-06-01 Epub Date: 2025-07-02 DOI: 10.1177/20533691251355965

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MenoScale: A novel digital tool to measure menopause symptoms and subjective quality of life - validation, preliminary insights on the menopausal experience and association with diet quality. 更年期量表：一种测量更年期症状和主观生活质量的新型数字工具-验证，更年期体验的初步见解及其与饮食质量的关系。

Post reproductive health Pub Date : 2025-06-01 Epub Date: 2025-04-22 DOI: 10.1177/20533691251335807

Curie Kim, Lucy Marples, Alexander Platts, Kate M Bermingham, Federica Amati, Haitham Hamoda, George Pounis, Jonathan Wolf, Tim D Spector, Wendy L Hall, Sarah E Berry

{"title":"MenoScale: A novel digital tool to measure menopause symptoms and subjective quality of life - validation, preliminary insights on the menopausal experience and association with diet quality.","authors":"Curie Kim, Lucy Marples, Alexander Platts, Kate M Bermingham, Federica Amati, Haitham Hamoda, George Pounis, Jonathan Wolf, Tim D Spector, Wendy L Hall, Sarah E Berry","doi":"10.1177/20533691251335807","DOIUrl":"10.1177/20533691251335807","url":null,"abstract":"BackgroundMenopause symptoms significantly impact women's quality of life, yet existing assessment tools may not fully capture the menopausal experience. The MenoScale is a new digital tool for reporting the number and impact of menopause-associated symptoms.ObjectiveTo evaluate the reliability and validity of the MenoScale, and explore its application as a research tool.Study designDevelopment of novel MenoScale tool and an online validation study comparing it to the Greene Climacteric Scale (GCS) and RAND 36-item Health Survey 1.0, with 1010 peri- and postmenopausal women aged 37-70 years.Main outcome measuresConstruct validity, internal consistency, test-retest reliability, and associations with quality of life and dietary intake.ResultsThe MenoScale showed good agreement between the MenoScale and GCS through Bland-Altman plot analysis. Internal consistency varied across four symptom domains: vasomotor, sexual, psychological and cognitive, and somatic (Cronbach's α = 0.5-0.8). Structural equation modelling revealed psychological and cognitive symptoms as central to the menopausal experience. Higher Healthy Eating Index scores were associated with slightly lower MenoScale scores (β = -0.132, p < .001). In the first 12 weeks post-launch, 65,181 women from 140 countries completed the online MenoScale.ConclusionThe MenoScale is a valid and reliable tool for assessing menopause symptoms, offering a comprehensive assessment of the menopausal experience. The association between diet quality and symptom burden warrants further investigation. The rapid uptake of the online MenoScale demonstrates its potential for large-scale data collection and empowering individuals in managing their menopausal experience.","PeriodicalId":52104,"journal":{"name":"Post reproductive health","volume":" ","pages":"73-86"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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News and views. 新闻和观点。

Post reproductive health Pub Date : 2025-05-27 DOI: 10.1177/20533691251345219

Simon Brown

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Cardiovascular outcomes of menopause hormone therapy initiated in women aged ≥60 years or ≥10 years post-menopause: A systematic review of the literature. ≥60岁或≥10年绝经后妇女开始绝经激素治疗的心血管结局：文献系统综述

Post reproductive health Pub Date : 2025-05-09 DOI: 10.1177/20533691251341713

Nancy Yaneth Contreras Garza, José Antonio Dávila Rivas, Carlos Félix Arce, María Elizabeth Fraustro Avila, Celina Salas Castro, Sergio Alejandro Villarreal González, Grecia Villa Cruz, Belinda Maricela Contreras Garza, José Luis Neyro Bilbao

