Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society最新文献_第5页

Evaluating the Prognostic Implication of the Collins Histology Scoring System in a Pediatric Eastern Ontario Population With Eosinophilic Esophagitis. 评价柯林斯组织学评分系统在安大略省东部儿童嗜酸性食管炎患者中的预后意义。

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Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2022-05-01 Epub Date: 2022-01-03 DOI: 10.1177/10935266211064698

Dina El Demellawy, Irina Oltean, Lamia Hayawi, Amisha Agarwal, Richard Webster, Joseph de Nanassy, Elizaveta Chernetsova

{"title":"Evaluating the Prognostic Implication of the Collins Histology Scoring System in a Pediatric Eastern Ontario Population With Eosinophilic Esophagitis.","authors":"Dina El Demellawy, Irina Oltean, Lamia Hayawi, Amisha Agarwal, Richard Webster, Joseph de Nanassy, Elizaveta Chernetsova","doi":"10.1177/10935266211064698","DOIUrl":"https://doi.org/10.1177/10935266211064698","url":null,"abstract":"Introduction: Collins et al developed a histology scoring system (EoE HSS) to assess multiple pathologic features. The aim of this study is to identify if the EoE HSS can better detect endoscopic and symptom improvement vs the Peak Eosinophilic Count (PEC).Methods: A retrospective chart review was performed for patients during 2014-2016. All patients ≤18 years old with a diagnosis of EoE and whose records included initial and follow-up upper gastrointestinal endoscopies were included. Severity and extent of endoscopic features were scored using 8 parameters, from normal to maximum change for each location of the esophageal biopsy.Results: Forty patients with EoE were included in the study, of which 35 (87.5%) patients demonstrated symptom and 25 (62.5%) endoscopic improvement at the time of follow-up. In the proximal esophagus, the EoE HSS outperformed the change in eosinophil count of the Children's Hospital of Eastern Ontario (CHEO) practice in predicting endoscopic improvement by 16.8% when examining the change in grade and 17.1% when examining the change in stage scores.Conclusions: At our institution, adoption of the EoE HSS in assessing biopsies of EoE patients might be warranted, compared to the traditional practice. However, a bigger sample size may give a more robust difference in all locations.","PeriodicalId":520743,"journal":{"name":"Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society","volume":" ","pages":"296-303"},"PeriodicalIF":1.9,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39777685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The EXTrauterine Environment for Neonatal Development: Present and Future. 新生儿发育的宫外环境:现在和未来。

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Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2022-05-01 Epub Date: 2022-02-01 DOI: 10.1177/10935266211067110

Abby C Larson, Felix R De Bie, Jonathan Chang, Marcus G Davey, Alan W Flake

引用次数: 3

Pseudodiverticulum of the Cervical Esophagus With Remnant of Branchial Tissues in a Newborn: A Case Report. 新生儿颈食管假性憩室伴鳃裂组织残留1例。

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Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2022-05-01 Epub Date: 2022-01-07 DOI: 10.1177/10935266211066398

Anne-Sophie Prevost, Sami Bannoura, Bo-Yee Ngan, Jennifer M Siu, Hedyeh Ziai, Paolo Campisi

引用次数: 0

High-Grade Fetal Vascular Malperfusion Is Associated With Diffuse Chorionic Hemosiderosis. 胎儿高级别血管灌注不良与弥漫性绒毛膜含铁血黄素沉着症有关。

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Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2022-05-01 Epub Date: 2021-12-28 DOI: 10.1177/10935266211064694

