Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology最新文献

{"title":"Subclinical small airway dysfunction in well-controlled asthmatic children with normal FEV₁ z-score.","authors":"Gökçen Kartal Öztürk, Hazal Gacemer, Ece Halis, Handan Duman Şenol, Esen Demir, Figen Gülen","doi":"10.1111/pai.70208","DOIUrl":"https://doi.org/10.1111/pai.70208","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the presence of subclinical small airway dysfunction (SAD), which is associated with risk for persistence, loss of control, and exacerbations, using the impulse oscillometry system (IOS) in children with well-controlled asthma and normal forced expiratory volume in one second (FEV₁) z-scores and to identify predictive pulmonary function test (PFT) parameters and associated risk factors for SAD.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted in children aged 6-18 years with well-controlled asthma and normal FEV₁, compared to healthy controls matched for age and sex. Spirometry and IOS parameters were assessed. Logistic regression and receiver operating characteristic (ROC) curve analyses were used to determine predictive PFT parameters.</p><p><strong>Results: </strong>A total of 194 asthmatic children and 151 healthy controls were included. Although spirometry parameters were within normal limits, FEV₁/FVC and FEF_25-75 (% predicted and z-scores) were significantly lower in the asthma group (p < .01). IOS parameters, including R5, R10, Fres, Ax, and ΔR5-20, were significantly higher in asthmatic children (p < .05), and reactance values (X5-X20) were more negative. ΔR5-20 was the moderately predictive parameter for SAD [OR (95% CI): 1.086 (1.017-1.159), p < .01] with a cutoff value of ≥22.15% (AUC 0.660, sensitivity 60%, specificity 68%). Younger age and atopy were independent risk factors for higher ΔR5-20.</p><p><strong>Conclusion: </strong>Subclinical SAD may be present in children with well-controlled asthma and normal FEV₁. IOS, particularly ΔR5-20, provides a sensitive, effort-independent tool for detecting SAD and should be considered for routine evaluation, especially in younger and atopic children.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 9","pages":"e70208"},"PeriodicalIF":4.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of maternal dietary diversity during pregnancy on infant atopic dermatitis: Exploring the microbiome link in a Taiwanese birth cohort.","authors":"Linh Ba Phuong Huynh, Hsien-Yu Fan, Shih-Yi Huang, Nguyen Nhat Nam, Tan Thanh Nguyen, Yang-Ching Chen","doi":"10.1111/pai.70200","DOIUrl":"https://doi.org/10.1111/pai.70200","url":null,"abstract":"<p><strong>Background: </strong>Maternal diet during pregnancy plays a critical role in shaping infant immune development, potentially influencing the risk of atopic dermatitis. However, the underlying mechanisms remain unclear. This study examined the association between maternal dietary diversity during pregnancy and the incidence of atopic dermatitis in early childhood and explored the potential mediating role of the infant gut microbiome.</p><p><strong>Methods: </strong>The Taipei Mother-Infant Nutrition Cohort study is a longitudinal birth cohort study tracking 677 mother-infant pairs from pregnancy to the children's third year. This study assessed maternal dietary diversity during pregnancy using the Food and Agriculture Organization's guidelines for Minimum Dietary Diversity for Women. Infant microbiota was analyzed at 2 months postpartum, and the incidence of atopic dermatitis in the offspring was monitored from birth to age three. Incidence risk was calculated using Cox proportional hazards regression with various confounders adjusted for. The study compared relative microbial abundances and alpha and beta diversity across different levels of maternal dietary diversity.</p><p><strong>Results: </strong>Higher maternal dietary diversity was associated with a lower risk of atopic dermatitis in offspring. Maternal dietary diversity did not significantly affect the alpha or beta diversity of the infant gut microbiome but influenced its composition. Greater abundance of Rothia and Parabacteroides genera was significantly associated with a lower risk of atopic dermatitis. Additionally, a higher relative abundance of the Parabacteroides genus was linked to maternal intake of Vitamin A-rich fruits and vegetables.</p><p><strong>Conclusions: </strong>These findings suggest that greater maternal dietary diversity during pregnancy may be associated with a lower risk of atopic dermatitis in early childhood, potentially through modulation of the infant gut microbiome. Further studies are warranted to validate these associations and clarify underlying mechanisms.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 9","pages":"e70200"},"PeriodicalIF":4.