Open medicine (Warsaw, Poland)最新文献_第4页

Association of gallstone and polymorphisms of UGT1A1*27 and UGT1A1*28 in patients with hepatitis B virus-related liver failure. 乙型肝炎病毒相关性肝衰竭患者UGT1A1*27和UGT1A1*28基因多态性与胆结石的关系

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-09-06 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0549

Haiyan Zhuo, Jinhai Fan, Bifeng Zhang, Yixian Shi, Liqing Zheng, Yihong Chai, Lvfeng Yao

{"title":"Association of gallstone and polymorphisms of UGT1A1*27 and UGT1A1*28 in patients with hepatitis B virus-related liver failure.","authors":"Haiyan Zhuo, Jinhai Fan, Bifeng Zhang, Yixian Shi, Liqing Zheng, Yihong Chai, Lvfeng Yao","doi":"10.1515/med-2022-0549","DOIUrl":"https://doi.org/10.1515/med-2022-0549","url":null,"abstract":"Genetic variation in UDP-glucuronosyltransferase 1A1 gene (UGT1A1) is a lithogenic risk factor for gallstone formation. This study aimed to assess genotype and allele frequencies of common UGT1A1 variants in patients with gallstone and hepatitis B virus (HBV)-related hepatic failure. This study enrolled 113 healthy individuals (CTRL), 54 patients with HBV infection (HBV), 134 patients with gallstone-free hepatic failure and HBV infection, and 34 patients with gallstone-related hepatic failure and HBV infection (GRHF). Peripheral venous blood samples were collected for genomic DNA isolation. Polymerase chain reaction amplification was carried out for UGT1A1, followed by direct sequencing. Analysis for genotype and allele frequencies of UGT1A1 variants (UGT1A1*6, UGT1A1*27, UGT1A1*28, and UGT1A1*60) was performed. The allele distributions of the four groups did not deviate from Hardy-Weinberg equilibrium. Allele (A) and genotype (CA) frequency distributions of UGT1A1*27 were significantly different between GRHF and CTRL, or between GRHF and HBV. GRHF and CTRL exhibited significant differences in allele (A) and genotype (CA) frequency distributions of UGT1A1*28. Linkage disequilibrium analysis suggested that haplotype G-G-[TA]7-T may be associated with gallstone in HBV-related hepatic failure. Our data reveal that UGT1A1*27 and UGT1A1*28 variants are significantly observed in patients with GRHF compared to healthy individuals.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1455-1465"},"PeriodicalIF":2.1,"publicationDate":"2022-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40373417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment and outcomes of mechanical complications of acute myocardial infarction during the Covid-19 era: A comparison with the pre-Covid-19 period. A systematic review and meta-analysis. 新型冠状病毒肺炎时期急性心肌梗死机械并发症的治疗及转归:与前期比较系统回顾和荟萃分析。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-09-06 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0545

Cristiano Spadaccio, Angelo Pisani, Antonio Salsano, Antonio Nenna, Alexander Fardman, David D'Alessandro, Francesco Santini, Mario F L Gaudino, Thoralf M Sundt, David Rose

{"title":"Treatment and outcomes of mechanical complications of acute myocardial infarction during the Covid-19 era: A comparison with the pre-Covid-19 period. A systematic review and meta-analysis.","authors":"Cristiano Spadaccio, Angelo Pisani, Antonio Salsano, Antonio Nenna, Alexander Fardman, David D'Alessandro, Francesco Santini, Mario F L Gaudino, Thoralf M Sundt, David Rose","doi":"10.1515/med-2022-0545","DOIUrl":"https://doi.org/10.1515/med-2022-0545","url":null,"abstract":"This study aims to compare treatments and outcomes of mechanical complications of acute myocardial infarction (MI) during the Covid-19 and in the pre-Covid-19 era. Electronic databases have been searched for MI mechanical complications during the Covid-19 era and in the previous period from January 1998 to January 2020 (pre-Covid-19 era), until October 2021. To perform a quantitative analysis of non-comparative series, a meta-analysis of proportion has been conducted. Early mortality after surgical treatment was 15.0% while it was significantly higher after conservative treatment (62.4%) (P = 0.026). Early mortality after surgical treatment was seemingly higher in the pre-Covid-19 era but the difference did not reach statistical significance (15.0% vs 38.9%; P = 0.13). Mortality in patients treated conservatively, or turned down for surgery, was lower during the Covid-19 pandemic (62.4% vs 97.7%; P = 0.001). The crude mean prevalence of the use rate of conservative or surgical treatment across the studies during Covid-19 and in the pre-Covid-19 era was comparable. The current increased incidence of MI mechanical complications might be a consequence of delayed presentation or restricted access to hospital facilities. Despite the general negative impact of Covid-19 on cardiac surgery volumes and outcomes and the apparent increase of the incidence of MI complications, the outcomes of their surgical and clinical treatment seem not to have been affected during the pandemic.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1412-1416"},"PeriodicalIF":2.1,"publicationDate":"2022-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40373414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Visfatin is negatively associated with coronary artery lesions in subjects with impaired fasting glucose. 在空腹血糖受损的受试者中，Visfatin与冠状动脉病变呈负相关。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-09-05 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0540

