The Annals of otology, rhinology, and laryngology最新文献

{"title":"Surgery-Induced Stress Promotes SOX9 Nuclear Localization and Increases COL2A1 in Tracheal Cartilage.","authors":"Sovannarath Pong, Lumei Liu, Jazmin Calyeca, Ada C Sher, Sarah Sussman, Tendy Chiang","doi":"10.1177/00034894261440648","DOIUrl":"10.1177/00034894261440648","url":null,"abstract":"<p><strong>Objective: </strong>Airway reconstruction triggers a surgery-induced stress (SIS) response, but its effect on cartilage regeneration remains elusive. SOX9 regulates cartilage regeneration by promoting type II collagen production and may aid in repair; however, the role of SOX9 in response to SIS is unclear. We utilized a mouse model to validate SOX9 nuclear expression in tracheal chondrocytes and assess its localization after segmental tracheal replacement.</p><p><strong>Methods: </strong>Tracheas from C57BL/6J mice were digested using Dispase-Collagenase-Trypsin, then collagenase II to isolate chondrocytes for primary culture. Syngeneic tracheal grafts were harvested from donor animals, and a 3 to 4 mm tracheal graft was implanted orthotopically to assess chondrocyte function in vivo. At 1 month, graft, anastomosis, and adjacent host tissues were harvested. Samples were stained for SOX9 and COL2A1, and their localization was analyzed with ImageJ.</p><p><strong>Results: </strong>Primary tracheal chondrocytes showed strong nuclear SOX9 and cytoplasmic COL2A1 expression. One month after orthotopic tracheal replacement, SOX9 nuclear colocalization increased in the host and anastomosis regions (<i>P</i> = .0269 and <i>P</i> = .0262, respectively), but not in the graft (<i>P</i> = .5958). COL2A1 intensity in the cartilage matrix was significantly higher in graft, host, and anastomosis compared to native cartilage (all <i>P</i> < .01), with no morphological differences.</p><p><strong>Conclusion: </strong>After tracheal reconstruction, increased SOX9 and COL2A1 intensities indicate a potential chondrocyte response to SIS. SOX9 nuclear localization may be involved in regulating COL2A1 in tracheal chondrocytes during cartilage injury and repair. This supports a possible role for SOX9 in maintaining cartilage function and its potential as a therapeutic target to improve graft integration and airway stability.</p>","PeriodicalId":520787,"journal":{"name":"The Annals of otology, rhinology, and laryngology","volume":" ","pages":"698-706"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147795880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Swallowing Rehabilitation with Motor Imagery in Patients Undergoing Radiation for Head & Neck Cancer: A Prospective Study.","authors":"Rishi Kondapaneni, Safa Shaikh, Kaitlyn Florence, Naiwei Chen, Laura Dooley, Gregory Biedermann, Stephanie Knollhoff","doi":"10.1177/00034894261476895","DOIUrl":"https://doi.org/10.1177/00034894261476895","url":null,"abstract":"<p><strong>Objectives: </strong>Radiation therapy (RT) for head and neck cancer (HNC) commonly causes dysphagia. Swallowing rehabilitation programs (SRPs) during RT improve functional outcomes, but adherence remains low due to RT-related pain. Motor imagery (MI) incorporated into SRPs may provide a low-burden adjunct to improve participation and outcomes. The purpose of this prospective pilot study is to evaluate adherence and clinical outcomes of an MI-based SRP for HNC patients undergoing RT.</p><p><strong>Methods: </strong>Between April 2021 and November 2023, 20 HNC patients receiving RT enrolled in an MI-incorporated SRP at a tertiary care center were compared with historical data of 36 HNC patients undergoing RT with standard-of-care SRP. MI-approach participants performed motor execution (ME) exercises for the first 3 weeks of RT, switching to MI-based exercises thereafter. The standard-of-care approach was ME-based exercises throughout RT. The primary outcome was SRP adherence, measured as the percentage of prescribed exercises completed weekly. Exploratory outcomes included pain, opioid prescriptions, weight, feeding tube dependency, and swallowing-related quality-of-life. Linear and logistic mixed-effects models assessed changes over time and between approaches.</p><p><strong>Results: </strong>About 70% of MI participants achieved strong adherence ($ge 70%$ completion of prescribed exercises). Adherence increased after transitioning to MI at week 4 despite rising pain levels. Though not statistically significant, the MI-approach showed a greater decline in pain scores (slope $-1.67$ vs $-0.50$), lower final pain scores ($1.01$ vs $1.68$), reduced post-treatment opioid use (mean log-MME $2.85$ vs $3.97$), smaller average monthly slope of decline in log-weight (slope $-0.125$ vs $-0.132$), lower odds of feeding tube dependency (aOR $0.18$), coughing while drinking (aOR $0.75$), and discomfort while eating with others (aOR $0.68$) as compared to standard of care.</p><p><strong>Conclusions: </strong>Incorporating MI into SRPs for HNC patients undergoing RT may improve SRP adherence and clinical outcomes. Larger, randomized studies are needed to validate the benefit.