The International journal of risk & safety in medicine最新文献

Trusted evidence for better health: Achievements and barriers over the 10 years of Cochrane Russia. 改善健康的可信证据：Cochrane俄罗斯10年来的成就和障碍。

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The International journal of risk & safety in medicine Pub Date : 2026-05-06 DOI: 10.1177/09246479261442605

Liliya Eugenevna Ziganshina

引用次数: 0

Excess mortality, statistical significance, and causation: Analyzing controversies in COVID-19 vaccine research. 超额死亡率、统计意义和原因：分析COVID-19疫苗研究中的争议。

IF 0.8

The International journal of risk & safety in medicine Pub Date : 2026-04-24 DOI: 10.1177/09246479261446501

Raphael Lataster

引用次数: 0

Comparison of hematological adverse reactions in patients with epilepsy on monotherapy versus polytherapy. 癫痫患者单药治疗与多药治疗血液学不良反应的比较。

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The International journal of risk & safety in medicine Pub Date : 2026-04-20 DOI: 10.1177/09246479261444923

Ogunjimi Luqman, Ogunjimi Olabisi, Kasali Adeola, Oyenuga Ibironke, Ogungbe Oluwatosin, Adegoke Joshua, Mudashiru Olajumoke, Odusoga Oluwatosin, Adubi Opeoluwa, Akindolani Precious, Omotayo Adedire, Abeeb Taofeekat, Sonde James, Doyin-Bello Adedoyinsola, Kuye Testimony, Osalusi Bamidele

{"title":"Comparison of hematological adverse reactions in patients with epilepsy on monotherapy versus polytherapy.","authors":"Ogunjimi Luqman, Ogunjimi Olabisi, Kasali Adeola, Oyenuga Ibironke, Ogungbe Oluwatosin, Adegoke Joshua, Mudashiru Olajumoke, Odusoga Oluwatosin, Adubi Opeoluwa, Akindolani Precious, Omotayo Adedire, Abeeb Taofeekat, Sonde James, Doyin-Bello Adedoyinsola, Kuye Testimony, Osalusi Bamidele","doi":"10.1177/09246479261444923","DOIUrl":"https://doi.org/10.1177/09246479261444923","url":null,"abstract":"BackgroundThis study compared the effects of anti-seizure medication (ASM) monotherapy and polytherapy on hematological parameters in patients with epilepsy (PWE).ObjectiveTo compare hematological parameters and derived inflammatory indices in patients with epilepsy receiving ASM monotherapy versus polytherapy and determine independent predictors and discriminatory performance of these parameters.MethodsA hospital-based cross-sectional study was conducted between January and June 2024 at the Neurology Clinic of Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria. Two hundred adult PWE were enrolled and classified into monotherapy or polytherapy groups. Sociodemographic and clinical data were collected. Venous blood samples were analyzed using the Sysmex XN-1000 hematology analyzer. Statistical analyses included independent t-tests, chi-square tests, logistic regression, and receiver operating characteristic (ROC) analysis (p < 0.05).ResultsMales predominated in the monotherapy group (58.8%), while females predominated in the polytherapy group (84.1%; p < 0.001). Monotherapy showed significantly higher neutrophils, hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin concentration, and neutrophil-lymphocyte ratio, but lower mean platelet volume. Neutrophils, hemoglobin, MCV, MCHC, and MPV independently predicted treatment pattern. ROC analysis showed moderate discrimination for MPV, while others performed poorly.ConclusionASM polytherapy is associated with greater hematological alterations. Monotherapy should be prioritized when feasible, with routine hematological monitoring recommended.","PeriodicalId":520800,"journal":{"name":"The International journal of risk & safety in medicine","volume":" ","pages":"9246479261444923"},"PeriodicalIF":0.8,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug-induced methemoglobinemia in a child with comorbidity and polypragmasia: Case report. 药物致高铁血红蛋白血症患儿合并多语用症1例。

