Open medicine (Warsaw, Poland)最新文献_第6页

Effect of femoral head necrosis cystic area on femoral head collapse and stress distribution in femoral head: A clinical and finite element study. 股骨头坏死囊区对股骨头塌陷及股骨头应力分布的影响:临床和有限元研究。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-07-13 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0506

Zhaoming Zhang, Tianye Lin, Yuan Zhong, Wenting Song, Peng Yang, Ding Wang, Fan Yang, Qingwen Zhang, Qiushi Wei, Wei He

{"title":"Effect of femoral head necrosis cystic area on femoral head collapse and stress distribution in femoral head: A clinical and finite element study.","authors":"Zhaoming Zhang, Tianye Lin, Yuan Zhong, Wenting Song, Peng Yang, Ding Wang, Fan Yang, Qingwen Zhang, Qiushi Wei, Wei He","doi":"10.1515/med-2022-0506","DOIUrl":"https://doi.org/10.1515/med-2022-0506","url":null,"abstract":"The purpose of this study was to investigate the effect of cystic areas of osteonecrosis of the femoral head (ONFH) on stress distribution and disease progression in the femoral head. A total of 85 patients (106 hips) diagnosed with Association Research Circulation Osseous stage II non-traumatic and non-surgical treatment were retrospectively analyzed. The presence of cystic areas and diameter of cystic areas were compared between the two groups. In addition, five spherical cystic areas of different diameters were constructed and the maximum stress was observed. There was a difference between the two groups in whether cystic areas appeared in the femoral head, with 49.1% in the collapse group showing cystic areas, which was significantly higher than that in the non-collapse group (18.4%) (P < 0.05). In addition, the diameter of the cystic areas was significantly larger in the collapsed group than in the non-collapsed group (P < 0.05). The maximum and mean von Mises stress value around the necrotic area and around the cystic area of the femoral head increased with the increase of the cystic diameter. Stress concentration areas can be generated around the cystic areas. The presence and increased diameter of the cystic areas accelerates the collapse of the ONFH femoral head.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1282-1291"},"PeriodicalIF":2.1,"publicationDate":"2022-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40646054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of ST-T changes with all-cause mortality among patients with peripheral T-cell lymphomas. 外周t细胞淋巴瘤患者ST-T变化与全因死亡率的关系

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-07-12 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0517

Hanzhi Du, Lihong Yang, Bin Yan, Juan Zhao, Mengchang Wang

{"title":"Association of ST-T changes with all-cause mortality among patients with peripheral T-cell lymphomas.","authors":"Hanzhi Du, Lihong Yang, Bin Yan, Juan Zhao, Mengchang Wang","doi":"10.1515/med-2022-0517","DOIUrl":"https://doi.org/10.1515/med-2022-0517","url":null,"abstract":"Research has suggested a significant prognostic value of ST-T changes in various cardiovascular diseases and malignant tumors. However, their role in predicting prognosis in patients with peripheral T-cell lymphomas (PTCLs) remains unknown. Here, we investigated the prognostic potential of ST-T changes in all-cause mortality of PTCLs patients. In total, 131 patients with PTCLs between January 2015 and April 2020 were enrolled. Univariable and multivariable COX proportional hazards regression models were used to find the relationship between ST-T changes and all-cause mortality in these patients. A significant difference in all-cause mortality was found between patients with ST-T abnormalities and those without definite abnormalities in the ST-T segments (P = 0.027). Multivariable Cox risk regression analysis indicated that patients with ST-T changes had greater all-cause mortality than patients with normal ST-T segments in the intermediate-high/high-risk groups (P < 0.001). In addition, ST-T changes were markedly distinction in patients with hypoproteinemia than in those with no definite abnormalities in the ST-T segments (P = 0.021). ST-T changes may serve as potential, simple, and effective prognostic factors for all-cause mortality in PTCLs patients, especially in the intermediate-high/high-risk and hypoproteinemia groups. Therefore, regular ECG monitoring is recommended to guide the clinical treatment of patients with PTCLs.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1252-1258"},"PeriodicalIF":2.1,"publicationDate":"2022-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40646489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

miR-212-5p inhibits nasopharyngeal carcinoma progression by targeting METTL3. miR-212-5p通过靶向METTL3抑制鼻咽癌进展。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-07-12 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0515