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of subcutaneous venom immunotherapy in children: A 24-year experience in a pediatric tertiary care center.","authors":"Mattia Giovannini, Francesco Catamerò, Marzio Masini, Federico Gelain, Elio Novembre, Simona Barni, Giulia Liccioli, Lucrezia Sarti, Leonardo Tomei, Benedetta Pessina, Claudia Valleriani, Chiara Marzi, Michela Baccini, Mohamed Shamji, Francesca Mori","doi":"10.1111/pai.70195","DOIUrl":"10.1111/pai.70195","url":null,"abstract":"<p><strong>Background: </strong>Hymenoptera venom allergy is a significant cause of morbidity and mortality, also in pediatric patients, highlighting the importance of effective management through venom immunotherapy (VIT). This study aimed to evaluate the safety profile of VIT, identify factors associated with adverse reactions (ARs), assess the accuracy of insect identification and its impact on VIT extract selection, and determine treatment efficacy by analyzing ARs following re-sting.</p><p><strong>Methods: </strong>The medical charts of patients followed up at the Allergy Unit of Meyer Children's Hospital IRCCS, Florence, Italy, who completed a VIT cycle between 1997 and 2021 were retrospectively analyzed. VIT extract selection was guided by a diagnostic workup following the European Academy of Allergy and Clinical Immunology guidelines and the Italian Consensus on Hymenoptera venom allergy management. We implemented a cluster protocol and adjusted it as needed for ARs during VIT.</p><p><strong>Results: </strong>Fifty-eight patients, from a total of 60 VIT (2 patients underwent VIT for both Vespula and Polistes) were included, using the following extracts: 17 Apis mellifera (28.4%), 20 Vespula (33.3%), 20 Polistes (33.3%), and 3 Vespa crabro (5.0%). Upon the 3739 injections administered, 355 ARs (9.5%) occurred: local reactions (LRs), 306 (8.2%); extended local reactions (ELRs), 34 (0.9%); and systemic reactions (SRs), 15 (0.4%). The build-up phase was associated with a higher number of ARs and LRs compared with the maintenance phase during VIT (p < .0001), normalized by the number of injections. No other significant factors related to the risk of developing any ARs were highlighted. The highest SR rate was found in the VIT for Polistes, with no significant differences in AR proportions among the venom extracts. Thirty patients reported 51 re-stings following VIT, with only 2 of 51 (3.9%) resulting in SRs. These reactions occurred in individuals stung by a different Hymenoptera species from the one targeted during the VIT.</p><p><strong>Conclusion: </strong>Cluster protocol VIT is safe and effective in pediatric patients.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 9","pages":"e70195"},"PeriodicalIF":4.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Early-life allergic sensitization and respiratory infection-Two hits on lung function?\"","authors":"","doi":"10.1111/pai.70205","DOIUrl":"https://doi.org/10.1111/pai.70205","url":null,"abstract":"","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 9","pages":"e70205"},"PeriodicalIF":4.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145071595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between dietary patterns, gut microbiome diversity, and itch severity in preschool aged children with atopic dermatitis: A cross-sectional study.","authors":"Jisu Park, Soo Jin Lee, Jing Yan, Sukyung Kim, Jihyun Kim, Chiehyeon Lim, Hyemee Kim, Minyoung Jung","doi":"10.1111/pai.70202","DOIUrl":"https://doi.org/10.1111/pai.70202","url":null,"abstract":"<p><strong>Background: </strong>The diet-gut microbiota-disease axis has been explored in infancy, but its role in preschool atopic dermatitis (AD) remains unclear. This study investigated associations between dietary patterns, gut microbiota, and AD severity in Korean preschoolers.</p><p><strong>Methods: </strong>We evaluated 75 preschool children aged 3-6 years, including 24 with AD and 51 healthy controls. AD severity was assessed by Eczema Area and Severity Index (EASI) and SCORing Atopic Dermatitis (SCORAD), and quality of life by Children's Dermatology Life Quality Index (CDLQI). Gut microbiota composition was characterized using 16S rRNA sequencing, and group differences were analyzed by Linear Discriminant Analysis Effect Size (LEfSe).</p><p><strong>Results: </strong>Based on factor analysis, dietary patterns were categorized into a Traditional Korean (TK) diet and a Processed food and Snack (PS) diet. Children with AD who followed the PS diet showed lower vitamin C intake and higher levels of Dorea and Anaerostipes (LDA scores: 3.4 and 3.9). This microbial composition was associated with greater sleep-disturbing itching and poorer CDLQI (p = .032 and .041). Lower vitamin C intake correlated with higher Anaerostipes abundance (r = -.436, p = .042) as well as with higher EASI (r = -.52, p = .03) and SCORAD (r = -.41, p = .045). Dorea abundance was positively correlated with daytime itching (r = .42, p = .049).</p><p><strong>Conclusions: </strong>In preschool children with AD, a dietary pattern high in processed foods and snacks was associated with increased Dorea and Anaerostipes and greater AD severity and poorer quality of life. These findings suggest that dietary modification may alleviate clinical symptoms in early childhood AD by modulating the diet-gut-skin axis.