Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology最新文献

{"title":"Machine learning-based prediction of food sensitization in infants and toddlers with atopic dermatitis.","authors":"Rıza Yıldırım, Ece Şenbaykal Yiğit, İkbal Nur Şafak, Hatemi Esam Demirtaş, Ayşe Pakel, Seda Tunca, Sanem Eren Akarcan, İdil Akay Hacı, İlke Taşkırdı, Tuba Tuncel","doi":"10.1111/pai.70518","DOIUrl":"https://doi.org/10.1111/pai.70518","url":null,"abstract":"<p><strong>Background: </strong>Food sensitization (FS) is a common comorbidity in children with atopic dermatitis (AD), often leading to the atopic march. Identifying high-risk patients in primary care is crucial to prioritize specialist referrals and prevent unnecessary elimination diets.</p><p><strong>Objective: </strong>To develop and validate a machine learning (ML) based clinical decision support tool to predict IgE-mediated FS risk in infants and toddlers (0-3 years) diagnosed with AD using routine clinical and laboratory parameters.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of children diagnosed with AD. Patients were classified as FS positive or FS negative based on specific IgE levels and skin prick tests. Ten ML algorithms were trained and compared using 5-fold stratified cross-validation. Feature importance was analyzed, and an interactive web-based tool was developed for clinical application.</p><p><strong>Results: </strong>Among 340 patients, 156 (45.8%) had IgE-mediated FS. Key independent predictors of FS included higher total IgE levels, younger age at presentation, elevated eosinophil counts, and breastfeeding at the time of symptom onset. Boosting-based models achieved superior performance; specifically, the AdaBoost model demonstrated high stability and discrimination (ROC AUC: 0.815 in CV and 0.819 in the held-out test set). By optimizing the probability threshold to 0.40, the model achieved a recall of 92% and an F1-score of 0.75, effectively minimizing false negatives.</p><p><strong>Conclusion: </strong>The ML model may serve as a screening and risk-stratification tool for IgE-mediated FS in children with AD. By utilizing routine laboratory data, this web-integrated tool can support primary care physicians in risk stratification, ensuring timely referral for high-risk cases while reducing unnecessary testing in low-risk infants.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"37 10","pages":"e70518"},"PeriodicalIF":4.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149130263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Prevalence of Avoidant/Restrictive Food Intake Disorder (ARFID) in children with and without food allergy\".","authors":"","doi":"10.1111/pai.70473","DOIUrl":"10.1111/pai.70473","url":null,"abstract":"","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"37 10","pages":"e70473"},"PeriodicalIF":4.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149198788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Environmental risk factors for allergic rhinitis differ by income level: A global asthma network survey\".","authors":"Madhuri Tribhuvan, Shashikant N Phatke","doi":"10.1111/pai.70502","DOIUrl":"10.1111/pai.70502","url":null,"abstract":"","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"37 10","pages":"e70502"},"PeriodicalIF":4.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149122917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duration and severity of asthma-like episodes in young children vary by viral and bacterial triggers.","authors":"Julie Nyholm Kyvsgaard, Jonathan Thorsen, Signe Kjeldgaard Jensen, Tamo Sultan, Nicklas Brustad, Casper-Emil Tingskov Pedersen, Anton Kjellberg, Thea K Fischer, Karen A Krogfelt, Nilo Vahman, James E Gern, Ann-Marie Malby Schoos, Klaus Bønnelykke, Bo Lund Chawes, Jakob Stokholm","doi":"10.1111/pai.70499","DOIUrl":"10.1111/pai.70499","url":null,"abstract":"<p><strong>Background: </strong>Asthma-like episodes with cough, wheeze and/or breathlessness are frequent in young children and often triggered by respiratory tract infections. We aimed to examine whether specific microbial triggers of asthma-like episodes were associated with episode duration and severity.</p><p><strong>Methods: </strong>We analyzed 453 nasopharyngeal aspirates collected during acute asthma-like episodes from 268 children aged 0-3 years from the COPSAC-2010 cohort. Samples were tested for common pathogenic respiratory viruses by PCR and for bacteria by culture. Asthma-like episodes were prospectively recorded in diaries. Associations between microbial triggers and episode duration and severity were analyzed by generalized estimating equations. Interactions between microbial triggers and selected asthma risk loci and polygenic risk scores (PRSs) were explored in relation to episode duration.