IF 0.8

The International journal of risk & safety in medicine Pub Date : 2026-04-17 DOI: 10.1177/09246479251405948

Alina B Strok, Maria N Kostyleva, Anna V Kostina

{"title":"Drug-induced methemoglobinemia in a child with comorbidity and polypragmasia: Case report.","authors":"Alina B Strok, Maria N Kostyleva, Anna V Kostina","doi":"10.1177/09246479251405948","DOIUrl":"https://doi.org/10.1177/09246479251405948","url":null,"abstract":"Background: The article describes a case of methemoglobinemia in a 4-year-old child with nephrotic syndrome with simultaneous use of therapeutic doses of three drugs that cause methemoglobinemia: lidocaine (topically), benzocaine (topically), and co-trimoxazole (systemically). An increase in the level of methemoglobin in the blood to 47.6% led to the development of respiratory failure. To correct the child's condition, high-flow oxygen therapy was performed and ascorbic acid was administered. During the day, there was a positive trend, the level of methemoglobin decreased to 1.5%. Toxicological examination of urine showed the presence of lidocaine, benzocaine, and trimethoprim. Thus, in conditions of polypragmasia in a child with comorbidity, the simultaneous use of three drugs with the potential of methemoglobinemia caused a significant increase in the level of methemoglobin and the development of respiratory failure, which required hospitalization in the intensive care unit. After 2 days, the patient's condition stabilized and he was transferred to a specialized department. As far as we know, this is the first documented case of methemoglobinemia in a child with polypragmasia.","PeriodicalId":520800,"journal":{"name":"The International journal of risk & safety in medicine","volume":" ","pages":"9246479251405948"},"PeriodicalIF":0.8,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147701783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feeding tube safety: National guidance is unsafe and must change. 饲管安全：国家指导是不安全的，必须改变。

IF 0.8

The International journal of risk & safety in medicine Pub Date : 2026-04-13 DOI: 10.1177/09246479261442065

Stephen J Taylor

引用次数: 0

Neuropsychiatric adverse events associated with lorlatinib in ALK-positive NSCLC. alk阳性NSCLC中氯拉替尼相关的神经精神不良事件。

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The International journal of risk & safety in medicine Pub Date : 2026-04-13 DOI: 10.1177/09246479261442221

Eleonora Castellana, Maria Rachele Chiappetta

{"title":"Neuropsychiatric adverse events associated with lorlatinib in ALK-positive NSCLC.","authors":"Eleonora Castellana, Maria Rachele Chiappetta","doi":"10.1177/09246479261442221","DOIUrl":"https://doi.org/10.1177/09246479261442221","url":null,"abstract":"BackgroundLorlatinib, a third-generation ALK/ROS1 inhibitor, is highly effective in ALK-positive non-small-cell lung cancer (NSCLC), particularly for intracranial disease. It is associated with a distinctive neuropsychiatric toxicity profile.ObjectiveTo characterize neuropsychiatric adverse events (AEs) of lorlatinib using FAERS post-marketing data.MethodsFAERS reports listing lorlatinib as the primary suspect (November 2018-December 2024) were analyzed via OpenVigil 2.1. Neuropsychiatric AEs were grouped into four domains: cognitive, mood, speech, and psychotic. Disproportionality was assessed using Reporting Odds Ratio (ROR) and Proportional Reporting Ratio (PRR).ResultsAmong 3452 reports, cognitive effects predominated: cognitive disorder (2.95%, ROR: 16.68, PRR: 16.22), memory impairment (2.35%, ROR: 4.07, PRR: 3.99), and confusional state (1.77%, ROR: 3.22, PRR: 3.18). Mood alterations included affective disorder (0.43%, ROR: 13.13, PRR: 13.08) and personality change (0.32%, ROR: 10.32, PRR: 10.29). Speech disturbances included slow speech (0.2%, ROR: 18.49, PRR: 18.45) and speech disorder (1.22%, ROR: 6.47, PRR: 6.40). Psychiatric manifestations were most pronounced: olfactory hallucinations (0.14%, ROR: 91.44, PRR: 91.31), auditory hallucinations (1.3%, ROR: 22.0, PRR: 21.7), and acute psychosis (0.2%, ROR: 22.12, PRR: 22.07).ConclusionsLorlatinib exhibits a multidimensional neuropsychiatric profile with rare but highly specific events. Proactive monitoring of cognitive, mood, speech, and psychotic domains is recommended in clinical practice.","PeriodicalId":520800,"journal":{"name":"The International journal of risk & safety in medicine","volume":" ","pages":"9246479261442221"},"PeriodicalIF":0.8,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147680296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic venlafaxine ingestion inducing bluish oral hyperpigmentation with dysgeusia and dysphagia: A case report. 慢性文拉法辛摄入诱发蓝色口腔色素沉着伴发音困难和吞咽困难1例。

