Pneumologie (Stuttgart, Germany)最新文献

{"title":"Highlights des DGP-Kongresses 2026 aus Sicht der YoungDGP.","authors":"Espen E Groth, Erik Büscher, Malek Chaabouni, Christoph Fisser, Klaas Franzen, Armin Frille, Sophia Kirstein, Andreas Knaack, Linda Kunz, Christoph Lederer, Gabriela Leuschner, Eldridge Limen, Eva Pappe, Nina Sicker, Charlotte Sieber, Franz-Xaver Weinzierl, Finn Wilkens, Katharina Buschulte","doi":"10.1055/a-2845-5938","DOIUrl":"https://doi.org/10.1055/a-2845-5938","url":null,"abstract":"","PeriodicalId":520755,"journal":{"name":"Pneumologie (Stuttgart, Germany)","volume":"80 5","pages":"334-340"},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147849058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Respiratory and lung diseases in patients with Down Syndrome].","authors":"Bernd Schönhofer, Tanja Sappok","doi":"10.1055/a-2733-3375","DOIUrl":"10.1055/a-2733-3375","url":null,"abstract":"<p><strong>Abstract: </strong>Among the pulmonary issues frequently observed in children with Down syndrome and in the further course of their lives are recurrent and severe respiratory infections, airway anomalies, pulmonary vascular diseases, cystic lung diseases, and obstructive sleep apnea.Common conditions associated with Down syndrome, such as hypotonia, dysphagia, and immune system disorders, can contribute to recurrent respiratory problems. Therefore, children and adults with Down syndrome and persistent or unexplained respiratory symptoms should have these underlying health conditions considered and be treated appropriately. In addition to these respiratory complications, increased morbidity and mortality are often due to further comorbidities, such as obesity, congenital heart defects, gastroesophageal reflux, other gastrointestinal disorders and perioperative complications.It is crucial to recognize that aspiration pneumonia is a significant risk factor; thus, all individuals with Down syndrome should be systematically evaluated for dysphagia, and preventive measures (such as oral hygiene and swallowing training) should be implemented as needed.Given the complexity of certain pulmonary conditions, such as pulmonary hypertension, treatment in specialized centers is recommended.The development of specialized medical care programs for the diagnosis and treatment of respiratory diseases in individuals with Down syndrome is of central importance.</p>","PeriodicalId":520755,"journal":{"name":"Pneumologie (Stuttgart, Germany)","volume":" ","pages":"360-366"},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145498107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Correction: White paper on identification, information, and eligibility assessment of potential participants in lung cancer screening in Germany].","authors":"Torsten Gerriet Blum, Jens Vogel-Claussen, Hans Hoffmann, Martin Reck, Volker Harth, Anton Faron, Ingrid Dänschel, Stefan Andreas, Alexander Rupp, Rudolf Kaaks, Gerald Schmid-Bindert","doi":"10.1055/a-2748-2597","DOIUrl":"10.1055/a-2748-2597","url":null,"abstract":"","PeriodicalId":520755,"journal":{"name":"Pneumologie (Stuttgart, Germany)","volume":" ","pages":"e1"},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13288553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145544838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical and economic role of FeNO measurements in adults with asthma].","authors":"Marek Lommatzsch, Roland Buhl, Christian Taube, Eckard Hamelmann, Ludger Klimek, Susanna Jörger-Tuti, Marcus Joest, Sebastian Sohrab","doi":"10.1055/a-2834-1743","DOIUrl":"10.1055/a-2834-1743","url":null,"abstract":"<p><strong>Abstract: </strong>According to national and international asthma guidelines, FeNO measurement is an indispensable element in the diagnosis and efficient management of asthma. Testing FeNO in a specialist medical care leads to improved treatment of patients with asthma through (1) improved diagnosis of asthma, (2) better control of inhaled therapy, (3) more accurate assessment of adherence, and (4) more precise evaluation of potential biologic therapy. Regular FeNO measurement should therefore be an essential part of specialist care for asthma patients in Germany. Improved asthma management through FeNO measurement also has significant health economic implications as it reduces direct and indirect costs. Reimbursement of FeNO measurement by statutory health insurance (GKV) would therefore not only lead to better care for asthma patients, but also to a reduction in healthcare costs in Germany.