Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology最新文献

{"title":"Hepatosplenic abscesses in a child with p40^phox deficiency due to a homozygous NCF4 variant.","authors":"Krishnan Chakkyar, Priya Saravanan, Adhiya Mathiyedath Habeeb, Shiny Padinjarayil Manakkad, Athulya Edavazhippurath, Rakesh Kumar Pradhan, Vinod Kumar Dorai, Siddharth Jhunjhunwala, Dhananjayan Dhanasooraj, Geeta Madathil Govindaraj","doi":"10.1111/pai.70226","DOIUrl":"https://doi.org/10.1111/pai.70226","url":null,"abstract":"","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 10","pages":"e70226"},"PeriodicalIF":4.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145357589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic inflammatory biomarkers in relation to lung function and exercise-induced bronchoconstriction in adolescents.","authors":"Karin Ersson, Kjell Alving, Margareta Emtner, Christer Janson, Henrik Johansson, Andrei Malinovschi","doi":"10.1111/pai.70231","DOIUrl":"https://doi.org/10.1111/pai.70231","url":null,"abstract":"<p><strong>Introduction: </strong>The forced oscillation technique (FOT) complements spirometry in assessing lung function, with higher sensitivity to small airway dysfunction. Systemic inflammation is thought to influence lung development and exercise-induced bronchoconstriction (EIB), but its relationship to circulating inflammatory proteins in adolescents is unclear.</p><p><strong>Objective: </strong>To investigate associations between systemic inflammatory biomarkers and baseline lung function and post-exercise airway responses in adolescents.</p><p><strong>Methods: </strong>In 143 adolescents (13-15 years) from a population-based cohort, baseline spirometry, FOT, and baseline blood samples were obtained. Participants completed an exercise challenge to assess EIB via changes in forced expiratory volume in 1 s (FEV₁), resistance at 5 Hz (R₅), and reactance at 5 Hz (X₅). Plasma protein levels were measured using the proximity extension assay technique (Olink Target Inflammation and Immune Response panels). Associations with lung function (FEV₁% predicted, R5, and X5 z-scores) and post-exercise responses (∆FEV₁, ∆R5, ∆X5) were analyzed using linear regression with false discovery rate correction. Interaction with atopy was also examined.</p><p><strong>Results: </strong>Higher plasma levels of C-C motif chemokine 19 (CCL19) were significantly associated with lower FEV₁% predicted and lower X₅ z-scores at baseline, indicating reduced lung function and impaired small airway function. No proteins were associated with post-exercise airway responses after correction. Five proteins showed significant interactions with atopy in relation to EIB.</p><p><strong>Conclusion: </strong>Elevated CCL19 may reflect systemic inflammatory processes contributing to impaired lung function in early adolescence. The observed atopy-related interactions suggest the need to consider atopy in studies of systemic inflammation and airway physiology.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 10","pages":"e70231"},"PeriodicalIF":4.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145357607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial comment on \"The effectiveness of an education program based on healthcare transition in adolescents with asthma: A randomized controlled trial\".","authors":"Bernardo Sousa-Pinto, Leticia de Las Vecillas, Carmen Riggioni, Philippe Eigenmann, Mattia Giovannini","doi":"10.1111/pai.70214","DOIUrl":"https://doi.org/10.1111/pai.70214","url":null,"abstract":"","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 10","pages":"e70214"},"PeriodicalIF":4.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of fever and infections with the subsequent risk of atopic diseases in children with genetic susceptibility for T1D: Results from the TEDDY cohort study.","authors":"Tiina Palmu, Jussi Lehtonen, Helena Elding Larsson, Kristian F Lynch, Berglind Jonsdottir, Corrado Cilio, Desmond Schatz, Marian Rewers, Heikki Hyöty, Maria Lönnrot","doi":"10.1111/pai.70209","DOIUrl":"10.1111/pai.70209","url":null,"abstract":"<p><strong>Background: </strong>The increased prevalence of atopic diseases may be due to lifestyle changes affecting our exposure to microbes. We investigated the association between infections, fever, and atopic diseases in a large international birth cohort setting.</p><p><strong>Methods: </strong>3842 children at genetic risk for type 1 diabetes were followed prospectively for the first 10 years for the occurrence of infections and atopic diseases within The Environmental Determinants of Diabetes in the Young (TEDDY) study. A time-discrete survival analysis was carried out to evaluate the association of self-reported febrile and non-febrile infections (respiratory, gastrointestinal, other, fever alone) and the risk of subsequent atopic eczema, allergic rhinitis, asthma, and allergies.</p><p><strong>Results: </strong>The rate of respiratory infections was positively associated with the subsequent risk of asthma (HR 1.30, 95% CI 1.25-1.35, p < .001). Febrile respiratory infections increased the risk of asthma more than non-febrile ones (febrile respiratory infection HR 1.50, 95% CI 1.42-1.59, p < .001; non-febrile respiratory infection HR 1.24, 95% CI 1.18-1.30, p < .001). In contrast, fever decreased the positive association of infections with the risk of other atopic diseases. Episodes of fever as the only reported symptom had a negative association particularly with the risk of atopic eczema (HR 0.53, 95% CI 0.39-0.71, p < .001).