Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society最新文献_第5页

Perinatal Autopsy Guidance for the General Pathologist. 一般病理学家围产期尸检指南。

IF 1.3

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2026-07-01 Epub Date: 2026-07-02 DOI: 10.1177/10935266261419538

Beverly B Rogers, M Halit Pinar, Linda M Ernst, Erica Price, Fusun Gundogan

{"title":"Perinatal Autopsy Guidance for the General Pathologist.","authors":"Beverly B Rogers, M Halit Pinar, Linda M Ernst, Erica Price, Fusun Gundogan","doi":"10.1177/10935266261419538","DOIUrl":"10.1177/10935266261419538","url":null,"abstract":"Purpose: The purpose of this article is to highlight the unique aspects of the perinatal autopsy, compared to the autopsy of patients outside the perinatal period. This article focuses on what would be useful to general pathologists who perform autopsies as a small portion of their practice. We will also discuss in some detail the autopsy of the macerated fetus and determining time of death prior to delivery.Background: General pathologists performing perinatal autopsies commonly lack specific training in perinatal autopsy techniques, where interpretation of detailed measurements and dissections are essential. Macerated fetuses provide an additional challenge, as planes of dissection are hard to see and microscopic examinations require interpretation of degenerated tissue.Content: This article describes the basic steps to perform a perinatal autopsy including tips to streamline dissections, which are useful for the general pathologist. It includes how to recognize features of maceration to provide an accurate time of death prior to delivery and information about the classification of the cause of death in stillbirth.","PeriodicalId":520743,"journal":{"name":"Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society","volume":"29 4","pages":"406-430"},"PeriodicalIF":1.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148379602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Foreword. 前言。

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Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2026-07-01 Epub Date: 2026-07-02 DOI: 10.1177/10935266251413364

Beverly B Rogers

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The Placenta: Identifying Normal. 胎盘：正常的识别。

IF 1.3

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2026-07-01 Epub Date: 2026-07-02 DOI: 10.1177/10935266251413974

Beverly B Rogers, Teck Yee Khong, Erica Price, Halit Pinar, Füsun Gündoğan, Linda M Ernst

{"title":"The Placenta: Identifying Normal.","authors":"Beverly B Rogers, Teck Yee Khong, Erica Price, Halit Pinar, Füsun Gündoğan, Linda M Ernst","doi":"10.1177/10935266251413974","DOIUrl":"https://doi.org/10.1177/10935266251413974","url":null,"abstract":"Purpose: To provide information for the general pathologist about what is considered normal in the placenta and to differentiate findings that are abnormal or pathologic.Background: The literature about the placenta is confusing. It can be opinionated, and terminology varies among authors. Even what is expected to be seen, which we refer to as normal, is not consistent among experts.Results: This article focuses on what the general pathologist should know about normal macroscopic and histologic features of the placenta throughout gestation, as well as alterations that are controversial related to whether they are normal or not. Normal findings are differentiated from pathology when the morphology is confusing or overlaps. We further guide the reader to selected literature that describes pathology in clear, understandable terms. This is not a consensus document but does represent agreement among the authors and, when agreement isn't reached, differing opinions are noted.Conclusion: This article is a report of normal features in the placenta based on distillation of evidence from the literature and personal experience in areas where the literature fails to provide clarity.","PeriodicalId":520743,"journal":{"name":"Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society","volume":"29 4","pages":"442-476"},"PeriodicalIF":1.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148379599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the Autopsy: The Role of Postmortem Conferences in Supporting Families. 超越尸检：尸检会议在支持家庭中的作用。

IF 1.3

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2026-07-01 Epub Date: 2026-07-02 DOI: 10.1177/10935266261417530

Halit Pinar, Füsun Gündoğan

{"title":"Beyond the Autopsy: The Role of Postmortem Conferences in Supporting Families.","authors":"Halit Pinar, Füsun Gündoğan","doi":"10.1177/10935266261417530","DOIUrl":"10.1177/10935266261417530","url":null,"abstract":"Purpose: This manuscript examines the role of postmortem conference in supporting families in their grief and enhancing care following perinatal loss. It synthesizes current knowledge, highlights challenges in recognition and support, and recommends evidence-based approaches for healthcare professionals to better address the needs of grieving families.Content: Perinatal loss, encompassing miscarriage, stillbirth, and neonatal death, is profoundly distressing, affecting individuals, couples, and families. This manuscript explores the complex nature of grief following perinatal loss, emphasizing the psychological, emotional, and social challenges bereaved parents may face. It synthesizes recent literature focused on grief and bereavement. The disenfranchised nature of perinatal grief, the insufficient recognition and support from social networks and healthcare providers, and implications for long-term mental health are discussed. Evidence-based interventions and supportive approaches include compassionate communication, memory-making practices, and psychological therapies tailored for perinatal loss. Best practices for healthcare professionals and recommendations for institutional policies that foster a supportive environment for grieving families are highlighted. The manuscript addresses the need for increased education, resources, and research to improve care outcomes. By recognizing the legitimacy and depth of perinatal grief, and addressing it through holistic, responsive care, both immediate suffering and long-term complications for parents and families can be mitigated.","PeriodicalId":520743,"journal":{"name":"Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society","volume":"29 4","pages":"438-441"},"PeriodicalIF":1.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13332183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148379578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Terminology in Perinatal Pathology. 围产期病理学术语。