{"title":"Cardiovascular outcomes of menopause hormone therapy initiated in women aged ≥60 years or ≥10 years post-menopause: A systematic review of the literature.","authors":"Nancy Yaneth Contreras Garza, José Antonio Dávila Rivas, Carlos Félix Arce, María Elizabeth Fraustro Avila, Celina Salas Castro, Sergio Alejandro Villarreal González, Grecia Villa Cruz, Belinda Maricela Contreras Garza, José Luis Neyro Bilbao","doi":"10.1177/20533691251341713","DOIUrl":"https://doi.org/10.1177/20533691251341713","url":null,"abstract":"IntroductionMenopause hormone therapy (MHT) is the most effective treatment for climacteric syndrome. However, its cardiovascular effects remain complex. The 'timing hypothesis' suggests these effects depend on the timing of initiation, but this has been increasingly questioned. This study evaluates evidence on cardiovascular risks associated with late MHT initiation in healthy women aged ≥60 years or ≥10 years post-menopause.MethodsA comprehensive literature search was conducted from the inception of each database until November 2023. The databases searched included PubMed, SciELO, Embase, and Cochrane. RCTs of human studies examining the cardiovascular effects of MHT in healthy women aged ≥60 years or those ≥10 years post-menopause were included. Eligibility screening, data extraction, risk of bias assessment were performed independently and in duplicate.ResultsNine RCTs comprising 36,051 participants were included. We focus on results from participants aged ≥60 years. The mean follow-up was 7.2 years. Six studies were sub-analyses of the Women's Health Initiative (WHI) trial, while three studies originated from other trials. Results from the WHI indicated no significant increase in cardiovascular risks with either CEE + MPA or Estrogen-only therapy. Non-WHI studies showed an elevated stroke risk with tibolone and higher doses of combined MHT, but no cardiovascular complications were observed with low doses.ConclusionThe increased risk of cardiovascular events in our target population is not statistically significant. There is a lack of high-quality evidence to suggest an increased risk of adverse cardiovascular outcomes in healthy women who initiate MHT at age ≥60 years or ≥10 years post-menopause.","PeriodicalId":52104,"journal":{"name":"Post reproductive health","volume":" ","pages":"20533691251341713"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Rethinking sarcopenia and frailty of the elderly. 老年人肌肉减少症与虚弱的再思考。

Post reproductive health Pub Date : 2025-04-22 DOI: 10.1177/20533691251337173

Janice Blumer, Bachtuyet Le

{"title":"Rethinking sarcopenia and frailty of the elderly.","authors":"Janice Blumer, Bachtuyet Le","doi":"10.1177/20533691251337173","DOIUrl":"https://doi.org/10.1177/20533691251337173","url":null,"abstract":"Sarcopenia, or 'frailty of the elderly', is a condition of low muscle mass which is prevalent in older adults and post-menopausal women, leading to falls or worsening after falls. Age-related muscle thinning contributes to falls and fractures. Fractures lead to downward spiral toward the loss of independence in the elderly and ultimately, increased health care expenditures of approximately 4 billion pounds a year. The diagnosis of sarcopenia is based on muscle mass, muscle strength, and physical performance. Sarcopenia is caused by imbalance between the anabolic and catabolic processes on the protein production pathway, as well as a decrease in satellite cells. Denervation, inflammation, hormonal changes, and mitochondrial decline further complicate the issue. Is it time that physicians begin to rethink the diagnosis of sarcopenia or frailty as a process that begins in mid-life? In women, it begins in menopause and ends with falls, fractures, or immobility due to weakness. Physicians often question which came first; frailty causing the fall or the fall worsening frailty, which leads to challenges in treatment. Sarcopenia treatment involves resistance training, appropriate diet and being proactive about the diagnosis. These low-risk lifestyle interventions should be recommended during mid-life well woman visits. Physicians can influence the outcomes of sarcopenia simply by providing an exercise prescription, supplement, and diet recommendation in early menopause. This article aims to change the thinking around sarcopenia from an 'end stage' diagnosis to a mid-life discussion around disease prevention and maintenance of health and muscle.","PeriodicalId":52104,"journal":{"name":"Post reproductive health","volume":" ","pages":"20533691251337173"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Feasibility of developing a new tool for assessing vaginal health in women with Genitourinary Syndrome of Menopause; The VAN study. 开发一种评估绝经期泌尿生殖系统综合征妇女阴道健康的新工具的可行性VAN研究。

Post reproductive health Pub Date : 2025-04-13 DOI: 10.1177/20533691251332321

Paula Briggs, Christopher Evans, Steven Lane, Lora Kiosseva, Jo Drury, Tim Hillard, Nick Panay, Dharani K Hapangama