</p><p><strong>Conclusions: </strong>In a longitudinal cohort study, fever shows a clear impact on how infections associate with subsequent atopic diseases. Understanding the modifying role of fever on risk offers new possibilities to explore the mechanisms that mediate the effect of infections in the atopic process.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 10","pages":"e70209"},"PeriodicalIF":4.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Model-informed exploration of the boundaries of safe aluminium exposure from allergen immunotherapy in children\".","authors":"","doi":"10.1111/pai.70206","DOIUrl":"https://doi.org/10.1111/pai.70206","url":null,"abstract":"","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 10","pages":"e70206"},"PeriodicalIF":4.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145277116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotics in infancy and the risk of asthma-Is there still a debate?","authors":"Bronwyn K Brew","doi":"10.1111/pai.70212","DOIUrl":"https://doi.org/10.1111/pai.70212","url":null,"abstract":"","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 10","pages":"e70212"},"PeriodicalIF":4.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145282564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eat the fruit, do not swallow the seed: A rare case of Cucurbitaceae allergy causing anaphylaxis.","authors":"Halime Yağmur, Damla Baysal Bakır, Gizem Kabadayı, Özge Atay, Nevin Uzuner","doi":"10.1111/pai.70221","DOIUrl":"https://doi.org/10.1111/pai.70221","url":null,"abstract":"","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 10","pages":"e70221"},"PeriodicalIF":4.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145282560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NOTIFICATION: Reply to Prof. Tiejuan Shao et al.","authors":"","doi":"10.1111/pai.70210","DOIUrl":"https://doi.org/10.1111/pai.70210","url":null,"abstract":"","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 10","pages":"e70210"},"PeriodicalIF":4.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive correlates of poor sleep associated with increased risk of severe asthma exacerbations among children with moderate-to-severe asthma.","authors":"Anuja Bandyopadhyay, Bowen Jiang, Yash Shah, Arthur H Owora","doi":"10.1111/pai.70229","DOIUrl":"https://doi.org/10.1111/pai.70229","url":null,"abstract":"<p><strong>Background: </strong>Sleep studies (polysomnography) are a diagnostic tool used to monitor various physiological parameters during sleep to diagnose and manage sleep disorders. However, the prognostic utility of sleep measures for the prediction of childhood asthma severe exacerbation (SE) risk is unknown.</p><p><strong>Methods: </strong>Retrospective cohort analysis to identify correlates and quantify the prognostic utility of poor sleep measures for the prediction of SE risk among children with moderate or severe asthma.</p><p><strong>Results: </strong>The study cohort included 161 patients (36% female, 33% African American, mean (standard deviation [SD]) age of 10 [4] years). A higher sleep arousal index (i.e., sleep fragmentation measured as disruptions in brainwave activity) was associated with increased risk of SE among male (adjusted odds ratio [aOR]: 1.13, 95% CI: 1.04, 1.23) but not female patients (aOR: 0.97, 95% CI: 0.88, 1.07). A history of SE(s) and use of inhaled glucocorticoid plus a long-acting β2-agonists (ICS plus LABA) were associated with higher odds of SE; conversely, a history of sleep latency reducing medication was associated with lower odds of SEs (p < .05). Inclusion of these sleep-related factors in the multivariable model to predict SE had higher prognostic accuracy than a model based on history of SE(s) alone (p < .01).</p><p><strong>Conclusion: </strong>In addition to prior SE(s), elevated sleep arousal index among male children, use of ICS plus LABA, and history of untreated sleep disturbance can improve the accuracy of SE risk prognosis to inform targeted preventive interventions to reduce excess acute healthcare utilization among children with comorbid sleep problems and moderate/severe asthma.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 10","pages":"e70229"},"PeriodicalIF":4.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145357591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive biomarkers for atopic dermatitis.","authors":"Jessica W Hui-Beckman, Elena Goleva, Donald Y M Leung","doi":"10.1111/pai.70215","DOIUrl":"https://doi.org/10.1111/pai.70215","url":null,"abstract":"<p><p>The discovery of early-life preclinical biomarkers for atopic dermatitis (AD) is an important area of research to prevent AD development and introduce treatment measures early to reduce AD severity. Birth cohort studies performed worldwide have given insights into skin barrier components, such as lipids and proteins, cytokine immunologic markers, and microbiome alterations that are present prior to the clinical diagnosis of AD. This article reviews the structure of the skin barrier and the early-life biomarkers that are present in children at risk for AD.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 10","pages":"e70215"},"PeriodicalIF":4.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}