Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology最新文献

{"title":"Impact of COVID-19 prevention policies on asthma, allergic rhinitis, and atopic dermatitis in early adolescents.","authors":"Chun-Hua Liao, An-Kuo Chou, Li-Chieh Wang, Bor-Luen Chiang, Yao-Hsu Yang","doi":"10.1111/pai.70164","DOIUrl":"https://doi.org/10.1111/pai.70164","url":null,"abstract":"<p><strong>Background: </strong>COVID-19 prevention policies significantly influenced the prevalence and severity of allergic diseases. While lockdown measures in many countries reduced asthma exacerbations by limiting exposure to respiratory infections and environmental triggers, Taiwan's non-lockdown strategy provided a unique public health model. This study evaluates the impact of Taiwan's COVID-19 prevention policies on the prevalence and severity of allergic diseases in early adolescents.</p><p><strong>Method: </strong>We collected 1519 questionnaires in 2021 and 1165 in 2023 from urban elementary schools. Self-reported data on asthma, allergic rhinitis, and atopic dermatitis were analyzed to assess changes in prevalence and severity. Comparisons were made between the two periods to determine the effects of public health measures on adolescent allergic diseases.</p><p><strong>Results: </strong>In 2021, our survey showed that 3% of participants had wheezing in the past 12 months, and 16.3% experienced nighttime cough. By 2023, both wheezing and nighttime cough significantly increased, along with a rise in rhinitis ever. In contrast, the prevalence of atopic dermatitis ever declined, as did the prevalence of recurrent eczema in the past 12 months over this period.</p><p><strong>Conclusion: </strong>Taiwan's non-lockdown COVID-19 prevention strategy was associated with divergent trends in allergic diseases among early adolescents. Between 2021 and 2023, the prevalence of wheezing and allergic rhinitis increased, while atopic dermatitis and recurrent eczema declined. These findings suggest that pandemic-related behavioral changes, including mask-wearing and social distancing, may have influenced both respiratory and skin-related allergic conditions, highlighting the need to evaluate a broad range of health outcomes when assessing the impact of public health interventions.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 8","pages":"e70164"},"PeriodicalIF":4.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importance of allergic sensitisation for normal range of fractional exhaled nitric oxide in adolescents.","authors":"Jenny Hallberg, Gang Wang, Anna Bergström, Inger Kull, Erik Melén, Andrei Malinovschi","doi":"10.1111/pai.70154","DOIUrl":"https://doi.org/10.1111/pai.70154","url":null,"abstract":"<p><strong>Background: </strong>In addition to body anthropometrics, allergen sensitization has been shown to influence the levels of exhaled fractional nitric oxide (FeNO) in adults, but whether this relationship is valid also in younger age groups, how it compares to the fixed cut-off levels recommended for clinical practice, and relates to respiratory symptoms remains to be confirmed.</p><p><strong>Method: </strong>FeNO, sensitization, respiratory symptoms, and spirometry were evaluated in 2054 adolescents taking part in the 16-year follow-up of the Swedish BAMSE birth cohort.</p><p><strong>Results: </strong>The median and upper limit of FeNO was related to the presence and type of allergic sensitisation and poorly represented by one fixed cutoff. For example, the 95th percentiles for sensitisation to dogs were 89 ppb in females and 87 ppb in males. A FeNO value above the sensitisation-specific 95th percentile was, in those with allergic sensitisation, related to significantly higher odds for current asthma (OR 4.10, 95% CI 2.44-6.89) and wheeze (OR 2.58, 95% CI 1.44-4.62). In those without allergic sensitisation, a FeNO above the 95th percentile was related to wheeze (OR 3.20, 95% CI 1.37-7.51). The odds for having airway obstruction were not related to any of the FeNO cutoffs for either of the groups.</p><p><strong>Conclusion: </strong>We have shown that the FeNO upper limit of normal is dependent on the presence and type of allergic sensitization and that these cutoffs differ from the fixed cutoffs of 25 and 50 ppb recommended in the literature. Sensitization specific rather than fixed limit cutoffs may be more relevant to asthma diagnosis and asthma symptoms in a general adolescent population.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 8","pages":"e70154"},"PeriodicalIF":4.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precautionary allergen labels and socioeconomic disparities among food allergy caregivers.","authors":"Grace Rabinowitz, Erika Tsutsui, David Sanchez, Ana Aguirre, Scott H Sicherer, Nicole B Ramsey","doi":"10.1111/pai.70159","DOIUrl":"https://doi.org/10.1111/pai.70159","url":null,"abstract":"","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 8","pages":"e70159"},"PeriodicalIF":4.