Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society最新文献

Multicystic Adenomatoid Pancreatic Hamartoma in a Child: Case Report. 儿童胰腺多囊腺瘤样错构瘤1例。

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Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2025-10-06 DOI: 10.1177/10935266251381436

Fatma Cavide Sönmez, Marcus Pauly, Annette M Müller

引用次数: 0

Left Pulmonary Artery Sling: Anatomy, Associations, and Outcome of Surgical Repair as Demonstrated by Autopsies. 左肺动脉悬吊：解剖、关联和解剖证实的手术修复结果。

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Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2025-10-03 DOI: 10.1177/10935266251366015

Yan Zhou, Stephen P Sanders, Chrystalle Katte Carreon

引用次数: 0

Letter to the Editor. 给编辑的信。

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Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2025-09-28 DOI: 10.1177/10935266251357777

Linda M Ernst

引用次数: 0

PRRX1-Rearranged Mesenchymal Tumor: A Case Report and Review of the Literature. prrx1 -重排间充质瘤1例报告及文献复习

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Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2025-09-16 DOI: 10.1177/10935266251374258

Geoffrey C Halling, Jonathan B McHugh, Amer Heider

引用次数: 0

High-Grade Malignant Pleuropulmonary Neoplasm With YAP1::MAML2 Gene Fusion. 高级别胸膜肺恶性肿瘤与YAP1::MAML2基因融合。

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Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2025-09-16 DOI: 10.1177/10935266251374255

Shengmei Zhou, Ryan Schmidt, Paul Zamiara, Nick Shillingford

引用次数: 0

Pregnancy Loss Associated with COVID-19 Infection: Associations with Detection of Viral RNA in Placental and Fetal Tissue. 与COVID-19感染相关的妊娠丢失：与胎盘和胎儿组织中病毒RNA检测的关联

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Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2025-09-11 DOI: 10.1177/10935266251368434

Ansa Mehreen, Erica Price, Vivien Wang, Sunitha Suresh, Kathy Mangold, Linda Sabatini, John Lee, Linda M Ernst

{"title":"Pregnancy Loss Associated with COVID-19 Infection: Associations with Detection of Viral RNA in Placental and Fetal Tissue.","authors":"Ansa Mehreen, Erica Price, Vivien Wang, Sunitha Suresh, Kathy Mangold, Linda Sabatini, John Lee, Linda M Ernst","doi":"10.1177/10935266251368434","DOIUrl":"https://doi.org/10.1177/10935266251368434","url":null,"abstract":"Background: The purpose of this study was to investigate placental pathology and cause of death (COD) in pregnancy losses associated with maternal COVID-19 infection and examine associations with detection of SARS-CoV-2 in placenta and fetal organs.Methods: Demographics, placental pathology, and COD information was collected from fetal autopsies done at Evanston hospital, IL between 03/1/2020 and 12/31/2022 where maternal history indicated positive SARS-CoV-2 test during pregnancy or SARS-CoV-2 infection was suspected after fetal autopsy. Polymerase chain reaction (PCR) testing for SARS-CoV-2 RNA was performed on placenta, fetal liver, and lung tissue.Results: We identified 13 autopsies and detected SARS-CoV-2 in placentas of 5 cases, all showed chronic histiocytic intervillositis (CHI) and massive perivillous fibrin deposition (MPVFD). CHI and MPVFD were absent in all the PCR-negative cases (P < .001). Fetal liver was positive for SARS-CoV-2 in 1 case, which was in the group with negative placental SARS-CoV-2 PCR. The lung tissue was negative in all cases.Conclusion: We confirm the association between detectable placental SARS-CoV-2 with CHI and MPVFD in placentas from pregnancy losses in mother who had COVID-19 during their pregnancy. Detection of SARS-CoV-2 in fetal liver, despite negative placental tissue, was unexpected and may be important for understanding the impact of maternal COVID infection on neonates.","PeriodicalId":520743,"journal":{"name":"Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society","volume":" ","pages":"10935266251368434"},"PeriodicalIF":1.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phyllodes Tumor of Breast in Pediatric and Adolescent Population: A Detailed Clinicopathological Study of 22 Cases. 儿童和青少年乳腺叶状瘤：22例详细临床病理研究。

