Bioinformatics-based analysis of SUMOylation-related genes in hepatocellular carcinoma reveals a role of upregulated SAE1 in promoting cell proliferation.

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Open medicine (Warsaw, Poland) Pub Date : 2022-07-06 eCollection Date: 2022-01-01 DOI:10.1515/med-2022-0510

Yang Liu, Xiang Wang, Xingzhi Zeng, Yinghua Wu, Xinrong Liu, Juan Tan, Xiaoyan Li

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引用次数: 3

Abstract

The function of small ubiquitin-like modifier (SUMO)-related genes in hepatocellular carcinoma (HCC) remains unclear. This study aimed to analyze the expression profile and prognostic relevance of SUMO-related genes using publicly available data. A set of bioinformatics tools and experiments were integrated to explore the mechanism of the genes of interest. The least absolute shrinkage and selection operator Cox regression analysis was used to construct a prognostic model. SUMO-2 and SUMO-activating enzyme subunit 1 (SAE1) were upregulated in HCC. The enrichment analysis indicated that SUMO-2 and SAE1 might regulate the cell cycle. The downregulation of SAE1 inhibited the proliferation of HCC cells, whereas the upregulation of the gene promoted cell proliferation. IGF2BP3 contributed to the upregulation of SAE1 in an N6-methyladenosine (m6A)-dependent way. Eventually, an SAE1-related risk score (SRRS) was developed and validated in HCC. SRRS could serve as an independent prognostic factor and predict the efficiency of transarterial chemoembolization in patients with HCC.

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基于生物信息学的肝细胞癌中sumoylation相关基因分析揭示了SAE1上调在促进细胞增殖中的作用。

小泛素样修饰因子(SUMO)相关基因在肝细胞癌(HCC)中的功能尚不清楚。本研究旨在利用公开数据分析sumo相关基因的表达谱和预后相关性。整合了一套生物信息学工具和实验来探索感兴趣的基因的机制。采用最小绝对收缩和选择算子Cox回归分析构建预后模型。SUMO-2和sumo活化酶亚单位1 (SAE1)在HCC中上调。富集分析表明SUMO-2和SAE1可能调控细胞周期。SAE1的下调抑制了HCC细胞的增殖，而SAE1的上调则促进了细胞的增殖。IGF2BP3以n6 -甲基腺苷(m6A)依赖的方式参与SAE1的上调。最终，在HCC中开发并验证了sae1相关风险评分(SRRS)。SRRS可作为独立的预后因素，预测HCC患者经动脉化疗栓塞的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Open medicine (Warsaw, Poland)

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