{"title":"Feasibility of developing a new tool for assessing vaginal health in women with Genitourinary Syndrome of Menopause; The VAN study.","authors":"Paula Briggs, Christopher Evans, Steven Lane, Lora Kiosseva, Jo Drury, Tim Hillard, Nick Panay, Dharani K Hapangama","doi":"10.1177/20533691251332321","DOIUrl":"https://doi.org/10.1177/20533691251332321","url":null,"abstract":"ObjectivesGenitourinary syndrome of menopause (GSM) is a common condition, yet there is no accessible, objective clinical method with which to make a diagnosis of vaginal changes associated with GSM. We undertook a feasibility study to assess suitability of different objective diagnostic methods and obtained quantitative scores using a new GSM Assessment Tool (NGAT) and vaginal maturation vlue (VMV). These scores were correlated with patient reported symptoms obtained via a questionnaire.Study DesignVAginal Health - What's Normal (VAN) Study is a prospective, observational, feasibility study, evaluating NGAT and VMV. Sixty women (12 healthy controls and 48 symptomatic) were recruited and had a baseline assessment. The symptomatic women were offered treatment and had a second assessment 16 weeks later.ResultsCompared with control group, symptomatic women had higher NGAT and VMV scores at baseline. After treatment, in symptomatic women, symptoms improved and NGAT scores reduced, while the median value for VMV was unexpectedly reduced.ConclusionsThis data suggests that clinical assessment and accurate recording of GSM can be supported by an objective scoring system, particularly in primary care and warrants adequately powered future studies to assess the utility of these methods in clinical and research setting.","PeriodicalId":52104,"journal":{"name":"Post reproductive health","volume":" ","pages":"20533691251332321"},"PeriodicalIF":0.0,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Results of a patient survey exploring skin symptoms in a menopause clinic. 绝经期门诊患者皮肤症状调查结果。

Post reproductive health Pub Date : 2025-04-02 DOI: 10.1177/20533691251332403

Hamisha Salih, Zoe Schaedel, Olivia Hum, Claudia DeGiovanni

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The presence of trigonal non-keratinising squamous metaplasia is not associated with menopausal or estrogen status but may be associated with urinary tract infection in women. 三角形非角化鳞状皮化生与绝经期或雌激素状态无关，但可能与女性尿路感染有关。

Post reproductive health Pub Date : 2025-03-18 DOI: 10.1177/20533691251327628

Bernadette Lemmon, Ruwan Fernando, Alex Digesu, Alka Bhide, Miriam Tadros, Vik Khullar

{"title":"The presence of trigonal non-keratinising squamous metaplasia is not associated with menopausal or estrogen status but may be associated with urinary tract infection in women.","authors":"Bernadette Lemmon, Ruwan Fernando, Alex Digesu, Alka Bhide, Miriam Tadros, Vik Khullar","doi":"10.1177/20533691251327628","DOIUrl":"https://doi.org/10.1177/20533691251327628","url":null,"abstract":"ObjectiveSquamous metaplasia (SM) at the bladder trigone is often seen during cystoscopy in women. It has previously been described as a normal finding in the literature under the influence of estrogen; however, metaplastic change in epithelium can be activated in response to infection. In this study, we hypothesise that trigonal SM is indicative of urinary tract infection (UTI) in pre- and post-menopausal women irrespective of estrogen status.Study DesignDescriptions of the bladder trigone were retrospectively reviewed in the surgical notes of pre- and post-menopausal women who underwent cystoscopy for presence of SM. Results of urine and tissue cultures were also reviewed with UTI being defined as a positive urine and/or bladder tissue culture.Main Outcome MeasuresThe statistical relationship between the presence of trigonal SM and culture positive UTI.Results97 women were included with 39 post-menopausal (40%) and 58 pre-menopausal (60%). SM had a 62% positive predictive value of UTI, and a negative predictive value of 73% (sensitivity = 93%, specificity = 76%). Chi-squared showed that there is a statistically significant relationship between trigonal SM and UTI p = .015. Bladder tissue was more likely to identify a uropathogen in women with severe SM. We found no significant relationship between estrogen status and the presence of SM (p = .866).ConclusionsThis study shows that the cystoscopic appearance of SM is associated with infection in the bladder independent of menopausal status or exposure to externally taken estrogen. This may be a particularly helpful finding in women with recurrent symptoms of UTI but negative culture results.","PeriodicalId":52104,"journal":{"name":"Post reproductive health","volume":" ","pages":"20533691251327628"},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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News and views. 新闻和观点。

Post reproductive health Pub Date : 2025-03-03 DOI: 10.1177/20533691251323842

Simon Brown

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