</p><p><strong>Results: </strong>Rhinovirus was associated with 27% longer episode duration compared to episodes without rhinovirus, predominantly driven by rhinovirus C (50% longer). Rhinovirus was also associated with a more than twofold increased risk of a severe asthma exacerbation (i.e., need for oral prednisolone, high-dose inhaled corticosteroids, and/or hospitalization) (OR 2.26; 95% CI 1.10-4.64; p = .027), with rhinovirus C exhibiting an even higher risk (OR 4.38; 95% CI 1.71-11.25; p = .002). Episodes with Streptococcus pneumoniae, Haemophilus influenzae, and/or Moraxella catarrhalis were associated with 61% longer duration than episodes without these bacteria, which was particularly pronounced for M. catarrhalis (47% longer). In contrast, RSV; parainfluenza and influenza viruses were associated with shorter duration. Younger age correlated with longer episode duration and risk of a severe asthma exacerbation. Exploratory analyses suggested pathogen-specific interactions with selected asthma risk loci and asthma exacerbartion PRS in relation to episode duration.</p><p><strong>Conclusion: </strong>Specific microbial triggers and younger age were associated with the duration and severity of asthma-like episodes in young children. These findings may improve prognostic assessment and support more individualized management.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"37 10","pages":"e70499"},"PeriodicalIF":4.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149123029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intranasal corticosteroids in pediatric airway inflammation: From pharmacokinetics and evidence to optimized clinical practice.","authors":"Athina Papadopoulou, Marios Papadopoulos, Sophia Tsabouri","doi":"10.1111/pai.70514","DOIUrl":"https://doi.org/10.1111/pai.70514","url":null,"abstract":"<p><p>Intranasal corticosteroids (INS) are widely recommended as first-line therapy for pediatric upper airway disorders due to their potent local anti-inflammatory effects and favorable safety profile. This narrative review evaluates current evidence regarding the pharmacologic properties, clinical efficacy, and safety of INS in children with allergic rhinitis (AR), adenoid hypertrophy (ADH), obstructive sleep apnea (OSA) or sleep-disordered breathing (SDB), otitis media with effusion (OME), and rhinosinusitis (RS). A structured literature search of PubMed, EMBASE, and Cochrane databases (2015-2025) identified randomized controlled trials, observational studies, systematic reviews, and meta-analyses assessing indications, efficacy outcomes, and adverse events. Evidence consistently supports INS as the most effective pharmacologic therapy for pediatric AR, with significant improvements in symptom scores and quality of life. In ADH and mild OSA/SDB, INS may reduce nasal obstruction and decrease adenoid size, potentially lowering the need for surgical intervention. Data for OME are inconsistent, and routine use is not universally recommended. In acute and chronic RS, INS demonstrates benefit, particularly when allergic inflammation predominates. Pharmacokinetic differences among agents influence safety. Newer molecules such as fluticasone propionate, fluticasone furoate, and mometasone furoate exhibit low systemic bioavailability and high receptor affinity, minimizing hypothalamic-pituitary-adrenal axis suppression. Local adverse effects are generally mild and comparable to placebo. Epistaxis is a recognized local adverse effect, although pediatric data do not demonstrate a significant increase compared with placebo. Available data suggest minimal, clinically insignificant effects on growth velocity when recommended doses are used. Overall, INS remain a cornerstone of AR therapy, with well-established efficacy and a favorable safety profile when appropriately used. There is also supportive and clinically meaningful evidence for their use in selected children with ADH, although the available evidence is heterogeneous. In contrast, evidence for INS in OME, OSA/SDB, and pediatric CRS remains limited or inconsistent and does not currently support their routine use solely for these pediatric upper airway conditions, particularly in the absence of concomitant nasal allergic inflammation.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"37 10","pages":"e70514"},"PeriodicalIF":4.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149140400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No demonstrated superiority of tropomyosin (Pen a 1) sIgE over crude shrimp sIgE in children.","authors":"Noriyuki Yanagida, Hironaga Yoshimoto, Kanako Ogura, Ken-Ichi Nagakura, Kyohei Takahashi, Kiyotake Ogura, Sakura Sato, Motohiro Ebisawa","doi":"10.1111/pai.70506","DOIUrl":"https://doi.org/10.1111/pai.70506","url":null,"abstract":"<p><strong>Background: </strong>Tropomyosin (Pen a 1)-specific IgE (sIgE) is a proposed diagnostic marker for shrimp allergy; however, its superiority over crude shrimp sIgE is unclear. This study aimed to determine whether Pen a 1 sIgE is superior to crude shrimp sIgE for predicting oral food challenge (OFC) outcomes in children.