IF 0.8

The International journal of risk & safety in medicine Pub Date : 2026-04-10 DOI: 10.1177/09246479261441855

Yamini Ajmera, Karandeep Paul, Prasun Chatterjee

{"title":"Chronic venlafaxine ingestion inducing bluish oral hyperpigmentation with dysgeusia and dysphagia: A case report.","authors":"Yamini Ajmera, Karandeep Paul, Prasun Chatterjee","doi":"10.1177/09246479261441855","DOIUrl":"https://doi.org/10.1177/09246479261441855","url":null,"abstract":"BackgroundMedication-induced oral hyperpigmentation represents an adverse drug reaction characterized by variable latency and unclear mechanism. Diagnosis is particularly challenging in older adults due to non-specific symptoms, multiple comorbidities and polypharmacy.Case reportWe present the first documented case of a woman in her 80s experiencing patchy, bluish hyperpigmentation of dorsum of tongue and buccal mucosa with altered taste sensation and swallowing difficulty, in association with chronic venlafaxine ingestion that remained undiagnosed for many years. To establish the current diagnosis, a comprehensive history taking, clinical examination, blood investigations and imaging studies were utilized to rule out the endogenous causes. Following discontinuation of venlafaxine, at 1 month follow-up, there was complete resolution of oral hyperpigmentation together with significant improvement in dysphagia and dysgeusia indicating a probable association with the drug.ConclusionThis report highlights the need for the healthcare professionals to be aware of the medications linked to oral hyperpigmentation to facilitate timely diagnosis, patient reassurance and optimize management.","PeriodicalId":520800,"journal":{"name":"The International journal of risk & safety in medicine","volume":" ","pages":"9246479261441855"},"PeriodicalIF":0.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147655620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How I contributed to Cochrane Crowd and why it matters for evidence synthesis. 我是如何为Cochrane Crowd做出贡献的，以及为什么它对证据合成很重要。

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The International journal of risk & safety in medicine Pub Date : 2026-04-06 DOI: 10.1177/09246479261441446

Vladimir Kataev

引用次数: 0

Clinical profile of healthcare employees with needlestick and sharps injuries and infectious body fluid exposure in tertiary care hospitals in southern India. 印度南部三级保健医院中针刺伤和锐器伤及感染性体液接触的医护人员的临床概况

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The International journal of risk & safety in medicine Pub Date : 2026-03-09 DOI: 10.1177/09246479261432856

Nitin Joseph, Jithin Surendran, Ayandeep Baruah, Sunny Dev, Aditi Raj Gupta, Aastha Shukla, Priyanka Roy, Nadia Ozair, Pranshi Agarwal

