Yoga in Fibrosing Interstitial Lung Diseases: a Feasibility Trial.

Abstract

Physical activity and quality of life (QoL) are reduced in patients with fibrosing interstitial lung diseases (fILD). Our aim was to assess the feasibility of a yoga intervention and an initial evaluation of effectiveness.Patients with fILD were randomized between yoga (2×/week, 12 weeks, n=9) and surveillance (n=7). The primary endpoint was change in QoL. Following the feasibility approach, we used a mixed method approach for assessing QoL. Qualitative data were collected in focus group interviews, quantitative data through established QoL questionnaires (K-BILD, HADS, LCQ, VAS) at baseline and at 12 weeks.Baseline characteristics in the yoga vs. surveillance groups were: median age 65 vs. 71 years, female 44% vs. 14%, forced vital capacity (FVC) 68% vs. 78%. The average participation rate was 82% and there was no evidence of a medical safety risk. After 12 weeks, there were no significant differences in FVC. However, results showed significant differences for K-BILD total and dyspnea score (p<0.05) favoring yoga, while HADS, LCQ and VAS showed no differences. Post intervention, health-related improvements and transfer of yoga practices into daily life to overcome dyspnea sensation were perceived as main benefits.The results suggest that yoga is feasible for patients with fILD. Moreover, yoga for fILD might be associated with significant benefits in QoL. Data interpretation is limited by imbalances in patient characteristics and small numbers due to its feasibility approach. However, this study provides valuable preliminary insights about acceptability, safety, and preliminary efficacy.