Phyllodes Tumor of Breast in Pediatric and Adolescent Population: A Detailed Clinicopathological Study of 22 Cases.

Abstract

Introduction: Phyllodes tumor (PT) are rarely seen in young population. Some authors believe that PT behave less aggressively in young patients and the need for aggressive management is questioned.

Objective: We aimed to describe the clinicopathological features of PT in pediatric and adolescent population.

Methodology: We reviewed the reports and microscopy glass slides of PT from 22 pediatric and adolescent patients (≤20 years old), diagnosed between 2010 and 2024.

Results: Eighteen cases were malignant PT (MPT), 3 benign PT, and 1 borderline PT. Median patient's age was 17 years (range: 14-20). Median tumor size was 11.25 cm (range: 1.3-22). Tumor margins were either positive or <1 mm away in 10/17 (58.9%) tumor excisions. Follow up information was available for 12 MPT patients with median follow up duration of 26.5 months. Recurrence was observed in 2/10 (20%) primary MPT cases at 2- and 3-months interval. Distant metastasis was observed in 4/12 (33.3%) cases at median interval of 12 months. One of the metastatic cases and another patient without definite treatment, died of disease.

Conclusion: We observed higher frequency of MPT patients, larger tumor size, and higher rate of mastectomy. MPT behave aggressively as evidenced by recurrence, metastasis, and tumor-related death.