Eoghan E Mooney, Emma Crotty

{"title":"High-Grade Fetal Vascular Malperfusion Is Associated With Diffuse Chorionic Hemosiderosis.","authors":"Eoghan E Mooney, Emma Crotty","doi":"10.1177/10935266211064694","DOIUrl":"https://doi.org/10.1177/10935266211064694","url":null,"abstract":"Introduction: Diffuse chorionic hemosiderosis (DCH) is an abnormality of the placental membranes characterized by the deposition of iron pigment. It is usually secondary to recurrent venous bleeding in early pregnancy. In many papers, it is associated with pre-term delivery. Fetal vascular malperfusion (FVM) is an abnormality of the feto-placental circulation that may be seen at any stage of gestation, but most often in the third trimester. It may be graded as low grade (LGFVM) or high grade (HGFVM). No link has been identified in the placental literature between DCH and FVM, but we have noted the 2 co-existing in placentas submitted for analysis. This study explored a possible association of these 2 entities.Methods: Laboratory records were searched for singleton cases coded as DCH based on diagnosis on H&E stain over a 6-year period. Of 4478 placentas reported, 66 cases were coded as DCH (1.5%). These were classified as showing HGFVM, LGFVM, or no FVM. Controls (n = 132) were gestational age-matched cases without DCH. Cord length, coiling, insertion, or other abnormalities were noted. Membranes were classified as normal or circumvallate. Results were analyzed using Graphpad.Results: Gestation ranged between 16 and 41 weeks gestation. 14/66 (21%) cases of DCH showed HGFVM and 2/66 (3%) showed LGFVM. 16/132 (12%) controls showed HGFVM and 21/132 (15.9%) had LGFVM. Where FVM is present, high-grade FVM is significantly associated with DCH versus controls (P < .0031 Fischer's Test).Discussion: HGFVM occurs significantly more often in placentas with DCH than in controls. Both FVM and DCH are associated with adverse perinatal outcomes, and a possible relationship between the 2 remains to be clarified.","PeriodicalId":520743,"journal":{"name":"Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society","volume":" ","pages":"292-295"},"PeriodicalIF":1.9,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39630355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mixed chorangioma and leiomyoma of the placenta, with a brief review of nontrophoblastic placental lesions. 胎盘混合性脉管瘤和平滑肌瘤，并简要回顾非滋养细胞性胎盘病变。

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Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2022-05-01 Epub Date: 2021-10-04 DOI: 10.1177/10935266211047775

Stacy D Webb, Maria Paola Bonasoni, Andrea Palicelli, Giuseppina Comitini, Debra S Heller

{"title":"Mixed chorangioma and leiomyoma of the placenta, with a brief review of nontrophoblastic placental lesions.","authors":"Stacy D Webb, Maria Paola Bonasoni, Andrea Palicelli, Giuseppina Comitini, Debra S Heller","doi":"10.1177/10935266211047775","DOIUrl":"https://doi.org/10.1177/10935266211047775","url":null,"abstract":"Chorangioma is the most common type of primary non-trophoblastic tumor of the placenta, usually identified incidentally on ultrasound or at delivery. Leiomyomas within the placenta have been described, though they are rare and usually of maternal origin. We present an unusual case of a placental tumor with combined histopathologic and immunohistochemical features of both chorangioma and leiomyoma. A 39-year-old woman was found to have an echogenic placental mass at 33 weeks of gestation on ultrasound, that was thought to be a chorangioma. They followed up weekly, and performed a cesarean section at 39 weeks, due to concern for intrauterine growth restriction. No fetal or maternal complications occurred. Grossly, a 9-cm, red-brown mass with a broad-based stalk was identified on the fetal surface of the placenta near the periphery. Microscopically, the lesion was found to display characteristic features of chorangioma, with vascular proliferation, which stained positive for CD34 and CD31. SMA and caldesmon immunohistochemical staining was also positive, highlighting the proliferation of smooth muscle throughout the neoplasm. Literature review revealed a single additional case with similar characteristics.","PeriodicalId":520743,"journal":{"name":"Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society","volume":" ","pages":"316-320"},"PeriodicalIF":1.9,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39486718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Authors' Reply. 作者的回答。

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Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2022-05-01 Epub Date: 2021-12-10 DOI: 10.1177/10935266211054280

Marcory Crf van Dijk, Robert Kornegoor, Suzanne Mol, Michael Rodriguez

引用次数: 0

On "Fetal and Perinatal Brain Autopsy: Useful Macroscopic Techniques Including Agar In-Situ and Pre-Embedding Methods". 关于“胎儿和围产期脑解剖:有用的宏观技术，包括琼脂原位和预包埋方法”。

IF 1.9

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2022-05-01 Epub Date: 2021-12-10 DOI: 10.1177/10935266211054589

Alfons Nadal

引用次数: 0

Characterization of the Transition Zone in Short Segment Hirschsprung Disease Using Calretinin Immunostaining. 用Calretinin免疫染色表征短节段巨结肠疾病的过渡区。

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Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2022-05-01 Epub Date: 2021-12-08 DOI: 10.1177/10935266211053973

Franziska Righini-Grunder, Dorothée Bouron-Dal Soglio, Lara Hart, Ann Aspirot, Christophe Faure, Natacha Patey