</p><p><strong>Methods: </strong>We retrospectively analyzed children who underwent OFCs using ≥40 g heated shrimp and had both shrimp sIgE and Pen a 1 sIgE data. Areas under the receiver operating characteristic curves (AUCs) were compared using the DeLong test, and the paired AUC difference with its 95% confidence interval (CI) was estimated.</p><p><strong>Results: </strong>Of 204 patients (median age 6.2 years; 70% male), 33 (16%) had a positive OFC. The AUCs for shrimp sIgE (0.629; 95% CI, 0.535-0.723) and Pen a 1 sIgE (0.622; 95% CI, 0.524-0.718) did not differ significantly (difference, 0.007; 95% CI, -0.069 to 0.083; DeLong p = .850). Pen a 1 sIgE correlated strongly with shrimp sIgE (r = .767, p < .001). Among 190 patients with Dermatophagoides pteronyssinus (Der p) sIgE data, Der p sIgE correlated weakly with both markers (r= .321 and .217) and did not differ by OFC outcome (p = .612).</p><p><strong>Conclusion: </strong>Superiority of Pen a 1 sIgE over crude shrimp sIgE was not demonstrated. The strong correlation suggests that tropomyosin is a major IgE-binding component of the crude extract. OFC remains essential.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"37 10","pages":"e70506"},"PeriodicalIF":4.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149130251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation and reliability of the Italian versions of the Food Allergy Quality of Life -Parental Burden (FAQL-PB) and -Parent Form 10 (FAQLQ-PF10) Questionnaires.","authors":"Pasquale Comberiati, Simona Barni, Mario Miccoli, Audrey DunnGalvin, Francesca Mori, Lucrezia Sarti, Andrea Poli, Daniel Munblit, Enza D'Auria, David Fleischer, Diego G Peroni, Mattew Greenhawt","doi":"10.1111/pai.70510","DOIUrl":"https://doi.org/10.1111/pai.70510","url":null,"abstract":"<p><strong>Background: </strong>Food allergy (FA) may substantially impair quality of life (QoL) in affected children and their families. Reliable and culturally adapted tools are needed to assess this burden. We aimed to translate, culturally adapt, and validate the Italian versions of the Food Allergy Quality of Life Questionnaire Parent Form 10 (FAQLQ-PF10) and the Food Allergy Quality of Life Parental Burden Questionnaire (FAQL-PB).</p><p><strong>Methods: </strong>Following World Health Organization recommendations, the questionnaires underwent forward-backward translation and psychometric validation. Internal consistency, test-retest reliability, convergent validity, and discriminant validity were assessed in caregivers of children with FA (n = 128) and without FA (n = 52).</p><p><strong>Results: </strong>Both questionnaires showed high internal consistency (Cronbach's α = 0.87 for FAQLQ-PF10 and 0.95 for FAQL-PB) and excellent test-retest reliability (Intraclass Correlation Coefficients 0.95 and 0.87, respectively). Moderate correlations with the Food Allergy Independent Measure (FAIM) supported convergent validity, whereas weak correlations with generic QoL and psychological distress measures confirmed disease specificity. FAQLQ-PF10 and FAQL-PB scores were significantly higher in the FA group than in controls (all p < .0001), supporting discriminant validity. Key clinical predictors of worse QoL included history of anaphylaxis, allergic comorbidities, and previous emergency department visits for FA. Parents of children with milk or egg allergy were a high-risk subgroup for impaired QoL, whereas increasing child age, longer elimination diet duration, and multiple affected siblings were associated with worse child QoL.</p><p><strong>Conclusions: </strong>The Italian versions of the FAQLQ-PF10 and FAQL-PB are valid, reliable, and disease-specific instruments for assessing FA-related QoL. Their use may facilitate routine QoL assessment and support patient-centered management of pediatric FA.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"37 10","pages":"e70510"},"PeriodicalIF":4.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13633388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149122579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of early life anti-pathogen immune responses with infant food sensitisation and allergy: An elastic-net stability-selection approach.","authors":"Ellie McDonald, Sofie Biering-Sørensen, Laure F Pittet, Nigel Curtis, Nicole L Messina","doi":"10.1111/pai.70513","DOIUrl":"https://doi.org/10.1111/pai.70513","url":null,"abstract":"<p><strong>Background: </strong>The development of food sensitisation (FS) and food allergy (FA) reflects complex interactions between genetic, environmental and immunological factors, which conventional univariate approaches may fail to capture. This exploratory study applied penalised regression to determine whether early-life immune responses to common pathogens are associated with infant FS and FA.