Open medicine (Warsaw, Poland)最新文献_第5页

Paraganglioma-induced inverted takotsubo-like cardiomyopathy leading to cardiogenic shock successfully treated with extracorporeal membrane oxygenation. 体外膜氧合成功治疗副神经节瘤诱导的倒立takotsubo样心肌病导致心源性休克。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-08-10 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0535

Fang-Fang Zhou, Jia-Sheng Ding, Min Zhang, Xin Tian

{"title":"Paraganglioma-induced inverted takotsubo-like cardiomyopathy leading to cardiogenic shock successfully treated with extracorporeal membrane oxygenation.","authors":"Fang-Fang Zhou, Jia-Sheng Ding, Min Zhang, Xin Tian","doi":"10.1515/med-2022-0535","DOIUrl":"https://doi.org/10.1515/med-2022-0535","url":null,"abstract":"Paragangliomas are rare neuroendocrine tumors that originate in the chromaffin cells of the adrenal medulla or lymph nodes. Paragangliomas manifest in rare cases as catecholamine crisis, leading to heart failure, intracranial hemorrhage, renal failure, arrhythmias, pulmonary edema, or multisystem failure. Takotsubo cardiomyopathy is also called apical ballooning syndrome or stress cardiomyopathy. Left ventricular dysfunction with apical hyperkinesis and basilar and midventricular akinesis in the absence of coronary artery disease is highly suggestive of a variant of stress cardiomyopathy (inverted takotsubo cardiomyopathy). Herein, we report the case of a 69-year-old man with an unknown retroperitoneal paraganglioma who suffered from cardiogenic shock due to inverted takotsubo cardiomyopathy. He was treated with venoarterial extracorporeal membrane pulmonary oxygenation (ECMO) in combination with an intra-aortic balloon pump. After the restoration of cardiac function, a successful transition to curative retroperitoneal paraganglioma resection was performed. We conclude that ECMO is a valuable option for undiagnosed endocrine emergencies, helping to restore cardiac function and allowing sufficient time for further accurate diagnosis and specific treatment.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1368-1375"},"PeriodicalIF":2.1,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40334686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Correlation of cardiac troponin T and APACHE III score with all-cause in-hospital mortality in critically ill patients with acute pulmonary embolism. 急性肺栓塞危重患者心肌肌钙蛋白T和APACHEⅲ评分与全因住院死亡率的相关性

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-08-01 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0534

Hongxia Wang, Yang Ji, Keke Zhang, Guangqiang Shao

{"title":"Correlation of cardiac troponin T and APACHE III score with all-cause in-hospital mortality in critically ill patients with acute pulmonary embolism.","authors":"Hongxia Wang, Yang Ji, Keke Zhang, Guangqiang Shao","doi":"10.1515/med-2022-0534","DOIUrl":"https://doi.org/10.1515/med-2022-0534","url":null,"abstract":"Pulmonary embolism (PE) is a fatal condition particularly in critically ill patients. We determined the association among the cardiac troponin T (cTnT) level, acute physiologic and chronic health evaluation (APACHE III) scoring system, and in-hospital mortality in critically ill patients with acute PE. A total of 501 patients with PE were initially enrolled. According to the multivariable logistic regression model for in-hospital mortality, the odds ratio of the cTnT level and APACHE III score was 1.96 (95% confidence interval [CI] = 1.18-3.24, P = 0.008) and 1.03 (95% CI = 1.02-1.05, P < 0.001), respectively. The area under the curve (AUC) of cTnT and APACHE III score for in-hospital mortality was 0.630 (95% CI = 0.586-0.672, P = 0.03) and 0.740 (95% CI = 0.699-0.778, P = 0.02), respectively. The discriminatory cTnT and APACHE III threshold values for in-hospital mortality were 0.08 ng/L and 38 score, respectively; the sensitivities and specificities of cTnT were 46.48 and 83.10%, respectively, whereas those of the APACHE III score were 74.88 and 54.19%, respectively. The cTnT and APACHE III scores were combined in the logistic analysis model, and a regression equation was derived to calculate the in-hospital mortality. The AUC was found to increase to 0.788 (95% CI = 0.734-0.840, P = 0.025). The sensitivity and specificity increased to 84.5 and 71.4%, respectively. The cTnT and APACHE III scores exhibited a significant association with in-hospital mortality of critically ill patients with PE. In conclusion, these parameters in combination can significantly improve the in-hospital mortality prediction.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1350-1356"},"PeriodicalIF":2.1,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40702578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