IF 1.3

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2026-07-01 Epub Date: 2026-07-02 DOI: 10.1177/10935266251411774

Beverly B Rogers, Linda M Ernst

引用次数: 0

Normal Fetal Growth and Development. 正常胎儿生长发育。

IF 1.3

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2026-07-01 Epub Date: 2026-07-02 DOI: 10.1177/10935266251410277

Beverly B Rogers, Teck Yee Khong

{"title":"Normal Fetal Growth and Development.","authors":"Beverly B Rogers, Teck Yee Khong","doi":"10.1177/10935266251410277","DOIUrl":"https://doi.org/10.1177/10935266251410277","url":null,"abstract":"Purpose: To explain which growth and development parameters are most useful when faced with a perinatal autopsy and identify factors complicating the use of these parameters.Background: Growth and development charts seem to be straightforward, but when faced with a perinatal autopsy, they may be confusing or misleading. Autopsy weight and measurement charts are based on much smaller groups of individuals than clinical charts. Perinatal postmortem growth charts are confounded by maceration, the small numbers of subjects to define normal, and population differences. Interpretation of growth and development parameters when performing a perinatal autopsy is complicated by the interpretation of deviations from expected or \"normal\" as defined by the charts.Results: This article provides an analysis of growth and development charts used in perinatal examinations and gives guidance about which charts are the most robust. Weights, measurements, and aspects of development will be described and distilled into those most relevant to the general pathologist.Conclusion: Growth and development charts are important when performing a perinatal autopsy to define what is normal versus pathologic, and a distillation of the key points with review of the literature is central to using them.","PeriodicalId":520743,"journal":{"name":"Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society","volume":"29 4","pages":"366-381"},"PeriodicalIF":1.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148379581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Founders in Pediatric Pathology. 儿科病理学的创始人。

IF 1.3

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2026-07-01 Epub Date: 2026-07-02 DOI: 10.1177/10935266251411765

Halit Pinar, Beverly B Rogers, Heather Rytting, C James Sung

引用次数: 0

Early-Onset Severe Liver Fibrosis in a Toddler with Erythropoietic Protoporphyria Associated with Rare Compound Heterozygous FECH Variants. 与罕见复合杂合FECH变异相关的促红细胞生成性原生卟啉症患儿早发性严重肝纤维化

IF 1.3

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2026-06-23 DOI: 10.1177/10935266261460719

Lilong Guo, Nagraj Kasi, David Lewin, Chadi Hajar

{"title":"Early-Onset Severe Liver Fibrosis in a Toddler with Erythropoietic Protoporphyria Associated with Rare Compound Heterozygous FECH Variants.","authors":"Lilong Guo, Nagraj Kasi, David Lewin, Chadi Hajar","doi":"10.1177/10935266261460719","DOIUrl":"https://doi.org/10.1177/10935266261460719","url":null,"abstract":"Background: Erythropoietic Protoporphyria (EPP) is a rare inherited disorder of heme biosynthesis caused by pathogenic variants in FECH. Although most patients present with cutaneous photosensitivity in childhood, clinically significant liver disease is uncommon, and severe fibrosis in early childhood is rarely reported.Case: A 2-year-old girl presented with recurrent photosensitivity and erythematous swelling after sun exposure. Laboratory evaluation revealed markedly elevated erythrocyte protoporphyrin (2406 µg/dL) and elevated plasma protoporphyrin. Genetic testing identified compound heterozygous FECH variants: c.901_902del (p.Trp301Alafs*23) and c.801G>A (p.Met267Ile). Liver enzymes were significantly elevated. Following liver biopsy demonstrated stage 3 bridging fibrosis with crystalline deposits in hepatocytes consistent with protoporphyric hepatopathy. The patient subsequently underwent hematopoietic stem cell transplantation with improvement of protoporphyrin levels and liver enzymes. However, the post-transplant course was complicated by severe infections, acute respiratory distress syndrome, and multiorgan failure, resulting in death.Conclusion: This case highlights rapidly progressive liver fibrosis in a toddler with EPP and emphasizes the importance of early hepatic monitoring in pediatric patients with markedly elevated protoporphyrin levels and rare FECH variants.","PeriodicalId":520743,"journal":{"name":"Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society","volume":" ","pages":"10935266261460719"},"PeriodicalIF":1.3,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148304648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fetiform Teratoma With a Digitiform Projection and Complex Organoid Differentiation (Adrenal and Pancreatic). 具有数字化投影和复杂类器官分化（肾上腺和胰腺）的畸胎瘤。