</p>","PeriodicalId":520787,"journal":{"name":"The Annals of otology, rhinology, and laryngology","volume":" ","pages":"34894261476895"},"PeriodicalIF":0.0,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148709373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sociodemographic Analysis of Pediatric Patients Undergoing Repeat Tympanostomy Tube Placement.","authors":"Grant E Gochman, Nina Dharmarajah, Veronica Drozdowski-Nuccio, Richard D Hubbell","doi":"10.1177/00034894261476823","DOIUrl":"https://doi.org/10.1177/00034894261476823","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study is to assess sociodemographic and medical factors associated with repeat bilateral myringotomy with tympanostomy tube placement (rBMT) in the diverse patient population at our academic medical center.</p><p><strong>Study design: </strong>Retrospective chart review.</p><p><strong>Setting: </strong>Tertiary academic medical center.</p><p><strong>Methods: </strong>A retrospective chart review of pediatric patients seen at a quaternary medical center who underwent BMT was conducted. Demographic, medical, and socioeconomic information was collected. Fisher's exact test was used to estimate the association between rBMT with all nominal responses. Logistic regression was used to estimate the association between patient variables and rBMT.</p><p><strong>Results: </strong>There were 216 (69% male) patients who underwent rBMT. The mean number of BMT surgeries in those requiring rBMT was 3.09. Black & Hispanic individuals were less likely to undergo rBMT (<i>P</i> < .05). There were no statistically significant association between social vulnerability index (SVI), type of insurance or distance from the medical center and rBMT (<i>P</i> > .05).</p><p><strong>Conclusion: </strong>When looking at sociodemographic disparities in those who underwent rBMT, our study demonstrates race and ethnicity were statistically significant factors for decreased likelihood of repeat BMT. SVI, insurance type, and distance from the medical center were not statistically significant in terms of likelihood of rBMT.</p>","PeriodicalId":520787,"journal":{"name":"The Annals of otology, rhinology, and laryngology","volume":" ","pages":"34894261476823"},"PeriodicalIF":0.0,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining Prognostic Stratification in Head and Neck Paragangliomas: Insights from a SEER-Based Population Study.","authors":"Andrea Carlini, Mirea Berti, Giuseppe Lamberti, Elisa Andrini, Francesca Carosi, Daria Maria Filippini, Davide Campana","doi":"10.1177/00034894261476767","DOIUrl":"https://doi.org/10.1177/00034894261476767","url":null,"abstract":"<p><strong>Objectives: </strong>Head and neck paragangliomas (HNPGLs) are rare neuroendocrine tumors with heterogeneous behavior, making prognostic assessment challenging. Although generally indolent, a subset exhibits malignant potential, and robust prognostic determinants remain insufficiently defined. This study aimed to identify clinical and pathological factors independently associated with overall survival (OS) in patients with HNPGLs.</p><p><strong>Methods: </strong>We performed a retrospective Surveillance, Epidemiology, and End Results (SEER)-based cohort study (1975-2021). Demographic, clinicopathologic, and treatment variables were evaluated using Kaplan-Meier survival estimates, Cox regression models, and receiver operating characteristic (ROC)-derived cutoffs.</p><p><strong>Results: </strong>Among 280 patients, most tumors originated in the carotid body (77.5%). In univariable analyses, extra-carotid location, tumor size ≥ 34.5 mm, absence of surgery, advanced stage, and older age were associated with poorer OS. In multivariable analysis, older age, advanced stage, and lack of surgery remained independently associated with reduced OS.</p><p><strong>Conclusions: </strong>Age at diagnosis, disease stage, and surgical resection status were independently associated with OS, with stage emerging as the strongest determinant in HNPGLs. Associations involving tumor size and extra-carotid location should be interpreted as exploratory findings.</p>","PeriodicalId":520787,"journal":{"name":"The Annals of otology, rhinology, and laryngology","volume":" ","pages":"34894261476767"},"PeriodicalIF":0.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of Targeted Recruitment Methods to Study Age-Related Otolaryngology Conditions.","authors":"Daniel Giles, Zach Soler, Mathew J Gregoski, Kristina A LaPointe, Daniel M Beswick, Adam DeConde, Amarbir S Gill, Jose L Mattos, Rodney J Schlosser","doi":"10.1177/00034894261476924","DOIUrl":"https://doi.org/10.1177/00034894261476924","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this study was to analyze the demographics and comorbidities associated with different recruitment methods employed for a clinical study investigating olfactory dysfunction in older adults. We hypothesize that a targeted approach would produce greater demographic and socioeconomic representation than recent online approaches.