lncRNA WT1-AS attenuates hypoxia/ischemia-induced neuronal injury during cerebral ischemic stroke via miR-186-5p/XIAP axis. lncRNA WT1-AS通过miR-186-5p/XIAP轴减弱缺氧/缺血引起的脑卒中神经元损伤。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-07-25 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0528

Jianquan You, Fei Qian, Yu Huang, Yingxuan Guo, Yaqian Lv, Yuqi Yang, Xiupan Lu, Ting Guo, Jun Wang, Bin Gu

{"title":"lncRNA WT1-AS attenuates hypoxia/ischemia-induced neuronal injury during cerebral ischemic stroke via miR-186-5p/XIAP axis.","authors":"Jianquan You, Fei Qian, Yu Huang, Yingxuan Guo, Yaqian Lv, Yuqi Yang, Xiupan Lu, Ting Guo, Jun Wang, Bin Gu","doi":"10.1515/med-2022-0528","DOIUrl":"https://doi.org/10.1515/med-2022-0528","url":null,"abstract":"This study aimed to investigate the role and mechanism of long non-coding RNA (lncRNA) WT1 antisense RNA (WT1-AS) in cerebral ischemic stroke. The Starbase database and dual-luciferase reporter gene assay were used to analyze the interaction between lncRNA WT1 antisense RNA (lncRNA WT1-AS) and microRNA-186-5p (miR-186-5p). Reverse transcription-quantitative PCR analysis was performed to determine lncRNA WT1-AS and miR-186-5p levels. An oxygen glucose deprivation (OGD)-induced SH-SY5Y cell injury model was established. Cell viability and apoptosis were determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide and flow cytometric assays, respectively. Caspase 3 activity was evaluated using a caspase 3 activity detection kit. The results showed that miR-186-5p is a direct target of the lncRNA WT1-AS. In addition, lncRNA WT1-AS levels were downregulated and miR-186-5p levels were upregulated in the blood samples of patients with ischemic stroke and OGD-induced SH-SY5Y cells. WT1-AS overexpression promoted OGD-induced cell viability and reduced the cell apoptosis and caspase 3 activity. However, these effects were reversed by miR-186-5p overexpression. Furthermore, the results demonstrated that the X-linked inhibitor of apoptosis (XIAP) was directly targeted by miR-186-5p. Similarly, transfection with the miR-186-5p inhibitor reduced OGD-induced neuronal damage by upregulating XIAP expression. In conclusion, lncRNA WT1-AS attenuates hypoxia/ischemia-induced neuronal injury in cerebral ischemic stroke through the miR-186-5p/XIAP axis.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1338-1349"},"PeriodicalIF":2.1,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40608183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Relationship between the height of fibular head and the incidence and severity of knee osteoarthritis. 腓骨头高度与膝骨关节炎发病率及严重程度的关系。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-07-22 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0523

