Nuclear medicine review. Central & Eastern Europe最新文献

{"title":"COVID-19 pneumonia detected by parathyroid scintigraphy.","authors":"Mehrosadat Alavi,&nbsp;Yalda Moafpourian","doi":"10.5603/NMR.a2022.0029","DOIUrl":"https://doi.org/10.5603/NMR.a2022.0029","url":null,"abstract":"<p><p>We report a case of incidental diagnosis of COVID-19 pneumonia by parathyroid scintigraphy. A 53-year-old woman who had severe fatigue, and mild dyspnea underwent parathyroid scintigraphy due to increased serum parathyroid hormone (PTH) and serum calcium levels. Parathyroid scan was negative for abnormal parathyroid tissue. Although the patient had three negative results of COVID-19 PCR tests, significant 99m Tchexakis-2-methoxyisobutylisonitrile ([99mTc]MIBI) uptake is noticed in both lungs that was suspicious for Covid-19 pneumonia. The patient underwent CT scan of the chest for further evaluation. Diffuse groundglass opacities were identified in both lungs which were interpreted as typical feature for COVID-19 pneumonia.</p>","PeriodicalId":520725,"journal":{"name":"Nuclear medicine review. Central & Eastern Europe","volume":" ","pages":"134-135"},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40603834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental detection of breast cancer by 18F-fluorocholine PET/CT performed for primary hyperparathyroidism.","authors":"Vlatka Jozanovic,&nbsp;Drazen Huic","doi":"10.5603/NMR.a2022.0013","DOIUrl":"https://doi.org/10.5603/NMR.a2022.0013","url":null,"abstract":"<p><p>We present a case report of incidental detection of breast cancer in a female patient referred for 18F-fluorocholine (FCH) positron emission tomography/computed tomography (PET/CT) due to primary hyperparathyroidism. This imaging method was recently shown as more sensitive for the detection of metabolically hyperactive parathyroid glands than neck ultrasound and (2-metoksyizobutyloizonitryl labeled with technetium-99m) [99mTc]MIBI. Increased accumulation of FCH was found in the hyperactive parathyroid gland and unexpectedly in the right breast lesion. The surgery confirmed parathyroid adenoma. One month later right upper medial quadrantectomy confirmed breast carcinoma - a combination of invasive ductal carcinoma and intracystic papillary breast carcinoma. To the best of our knowledge, this is the first reporting of simultaneous detection of parathyroid adenoma and breast cancer by using 18F-fluorocholine PET/CT.</p>","PeriodicalId":520725,"journal":{"name":"Nuclear medicine review. Central & Eastern Europe","volume":" ","pages":"66-67"},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39764937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimized method for normal range estimation of standardized uptake values (SUVmax, SUVmean) in liver SPECT/CT images with somatostatin analog [99mTc]-HYNIC-TOC (Tektrotyd).","authors":"Hanna Piwowarska-Bilska,&nbsp;Sara Kurkowska,&nbsp;Bozena Birkenfeld","doi":"10.5603/NMR.a2022.0008","DOIUrl":"https://doi.org/10.5603/NMR.a2022.0008","url":null,"abstract":"<p><strong>Background: </strong>99mTc-hydrazinonicotinyl-Tyr3-octreotide ([99mTc]-HYNIC-TOC [Tektrotyd]) is a radiopharmaceutical used for the diagnosis of lesions with overexpression of somatostatin receptors. The purpose of this study was to optimize the method and estimate normal ranges for standardized uptake values of Tektrotyd in healthy livers.</p><p><strong>Material and methods: </strong>An analysis of standardized uptake value (SUVs) normal ranges was performed for images acquired in a selected \"healthy group\" of 42 patients evaluated for neuroendocrin tumors. The \"pathological group\" comprised 20 patients with liver lesions detected by scintigraphic imaging. Normal ranges for radiopharmaceutical uptake values were estimated based on the quantitative analysis of images acquired with a GE Healthcare NM/CT 850 gamma camera.</p><p><strong>Results: </strong>The method for healthy liver segmentation in single photon emission computed tomography/computed tomography (SPECT/CT) was optimized. The normal range of SUVs for the liver was: standardized uptake value body weight (SUVbw) max [5.2-14.0] g/mL and standardized uptake value lean body mass (SUVlbm) [3.5-9.5] g/mL. The relative standard error (relative SE) of activity concentration estimated in the phantom study for the largest hot spheres was: ϕ = 37 mm - 5.9%, ϕ = 28 mm - 7.1%, ϕ = 22 mm - 11.4%, and ϕ = 17 mm - 22%.</p><p><strong>Conclusions: </strong>Segmentation in the mid-coronal computed tomography (CT) image, at one-fourth of the height of the liver measured from the top, with a medium-sized volume of interest (VOI) outlined on a given transverse SPECT slice was regarded as the optimal method for estimating normal ranges for standardized uptake values. It is necessary to standardize quantification methods in the SPECT/CT studies. Our work is a step forward in obtaining standardization of SPECT/CT SUV calculation methods. Calculations for radiopharmaceutical uptake in tumors with volumes smaller than 5 mL are biased with a significant measurement error.</p>","PeriodicalId":520725,"journal":{"name":"Nuclear medicine review. Central & Eastern Europe","volume":" ","pages":"37-46"},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39902629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitivity of [18F]FDG PET/CT and classification of the primary tumor site in patients with carcinoma of unknown primary.","authors":"Hasan Ikbal Atilgan,&nbsp;Hulya Yalcin","doi":"10.5603/NMR.a2022.0002","DOIUrl":"https://doi.org/10.5603/NMR.a2022.0002","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study is to find the sensitivity of the [18F]FDG PET/CT and the classification of the primary sites of carcinoma of unknown primary (CUP) as a single-center experience.