Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology最新文献

{"title":"Editorial comment on \"food allergy-related bullying: Risk factors and psychosocial functioning\".","authors":"Laura Polloni, Ömer Kalayci, Philippe Eigenmann","doi":"10.1111/pai.70125","DOIUrl":"https://doi.org/10.1111/pai.70125","url":null,"abstract":"","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 6","pages":"e70125"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal BCG vaccination to prevent asthma: Results from the MIS BAIR randomized controlled trial.","authors":"Laure F Pittet, Emily K Forbes, Susan Donath, Kate L Francis, Kaya Gardiner, Katie L Flanagan, Anne-Louise Ponsonby, Roy Robins-Browne, Frank Shann, Mike South, Peter Vuillermin, Dan Casalaz, Nigel Curtis, Nicole L Messina","doi":"10.1111/pai.70110","DOIUrl":"10.1111/pai.70110","url":null,"abstract":"<p><strong>Background: </strong>Asthma has a significant impact worldwide, but prevention strategies remain limited. We aimed to evaluate the efficacy of neonatal BCG vaccination in preventing asthma by modulating early-life immunity.</p><p><strong>Methods: </strong>The Melbourne Infant Study: BCG for Allergy and Infection Reduction (MIS BAIR) was a phase 3 multicentre randomized controlled trial in Victoria, Australia. Infants were randomly assigned to receive the BCG-Denmark vaccine or no intervention within 10 days of birth. The incidence of asthma at 5 years of age was estimated using the International Study of Asthma and Allergies in Childhood questions.</p><p><strong>Clinicaltrial: </strong>gov (NCT01906853).</p><p><strong>Results: </strong>A total of 1272 infants were randomized. The adjusted incidence of asthma was 14.4% in the BCG group compared to 16.0% in the control group (adjusted risk difference [aRD] -1.7 percentage points; 95%CI -7.4, 3.9). Secondary outcomes, including severe asthma and use of preventer medication, showed similar trends, with an aRD of -3.9 (95%CI -7.7, 0.0), and -5.6 (95%CI -10.9, -0.4), respectively, favoring the BCG group. Among participants with one or both parents asthmatic, the rate of asthma was also lower in the BCG group (17.6%) compared with the control group (24.7%; aRD -7.2; 95%CI -15.9, 1.5), although a test for interaction was not significant (p = .07).</p><p><strong>Conclusions: </strong>While the point estimates suggested BCG vaccination might protect against asthma, the wide uncertainty around the estimates means further studies with larger sample sizes are needed to evaluate the long-term benefits of BCG vaccination beyond its primary indication.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 6","pages":"e70110"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144218578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FPIES after umbilical cord blood transplantation: A case series.","authors":"Ludo Cuppen, Annemieke Schuurhof, Birgitta Versluijs, Dorine Bresters, Marc Bierings, Marike Stadermann, Caroline A Lindemans","doi":"10.1111/pai.70121","DOIUrl":"10.1111/pai.70121","url":null,"abstract":"","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 6","pages":"e70121"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Month of birth and outdoor temperature after birth predict childhood atopic diseases in Finland.","authors":"Juha Luukkonen, Heta Moustgaard, Hanna Remes, Pekka Martikainen","doi":"10.1111/pai.70118","DOIUrl":"10.1111/pai.70118","url":null,"abstract":"<p><strong>Background: </strong>Previous evidence on season-of-birth differences in atopic diseases is partially mixed, and the etiology behind them is not well understood. For example, outdoor temperature may be an important modifier of the association but has been previously neglected.</p><p><strong>Methods: </strong>We assess how the month of birth is associated with medication use for atopic diseases at ages 0-15 and how outdoor temperatures after birth modify these associations for 0.55 million Finns born during 1995-2004. We used Finnish register data on purchases of medications used for allergic rhinitis, eczema, asthma, and food allergies. We predicted month-of-birth associations with medication use using extensive controls for observed and unobserved confounders and assessed effect modification by 3-month mean outdoor temperature after birth.</p><p><strong>Results: </strong>Approximately half of the children had at least one purchase of medication used for atopic diseases. For children born in spring or summer, the probability of medication use was moderately lower than for children born in the autumn or winter. Among children born in the autumn or winter, exposure to the coldest outdoor temperatures in the first 3 months of life was associated with a nearly 10-percentage-point increase in the risk for medication use compared with the warmest temperatures.