Hongyu Zhou, Nana Zhang

{"title":"miR-212-5p inhibits nasopharyngeal carcinoma progression by targeting METTL3.","authors":"Hongyu Zhou, Nana Zhang","doi":"10.1515/med-2022-0515","DOIUrl":"https://doi.org/10.1515/med-2022-0515","url":null,"abstract":"This study was conducted to investigate the effect of microRNA-212-5p (miR-212-5p) on the proliferation and apoptosis of nasopharyngeal carcinoma (NPC) cells. Microarray datasets (EXP00394 and EXP00660) were downloaded from the dbDEMC database, and the differentially expressed microRNAs between high-grade and low-grade NPC were analyzed. miR-212-5p and methyltransferase like 3 (METTL3) expression levels in NPC tissues and cells were determined by the quantitative real-time polymerase chain reaction and Western blot. Besides, the relationship between miR-212-5p expression and clinicopathological characteristics of patients was analyzed by the Chi-square test. Cell counting kit-8 assay, 5-ethynyl-2-deoxyuridine (EdU) assay, and flow cytometry were adopted to detect the effect of miR-212-5p on the cell proliferation and apoptosis. Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analysis were performed to explore the potential biological functions and the signal pathways related to the target genes of miR-212-5p. Bioinformatics prediction and dual luciferase reporter gene assay were used to verify the relationship between miR-212-5p and METTL3 3' untranslated region. Besides, western blot was adopted to detect the expression of METTL3. Gene set enrichment analysis was performed to analyze the downstream pathways in which METTL3 was enriched. It was found that miR-212-5p was downregulated in NPC tissues, and the low miR-212-5p expression was associated with lymph node metastasis and poor differentiation. miR-212-5p overexpression inhibited the growth and promoted apoptosis of NPC cells; miR-212-5p inhibition functioned oppositely. Mechanistically, miR-212-5p inhibited the proliferation and promoted apoptosis of NPC cells via suppressing METTL3 expression. miR-212-5p/METTL3 was associated with processes of RNA transport and cell cycle. In conclusion, miR-212-5p inhibits the progression of NPC by targeting METTL3.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1241-1251"},"PeriodicalIF":2.1,"publicationDate":"2022-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40646487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Tanshinone IIA reverses oxaliplatin resistance in colorectal cancer through microRNA-30b-5p/AVEN axis. 丹参酮IIA通过microRNA-30b-5p/AVEN轴逆转结直肠癌患者的奥沙利铂耐药。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-07-12 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0512

Tingrui Ge, Yonggang Zhang

{"title":"Tanshinone IIA reverses oxaliplatin resistance in colorectal cancer through microRNA-30b-5p/AVEN axis.","authors":"Tingrui Ge, Yonggang Zhang","doi":"10.1515/med-2022-0512","DOIUrl":"https://doi.org/10.1515/med-2022-0512","url":null,"abstract":"This research aims to explore the role of Tanshinone IIA (Tan IIA) and microRNA (miR)-30b-5p in chemoresistance of colorectal cancer (CRC). The expression levels of miR-30b-5p and apoptosis and caspase activation inhibitor (AVEN) was detected by reverse transcription-quantitative polymerase chain reaction assay. The cell proliferation and apoptosis were examined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and flow cytometry assays. The target relationship between miR-30b-5p and AVEN was confirmed by Dual-luciferase reporter assay. Transwell assay was performed to assess CRC cells' metastasis. Western blot was carried out to measure the apoptosis-related protein. The results showed that miR-30b-5p was lowly expressed in oxaliplatin-resistance CRC cells SW480 (SW480/R) compared to SW480 cells. Overexpression of miR-30b-5p significantly suppressed the malignant biological behaviors of SW480/R cells and significantly promoted the sensitivity of SW480/R cells to oxaliplatin by down-regulated AVEN expression. Besides, Tan IIA treatment upregulated miR-30b-5p expression in SW480/R cells. Moreover, miR-30b-5p upregulation strengthened the promoting effect of Tan IIA on the sensitivity of SW480/R cells to oxaliplatin. In conclusion, Tan IIA and miR-30b-5p could reverse oxaliplatin resistance of CRC cells and may thus be potential treatment strategies for treating patients with CRC.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1228-1240"},"PeriodicalIF":2.1,"publicationDate":"2022-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40646488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Effectiveness and clinical benefits of new anti-diabetic drugs: A real life experience. 新型抗糖尿病药物的有效性和临床益处:一个真实的生活体验。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-07-07 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0504