</p><p><strong>Methods: </strong>This cross-sectional study analyzed the recruiting methods used to enroll Community-dwelling adults over 50 years of age. Participants were recruited from October 2024 to September 2025. A total of 376 participants were recruited. Recruitment methods were divided into 1 of 8 categories. After recruitment, participants would fill out a survey containing demographic information, comorbidities, and olfactory health. Descriptive statistics were used to analyze the cohort.</p><p><strong>Results: </strong>Targeted recruitment resulted in more Non-Whites, lower educational status, lower alcohol use, and higher rates of hypertension, non-insulin dependent diabetes, and cardiac comorbidities than non-targeted methods.</p><p><strong>Conclusion: </strong>This study demonstrates the ability to recruit a representative population through the use of tailored recruiting methods. Underrepresentation in clinical research is a widespread problem that affects a host of fields. This study addresses this issue and demonstrates that it can be improved upon through the use of targeted recruiting strategies.</p>","PeriodicalId":520787,"journal":{"name":"The Annals of otology, rhinology, and laryngology","volume":" ","pages":"34894261476924"},"PeriodicalIF":0.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148687439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limitations of PET/CT in Detecting Cervical Lymph Node Metastases in Betel Nut Induced Oral Cancer.","authors":"Kurtis Young, Adeeba F Ghias, Nicholas Fancher, Hyeong Jun Ahn, Taimur Khalid, Alberto Nunez, Elliott J Koshi, Kelly G Anderson, Karina R Marcelo, Eric D Wirtz","doi":"10.1177/00034894261427917","DOIUrl":"10.1177/00034894261427917","url":null,"abstract":"<p><strong>Objective: </strong>Limited research has been done previously in examining the utility of PET/CT in the preoperative staging of betel nut associated OSCC (BNOSCC). This study was conducted to evaluate the relationship between the standardized uptake values (SUV) of lymph nodes via FDG-PET/CT and their corresponding pathological specimens in betel nut chewers.</p><p><strong>Study design: </strong>Retrospective review.</p><p><strong>Setting: </strong>Single-institution academic center.</p><p><strong>Methods: </strong>A retrospective review of patients with BNOSCC seen at the Tipler Army Medical Center (TAMC) Head and Neck Surgery clinic from October 2004 to October 2019 was conducted. Preoperative FDG-PET/CT images were analyzed for the SUVmax of regional lymph nodes, with a node positive for malignancy defined as >3. The extent of disease spread predicted by FDG-PET/CT was then compared to the postoperative histopathological results.</p><p><strong>Results: </strong>Among patients with BNOSCC, FDG-PET/CT was found to significantly overpredict the extent of lymph node involvement identified on pathological analysis. Metabolic activity of lymph nodes was significantly overestimated on preoperative imaging. These findings highlight a clear discrepancy between the sensitivity and specificity of FDG-PET/CT found in BNOSCC and that in non-betel nut related disease.</p><p><strong>Conclusion: </strong>Elevated false-positive rates for LN positivity on FDG-PET/CT have been observed in BNOSCC patients. This finding could potentially lead to upstaging, and lead to excessive, more invasive treatment courses and interventions. This is a phenomenon that Head and Neck surgeons should be cautious about when working with BNOSCC patients.</p><p><strong>Level of evidence: </strong>3.</p>","PeriodicalId":520787,"journal":{"name":"The Annals of otology, rhinology, and laryngology","volume":" ","pages":"572-579"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147583580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjunctive Serum Drops to Paper Patch for Tympanic Membrane Perforation.","authors":"Yalda Yazdani, Ella J Lee, Karen Tawk, Mehdi Abouzari, Hamid R Djalilian","doi":"10.1177/00034894261436880","DOIUrl":"10.1177/00034894261436880","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effectiveness of autologous serum drops combined with paper patch myringoplasty in enhancing tympanic membrane (TM) perforation closure among patients with prior patch failure.</p><p><strong>Methods: </strong>This retrospective chart review included 81 patients with chronic TM perforations unresponsive to initial paper patching. Patients were divided into 2 groups: the experimental group received autologous serum drops alongside secondary paper patching, while the control group received patching alone. The primary outcome was TM closure at 8 weeks. Kaplan-Meier survival analysis and Cox regression were used to evaluate time-to-closure and the effect of patient variables.</p><p><strong>Results: </strong>Closure rates were significantly higher in the experimental group (54.5%) compared to the control group (21.6%; <i>P</i> = .002). The addition of serum drops was associated with improved healing outcomes, even in cases unresponsive to initial patching. Perforation size and location influenced closure, with smaller and posterior TM perforations showing higher success. No significant associations were found between healing and age, sex, race, comorbidities, or perforation etiology. No adverse effects from serum drops were reported.