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 9","pages":"e70202"},"PeriodicalIF":4.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145077162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of birth order on the prevalence of allergic diseases in Taiwanese children: A 16-year study using two national databases.","authors":"Chin-Kan Chan, Chi-Jen Chen, Yi-Yu Su, Mei-Huei Chen, Ching-Chun Lin, Yu-Cheng Lin, Wu-Shiun Hsieh, Hung-Yi Chiou, Pau-Chung Chen","doi":"10.1111/pai.70203","DOIUrl":"10.1111/pai.70203","url":null,"abstract":"<p><strong>Background: </strong>Taiwan has experienced a significant decline in fertility rates, from 3.69 in 1970 dropping to 1.5 in 1998, and 0.87 in 2023. Simultaneously, the prevalence of childhood allergic conditions has surged: atopic dermatitis increased from 1.4% in 1974 to 11.3% in 2019, asthma from 1.3% to 20.3%, and allergic rhinitis from 7.8% to 50.6%. This study investigates the relationship between Taiwan's declining birth rate and the rising prevalence of allergic diseases among children.</p><p><strong>Methods: </strong>We analyzed data from the Taiwan Birth Registration Database (2004-2014) linked to the National Health Insurance Research Database. Children were categorized by birth order, and adjusted hazard ratios were used using multivariable Cox proportional hazards models. Subgroup analyses confirmed consistency across sex, maternal age, SES, and birth characteristics. National total fertility rate and allergy prevalence data from 1974 to 2023 were analyzed to explore long-term trends.</p><p><strong>Results: </strong>Higher birth order was associated with lower allergic disease risk. Compared to first-borns, second-born and third-or-later-born children had reduced risks of atopic dermatitis (by 21.3% and 37.5%), asthma (25.0% and 26.9%) and allergic rhinitis (16.3% and 29.3%). Nationally, the total fertility rate was strongly inversely correlated with the prevalence of AD (r = -.91), asthma (r = -.88), and AR (r = -.95) (all p < .001).</p><p><strong>Conclusion: </strong>These findings suggest that declining fertility and smaller family size may contribute to increased childhood allergy prevalence, potentially through reduced microbial exposure in early life.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 9","pages":"e70203"},"PeriodicalIF":4.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric cofactor-enhanced food anaphylaxis: A narrative review of epidemiology, pathophysiology, and clinical phenotypes.","authors":"Alpana Mohta, Emilio Narvaez, Patricia Mir-Ihara, Joan Bartra, Rosa Muñoz-Cano","doi":"10.1111/pai.70194","DOIUrl":"https://doi.org/10.1111/pai.70194","url":null,"abstract":"<p><p>Cofactors are external factors that can lower the threshold dose of an allergen and amplify the severity of allergic reactions, turning mild or moderate responses into severe anaphylaxis. These include exercise, nonsteroidal anti-inflammatory drugs (NSAIDs), alcohol, menstruation, and infections. Initially described in relation to food allergens and physical activity or NSAIDs, these reactions have been labeled under various terms, such as food-dependent exercise-induced anaphylaxis (FDEIA), wheat-dependent exercise-induced anaphylaxis (WDEIA), and food-dependent NSAID-induced anaphylaxis (FDNIA). However, cofactor-enhanced food allergy (CEFA), a recently proposed concept, serves as an umbrella term to encompass these conditions and is applied in this text for consistency. Pediatric cofactor-enhanced food anaphylaxis (PCEFA) is a rare but severe condition in which a food allergy becomes significantly more severe in the presence of one or more cofactors. Cofactors are documented in 14%-18.3% of pediatric food anaphylactic reactions; however, the true burden is likely higher due to frequent underdiagnosis from variable and unpredictable presentations. Exercise and infections are the most common cofactors in PCEFA, while ω-5 gliadin is the predominant allergen. PCEFA is frequently misdiagnosed as idiopathic anaphylaxis, exercise-induced anaphylaxis (EIA), or asthma when subtle or delayed food triggers go undetected. Some cases may represent high-threshold food allergies rather than true cofactor-dependent anaphylaxis, challenging conventional definitions. Research on cofactors in anaphylaxis is still in its early stages, with most studies focusing on adults. More research is needed to improve diagnostic accuracy and treatment strategies for pediatric cases.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 9","pages":"e70194"},"PeriodicalIF":4.