Giuseppina Piazzolla, Alfredo Vozza, Sara Volpe, Alessandro Bergamasco, Vincenzo Triggiani, Giuseppe Lisco, Michela Falconieri, Cosimo Tortorella, Vincenzo Solfrizzi, Carlo Sabbà

{"title":"Effectiveness and clinical benefits of new anti-diabetic drugs: A real life experience.","authors":"Giuseppina Piazzolla, Alfredo Vozza, Sara Volpe, Alessandro Bergamasco, Vincenzo Triggiani, Giuseppe Lisco, Michela Falconieri, Cosimo Tortorella, Vincenzo Solfrizzi, Carlo Sabbà","doi":"10.1515/med-2022-0504","DOIUrl":"https://doi.org/10.1515/med-2022-0504","url":null,"abstract":"We evaluated the clinical impact, in daily clinical practice, of sodium-glucose co-transporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP1RA) therapies in patients with type 2 diabetes. Data from 500 unselected consecutive patients were retrospectively analyzed. Only those with a full assessment at baseline (T0) and after 3 (T3), 6 (T6), and 12 (T12) months of treatment with SGLT2i or GLP1RA were included in the study (n = 167). At baseline, patients had a high mean body weight (BW), abdominal circumference (AC), body mass index (BMI), and HOMA index. Despite normal C-peptide values, 39 patients were being treated with insulin (up to 120 IU/day). During therapy, a progressive improvement in BW, BMI, and AC was observed with both the molecules. Fasting glucose and glycated Hb decrease was already significant at T3 in all patients, while the HOMA index selectively improved with SGLT2i therapy. Renal function parameters remained stable regardless of the drug used. Finally, SGLT2i reduced serum uric acid and improved the lipid profile, while GLP1RA reduced serum levels of liver enzymes. Both the therapeutic regimens allowed a significant reduction or complete suspension of unnecessary insulin therapies. Our real life data confirm the results obtained from randomized clinical trials and should be taken as a warning against inappropriate use of insulin in patients with preserved β-cell function.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1203-1215"},"PeriodicalIF":2.1,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40540549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Identification of osteoporosis based on gene biomarkers using support vector machine. 基于支持向量机的基因生物标记识别骨质疏松症。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-07-07 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0507

Nanning Lv, Zhangzhe Zhou, Shuangjun He, Xiaofeng Shao, Xinfeng Zhou, Xiaoxiao Feng, Zhonglai Qian, Yijian Zhang, Mingming Liu

引用次数: 1

Bioinformatics-based analysis of SUMOylation-related genes in hepatocellular carcinoma reveals a role of upregulated SAE1 in promoting cell proliferation. 基于生物信息学的肝细胞癌中sumoylation相关基因分析揭示了SAE1上调在促进细胞增殖中的作用。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-07-06 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0510

Yang Liu, Xiang Wang, Xingzhi Zeng, Yinghua Wu, Xinrong Liu, Juan Tan, Xiaoyan Li

{"title":"Bioinformatics-based analysis of SUMOylation-related genes in hepatocellular carcinoma reveals a role of upregulated SAE1 in promoting cell proliferation.","authors":"Yang Liu, Xiang Wang, Xingzhi Zeng, Yinghua Wu, Xinrong Liu, Juan Tan, Xiaoyan Li","doi":"10.1515/med-2022-0510","DOIUrl":"https://doi.org/10.1515/med-2022-0510","url":null,"abstract":"The function of small ubiquitin-like modifier (SUMO)-related genes in hepatocellular carcinoma (HCC) remains unclear. This study aimed to analyze the expression profile and prognostic relevance of SUMO-related genes using publicly available data. A set of bioinformatics tools and experiments were integrated to explore the mechanism of the genes of interest. The least absolute shrinkage and selection operator Cox regression analysis was used to construct a prognostic model. SUMO-2 and SUMO-activating enzyme subunit 1 (SAE1) were upregulated in HCC. The enrichment analysis indicated that SUMO-2 and SAE1 might regulate the cell cycle. The downregulation of SAE1 inhibited the proliferation of HCC cells, whereas the upregulation of the gene promoted cell proliferation. IGF2BP3 contributed to the upregulation of SAE1 in an N6-methyladenosine (m6A)-dependent way. Eventually, an SAE1-related risk score (SRRS) was developed and validated in HCC. SRRS could serve as an independent prognostic factor and predict the efficiency of transarterial chemoembolization in patients with HCC.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1183-1202"},"PeriodicalIF":2.1,"publicationDate":"2022-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40524934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Identification of autophagy-related biomarkers in patients with pulmonary arterial hypertension based on bioinformatics analysis. 基于生物信息学分析的肺动脉高压患者自噬相关生物标志物鉴定