Xinghui Xu, Jin Yang, Jun Li, Deping Yao, Pan Deng, Boliang Chen, Yifei Liu

{"title":"Relationship between the height of fibular head and the incidence and severity of knee osteoarthritis.","authors":"Xinghui Xu, Jin Yang, Jun Li, Deping Yao, Pan Deng, Boliang Chen, Yifei Liu","doi":"10.1515/med-2022-0523","DOIUrl":"https://doi.org/10.1515/med-2022-0523","url":null,"abstract":"The purpose of this study was to investigate the correlation between fibular head height and the incidence and severity of osteoarthritis associated with varus knee deformity. The fibular head height, joint line convergence angle (JLCA) and medial proximal tibial angle (MPTA) were measured in a three-dimensional model. Ordinal multivariate logistic regression was used to analyze the correlation between fibular head height and Kellgren-Lawrence (K-L) grade. Pearson correlation was used to analyze the correlation between fibular head height and K-L grade. A total of 232 patients (232 knees) were finally included in the study. There were significant differences in JLCA and hip-knee-ankle angle (P < 0.05), and both JLCA and hip-knee-ankle angle increased with severe aggravation of K-L grade. Both fibular head height and MPTA decreased as the K-L grade was severely aggravated. There was a significant negative correlation between K-L grade and fibular head height (r = -0.812, P < 0.001). Furthermore, there was a significant negative correlation between fibular head height and hip-knee-ankle angle (r = -0.7905, P < 0.001). In addition to body mass index, fibular head height is a risk factor for the pathogenesis of osteoarthritis associated with varus knee deformity; the smaller the fibular head height, the more severe the degree of varus deformity.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1330-1337"},"PeriodicalIF":2.1,"publicationDate":"2022-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40608149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vivo knee kinematics of an innovative prosthesis design. 一种创新假体设计的体内膝关节运动学。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-07-20 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0518

Michael Worlicek, Jens Schaumburger, Robert Springorum, Guenther Maderbacher, Florian Zeman, Joachim Grifka, Clemens Baier

{"title":"In vivo knee kinematics of an innovative prosthesis design.","authors":"Michael Worlicek, Jens Schaumburger, Robert Springorum, Guenther Maderbacher, Florian Zeman, Joachim Grifka, Clemens Baier","doi":"10.1515/med-2022-0518","DOIUrl":"https://doi.org/10.1515/med-2022-0518","url":null,"abstract":"Up to 20% of patients after total knee arthroplasty (TKA) are not satisfied with the result. Several designs of new implants try to rebuild natural knee kinematics. We hypothesized that an innovative implant design leads to better results concerning femoral rollback compared to an established implant design. For this pilot study, 21 patients were examined during TKA, receiving either an innovative (ATTUNETM Knee System (DePuy Inc.), n = 10) or an established (PFCTM (DePuy Inc.), n = 11) knee system. All patients underwent computer navigation. Knee kinematics was assessed after implantation. Outcome measure was anterior-posterior translation between femur and tibia. We were able to demonstrate a significantly higher femoral rollback in the innovative implant group (p < 0.001). The mean rollback of the innovative system was 11.00 mm (95%-confidence interval [CI], 10.77-11.24), of the established system 8.12 mm (95%-CI, 7.84-8.42). This study revealed a significantly increased lateral as well as medial femoral rollback of knees with the innovative prosthesis design. Our intraoperative finding needs to be confirmed using fluoroscopic or radiographic three-dimensional matching under full-weight-bearing conditions after complete recovery from surgery.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1318-1324"},"PeriodicalIF":2.1,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40608147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concurrent aspergillosis and cystic pulmonary metastases in a patient with tongue squamous cell carcinoma. 舌鳞癌并发曲霉病和囊性肺转移1例。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-07-20 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0527