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving immune-related health outcomes post-cesarean birth with a gut microbiome-based program: A randomized controlled trial.","authors":"Pamela A Nieto, Claudia Nakama, Julian Trachsel, David Goad, Taylor K Soderborg, Danielle Shea Tan, Amy Orlandi, Qian Yuan, Elisa Song, Noel T Mueller, Ruben A Mars, Cheryl Sew Hoy, Kimberley V Sukhum","doi":"10.1111/pai.70182","DOIUrl":"10.1111/pai.70182","url":null,"abstract":"<p><strong>Background: </strong>Infants born via Cesarean section (C-section) often have a distinct gut microbiome and higher risks of atopic and immune-related conditions than vaginally delivered infants. We evaluated whether a microbiome-based program could shift gut microbiome composition and improve microbiome-associated health outcomes in C-section born infants.</p><p><strong>Methods: </strong>This open-label, randomized, controlled trial included full-term C-section-born infants aged 0-3 months, randomized to an intervention (n = 25) or control arm (n = 29). Over 6 months, the intervention arm received two microbiome reports, personalized recommendations based on their microbiome, educational materials, and coaching calls focused on microbiome health. Parents reported health conditions via surveys.</p><p><strong>Primary outcome: </strong>Difference between study arms in relative abundance of key gut microbiome taxa and functional genes. Other outcomes: Changes in a C-section index-a taxonomy-based metric comparing C-section-associated taxa to vaginally-associated taxa-and prevalence of atopic conditions.</p><p><strong>Results: </strong>Compared to controls, the intervention arm had higher Bifidobacterium (p = .025, q = .121) and higher abundance of genes associated with human milk oligosaccharide degradation (e.g., α-L-fucosidase, p = .019, q = .046) at timepoint 2. In the intervention arm, the C-section index decreased to a level similar to vaginally born infants (p = .807, q = .807). At the end of the intervention, atopic dermatitis prevalence was lower in the intervention arm than in controls (odds ratio, 0.17 [95% CI, 0.023-0.723], p = .031).</p><p><strong>Conclusion: </strong>A personalized microbiome-based program can modulate the gut microbiome of C-section-born infants and may reduce the risk of atopic conditions (ClinicalTrials.gov: NCT06424691).</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 9","pages":"e70182"},"PeriodicalIF":4.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12405607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal first-trimester serum vitamin A/E concentration and risk of infant atopic dermatitis within 12 months.","authors":"Ying Ye, Yuanzhou Peng, Yi Zhang, Xiaotian Chen, Wei Song, Wenmin Lu, Yalan Dou, Mengru Li, Yun Li, Jun Huang, Xiaohua Zhang, Liuhui Wang, Weili Yan","doi":"10.1111/pai.70204","DOIUrl":"https://doi.org/10.1111/pai.70204","url":null,"abstract":"<p><strong>Background: </strong>The relationship between maternal antioxidative vitamins intake and infant atopic dermatitis (AD) remains inconclusive, and evidence of maternal serum vitamin levels is scarce. This study aimed to quantify the association of maternal serum vitamin A and E concentrations at first trimester with the risk of infant AD.</p><p><strong>Methods: </strong>A cohort of 456 pregnant women was recruited at 12-14 weeks gestation, serum vitamin A (retinol) and vitamin E (alpha-tocopherol) concentrations were assessed by liquid chromatography-mass spectrometry at enrollment. Their offspring were followed up at birth, 42 days, 6 months, and 12 months for AD occurrence. Multivariable discrete-time survival analyses were employed for association analyses.</p><p><strong>Results: </strong>A total of 121 (26.5%) infants developed AD. The median (interquartile range) of maternal serum vitamin E and vitamin A concentrations at first trimester was 13.1 (11.1, 15.3) and 0.52 (0.45, 0.60) μg/mL, respectively. Each μg/mL increase in vitamin E concentration was linearly associated with an 8% reduction in infant AD risk (adjusted hazard ratio [aHR] = 0.92, 95% CI: 0.86-0.98); the association remained after adjustment of covariates including folate and vitamin D concentration. Infants born to mothers with the highest tertile of vitamin E had a 46% reduced AD risk (aHR = 0.54, 95% CI: 0.32-0.91) compared to those in the middle tertile. No association was found between maternal vitamin A concentration and infant AD.</p><p><strong>Conclusion: </strong>There is a linear relationship between higher maternal serum vitamin E concentration at first trimester and reduced risk of infant AD. The findings underscore the potentials of achieving sufficient maternal vitamin E during pregnancy in preventing infant AD.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 9","pages":"e70204"},"PeriodicalIF":4.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145083225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-dose oral immunotherapy with Lacticaseibacillus rhamnosus GG for severe peanut allergy.","authors":"Noriyuki Yanagida, Yoko Miura, Gaku Harata, Kenji Miyazawa, Ken-Ichi Nagakura, Kyohei Takahashi, Sakura Sato, Motohiro Ebisawa","doi":"10.1111/pai.70190","DOIUrl":"https://doi.org/10.1111/pai.70190","url":null,"abstract":"","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 9","pages":"e70190"},"PeriodicalIF":4.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}