Fei Xu, Xiang Ning, Tong Zhao, Qinghua Lu, Huiqiang Chen

{"title":"Visfatin is negatively associated with coronary artery lesions in subjects with impaired fasting glucose.","authors":"Fei Xu, Xiang Ning, Tong Zhao, Qinghua Lu, Huiqiang Chen","doi":"10.1515/med-2022-0540","DOIUrl":"https://doi.org/10.1515/med-2022-0540","url":null,"abstract":"It is not determined whether serum visfatin levels are related to the presence and severity of coronary artery disease (CAD) in non-diabetic subjects. In this study, a total of 65 consecutive non-diabetic participants who underwent coronary angiography were enrolled. Serum visfatin and fasting glucose, as well as the serum total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride, were measured in all participants before the procedure. The extent of coronary artery lesions was determined by Gensini score. Serum visfatin levels were significantly lower in patients with CAD compared to participants with normal coronary arteries. Inversely, the circulating levels of fasting glucose were found to be elevated in patients with CAD compared with the control subjects. Multivariable logistic regression analysis demonstrated that visfatin and impaired fasting glucose (IFG) were independently associated with the presence of CAD in non-diabetics. No significant relationship was found between serum visfatin and fasting glucose levels in IFG subjects. However, there was a negative association between visfatin concentrations and Gensini score in participants with IFG. Both circulating visfatin concentrations and IFG are independently associated with CAD in non-diabetics. Serum visfatin levels are negatively related to the angiographic severity of CAD in subjects with IFG.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1405-1411"},"PeriodicalIF":2.1,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40373416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Mean corpuscular hemoglobin predicts the length of hospital stay independent of severity classification in patients with acute pancreatitis. 平均红细胞血红蛋白预测急性胰腺炎患者的住院时间，与严重程度分级无关。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-09-05 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0559

Hao Lin, Ting Yu, Rong Xu, Xing Li

{"title":"Mean corpuscular hemoglobin predicts the length of hospital stay independent of severity classification in patients with acute pancreatitis.","authors":"Hao Lin, Ting Yu, Rong Xu, Xing Li","doi":"10.1515/med-2022-0559","DOIUrl":"https://doi.org/10.1515/med-2022-0559","url":null,"abstract":"Mean corpuscular hemoglobin (MCH) is a common blood routine test index. To explore the relationship between MCH and length of hospital stay in patients with acute pancreatitis (AP), we included 273 patients with AP without coronary heart disease, diabetes, hypertension and anemia in this study. All data were separated into three groups according to the length of hospital stay. Gender (p = 0.017) and severity classification (p < 0.001) were significantly correlated with length of hospital stay among three groups. Notably, MCH level was significant different among three groups (p = 0.009). Thus, all data were separated into two groups according to MCH level, and significant increases in the length of hospital stay were observed between two groups (p = 0.030). A positive correlation between length of hospital stay and MCH was observed (r = 0.172, p = 0.004). Multiple linear regression analysis showed that MCH was independent correlated with the length of hospital stay, no matter whether severity classification of AP was included (beta = 0.248, p < 0.001; beta = 0.212, p < 0.001). Our results demonstrated that the length of hospital stay was correlated with MCH level in patients with AP, and MCH level at admission may predict the length of hospital stay independent of severity classification in AP. These results may provide a potential evaluation basis for the management of patients with AP.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1449-1454"},"PeriodicalIF":2.1,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40373415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Oncogenic role of TWF2 in human tumors: A pan-cancer analysis. TWF2在人类肿瘤中的致癌作用:一项泛癌症分析。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-09-05 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0547

Wenjie Liu, Gengwei Huo, Peng Chen

引用次数: 1

Neonatal stroke surveillance study protocol in the United Kingdom and Republic of Ireland. 英国和爱尔兰共和国新生儿卒中监测研究方案。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-09-05 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0554

T'ng Chang Kwok, Robert A Dineen, William Whitehouse, Richard M Lynn, Niamh McSweeney, Don Sharkey