</p><p><strong>Material and methods: </strong>Sixty-eight patients with a mean age of 62.43 ± 12.78 years were included in this study retrospectively. Sixty-five patients had biopsy or surgery after PET/CT, which revealed pathological diagnoses of malign primary tumors, while primary tumor site could not be detected in three patients with histopathological examination. We evaluated the primary site of CUP with [18F]FDG PET/CT.</p><p><strong>Results: </strong>Primary sites of three patients were not determined by histopathological examination. Malign lesions indicating the primary site of tumor were identified in 52 of 68 patients with PET/CT correctly. The primary tumor was lung cancer in 14 patients, cholangiocellular cancer in 9 patients, lymphoma in 9 patients, pancreas cancer in 6 patients, gastric cancer in 4 patients, ovary cancer in 4 patients, colon cancer in 4 patients, breast cancer in 3 patients, hepatocellular cancer in 2 patients, rectal cancer in 2 patients, sarcoma in 2 patients, esophagus, renal cell cancer, squamous cell cancer, endometrium cancer, malign melanoma, and multiple myeloma in 1 patient with histopathological examination. PET/CT was false positive in one patient. There were 13 patients in whom primary tumor could not be localized by PET/CT, but was diagnosed by histopathological evaluation.</p><p><strong>Conclusions: </strong>PET/CT should be the first-line diagnostic tool for CUP, other diagnostic imaging tools should be applied after a negative whole-body PET/CT.</p>","PeriodicalId":520725,"journal":{"name":"Nuclear medicine review. Central & Eastern Europe","volume":" ","pages":"1-5"},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39902623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitivity and specificity of nuclear medicines (DTPA and DMSA) with magnetic resonance imaging in diagnosing bone metastasis.","authors":"Shoaa G Shetewi,&nbsp;Jaber Alyami,&nbsp;Bander S Al Mutairi,&nbsp;Saeed M Bafaraj","doi":"10.5603/NMR.a2022.0019","DOIUrl":"https://doi.org/10.5603/NMR.a2022.0019","url":null,"abstract":"<p><strong>Background: </strong>The frequency of bone metastases in individuals increases at advanced stages of cancer, mostly in patients suffering from lung, breast, or prostate cancer. The study aims to evaluate the effectiveness of bone metastases diagnosis of nuclear medicine, CT scan, and MRI in detecting bone metastases among patients with lung, breast, and prostate carcinoma.</p><p><strong>Material and methods: </strong>Retrospective study design was adopted for the analysis of 120 recruited patients (with the presence of bone metastasis) following a series of examinations and tests.</p><p><strong>Results: </strong>Better sensitivity (73.33%) and specificity (94.66%) for MRI as compared to SPECT. MRI also proved to be more sensitive (68%) and specific (95.74%), as compared to the findings of the CT scan.</p><p><strong>Conclusions: </strong>The results conclude that MRI provided favorable diagnostic performance for bone metastasis. It emphasizes that diagnosis using MRI may enable practitioners to devise optimal carcinoma treatment strategies. The healthcare practitioners need to assess the MRI findings to determine improved treatment plans.</p>","PeriodicalId":520725,"journal":{"name":"Nuclear medicine review. Central & Eastern Europe","volume":" ","pages":"85-88"},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40515964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of diffusion MRI versus [18F]FDG PET/CT in detection of cervical nodal metastases in differentiated thyroid cancer patients.","authors":"Ahmed M Shalash,&nbsp;Mai Amr Elahmadawy,&nbsp;Samia Y Heikal,&nbsp;Ayman A Amin,&nbsp;Ayda A Youssef","doi":"10.5603/NMR.a2022.0035","DOIUrl":"https://doi.org/10.5603/NMR.a2022.0035","url":null,"abstract":"<p><strong>Background: </strong>In differentiated thyroid cancer (DTC) patients, cervical nodal metastasis is a negative prognostic factor. Preoperative imaging plays an important role in treatment planning for nodal metastasis and recurrence. The aim of the study is to compare the diagnostic performance of the diffusion-weighted magnetic resonance imaging (DW-MRI) and the F-18 flurodeoxyglucose positron emission computed tomography ([18F]FDG PET/CT) in detection of cervical nodal deposits in DTC patients.</p><p><strong>Materal and methods: </strong>The study was conducted on 30 patients, each performed both modalities just before the surgery. The gold standard was the pathological specimens with post-operative clinico-radiological follow-up, to assess the diagnostic performance of each modality.</p><p><strong>Results: </strong>Based on pathological and post-operative clinico-radiological follow up data. Sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV) and accuracy were 84%, 80%, 50%, 95% and 83% for PET/CT compared to 84%, 60%, 42.8%, 91.3% and 80% for DW-MRI. On comparing the diagnostic performance of combined DW-MRI and PET/CT to each modality alone, the sensitivity and NPV were improved to 96% and 80% respectively.</p><p><strong>Conclusions: </strong>[18F]FDG PET/CT study is a valuable diagnostic modality for the assessment of cervical nodal deposits in DTC patients, surpassing DW-MRI. Combined PET/CT and DW-MRI techniques seemed to have synergistic performance, mainly in terms of sensitivity and NPV, for detection of nodal metastases.</p>","PeriodicalId":520725,"journal":{"name":"Nuclear medicine review. Central & Eastern Europe","volume":" ","pages":"112-118"},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40417923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}