Hung-Chieh Su, Che-Chi Liao, Chieh-Lung Chen, Wei Chih Liao, Wen-Chien Cheng

{"title":"Concurrent aspergillosis and cystic pulmonary metastases in a patient with tongue squamous cell carcinoma.","authors":"Hung-Chieh Su, Che-Chi Liao, Chieh-Lung Chen, Wei Chih Liao, Wen-Chien Cheng","doi":"10.1515/med-2022-0527","DOIUrl":"https://doi.org/10.1515/med-2022-0527","url":null,"abstract":"Pulmonary Aspergillus infection may have a variety of manifestations depending on the patients' immunity status and pre-existing lung conditions. Radiographically, aspergilloma, which is usually associated with noninvasive Aspergillus fumigatus conidia, may feature a characteristic mass in a cavity commonly located in the upper lobes of the lung. It is typically encountered upon pre-existing lung damage. Here we report Aspergillus growing in a pulmonary metastatic cavity in a 47-year-old male worker with a history of tongue cancer after a radical operation with neck dissection and concurrent chemotherapy in 2014. Chest radiography and computed tomography showed a cavitary lesion with a ball-in-hole lesion in the right upper lobe (RUL) and two cystic lesions within the bilateral upper lung field. Endobronchial ultrasound-guided transbronchial biopsy (EBUS-TBB) from the RUL anterior segmental bronchus (RB3) revealed the presence of Aspergillus conidia and squamous cell carcinoma. Wedge resection of the cystic lesion within the left upper lobe confirmed the diagnosis of metastatic squamous cell carcinoma. This is a rare case of aspergillosis within cavities of pulmonary metastases in a patient who was diagnosed with tongue squamous cell carcinoma. The conclusive distinction between neoplasm and fungal infection is difficult to achieve by radiography, and a pathological biopsy by EBUS-TBB is necessary to aid diagnosis. Clinicians should be aware of such an atypical presentation of metastases coexisting with Aspergillus infection.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1325-1329"},"PeriodicalIF":2.1,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40608150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effect of ghrelin on intestinal I/R injury in rats. 胃饥饿素对大鼠肠I/R损伤的保护作用。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-07-20 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0520

Meng Jiang, Shengxia Wan, Xiaoyong Dai, Youwen Ye, Wei Hua, Guoguang Ma, Xiufeng Pang, Huanhuan Wang, Bin Shi

{"title":"Protective effect of ghrelin on intestinal I/R injury in rats.","authors":"Meng Jiang, Shengxia Wan, Xiaoyong Dai, Youwen Ye, Wei Hua, Guoguang Ma, Xiufeng Pang, Huanhuan Wang, Bin Shi","doi":"10.1515/med-2022-0520","DOIUrl":"https://doi.org/10.1515/med-2022-0520","url":null,"abstract":"This study aimed to investigate whether ghrelin affected the autophagy and inflammatory response of intestinal intraepithelial lymphocytes (IELs) by regulating the NOD2/Beclin-1 pathway in an intestinal ischemia-reperfusion (I/R) injury model. Twenty hours after implementing the intestinal I/R injury rat model, the small intestine and both lungs were collected for histological analysis. The morphological changes in the intestinal mucosa epithelium and lung tissues were evaluated using hematoxylin-eosin staining. The activity of autophagic vacuoles and organ injury were evaluated using electron microscopy. The cytokine levels (IL-10 and TNF-α) in IEL cells and lung tissue were determined using enzyme-linked immunosorbent assay. RT-qPCR and western blot assays were conducted to check the NOD2, Beclin-1, and ATG16 levels. Ghrelin relieved the I/R-induced destruction of the intestinal mucosa epithelium and lung tissues. Moreover, ghrelin enhanced autophagy in the intestinal epithelium and lungs of I/R rats. In addition, the levels of autophagy-associated proteins (Beclin-1, ATG16, and NOD2) were higher in the ghrelin treatment group than in rats with I/R. Ghrelin reduced significantly the IL-10 and TNF-α levels. However, these changes were reversed by the NOD2 antagonist. In conclusion, ghrelin may relieve I/R-induced acute intestinal mucosal damage, autophagy disorder, and inflammatory response in IELs by regulating the NOD2/Beclin-1 pathway.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1308-1317"},"PeriodicalIF":2.1,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40608148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

lncRNA HAGLR modulates myocardial ischemia-reperfusion injury in mice through regulating miR-133a-3p/MAPK1 axis. lncRNA HAGLR通过调控miR-133a-3p/MAPK1轴调控小鼠心肌缺血-再灌注损伤。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-07-19 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0519

Zi Wang, Wenqi Luo, Peng Zhong, Yifan Feng, Huaibin Wang

引用次数: 3

Does the use of 3D-printed cones give a chance to postpone the use of megaprostheses in patients with large bone defects in the knee joint? 3d打印锥体的使用是否有机会推迟膝关节大骨缺损患者使用大型假体?