{"title":"Neonatal stroke surveillance study protocol in the United Kingdom and Republic of Ireland.","authors":"T'ng Chang Kwok, Robert A Dineen, William Whitehouse, Richard M Lynn, Niamh McSweeney, Don Sharkey","doi":"10.1515/med-2022-0554","DOIUrl":"https://doi.org/10.1515/med-2022-0554","url":null,"abstract":"Neonatal stroke is a devastating condition that causes brain injury in babies and often leads to lifelong neurological impairment. Recent prospective population studies of neonatal stroke are lacking. Neonatal strokes are different from those in older children and adults. A better understanding of its aetiology, current management, and outcomes could reduce the burden of this rare condition. The study aims to explore the incidence and 2 year outcomes of neonatal stroke across an entire population in the UK and Republic of Ireland. This is an active national surveillance study using a purpose-built integrated case notification-data collection online platform. Over a 13 month period, with a potential 6 month extension, clinicians will notify neonatal stroke cases presenting in the first 90 days of life electronically via the online platform monthly. Clinicians will complete a primary questionnaire via the platform detailing clinical information, including neuroimaging, for analysis and classification. An outcome questionnaire will be sent at 2 years of age via the platform. Appropriate ethics and regulatory approvals have been received. The neonatal stroke study represents the first multinational population surveillance study delivered via a purpose-built integrated case notification-data collection online platform and data safe haven, overcoming the challenges of setting up the study.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1417-1424"},"PeriodicalIF":2.1,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40374346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Usefulness of close surveillance for rectal cancer patients after neoadjuvant chemoradiotherapy. 直肠癌患者新辅助放化疗后密切监测的意义。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-09-05 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0555

Yu-Jen Hsu, Yih-Jong Chern, I-Li Lai, Sum-Fu Chiang, Chun-Kai Liao, Wen-Sy Tsai, Hsin-Yuan Hung, Pao-Shiu Hsieh, Chien-Yuh Yeh, Jy-Ming Chiang, Yen-Lin Yu, Jeng-Fu You

{"title":"Usefulness of close surveillance for rectal cancer patients after neoadjuvant chemoradiotherapy.","authors":"Yu-Jen Hsu, Yih-Jong Chern, I-Li Lai, Sum-Fu Chiang, Chun-Kai Liao, Wen-Sy Tsai, Hsin-Yuan Hung, Pao-Shiu Hsieh, Chien-Yuh Yeh, Jy-Ming Chiang, Yen-Lin Yu, Jeng-Fu You","doi":"10.1515/med-2022-0555","DOIUrl":"https://doi.org/10.1515/med-2022-0555","url":null,"abstract":"It is controversial whether patients who achieve clinical complete remission (cCR) of rectal cancer should be treated with the \"watch and wait\" (W&W) or radical resection (RR) strategy. Our study aimed to compare the survival outcomes and ostomy rate of the W&W and RR strategies. Between January 2008 and December 2015, we investigated 26 patients who achieved pathologic complete remission after undergoing RR and 36 patients who adopted the W&W strategy because of cCR. The tumor regrowth, salvage surgery, recurrence, disease-free, and overall survival (OS) rates were assessed. In our study, recurrences occurred in nine and two patients from the W&W and RR groups, respectively. Each patient in the RR group had a temporary or permanent ostomy, but only three (8.3%) had an ostomy in the W&W group. The 5-year recurrence rate was 25.0% in the W&W group and 7.7% in the RR group. Six patients (16.7%) had tumor regrowth in the W&W group, and all were resectable when regrowth. The 5-year OS rates between the two groups were nonsignificant. There is no specific risk factor for recurrence and OS. Under close surveillance, the W&W group achieved similar OS to the RR group and benefited from a lower ostomy rate.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1438-1448"},"PeriodicalIF":2.1,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40374347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

SELENBP1 inhibits progression of colorectal cancer by suppressing epithelial-mesenchymal transition. SELENBP1通过抑制上皮-间质转化抑制结直肠癌的进展。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-09-01 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0532

Xiaotian Zhang, Runqi Hong, Lanxin Bei, Zhiqing Hu, Ximin Yang, Tao Song, Liang Chen, He Meng, Gengming Niu, Chongwei Ke