{"title":"Characterization of the Transition Zone in Short Segment Hirschsprung Disease Using Calretinin Immunostaining.","authors":"Franziska Righini-Grunder, Dorothée Bouron-Dal Soglio, Lara Hart, Ann Aspirot, Christophe Faure, Natacha Patey","doi":"10.1177/10935266211053973","DOIUrl":"https://doi.org/10.1177/10935266211053973","url":null,"abstract":"Introduction: The detailed expression pattern of calretinin immunohistochemistry in the transition zone (TZ) of Hirschsprung disease (HSCR) has not yet been reported. This study aims to examine the value of calretinin immunohistochemistry for more accurately determining the distal and proximal border of the TZ in short segment HSCR. Methods: Specimens of pull-through surgery from 51 patients with short form of HSCR were analyzed on two longitudinal strips using hematoxylin and eosin (H&E) staining and calretinin immunohistochemistry. Results: In all but two patients, the first appearance of calretinin expression was seen on mucosal nerve fibers before the appearance of any ganglion cells, indicating the distal border of the TZ. The maximum distance between the distal border of the TZ and the proximal border of the TZ, defined by ganglion cells in a normal density on H&E stained sections, a strong calretinin expression on mucosal nerve fibers and in >80% of submucosal and myenteric ganglion cells, with no nerve hypertrophy and absence of ganglionitis was 60 mm. Conclusion: The distal border of the TZ is characterized by calretinin positive intramucosal neurites in nearly all of short form of HSCR and not by calretinin expression on ganglion cells.","PeriodicalId":520743,"journal":{"name":"Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society","volume":" ","pages":"270-277"},"PeriodicalIF":1.9,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39699904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Collagen XI Alpha 1 (COL11A1) Expression in the Tumor Microenvironment Drives Neuroblastoma Dissemination.

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Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2022-03-01 Epub Date: 2021-08-30 DOI: 10.1177/10935266211039200

Dinh Quang Truong, Ban Tran Ho, Gia-Cac Chau, Dinh Khai Truong, Thuy Thi Thanh Pham, Akira Nakagawara, Chi-Bao Bui

{"title":"Collagen XI Alpha 1 (COL11A1) Expression in the Tumor Microenvironment Drives Neuroblastoma Dissemination.","authors":"Dinh Quang Truong, Ban Tran Ho, Gia-Cac Chau, Dinh Khai Truong, Thuy Thi Thanh Pham, Akira Nakagawara, Chi-Bao Bui","doi":"10.1177/10935266211039200","DOIUrl":"https://doi.org/10.1177/10935266211039200","url":null,"abstract":"Background: Neuroblastoma (NB) is among the most common cancers in children. A highly aggressive form of cancer, NB relies on cells in the microenvironment for dissemination particularly cancer associated fibroblast (CAFs). CAFs synthesise the extracellular matrix to create a scaffold for tumor growth thus enabling the carcinogenesis of NB, Collagen, an abundant scaffold protein produced by CAFs, has been implicated in the creation of an optimal tumor microenvironment, however, the expression profile of collagen within NB is not yet known.Methods: We characterised collagen expression within the tumor-stroma boundary by microarray and confirmed by qRT-PCR and immunohistochemistry.Results: The collagen marker, COL11A1, was also upregulated in NB CD45+ cells and SMA+ CAFs. Furthermore, SMA+ CAFs led to neuroblastoma cell invasion in an in vitro co-culture system which was subsequently attenuated by gene silencing COL11A1. Immunohistochemical staining of clinical tumor samples revealed that high COL11A1 expression in the stroma adjacent to tumour site, significantly associated with advanced cancer stages, age ≥18 months, undifferentiated tumor status, relapse and poor overall survival.Conclusion: Collectively, these results suggest that a COL11A1 signature in the NB microenvironment could represent a novel target for therapeutic intervention.","PeriodicalId":520743,"journal":{"name":"Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society","volume":" ","pages":"91-98"},"PeriodicalIF":1.9,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39367138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Biallelic Mutations in Ubiquitin-Specific Peptidase 53 (USP53) Causing Progressive Intrahepatic Cholestasis. Report of a Case With Review of Literature. 泛素特异性肽酶53 (USP53)引起进行性肝内胆汁淤积的双等位基因突变。一例病例报告并文献复习。

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Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2022-03-01 Epub Date: 2021-11-22 DOI: 10.1177/10935266211051175

Mukul Vij, Srinivas Sankaranarayanan

引用次数: 5