</p>","PeriodicalId":520755,"journal":{"name":"Pneumologie (Stuttgart, Germany)","volume":" ","pages":"341-349"},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147702020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rechtsherzechokardiografie bei Patient*innen mit COPD – Schritt für Schritt.","authors":"Eva Pappe, Finn Moritz Wilkens, Matthias Begoihn, Yaosi Li, Max Fritschka","doi":"10.1055/a-2415-8481","DOIUrl":"https://doi.org/10.1055/a-2415-8481","url":null,"abstract":"","PeriodicalId":520755,"journal":{"name":"Pneumologie (Stuttgart, Germany)","volume":"80 5","pages":"391-401"},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147849188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[White paper on identification, information, and eligibility assessment of potential participants in lung cancer screening in Germany].","authors":"Torsten Gerriet Blum, Jens Vogel-Claussen, Hans Hoffmann, Martin Reck, Volker Harth, Anton Faron, Ingrid Dänschel, Stefan Andreas, Alexander Rupp, Rudolf Kaaks, Gerald Schmid-Bindert","doi":"10.1055/a-2697-6434","DOIUrl":"10.1055/a-2697-6434","url":null,"abstract":"<p><strong>Abstract: </strong>The nationwide introduction of lung cancer screening using low-dose computed tomography (LDCT) is imminent in Germany. In contrast to other cancer screening programs, lung cancer screening follows a risk-based approach and specifically targets heavy current and former smokers aged 50 to 75 years. Following several years of pilot phases and regulatory preparation, the Federal Joint Committee (G-BA) decided in June 2025 to include this program as a regular benefit covered by statutory health insurance starting in 2026.Evidence from large international studies demonstrates a significant reduction in lung cancer mortality of approximately 20%. However, there are also risks such as overdiagnosis, unnecessary invasive procedures in false-positive findings, secondary cancers due to radiation exposure, and psychological burden.Key factors for program success include the structured involvement of qualified physicians in the identification, information, and assessment of eligibility of potential participants. Physicians in the fields of general medicine, occupational medicine, and internal medicine have been authorized after specific qualification, the latter of which includes pulmonologists - who, while not explicitly mentioned, will certainly have the closest contact with the high-risk population of smokers. This white paper provides practical information and materials for participating in lung cancer screening. It highlights the importance of dedicated interdisciplinary collaboration to detect as many lung cancer patients as possible at an early and therefore potentially curable stage.</p>","PeriodicalId":520755,"journal":{"name":"Pneumologie (Stuttgart, Germany)","volume":" ","pages":"375-384"},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13314295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145295003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Adult Middle Mediastinal Cystic Lymphangioma: Two Case Reports and Review of Diagnostic and Therapeutic Challenges].","authors":"Naoufal Benabdallah, Erik Büscher, Marcel Opitz, Uta Wülfing, Ahmed Ehab, Kaid Darwiche","doi":"10.1055/a-2831-6578","DOIUrl":"10.1055/a-2831-6578","url":null,"abstract":"<p><strong>Abstract: </strong>Cystic lymphangiomas are rare (1% of all lymphangiomas, 0.7% of mediastinal tumors), predominantly occurring in the anterior mediastinum. Middle mediastinal localization is rare. They are typically asymptomatic and often found as an incidental finding. EBUS-TBNA serves as a minimally invasive diagnostic and occasionally therapeutic approach, while surgical resection remains the definitive treatment with potential recurrence if resected incompletely. Herein, we present two histologically confirmed middle mediastinal cases managed via EBUS-TBNA aspiration and surgical resection, respectively.</p>","PeriodicalId":520755,"journal":{"name":"Pneumologie (Stuttgart, Germany)","volume":" ","pages":"385-390"},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world diagnostic yield and safety of electromagnetic navigation bronchoscopy for pulmonary nodules: Experience of a single centre.","authors":"Carolin Kraska, Susanne M Lang","doi":"10.1055/a-2831-4870","DOIUrl":"https://doi.org/10.1055/a-2831-4870","url":null,"abstract":"<p><p>Electromagnetic navigation bronchoscopy (ENB) is a minimally invasive technology enabling the navigation of bronchoscopic instruments to reach peripheral pulmonary lesions (PPLs) that are otherwise challenging to reach. To date, ENB has primarily been assessed in high-volume centres or within the framework of multicentre trials. Consequently, the actual diagnostic yield in a real-world setting, particularly among patients with varying levels of risk, remains largely unknown.This prospective single-centre cohort study enrolled consecutive patients with PPLs between February 2023 and April 2024. The Medtronic ILLUMISITE platform was utilised to perform ENB procedures. The primary endpoints of the study were the diagnostic yield of ENB as a standalone procedure, assessed at the end of the intervention, and the overall diagnostic accuracy, which incorporated ENB in combination with other diagnostic techniques, evaluated after a 12-month follow-up period. The secondary endpoint was the rate of procedural complications.A total of thirty patients participated in this study. The median lesion size was 16.5 mm. ENB achieved a technical success rate of 93%. The diagnostic yield was 57%. When considering the combination of ENB and other diagnostic methods over the course of a year, the diagnostic accuracy increased to 67%. Two cases of pneumothorax (6.6%), but no instances of bronchopulmonary haemorrhage requiring intervention were observed.This small, single-centre, real-world cohort study, which applied strict definitions for diagnostic yield and accuracy, demonstrates that ENB-aided diagnosis can be successfully achieved in approximately two-thirds of eligible patients, with a low rate of procedural complications.