</p><p><strong>Methods: </strong>At 1 year of age, FS was determined by skin prick test and FA by allergy/tolerance history and oral food challenge. Elastic net regression (ENR) was applied to cytokine response data (13 cytokines) from whole blood stimulation (11 microbial stimuli) collected at 6 months of age (n = 147), together with longitudinal clinical data from MIS BAIR trial infants. Stably selected variables (0.75) were analysed by multivariable logistic regression to explore the direction of association of the stably selected variables.</p><p><strong>Results: </strong>For FS, 13 cytokine-stimulant pairs were stably selected in cytokine-only ENR models. After including early-life clinical factors, four pairs were retained. Two were inversely associated with FS (Haemophilus influenzae IL-1Ra and Pam3CSK4 MIP-1α). Two were positively associated (Streptococcus pyogenes IL-1Ra and peptidoglycan IFN-γ). For FA, four cytokine-stimulant pairs were selected in cytokine-only ENR models. Two were positively associated with FA (Escherichia coli-stimulated MCP-1 and S. pyogenes IP-10), and two inversely associated (Pam3CSK4 IL-1Ra and H. influenzae IL-1Ra). No cytokine responses were selected after inclusion of clinical factors in the FA model. The most consistently selected clinical factors were infant eczema for FS and topical corticosteroid treatment by 6 months for FA likely due to disease severity.</p><p><strong>Conclusion: </strong>Early-life cytokine responses to pathogens associated with FS and FA at 1 year were identified through stability selection. While hypothesis-generating, findings were consistent with a role for early immune perturbation in the development of food sensitisation.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"37 10","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13688703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149248445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral effector-memory CD4⁺ T cells reflect clinical symptom burden in pediatric allergic rhinitis.","authors":"Takeshi Yamamoto, Eri Hayata, Terumi Ikarashi, Haruna Tokitomo, Katsuki Tanaka, Azusa Hiraoka, Kenta Zushi, Kei Watanabe, Toshiyuki Kobayashi, Taiji Nakano, Hiromichi Hamada","doi":"10.1111/pai.70509","DOIUrl":"10.1111/pai.70509","url":null,"abstract":"<p><strong>Background: </strong>Pediatric allergic rhinitis (AR) can substantially affect quality of life and school performance, yet conventional sensitization markers such as allergen-specific immunoglobulin E (sIgE) do not consistently reflect symptom severity. We examined whether activation-induced marker (AIM)-defined allergen-specific peripheral effector-memory CD4⁺ T-cell (peff-mCD4) frequencies were associated with symptom burden.</p><p><strong>Methods: </strong>In this pilot, single-center observational study, house dust mite (HDM)-specific responses were analyzed in 20 children and Japanese cedar pollen (JCP)-specific responses in 19. Nasal symptom numerical rating scale (NRS) and total nasal symptom score (TNSS) were recorded. Peff-mCD4 cells were quantified as CD154⁺CD137⁺ cells within memory CD4⁺ T cells after short-term ex vivo allergen stimulation.</p><p><strong>Results: </strong>Peff-mCD4 frequency was strongly associated with NRS and TNSS in both the HDM-specific (Spearman ρ = 0.882 and 0.835, respectively) and JCP-specific analyses (ρ = 0.828 and 0.769, respectively; all q < 0.001). In contrast, sIgE showed weaker associations with symptom scores, and none of the four sIgE-symptom associations remained significant after FDR adjustment. These peff-mCD4 associations remained significant after adjustment for age and sex. In exploratory ROC analyses using TNSS ≥8 as an operational threshold, peff-mCD4 yielded AUCs of 0.867 for HDM and 0.910 for JCP.</p><p><strong>Conclusion: </strong>Peff-mCD4 frequency was strongly associated with symptom burden in pediatric AR. Larger longitudinal and externally validated studies are required to determine its potential utility as a peripheral blood cellular correlate of clinical symptom burden.</p>","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"37 10","pages":"e70509"},"PeriodicalIF":4.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149198808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Dr. Christos Zavos.","authors":"Silvia Rodríguez-Manchón, Teresa Alarcón-Cavero, Alejandro Mira-Obrador, Carolina Gutiérrez-Junquera, Sonia Fernández-Fernández, María Mercedes Alonso-Saiz, Claudio Alba-Rubio, Rosa Ana Muñoz Codoceo, Gloria Domínguez-Ortega","doi":"10.1111/pai.70515","DOIUrl":"https://doi.org/10.1111/pai.70515","url":null,"abstract":"","PeriodicalId":520742,"journal":{"name":"Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology","volume":"37 10","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149248460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}