IF 1.3

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2026-06-17 DOI: 10.1177/10935266261457324

Svetlana Shalygina, Leticia Gracia Sáenz, Jerónimo Gonzálvez Piñera, Diana Patricia Cañón Murillo, Francisca María Peiró Marqués, Gloria Peiró Cabrera

{"title":"Fetiform Teratoma With a Digitiform Projection and Complex Organoid Differentiation (Adrenal and Pancreatic).","authors":"Svetlana Shalygina, Leticia Gracia Sáenz, Jerónimo Gonzálvez Piñera, Diana Patricia Cañón Murillo, Francisca María Peiró Marqués, Gloria Peiró Cabrera","doi":"10.1177/10935266261457324","DOIUrl":"https://doi.org/10.1177/10935266261457324","url":null,"abstract":"Fetiform teratoma (FT) and fetus-in-fetu (FIF) represent a spectrum of rare retroperitoneal masses containing organoid structures. While FIF is classically defined by the presence of a vertebral axis, FT lacks this organized skeletal development. Distinguishing between these entities is critical given the malignant potential associated with FT, estimated at approximately 10%. We report a case of a 5-month-old male presenting with a large (12 cm) retroperitoneal mass and elevated alpha-fetoprotein (AFP 56.8 IU/mL; age-matched reference <7 IU/mL). Macroscopically, the resected tumor featured a distinct rudimentary digitiform projection with a nail bed. Histopathology demonstrated extensive organoid differentiation, including gastrointestinal loops with muscular layers, respiratory epithelium, and well-formed pancreatic parenchyma and adrenal cortex. Despite the complex organogenesis and limb-like morphology, the absence of a vertebral column or ossified long bones supported a diagnosis of mature cystic teratoma with fetiform features (FT) over FIF. This report highlights the diagnostic ambiguity within the \"gray zone\" of these lesions and emphasizes the role of axial skeletal organization and serum AFP levels as complementary tools for classification and oncologic surveillance.","PeriodicalId":520743,"journal":{"name":"Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society","volume":" ","pages":"10935266261457324"},"PeriodicalIF":1.3,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148274304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterizing Fetal Hemorrhage in a Perinatal Autopsy Cohort. 围产期尸检队列中胎儿出血的特征。

IF 1.3

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2026-06-16 DOI: 10.1177/10935266261458194

Erica Price, Sunitha Suresh, Linda M Ernst

{"title":"Characterizing Fetal Hemorrhage in a Perinatal Autopsy Cohort.","authors":"Erica Price, Sunitha Suresh, Linda M Ernst","doi":"10.1177/10935266261458194","DOIUrl":"https://doi.org/10.1177/10935266261458194","url":null,"abstract":"Background: Fetal hemorrhage (FH) is an important and difficult cause of death to recognize at perinatal autopsy. Existing literature is restricted to case reports and small case series, and none comprehensively describe both placental and autopsy findings. We sought to characterize fetal and placenta findings where the ultimate cause of death was determined to be FH to aid in the identification of these cases.Materials and methods: This is an autopsy series of perinatal deaths with fetomaternal hemorrhage (FMH) and FH into the amnionic sac. We included singleton pregnancies with Kleihauer Betke (KB) testing, and divided cases into 3 groups: FMH with ≥40% of fetal blood volume, FMH ≤39%, and suspected FH into the amnionic sac with negative KB test.Results: We identified 20 cases from 691 perinatal autopsies, 10 with FMH ≥40%, 5 with FMH ≤39%, and 5 suspected FH into the amnionic sac. Cases with FMH≥40% were likely to have a normal placental weight, villous edema, and fetal hydrops. While FH into the amnionic sac was more likely to have a small placenta with disruption/defect of fetal vessels, and less likely to have fetal hydrops.Conclusion: This study describes the differences and similarities between cases with FMH and FH in to the amnionic sac, and highlights the need for careful placenta and fetal autopsy examinations.","PeriodicalId":520743,"journal":{"name":"Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society","volume":" ","pages":"10935266261458194"},"PeriodicalIF":1.3,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148267898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0