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-07-15 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0494

Daniel Kotrych, Sławomir Marcinkowski, Adam Brodecki, Marcin Anuszkiewicz, Jakub Kleszowski, Andrzej Bohatyrewicz, Dawid Ciechanowicz

{"title":"Does the use of 3D-printed cones give a chance to postpone the use of megaprostheses in patients with large bone defects in the knee joint?","authors":"Daniel Kotrych, Sławomir Marcinkowski, Adam Brodecki, Marcin Anuszkiewicz, Jakub Kleszowski, Andrzej Bohatyrewicz, Dawid Ciechanowicz","doi":"10.1515/med-2022-0494","DOIUrl":"https://doi.org/10.1515/med-2022-0494","url":null,"abstract":"Revision procedures and the resulting bone loss are a big challenge for orthopedic surgeons. Therefore, we checked what functional outcomes that 3D-printed cone augments can offer to patients with bone defects (Anderson Orthopedic Research Institute [AORI] classification type 2B and 3) in the knee and whether the use of cones can delay the necessity to use a megaprotheses. Data from 64 patients (M = 22; W = 42) who underwent total knee arthroplasty (TKA) revision were included in the analysis. The Knee Society Clinical Rating System (KSS) and the range of motion in the knee joint were used for the functional assessment. The mean follow-up was 28 months (range: 18-44 months). The survival rate for aseptic loosening at follow-up was 100%. Infection occurred in two (3.1%) patients. The mean KSS score increased from 12.75 points preoperatively to 66.56 postoperatively (p < 0.001). The mean range of motion in the knee changed from 61.15° preoperatively to 115.93° postoperatively (p < 0.001). 3D-printed cone augments seem to be a good solution for patients requiring a TKA revision procedure. When used in patients with bone defects classified as 2B and 3 (AORI), they can be a good alternative, delaying the need for megaprotheses.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1292-1298"},"PeriodicalIF":2.1,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40556120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

LINC00665/miRNAs axis-mediated collagen type XI alpha 1 correlates with immune infiltration and malignant phenotypes in lung adenocarcinoma.

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-07-13 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0478

Jun Zhu, Yuan Weng, Fudong Wang, Jun Zhao

{"title":"LINC00665/miRNAs axis-mediated collagen type XI alpha 1 correlates with immune infiltration and malignant phenotypes in lung adenocarcinoma.","authors":"Jun Zhu, Yuan Weng, Fudong Wang, Jun Zhao","doi":"10.1515/med-2022-0478","DOIUrl":"https://doi.org/10.1515/med-2022-0478","url":null,"abstract":"Collagen type XI alpha 1 (COL11A1) as an oncogene has been reported in several malignant tumors. Herein, we aimed to explore the function of COL11A1 and its upstream regulators in lung adenocarcinoma (LUAD). COL11A1 expression prognostic significance, gene ontology, Kyoto Encyclopedia of Genes and Genomes, and immune infiltration were explored in LUAD. In vitro experimental measurements were implemented to validate the function of COL11A1 and LINC00665 in LUAD cells. Our study demonstrated that LINC00665-2 and COL11A1 were significantly upregulated in LUAD tissues compared with nontumor tissues. COL11A1 was positively correlated with multiple immune cell enrichment, suggesting that COL11A1 may be a prospective therapeutic target to enhance the efficacy of immunotherapy in LUAD. A regulatory mechanism LINC00665-2/microRNAs (miRNAs)/COL11A1 axis was identified to facilitate the tumorigenesis of LUAD. si-LINC00665 transfection induced the inhibition of growth and migration, and apoptosis was reversed by the overexpression of COL11A1 in LUAD cells. In conclusion, LINC00665 as a competing endogenous RNA sponging multiple miRNAs to modulate COL11A1 expression in LUAD, suggesting that LINC00665/miRNAs/COL11A1 axis may contribute to the pathogenesis of LUAD.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1259-1274"},"PeriodicalIF":2.1,"publicationDate":"2022-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40646490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0