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-07-06 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0497

Zhisong Yang, Li Zhou, Haiyan Ge, Weimin Shen, Lin Shan

{"title":"Identification of autophagy-related biomarkers in patients with pulmonary arterial hypertension based on bioinformatics analysis.","authors":"Zhisong Yang, Li Zhou, Haiyan Ge, Weimin Shen, Lin Shan","doi":"10.1515/med-2022-0497","DOIUrl":"https://doi.org/10.1515/med-2022-0497","url":null,"abstract":"Autophagy participates in the regulation of pulmonary arterial hypertension (PAH). However, the role of autophagy-related genes (ARGs) in the pathogenesis of the PAH is still unclear. This study aimed to identify the ARGs in PAH via bioinformatics analysis. A microarray dataset (GSE113439) was downloaded from the Gene Expression Omnibus database to identify differentially expressed ARGs (DEARGs). Protein-protein interactions network, gene ontology, and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed to screen hub genes and the underlying molecular mechanisms of PAH. Finally, the mRNA expression of the hub genes was validated using the GSE53408 dataset. Twenty-six DEARGs were identified, all of which were upregulated. Enrichment analyses revealed that these DEARGs were mainly enriched in the nucleotide-binding oligomerization domain (NOD)-like receptor signaling pathway, PI3K-Akt signaling pathway, response to hypoxia, response to nutrient levels, and autophagy. Among these hub genes, the mRNA expression levels of HSP90AA1, HIF1A, MET, IGF1, LRRK2, CLTC, DNM1L, MDM2, RICTOR, and ROCK2 were significantly upregulated in PAH patients than in healthy individuals. Ten hub DEARGs were identified and may participate in the pathogenesis of the PAH via the regulation of autophagy. The present study may provide novel therapeutic targets for PAH prevention and treatment and expand our understanding of PAH.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1148-1157"},"PeriodicalIF":2.1,"publicationDate":"2022-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40540550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Advantages of ketamine in pediatric anesthesia. 氯胺酮在小儿麻醉中的优势。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-07-06 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0509

Alessandro Simonini, Etrusca Brogi, Marco Cascella, Alessandro Vittori

{"title":"Advantages of ketamine in pediatric anesthesia.","authors":"Alessandro Simonini, Etrusca Brogi, Marco Cascella, Alessandro Vittori","doi":"10.1515/med-2022-0509","DOIUrl":"https://doi.org/10.1515/med-2022-0509","url":null,"abstract":"Although ketamine is primarily used for induction and maintenance of general anesthesia, it also presents sedative, amnestic, anesthetics, analgesic, antihyperalgesia, neuroprotective, anti-inflammatory, immunomodulant, and antidepressant effects. Its unique pharmacodynamics and pharmacokinetic properties allow the use of ketamine in various clinical settings including sedation, ambulatory anesthesia, and intensive care practices. It has also adopted to manage acute and chronic pain management. Clinically, ketamine produces dissociative sedation, analgesia, and amnesia while maintaining laryngeal reflexes, with respiratory and cardiovascular stability. Notably, it does not cause respiratory depression, maintaining both the hypercapnic reflex and the residual functional capacity with a moderate bronchodilation effect. In the pediatric population, ketamine can be administered through practically all routes, making it an advantageous drug for the sedation required setting such as placement of difficult vascular access and in uncooperative and oppositional children. Consequently, ketamine is indicated in prehospital induction of anesthesia, induction of anesthesia in potentially hemodynamic unstable patients, and in patients at risk of bronchospasm. Even more, ketamine does not increase intracranial pressure, and it can be safely used also in patients with traumatic brain injuries. This article is aimed to provide a brief and practical summary of the role of ketamine in the pediatric field.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1134-1147"},"PeriodicalIF":2.1,"publicationDate":"2022-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40540552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Bioinformatics analysis reveals three key genes and four survival genes associated with youth-onset NSCLC. 生物信息学分析揭示了3个关键基因和4个存活基因与青年发病NSCLC相关。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-07-06 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0492

Xuan Han, Peng Ren, Shaohua Ma

引用次数: 2