</p>","PeriodicalId":520755,"journal":{"name":"Pneumologie (Stuttgart, Germany)","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147611608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yoga in Fibrosing Interstitial Lung Diseases: a Feasibility Trial.","authors":"Katharina Buschulte, Mareike Kotzerke, Linda Waßmuth, Claudia Ganter, Rembert Koczulla, Philipp Höger, Markus Polke, Nikola Stenzel, Michael Kreuter","doi":"10.1055/a-2831-6649","DOIUrl":"https://doi.org/10.1055/a-2831-6649","url":null,"abstract":"<p><p>Physical activity and quality of life (QoL) are reduced in patients with fibrosing interstitial lung diseases (fILD). Our aim was to assess the feasibility of a yoga intervention and an initial evaluation of effectiveness.Patients with fILD were randomized between yoga (2×/week, 12 weeks, n=9) and surveillance (n=7). The primary endpoint was change in QoL. Following the feasibility approach, we used a mixed method approach for assessing QoL. Qualitative data were collected in focus group interviews, quantitative data through established QoL questionnaires (K-BILD, HADS, LCQ, VAS) at baseline and at 12 weeks.Baseline characteristics in the yoga vs. surveillance groups were: median age 65 vs. 71 years, female 44% vs. 14%, forced vital capacity (FVC) 68% vs. 78%. The average participation rate was 82% and there was no evidence of a medical safety risk. After 12 weeks, there were no significant differences in FVC. However, results showed significant differences for K-BILD total and dyspnea score (p<0.05) favoring yoga, while HADS, LCQ and VAS showed no differences. Post intervention, health-related improvements and transfer of yoga practices into daily life to overcome dyspnea sensation were perceived as main benefits.The results suggest that yoga is feasible for patients with fILD. Moreover, yoga for fILD might be associated with significant benefits in QoL. Data interpretation is limited by imbalances in patient characteristics and small numbers due to its feasibility approach. However, this study provides valuable preliminary insights about acceptability, safety, and preliminary efficacy.</p>","PeriodicalId":520755,"journal":{"name":"Pneumologie (Stuttgart, Germany)","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147611642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-Data Analysis to Explore the Interaction of the Hub-Genes interlinking SARS-CoV-2 and Cardiovascular Diseases.","authors":"Haily Liduin Koyou, Vasudevan Ramachandran, Mohd Nazil Salleh","doi":"10.1055/a-2698-0433","DOIUrl":"10.1055/a-2698-0433","url":null,"abstract":"<p><p>The impact of the pandemic of SARS-CoV-2 infections in the population has caused many diseases onset, post the recovery. The most common is Cardiac injury, which causes further complications that lead to cardiovascular diseases (CVD). This study aimed to analyse the hub genes with a high correlation between SARS-CoV-2 and cardiovascular diseases.The datasets were obtained from the already available GSE196822, GSE196656, and GSE169241 data sets. DESec 2 in R was used for differentially expressed genes, and enriched pathway analysis was performed. Further, Cytoscape used the protein-protein interactions by STRING and hub genes for the common DEGs.The transcriptome analysis of GSE196822 revealed that 7,376 upregulated and 3,673 downregulated genes were the differentially expressed genes (DEGs) among the three selected datasets. Combining the overlap of these data sets for the common genes involved in COVID-19 and CVD, 169 upregulated and 123 downregulated DEGs were observed. These DEGs are further examined with GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes). The KEGG pathway revealed 21 upregulated and 11 downregulated pathways, where the highest count was recorded in transcriptional misregulations in cancer and metabolic pathways, respectively. The top 10 hub genes analysis and PPI network analysis revealed their interlinings for upregulation and downregulations, respectively. The top three upregulated genes (TIMP1, MPO, NFKBIA) and downregulated genes (ACSS1, OXCT1, ADHFE1) identified by differential expression analysis were validated by qRT-PCR, confirming their significant and consistent expression changes under the experimental conditions.The 9 out of 10 hub genes with elevated co-expressibility of linked genes between COVID-19 and CVD showed complications consistent with previous reports. Our findings further suggest that these hub genes may serve dual purposes: as indicators of early viral infection, including COVID-19 and related viral illnesses, and as potential predictors of cardiovascular disease (CVD) onset following COVID-19 infection. This work strongly urges health policymakers to implement screening for COVID-19 complications, especially CVDs, in the general public.</p>","PeriodicalId":520755,"journal":{"name":"Pneumologie (Stuttgart, Germany)","volume":" ","pages":"271-282"},"PeriodicalIF":1.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}