{"title":"Clinical profile of healthcare employees with needlestick and sharps injuries and infectious body fluid exposure in tertiary care hospitals in southern India.","authors":"Nitin Joseph, Jithin Surendran, Ayandeep Baruah, Sunny Dev, Aditi Raj Gupta, Aastha Shukla, Priyanka Roy, Nadia Ozair, Pranshi Agarwal","doi":"10.1177/09246479261432856","DOIUrl":"https://doi.org/10.1177/09246479261432856","url":null,"abstract":"BackgroundNeedle-stick and sharps injuries (NSSIs) are major occupational hazards faced by healthcare employees (HCEs) worldwide.ObjectivesThis study aimed to assess trends of NSSIs among HCEs and their exposure to other infected body fluids, as well as to determine their risk factors.MethodsThis retrospective observational study involved secondary data of NSSIs collected from January 2016 to June 2023.ResultsThere was a constant decline in the number of NSSI incidents over the time, except in 2021. Among the 334 HCEs with a history of exposure, 129 (38.6%) were staff nurses. Most HCEs [274 (82.0%)] developed a prick from the injector needle, and the majority (39.4%) received a prick on the fingers of the left hand. The majority (24.1%) were exposed to NSSIs and infectious body fluids while handling/discarding biomedical wastes (BMWs). Delays in screening and initiation of postexposure prophylaxis (>24 h) were observed among 10.3% and 15.1% of HCEs, respectively. There were significantly more NSSIs than other forms of occupational exposure during the COVID-19 period (p = 0.046) and among HCEs aged 18-25 years (p = 0.033). Females were more prone to exposure while handling/discarding BMWs (p = 0.0001).ConclusionTraining, particularly among junior HCEs, is needed to prevent NSSIs and exposure to infectious body fluids.","PeriodicalId":520800,"journal":{"name":"The International journal of risk & safety in medicine","volume":" ","pages":"9246479261432856"},"PeriodicalIF":0.8,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147392044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of pathological autopsy in determining the cause of death in cases of unexpected clinical deterioration or medical incidents. 病理解剖在确定意外临床恶化或医疗事故中死亡原因的作用。

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The International journal of risk & safety in medicine Pub Date : 2026-03-07 DOI: 10.1177/09246479261432855

Sachi Miyashita, Tadashi Kamio, Hiroshi Koyama, Shingo Ohki, Yumiko Tsunano, Mizuki Sato, Kiyomitsu Fukaguchi, Hiroki Hadano

{"title":"Role of pathological autopsy in determining the cause of death in cases of unexpected clinical deterioration or medical incidents.","authors":"Sachi Miyashita, Tadashi Kamio, Hiroshi Koyama, Shingo Ohki, Yumiko Tsunano, Mizuki Sato, Kiyomitsu Fukaguchi, Hiroki Hadano","doi":"10.1177/09246479261432855","DOIUrl":"https://doi.org/10.1177/09246479261432855","url":null,"abstract":"BackgroundThe extent to which autopsies are conducted and their role in determining the cause of death has not been sufficiently examined. We aimed to evaluate the contribution of autopsy in determining the cause of death in cases of unexpected clinical deterioration or medical accidents, using data from the Japan Center for Quality Health Care database.MethodsWe analysed data from patients with unexpected clinical deterioration who required pathological autopsy between January 2010 and November 2024. Cases were categorised based on whether autopsies were performed, and the reasons for not performing autopsies were examined.ResultsIn total, 682 reports were identified. Pathological autopsies were performed in 341 patients, and the cause of death was determined in 64.2% of cases (219 patients). The cause of death remained undetermined in 25.2% of cases (86 patients) despite autopsy. Among the 341 patients in whom autopsies were not performed, the primary reason was the family refusal (81.5%, 278 patients).ConclusionsPathological autopsies are essential for determining the cause of death in cases of unexpected clinical deterioration. Family refusal was identified as the principal barrier to autopsy, whereas lack of autopsy proposal accounted for only a small proportion of cases.","PeriodicalId":520800,"journal":{"name":"The International journal of risk & safety in medicine","volume":" ","pages":"9246479261432855"},"PeriodicalIF":0.8,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147372713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0