IF 1.3

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2025-09-09 DOI: 10.1177/10935266251369273

Muhammad Usman Tariq, Nasir Ud Din, Taha Nafees, Naila Kayani

{"title":"Phyllodes Tumor of Breast in Pediatric and Adolescent Population: A Detailed Clinicopathological Study of 22 Cases.","authors":"Muhammad Usman Tariq, Nasir Ud Din, Taha Nafees, Naila Kayani","doi":"10.1177/10935266251369273","DOIUrl":"https://doi.org/10.1177/10935266251369273","url":null,"abstract":"Introduction: Phyllodes tumor (PT) are rarely seen in young population. Some authors believe that PT behave less aggressively in young patients and the need for aggressive management is questioned.Objective: We aimed to describe the clinicopathological features of PT in pediatric and adolescent population.Methodology: We reviewed the reports and microscopy glass slides of PT from 22 pediatric and adolescent patients (≤20 years old), diagnosed between 2010 and 2024.Results: Eighteen cases were malignant PT (MPT), 3 benign PT, and 1 borderline PT. Median patient's age was 17 years (range: 14-20). Median tumor size was 11.25 cm (range: 1.3-22). Tumor margins were either positive or <1 mm away in 10/17 (58.9%) tumor excisions. Follow up information was available for 12 MPT patients with median follow up duration of 26.5 months. Recurrence was observed in 2/10 (20%) primary MPT cases at 2- and 3-months interval. Distant metastasis was observed in 4/12 (33.3%) cases at median interval of 12 months. One of the metastatic cases and another patient without definite treatment, died of disease.Conclusion: We observed higher frequency of MPT patients, larger tumor size, and higher rate of mastectomy. MPT behave aggressively as evidenced by recurrence, metastasis, and tumor-related death.","PeriodicalId":520743,"journal":{"name":"Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society","volume":" ","pages":"10935266251369273"},"PeriodicalIF":1.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fusion-Negative Rhabdomyosarcoma: Clinical Application of Targeted RNA Sequencing. 融合阴性横纹肌肉瘤：靶向RNA测序的临床应用。

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Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2025-09-09 DOI: 10.1177/10935266251370493

Aida Glembocki, Robert Siddaway, Anthony Arnoldo, Gino R Somers

{"title":"Fusion-Negative Rhabdomyosarcoma: Clinical Application of Targeted RNA Sequencing.","authors":"Aida Glembocki, Robert Siddaway, Anthony Arnoldo, Gino R Somers","doi":"10.1177/10935266251370493","DOIUrl":"https://doi.org/10.1177/10935266251370493","url":null,"abstract":"Background: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood. For stratification purposes, rhabdomyosarcoma is classified into fusion-positive RMS (alveolar rhabdomyosarcoma) and fusion-negative RMS (embryonal or spindle cell/sclerosing, FN-RMS) subtypes according to its PAX::FOXO1 fusion status. This study aims to highlight the pathologic and molecular characteristics of a cohort of FN-RMS using a targeted NGS RNA-Seq assay.Methods: Twelve tumors were analyzed through targeted RNA-Seq using the Trusight Pancancer panel from Illumina. Molecular alterations were then correlated with the clinicopathological features.Results: Of the 12 tumors analyzed, we identified 6 embryonal rhabdomyosarcomas (ERMSs) harboring mutations in key signaling molecules (KRAS, HRAS, NRAS, and FGFR4), oncogenic DICER1 mutations in 2 ERMS, pathogenic TP53 and NF1 mutations in an ERMS with features of anaplasia, a TEAD1::NCOA2 gene fusion in a congenital spindle cell and sclerosing rhabdomyosarcoma (SSRMS), and a FUS::TFCP2 gene fusion in a skull base SSRMS. Only 1 ERMS in the bladder showed no reportable molecular alterations.Conclusion: We illustrate case examples demonstrating how a combined morphological and molecular approach with targeted RNA-Seq can aid in diagnosis and identify clinically actionable alterations in pediatric FN-RMS.","PeriodicalId":520743,"journal":{"name":"Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society","volume":" ","pages":"10935266251370493"},"PeriodicalIF":1.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating Intestinal Metaplasia in Pediatric Gallbladder Specimens: Clinicopathologic Significance and Sampling Thresholds. 评估儿童胆囊标本肠化生：临床病理意义和抽样阈值。