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mannose-binding lectin insufficiency is associated with airway Haemophilus colonization and a higher risk of post-RSV bronchiolitis recurrent wheezing.","authors":"Xiaoyan Zhang, Xiang Zhang, Xinglan Wang, Xiaolei Tang, Hui Xu, Nan Zhang, Shunying Zhao, Haiming Yang, Qiushui He","doi":"10.1111/pai.70158","DOIUrl":"https://doi.org/10.1111/pai.70158","url":null,"abstract":"<p><strong>Objective: </strong>To investigate whether mannose-binding lectin (MBL) insufficiency influences the airway microbiota composition and development of subsequent recurrent wheezing in infants with severe respiratory syncytial virus (RSV) bronchiolitis.</p><p><strong>Methods: </strong>Sixty-seven infants who were hospitalized during an initial episode of severe RSV bronchiolitis at 6 months of age or less were included in the study and followed up until the age of 3 years. Serum and sputum samples were collected. The serum MBL concentrations were determined by ELISA; the sputum microbiota and cytokines were analyzed by 16S rRNA-based sequencing and multiplex immunoassay, respectively.</p><p><strong>Results: </strong>Twenty-six infants developed recurrent wheezing by the age of 3 years, and 41 did not. The rate of MBL insufficiency was significantly higher among infants who developed recurrent wheezing compared to those who did not [50.0% (13/26) vs. 24.4% (10/41), (p = .031)]. MBL insufficiency was independently associated with a higher risk of subsequent development of recurrent wheezing (adjusted Odds Ratio: 3.5, 95% CI 1.1-12.3, p = .035). Haemophilus was found to be the most discriminative genus between infants with and without MBL insufficiency (LDA >4.0). The level of INF-γ (p = .019) in infants with MBL insufficiency was significantly lower than that among infants with normal MBL.</p><p><strong>Conclusion: </strong>During the first episode of severe RSV bronchiolitis in infants <6 months of age, MBL insufficiency was associated with a higher risk of developing subsequent recurrent wheezing by age three. Infants with MBL insufficiency were more likely to be colonized with Haemophilus and have weaker airway IFN-γ response.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 8","pages":"e70158"},"PeriodicalIF":4.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocol: Scoping review of the association between complementary feeding, growth, and immune health in infants and toddlers-An EAACI guideline paper.","authors":"Carina Venter, Pablo Alonso-Coello, Jessica Beltran, Javier Bracchiglione, Karina Fernandez-Saenz, Pau Riera, Ivan Solà, Stefania Arasi, Roberto Berni Canani, David Fleischer, Ibon Eguíluz-Gracia, Rosan Meyer, Graham Roberts, Franziska Roth-Walter, Alexandra F Santos, Isabel Skypala, Peter K Smith, Milena Sokolowska, Maria J Torres, Emilia Vassilopoulou, Jens Walter, Liam O'Mahony","doi":"10.1111/pai.70145","DOIUrl":"https://doi.org/10.1111/pai.70145","url":null,"abstract":"<p><p>The European Academy of Allergy and Clinical Immunology (EAACI) is currently developing guidelines on immunomodulation and nutrition. To inform these recommendations, a scoping review will be conducted to synthesize and map the available empirical evidence on how complementary feeding affects immune health in infants and toddlers to explore the association between complementary feeding during the first year of life and immune health outcomes in children up to 3 years of age. The scoping review will be conducted using the Preferred Reporting Items for Systematic Reviews and Meta-analysis Scoping Review Extension for scoping reviews (PRISMA-ScR) guidelines. We have developed inclusion criteria using the PCC (Population, Concept and Context) format: the population will include healthy infants; the concept refers to specific factors related to introduction of complementary feeding; and the context will focus on studies conducted in settings representative of everyday nutrition and feeding practices for infants and toddlers. Evidence sources include systematic reviews. We will search in MEDLINE and Epistemonikos. Data will be extracted using a standardized form developed in REDCap, and the findings will be synthesized narratively. Only published literature will be included in this systematic review. Therefore, no ethical approval is required. The final review paper will be published in a peer-reviewed journal. OSF registration DOI: 10.17605/OSF.IO/T5F8.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 8","pages":"e70145"},"PeriodicalIF":4.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of maternal allergy and supplementation with ω-3 fatty acid and probiotic on human milk oligosaccharides.","authors":"Ahmed Al-Kaabawi, Eva Landberg, Magalí Martí, Elisabet Severin, Lina Tingö, Karel Duchén, Maria C Jenmalm","doi":"10.1111/pai.70162","DOIUrl":"https://doi.org/10.1111/pai.70162","url":null,"abstract":"<p><strong>Background: </strong>Human milk oligosaccharides (HMOs) are complex carbohydrates that act as prebiotics, supporting infants' gut microbial colonization and immune development. HMO levels are influenced by several maternal factors, including genetics, diet, and health status. In this study, we aim to investigate the effects of ω-3 PUFA (polyunsaturated fatty acids) and Limosilactobacillus (L.) reuteri supplementation on HMO levels in colostrum and mature milk. Another aim is to compare HMO levels between allergic and non-allergic mothers and to explore the correlation between HMOs and secretory immunoglobulin A (SIgA) in milk.