{"title":"SELENBP1 inhibits progression of colorectal cancer by suppressing epithelial-mesenchymal transition.","authors":"Xiaotian Zhang, Runqi Hong, Lanxin Bei, Zhiqing Hu, Ximin Yang, Tao Song, Liang Chen, He Meng, Gengming Niu, Chongwei Ke","doi":"10.1515/med-2022-0532","DOIUrl":"https://doi.org/10.1515/med-2022-0532","url":null,"abstract":"Selenium-binding protein 1 (SELENBP1) is frequently dysregulated in various malignancies including colorectal cancer (CRC); however, its roles in progression of CRCs and the underlying mechanism remain to be elucidated. In this study, we compared the expression of SELENBP1 between CRCs and colorectal normal tissues (NTs), as well as between primary and metastatic CRCs; we determined the association between SELENBP1 expression and CRC patient prognoses; we conducted both in vitro and in vivo experiments to explore the functional roles of SELENBP1 in CRC progression; and we characterized the potential underlying mechanisms associated with SELENBP1 activities. We found that the expression of SELENBP1 was significantly and consistently decreased in CRCs than that in adjacent NTs, while significantly and frequently decreased in metastatic than primary CRCs. High expression of SELENBP1 was an independent predictor of favorable prognoses in CRC patients. Overexpression of SELENBP1 suppressed, while silencing of SELENBP1 promoted cell proliferation, migration and invasion, and in vivo tumorigenesis of CRC. Mechanically, SELENBP1 may suppress CRC progression by inhibiting the epithelial-mesenchymal transition.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1390-1404"},"PeriodicalIF":2.1,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9438969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40367258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Endothelial cell-specific molecule 1 (ESM1) promoted by transcription factor SPI1 acts as an oncogene to modulate the malignant phenotype of endometrial cancer. 由转录因子SPI1促进的内皮细胞特异性分子1 (Endothelial cell-specific molecule 1, ESM1)作为癌基因调控子宫内膜癌的恶性表型。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-08-26 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0529

Yu He, Lu Lin, Yurong Ou, Xiaowen Hu, Chi Xu, Caizhi Wang

{"title":"Endothelial cell-specific molecule 1 (ESM1) promoted by transcription factor SPI1 acts as an oncogene to modulate the malignant phenotype of endometrial cancer.","authors":"Yu He, Lu Lin, Yurong Ou, Xiaowen Hu, Chi Xu, Caizhi Wang","doi":"10.1515/med-2022-0529","DOIUrl":"https://doi.org/10.1515/med-2022-0529","url":null,"abstract":"We aimed to study the function and mechanism of endothelial cell-specific molecule 1 (ESM1) in endometrial cancer (EC). The binding relationship between SPI1 and ESM1 was predicted by bioinformatics analysis and verified by the dual-luciferase reporter assay. The expressions and effects of SPI1 and ESM1 were determined using quantitative real-time PCR, immunohistochemistry, Western blot, and functional experiments. ESM1 was highly expressed in EC and was associated with the poor prognosis of patients. ESM1 silencing suppressed the viability, proliferation, invasion, and angiogenesis of EC cells, down-regulated expressions of PCNA, N-cadherin, Vimentin, VEGFR-1, VEGFR2, and EGFR, but upregulated E-cadherin level, while ESM1 overexpression did oppositely. Moreover, SPI1 bound to ESM1. Overexpressed SPI1 promoted the expression of ESM1 and induced malignant phenotype (viability, proliferation, and invasion), which were countervailed by ESM1 silencing. Collectively, ESM1 induced by SPI1 promotes the malignant phenotype of EC.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1376-1389"},"PeriodicalIF":2.1,"publicationDate":"2022-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40367259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

LncRNA LINC01857 reduces metastasis and angiogenesis in breast cancer cells via regulating miR-2052/CENPQ axis. LncRNA LINC01857通过调节miR-2052/CENPQ轴减少乳腺癌细胞的转移和血管生成。

IF 2.1

Open medicine (Warsaw, Poland) Pub Date : 2022-08-10 eCollection Date: 2022-01-01 DOI: 10.1515/med-2022-0525

Weiwei Qian, Linlin Yang, Yi Ni, Fei Yin, Lili Qin, Yang Yang

{"title":"LncRNA LINC01857 reduces metastasis and angiogenesis in breast cancer cells via regulating miR-2052/CENPQ axis.","authors":"Weiwei Qian, Linlin Yang, Yi Ni, Fei Yin, Lili Qin, Yang Yang","doi":"10.1515/med-2022-0525","DOIUrl":"https://doi.org/10.1515/med-2022-0525","url":null,"abstract":"Long non-coding RNAs have been confirmed closely related to the metastasis and angiogenesis of breast cancer (BC). LINC01857 can promote the growth and metastasis of BC cells. The present work focused on exploring the role of LINC01857 in BC metastasis and angiogenesis and investigating the possible mechanisms. The results showed that LINC01857 and CENPQ were highly expressed in BC tissues and cells, while miR-2052 was contrarily expressed. In vitro study showed that low expression of linc01857 could inhibit the migration ability and vascularization of BC cells, and mir-2052 inhibitor partially restored the effect of si-LINC01857 on the migration ability and vascularization of BC cells. Likewise, inhibition of CENPQ can partially rescue the effects of miR-2052 inhibitor on the migration ability and vascularization of BC cells. In vivo studies showed that down-regulation of LINC01857 notably suppressed tumor growth and angiogenesis in nude mice. The miR-2052 inhibitor partially restored the effects of si-LINC01857. CENPQ suppression partially rescued the effects of the miR-2052 inhibitor. To conclude, LINC01857/miR-2052/CENPQ is the potential novel target for BC treatment.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"1357-1367"},"PeriodicalIF":2.1,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40334685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0