</p><p><strong>Conclusions: </strong>Behind the moderate overall associations between month of birth and childhood atopic diseases, there was notable variation by environmental conditions after birth, with cold weather after birth being particularly harmful. Future studies should assess what specific exposures do the outdoor temperatures affect, and in turn how they affect the development of atopic diseases.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 6","pages":"e70118"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pen-demic? Audit of existing adrenaline auto-injector prescription among new referrals to pediatric allergy clinics, according to the EAACI guidelines.","authors":"Catherine Breen, Aideen Byrne, Jonathan O'B Hourihane","doi":"10.1111/pai.70126","DOIUrl":"10.1111/pai.70126","url":null,"abstract":"","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 6","pages":"e70126"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on Hugh Sampson et al.","authors":"Stefano Miceli Sopo, Angela Aurelio, Francesco Mastellone, Giulia Bersani, Tecla Fontana","doi":"10.1111/pai.70095","DOIUrl":"https://doi.org/10.1111/pai.70095","url":null,"abstract":"","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 6","pages":"e70095"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144218576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omalizumab in pediatric chronic spontaneous urticaria: A systematic review and meta-analysis of efficacy and safety.","authors":"Omar Alomari, Deniz Ozceker, Muhammed Edib Mokresh, Asli Berivan Topçak, Sinem Nur Ertan, Merve Karaca Şahin, Nilay Çalışkan, Sefika Ilknur Kökcü Karadag, Muhammed Fatih Erbay, Güler Yıldırım, Hamit Bologur, Hilal Güngör, Ozlem Kaplan, Hasan Sarman Tunç, Emek Kocatürk Göncü","doi":"10.1111/pai.70132","DOIUrl":"10.1111/pai.70132","url":null,"abstract":"<p><p>Chronic spontaneous urticaria significantly impairs quality of life in children, with limited treatment options beyond antihistamines. Omalizumab, an anti-IgE antibody, has shown promise in adults but data on its use in children, especially those under 12, are scarce. This systematic review and meta-analysis aim to evaluate the efficacy and safety of omalizumab in pediatric chronic spontaneous urticaria, providing insights to inform clinical practice and future guidelines. PubMed, Scopus, Embase, Cochrane, and Web of Science databases have been searched for relevant studies. The \"R\" software has been utilized to analyze the response and relapse rates, changes in urticaria scores, and adverse event rates. Subgroup analyses were also done based on response rate. The assessment of heterogeneity utilized the I² and chi-squared tests, applying the random effect model. This systematic review included 36 studies met the inclusion criteria. The pooled response rate for omalizumab was 88.0% (95% CI: 80.7%-95.2%; I² = 61.0%; p = .001), with a complete response rate of 51.0% (95% CI: 32.7%-69.2%; I² = 90.0%; p < .001). Good or well-controlled response rates were 50.5% (95% CI: 33.9%-67.1%; I² = 54.2%; p = .068), while poor or partial responses were 20.1% (95% CI: 14.3%-27.3%; I² = 0.0%; p = .787). Relapse rate were 24.3% (95% CI: 8.1%-40.6%; I² = 66.6%; p = .006). The Urticaria Activity Score showed a significant mean reduction in symptoms (SMD = -3.08; 95% CI: -5.45 to -0.71; I² = 89.1%; p < .001). Adverse events occurred in 3.4% of patients, with specific events including urticaria, angioedema, headaches, fatigue, flu-like symptoms, and mild joint pain. In pediatric patients under 12 years, 18 out of 21 achieved complete response, with a median age of 8 years and follow-up durations between 4 and 18 months. Adverse events in this group included serum sickness in one patient. Omalizumab appears to be an effective treatment option for chronic spontaneous urticaria, demonstrating effectiveness in improving symptoms and providing significant relief. The treatment is generally well-tolerated, with adverse events being rare and manageable. Overall, omalizumab contributing to better disease management and quality of life.