Effect of Perioperative Sucralfate Administration on Pain Control After Tonsillectomy: A Systemic Review and Meta-Analysis.

The Annals of otology, rhinology, and laryngology Pub Date : 2026-10-01 Epub Date: 2026-05-13 DOI:10.1177/00034894261449776

Do Hyun Kim, David W Jang, Se Hwan Hwang

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Abstract

Objectives: This study evaluated the efficacy of perioperative intraoral sucralfate in reducing postoperative pain following tonsillectomy through a systematic review and meta-analysis.

Methods: A comprehensive search of PubMed, SCOPUS, Embase, Web of Science, and Cochrane up to September 2025 identified 13 studies comparing perioperative intraoral sucralfate with placebo or no treatment. Outcomes included throat pain, otalgia, swallowing pain, analgesic consumption, and perioperative morbidities.

Results: Sucralfate increased the proportion of patients reporting no or mild throat pain and otalgia, improved mucosal healing at 5 to 7 days, and reduced throat pain, swallowing pain, otalgia, analgesic use, and time to resume >50% of a regular diet. No significant differences were observed in postoperative bleeding or nausea/vomiting.

Conclusion: Perioperative intraoral sucralfate may be an effective adjuvant therapy that improves postoperative pain control, enhances wound healing, reduces analgesic requirements, and facilitates earlier dietary resumption after tonsillectomy.

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扁桃体切除术后围手术期给药硫硫钠对疼痛控制的影响：一项系统回顾和荟萃分析。

目的：本研究通过系统回顾和荟萃分析，评估围手术期口服硫硫钠减轻扁桃体切除术后疼痛的疗效。方法：综合检索PubMed、SCOPUS、Embase、Web of Science和Cochrane，截至2025年9月，确定了13项比较围手术期口服硫糖钠与安慰剂或无治疗的研究。结果包括咽喉痛、耳痛、吞咽痛、镇痛药消耗和围手术期发病率。结果：硫硫钙增加了无或轻度咽喉痛和耳痛患者的比例，改善了5至7天的粘膜愈合，减少了咽喉痛、吞咽痛、耳痛、止痛药的使用，并缩短了恢复正常饮食的时间。术后出血或恶心/呕吐无显著差异。结论：围手术期口服硫硫钠可能是一种有效的辅助治疗，可改善术后疼痛控制，促进伤口愈合，减少镇痛需求，促进扁桃体切除术后早期饮食恢复。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Annals of otology, rhinology, and laryngology

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