</p><p><strong>Methods: </strong>Milk samples (n = 136) were collected from mothers enrolled in a clinical trial (PROOM-3) designed to investigate the effect of pre- and postnatal supplementation with ω-3 PUFA and L. reuteri on allergy development in early childhood. HMOs were measured in colostrum and mature milk collected 3 months postpartum using high-performance anion exchange chromatography. SIgA was measured in colostrum, 1-, 2-, 3-, and 4-month milk using ELISA.</p><p><strong>Results: </strong>The supplements did not affect HMO levels in colostrum or mature milk. However, maternal supplementation with ω-3 PUFA decreased the HMO diversity over time. Additionally, allergic mothers expressed significantly lower levels of several HMOs compared to non-allergic mothers. Additionally, SIgA correlated positively with fucosylated and negatively with sialylated HMOs.</p><p><strong>Conclusion: </strong>Supplementation with ω-3 PUFA could reduce the HMO diversity over the course of lactation. Also, maternal allergy seems to be associated with a reduction in levels of several HMOs. Furthermore, there is a possible dynamic interplay between HMOs and SIgA in milk.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov-ID: NCT01542970.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 8","pages":"e70162"},"PeriodicalIF":4.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of oral immunotherapy on diversity of gut microbiota in food-allergic children.","authors":"Thanina Bouabid, Bénédicte L Tremblay, Marie-Ève Lavoie, Anne-Marie Boucher-Lafleur, Frédérique Gagnon-Brassard, Philippe Bégin, Sarah Lavoie, Cloé Rochefort-Beaudoin, Claudia Nuncio-Naud, Guy Parizeault, Charles Morin, Catherine Girard, Anne-Marie Madore, Catherine Laprise","doi":"10.1111/pai.70156","DOIUrl":"https://doi.org/10.1111/pai.70156","url":null,"abstract":"<p><strong>Background: </strong>Food allergies (FAs) are an increasing public health concern, particularly in children. Oral immunotherapy (OIT) is an emerging treatment strategy under clinical investigation for desensitization of children with FA to food allergens. Dysbiosis of the gut microbiota has been implicated in FAs, and various factors influence its composition; however, the impact of OIT on the gut microbiota remains largely unexplored.</p><p><strong>Objective: </strong>This study aimed to identify the changes in diversity of the gut microbiota following OIT in children with FA.</p><p><strong>Methods: </strong>Thirty children with FA (mean age 3.93 years, age range 2.00-14.00) undergoing oral immunotherapy targeting legumes (lentils, peanuts, peas), tree nuts (cashews, hazelnuts, pistachios), animal products (milk, egg), and fish and shellfish (salmon, shrimp), as well as seven non-allergic controls (mean age 2.65 years, age range 0.25-5.00) participated in this study. Fecal samples were collected before and after OIT from children with FA, and once from controls. The gut microbiota was profiled using 16S rRNA sequencing, followed by diversity and differential abundance analyses. Alpha and beta diversities were compared, and differential abundance was assessed.</p><p><strong>Results: </strong>Beta diversity analysis revealed small but significant differences in microbial composition between children with FA before and after OIT, and between controls and children with FA before OIT. Differential abundance analysis showed that OIT induced a reversion of the abundance levels of Bacteroidota and Verrucomicrobiota toward those observed in controls.</p><p><strong>Conclusion: </strong>To our knowledge, this is the first study to investigate the impact of OIT on the gut microbiota in children with different FAs for identifying potential microbial biomarkers and convincingly demonstrated their interrelation. These findings may help improve and personalize FA treatment.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 8","pages":"e70156"},"PeriodicalIF":4.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FcεRI-bound OVM-sIgE detection: A promising predictor of boiled egg white OFC outcomes.","authors":"Rosa Rodríguez-Pérez, Elisa Pulido, Teresa Bellón, Mónica Rodríguez-Álvarez, Carmen Gómez-Traseira, Maria Ángeles López-Matas, Javier Dominguez-Ortega, Jerónimo Carnés, María Pedrosa","doi":"10.1111/pai.70149","DOIUrl":"https://doi.org/10.1111/pai.70149","url":null,"abstract":"","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 7","pages":"e70149"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144629416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age differences in health-related quality of life for children with hen's egg FPIES.","authors":"Naoki Kajita, Makoto Kaneko, Yuki Murata, Ryosuke Kagami, Kumiko Morita, Koichi Yoshida","doi":"10.1111/pai.70153","DOIUrl":"https://doi.org/10.1111/pai.70153","url":null,"abstract":"","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 7","pages":"e70153"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144677219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Dr. Muhammad Zarrar.","authors":"Regina Nakiranda, Linda Malan, Hannah Ricci, Arista Nienaber, Cecile Cooke, Cristian Ricci, Mieke Faber, Cornelius M Smuts","doi":"10.1111/pai.70120","DOIUrl":"https://doi.org/10.1111/pai.70120","url":null,"abstract":"","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 7","pages":"e70120"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}