</p><p><strong>Conclusion: </strong>Autologous serum drops significantly improve TM closure rates when added to paper patch myringoplasty, offering a safe, cost-effective, and non-surgical option for managing chronic perforations. Further studies with larger sample sizes and long-term follow-ups are warranted.</p>","PeriodicalId":520787,"journal":{"name":"The Annals of otology, rhinology, and laryngology","volume":" ","pages":"631-637"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13173778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Management of Recurrent Tracheal Stenosis in the Setting of Riedel's Thyroiditis.","authors":"Sherna S Sheth, Florencia A Monge, Duncan A Meiklejohn, Michael F Spafford","doi":"10.1177/00034894261431483","DOIUrl":"10.1177/00034894261431483","url":null,"abstract":"<p><strong>Objectives: </strong>Riedel's thyroiditis (RT) is a rare, severe IgG4-related fibrosing inflammatory process of the thyroid gland that may present with airway obstruction, dysphagia, and/or dysphonia. Most published reports of treatment of airway obstruction from RT focus on thyroid isthmectomy to relieve compressive or restrictive symptoms, however tracheal stenosis from direct invasion is a more unusual cause of obstruction. Our objectives were to report surgical management of a case of severe, recurrent tracheal stenosis secondary to RT and to review the management of this rare condition.</p><p><strong>Methods: </strong>Case report of single patient with recurrent, severe tracheal stenosis secondary to RT, with literature review of similar cases.</p><p><strong>Results: </strong>We report a case of severe recurrent tracheal stenosis in the setting of RT managed with bilateral subtotal thyroidectomy and slide tracheoplasty, a previously unreported intervention. Review of the literature identified a single case report in which stenosis secondary to RT was successfully managed with endoscopic dilation.</p><p><strong>Conclusions: </strong>Tracheal stenosis is an extremely rare complication of RT. In patients with recurrent or severe tracheal stenosis secondary to RT, slide tracheoplasty may be considered after failure of endoscopic dilation.</p>","PeriodicalId":520787,"journal":{"name":"The Annals of otology, rhinology, and laryngology","volume":" ","pages":"638-641"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147492459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Reported Outcome Measures in Sinonasal Malignancies and Beyond.","authors":"Matthew Y Liu, Philip G Chen","doi":"10.1177/00034894261429636","DOIUrl":"10.1177/00034894261429636","url":null,"abstract":"","PeriodicalId":520787,"journal":{"name":"The Annals of otology, rhinology, and laryngology","volume":" ","pages":"569-571"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Topical Anesthesia Before Fine Needle Aspiration of Thyroid Nodule: A Randomized Clinical Trial.","authors":"Panida Charoonwattanalaoha, Vipa Rath Marpukdee, Panus Binsirawanich, Yosita Muenkaew","doi":"10.1177/00034894261435254","DOIUrl":"10.1177/00034894261435254","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the effectiveness of local anesthesia in reducing pain associated with fine needle aspiration (FNA) of thyroid nodules, examine the side effects of local anesthesia, and identify factors that influence pain during FNA of thyroid nodules.</p><p><strong>Method: </strong>We conducted a randomized clinical trial in the Department of Otolaryngology at Ramathibodi Hospital. Patients scheduled to undergo FNA of thyroid nodules were divided into four groups and subsequently administered four types of local anesthesia: Group A (Placebo cream), Group B (Cold placebo cream), Group C (Topical anesthetic cream), and Group D (Cold topical anesthetic cream). The primary outcome was the mean difference in pain levels (measured using a visual analog scale [VAS] and a numeric rating scale [NRS]) between the treatment and control groups.</p><p><strong>Results: </strong>Initially, 72 participants were enrolled in this study, and data from 62 participants were analyzed. The VAS scores were measured at 0, 10, and 30 minutes post-procedure, with mean scores of 25.85 ± 4.65 (Group A), 21.26 ± 4.81 (Group B), 18.05 ± 4.51 (Group C), and 16 ± 4.97 (Group D). Although Group D showed the lowest pain scores, statistical analysis revealed no significant differences between groups (all <i>P</i> > .05).</p><p><strong>Conclusion: </strong>Local anesthesia and cooling can decrease the level of pain. However, in this study, topical anesthetic did not significantly reduce pain compared to non-anesthetic treatments.</p><p><strong>Level of evidence: </strong>2.</p>","PeriodicalId":520787,"journal":{"name":"The Annals of otology, rhinology, and laryngology","volume":" ","pages":"600-606"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}