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 6","pages":"e70132"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concentration of food allergens in breastmilk and association with maternal factors- A systematic review.","authors":"Sophie A Hughes, Zoya Gridneva, Sharon L Perrella, Donna T Geddes, Debra J Palmer","doi":"10.1111/pai.70117","DOIUrl":"10.1111/pai.70117","url":null,"abstract":"<p><p>Common food allergens have been detected in breast milk with wide inter-individual variations in concentrations. As maternal factors, such as age, smoking, and body mass index have been associated with breast milk composition, we aimed to identify maternal characteristics associated with the concentration of food allergens in breast milk. A PROSPERO (CDR42024558231) registered systematic review search was conducted in MEDLINE, EMBASE, Cochrane Library, CINAHL and Scopus until March 10th, 2025. Article inclusion criteria were human studies, where participants consumed a standardized amount of a common food allergen prior to breast milk sampling, and the concentration of that food allergen was measured in their breast milk. Seventeen articles were included in the systematic review. Despite a standardized amount of food allergen consumption, large inter-individual variations were reported in food allergen breast milk concentrations. Maternal allergic disease (four studies), amount of the food allergen typically eaten by the mother (two studies), stage of lactation (one study) and mammary epithelium permeability (one study) were the only maternal factors examined. No studies reported significant associations between these maternal characteristics and food allergen breast milk concentrations. No previous studies have been specifically designed to determine whether maternal characteristics are associated with food allergen breast milk concentrations. We therefore remain unable to explain large variations in inter-individual food allergen breast milk concentrations. New adequately powered studies are needed to investigate associations with maternal factors previously found to influence breast milk composition, such as age, smoking, body mass index and stage of lactation.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 6","pages":"e70117"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal metabolomics insights into feeding patterns, overweight/obesity, and atopic diseases from birth to childhood.","authors":"Chih-Yung Chiu, Meng-Han Chiang, Chieh-Ni Kuo, Kuan-Wen Su, Jing-Long Huang, Kuo-Wei Yeh","doi":"10.1111/pai.70119","DOIUrl":"https://doi.org/10.1111/pai.70119","url":null,"abstract":"<p><strong>Background: </strong>During early childhood, significant changes occur, including shifts in dietary patterns, accelerated growth, and the emergence of overweight and allergic diseases. However, a longitudinal metabolomic analysis from birth to childhood for the relationships between these factors remains lacking.</p><p><strong>Methods: </strong>A total of 144 children, who completed a 5-year follow-up from a birth cohort, were enrolled. Time series analysis of urinary metabolites collected at ages 1 and 6 months, and at 1, 3, and 5 years was conducted using ¹H nuclear magnetic resonance (NMR) spectroscopy with partial least squares discriminant analysis (PLS-DA). Identified metabolites were studied in relation to changes over time and associations with breastfeeding patterns, allergen sensitizations, overweight/obesity, and atopic diseases during childhood.</p><p><strong>Results: </strong>C-means clustering identified three distinct modules of metabolite abundance patterns, highlighting an increase in amino acid and a decrease in carbohydrate metabolism across ages. The Bray-Curtis dissimilarity indices of metabolic profiles increased with age, showing lower indices in formula-fed infants and children with overweight/obesity, but a higher index in atopic diseases during childhood. Metabolites differentially expressed between breastfeeding patterns were primarily identified within the first year of life, particularly in relation to milk sensitization at age 1. Venn diagrams illustrated metabolite distributions, showing an 80% overlap between breastfeeding patterns and infant overweight/obesity, and a 53% overlap between overweight/obesity and atopic diseases in childhood.</p><p><strong>Conclusion: </strong>Longitudinal metabolomics analysis revealed associations between gut microbiota-related metabolites and feeding patterns, linking formula feeding to infant overweight/obesity, as well as connections between overweight/obese children and atopic diseases during childhood.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 6","pages":"e70119"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Gonzalez-Labrador et al.","authors":"Yuki Sakaguchi, Ken-Ichi Nagakura, Sakura Sato, Noriyuki Yanagida, Motohiro Ebisawa","doi":"10.1111/pai.70128","DOIUrl":"https://doi.org/10.1111/pai.70128","url":null,"abstract":"","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"36 6","pages":"e70128"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}