{"title":"Impact of hormonal replacement therapy on menopausal women with psychosis: A literature review.","authors":"Nora Shero, Valérie Giroux","doi":"10.1177/20533691251361018","DOIUrl":null,"url":null,"abstract":"<p><p>IntroductionRecent literature has explored the use of hormone replacement therapy (HRT) in menopausal women experiencing psychosis. Menopause women with previous psychotic events in their lifetime experience psychotic symptoms at later peak due to the low estrogen production in their bodies, known as menopause-associated psychosis, which can potentially be improved with the help of HRT. This review aims to discuss the effects of HRT on menopausal women with psychosis by comparing studies with combination of antipsychotic drugs.MethodsA literature review using Ovid Medline search was used.ResultsThese results indicate that HRT may have a positive impact on mood and cognition to decrease the expression of psychotic signs. Some estrogen-derived treatments, such as SERM (selective estrogen receptor modulator), might also improve the impact of the antipsychotics, giving the possibility of dosage reduction and fewer side effects.ConclusionSince the management of psychosis is challenging in menopausal women due to hormonal change and antipsychotic adjustment dosage, interdisciplinary management involving psychiatry, gynecology, and family medicine specialities is crucial. This approach can manage the hormonal, psychiatric, and overall medical issues of these patients, provide better psychiatric care, and improve their quality of life. Further research should validate the HRT protocols along with the enhancement of the technique when used in combination with antipsychotic drugs.</p>","PeriodicalId":52104,"journal":{"name":"Post reproductive health","volume":" ","pages":"20533691251361018"},"PeriodicalIF":0.0000,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Post reproductive health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/20533691251361018","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
IntroductionRecent literature has explored the use of hormone replacement therapy (HRT) in menopausal women experiencing psychosis. Menopause women with previous psychotic events in their lifetime experience psychotic symptoms at later peak due to the low estrogen production in their bodies, known as menopause-associated psychosis, which can potentially be improved with the help of HRT. This review aims to discuss the effects of HRT on menopausal women with psychosis by comparing studies with combination of antipsychotic drugs.MethodsA literature review using Ovid Medline search was used.ResultsThese results indicate that HRT may have a positive impact on mood and cognition to decrease the expression of psychotic signs. Some estrogen-derived treatments, such as SERM (selective estrogen receptor modulator), might also improve the impact of the antipsychotics, giving the possibility of dosage reduction and fewer side effects.ConclusionSince the management of psychosis is challenging in menopausal women due to hormonal change and antipsychotic adjustment dosage, interdisciplinary management involving psychiatry, gynecology, and family medicine specialities is crucial. This approach can manage the hormonal, psychiatric, and overall medical issues of these patients, provide better psychiatric care, and improve their quality of life. Further research should validate the HRT protocols along with the enhancement of the technique when used in combination with antipsychotic drugs.
期刊介绍:
Post Reproductive Health (formerly Menopause International) is a MEDLINE indexed, peer reviewed source of news, research and opinion. Aimed at all those involved in the field of post reproductive health study and treatment, it is a vital resource for all practitioners and researchers. As the official journal of the British Menopause Society (BMS), Post Reproductive Health has a broad scope, tackling all the issues in this field, including the current controversies surrounding postmenopausal health and an ageing and expanding female population. Initially this journal will concentrate on the key areas of menopause, sexual health, urogynaecology, metabolic bone disease, cancer diagnosis and treatment, recovering from cancer, cardiovascular disease, cognition, prescribing, use of new hormone therapies, psychology, the science of ageing, sociology, economics, and quality of life. However as a progressive and innovative journal the Editors are always willing to consider other areas relevant to this rapidly expanding area of healthcare.