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Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2025-09-01 Epub Date: 2025-05-20 DOI: 10.1177/10935266251341508

Adeyinka Akinsanya, Iván A González

{"title":"Evaluating Intestinal Metaplasia in Pediatric Gallbladder Specimens: Clinicopathologic Significance and Sampling Thresholds.","authors":"Adeyinka Akinsanya, Iván A González","doi":"10.1177/10935266251341508","DOIUrl":"10.1177/10935266251341508","url":null,"abstract":"Background: Gallbladders are a commonly encounter specimen in pediatric pathology practice. In the adult population, intestinal metaplasia (IM) in the gallbladder is associated with the development of dysplasia and adenocarcinoma; however, in children its significance is unknown, and the appropriate sampling has not been described which is the goal of this study.Methods: Twenty-five routine pediatric cholecystectomy cases with IM were identified, and their clinical and histologic findings were reviewed.Results: Of these 25 cases, 23 were female (92%). The most common indication for surgery was cholelithiasis (84%). Stones were present in 21 cases (84%). Twenty-three cases (92%) had additional sections submitted with an average of 3.9 slides (range = 3-6), and 52% had IM in additional blocks. However, no dysplasia or carcinoma was identified in any case.Conclusion: IM in the gallbladder is frequently seen in the setting of gallstones and chronic inflammation. Based on our experience, no additional sampling is required when incidentally identified.","PeriodicalId":520743,"journal":{"name":"Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society","volume":" ","pages":"362-368"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lethal Neonatal Pulmonary Hypertension in Trisomy 21 (T21) Likely Due to Congenital Portosystemic Shunts. 21三体（T21）致死性新生儿肺动脉高压可能由先天性门静脉分流引起。

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Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Pub Date : 2025-09-01 Epub Date: 2025-05-24 DOI: 10.1177/10935266251343287

Rachel Guest, Dilshad Dhaliwal, Darryl Kinnear, Debra Kearney, Nahir Cortes-Santiago, Nidhy Varghese, Kalyani R Patel

{"title":"Lethal Neonatal Pulmonary Hypertension in Trisomy 21 (T21) Likely Due to Congenital Portosystemic Shunts.","authors":"Rachel Guest, Dilshad Dhaliwal, Darryl Kinnear, Debra Kearney, Nahir Cortes-Santiago, Nidhy Varghese, Kalyani R Patel","doi":"10.1177/10935266251343287","DOIUrl":"10.1177/10935266251343287","url":null,"abstract":"Children with Trisomy 21 (T21) have an increased incidence of pulmonary hypertension (PHTN); most commonly due to congenital heart/lung diseases but also in conjunction with other T21-associated gastrointestinal and metabolic abnormalities. This report describes a 2 days old, full-term male neonate with T21, without significant cardiac anomalies presenting with severe hypoxic respiratory failure eventually leading to death. Autopsy confirmed T21-associated dysmorphic features and revealed both extra and intrahepatic congenital portosystemic shunts (CPSS). Additionally, the liver demonstrated dilated hepatic and portal veins and mildly altered lobular architecture without any focal lesions. Bilateral lungs showed mild alveolar maldevelopment, double capillary loops, and normal lung to body weight ratio without vascular hypertensive changes. This case underscores the importance of careful examination of the liver hilum and considering CPSS as a potential etiology of PHTN in neonates with T21 in the absence of cardiac defects or significant lung disease.","PeriodicalId":520743,"journal":{"name":"Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society","volume":" ","pages":"416-419"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0